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mAbs Volume 14, 2022 - Issue 1
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Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice

Peng Zhaoa Brown Foundation Institute of Molecular Medicine, Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, USAView further author information
,
Yuanzhong Xub Center for Metabolic and Degenerative Diseases, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USAView further author information
,
Xuejun Fana Brown Foundation Institute of Molecular Medicine, Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, USAView further author information
,
Leike Lia Brown Foundation Institute of Molecular Medicine, Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, USAView further author information
,
Xin Lia Brown Foundation Institute of Molecular Medicine, Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, USAView further author information
,
Hisashi Arasec Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, JapanView further author information
,
Qingchun Tongb Center for Metabolic and Degenerative Diseases, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USAView further author information
,
Ningyan Zhanga Brown Foundation Institute of Molecular Medicine, Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, USACorrespondence[email protected]
View further author information
&
Zhiqiang Ana Brown Foundation Institute of Molecular Medicine, Texas Therapeutics Institute, University of Texas Health Science Center at Houston, Houston, Texas, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9309-2335View further author information
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Article: 2107971 | Received 18 May 2022, Accepted 27 Jul 2022, Published online: 03 Aug 2022

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Izabela Lepiarz-Raba, Taufik Hidayat, Anthony J. Hannan & Ali Jawaid. (2024) Potential Alzheimer’s disease drug targets identified through microglial biology research. Expert Opinion on Drug Discovery 19:5, pages 587-602.
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Articles from other publishers (6)

Sujun Jiang, Guoen Cai, Zhimin Yang, Haoyuan Shi, Huajie Zeng, Qinyong Ye, Zhiyuan Hu & Zihua Wang. (2024) Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer’s Disease. ACS Nano 18:18, pages 11753-11768.
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Joanna Mackiewicz, Malwina Lisek & Tomasz Boczek. (2023) Targeting CaN/NFAT in Alzheimer’s brain degeneration. Frontiers in Immunology 14.
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Kai Schlepckow, Estrella Morenas-Rodríguez, Soyon Hong & Christian Haass. (2023) Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease. The Lancet Neurology 22:11, pages 1048-1060.
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Marina Passero, Tianhua Zhai & Zuyi Huang. (2023) Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer’s Disease. International Journal of Environmental Research and Public Health 20:13, pages 6217.
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Gunel Ayyubova. (2023) TREM2 signalling as a multifaceted player in brain homoeostasis and a potential target for Alzheimer's disease treatment. European Journal of Neuroscience 57:4, pages 718-733.
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Wandong Zhang. 2024. Drug Delivery and Targeting. Drug Delivery and Targeting 213 230 .

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