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mAbs Volume 15, 2023 - Issue 1
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A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

Paul Arrasa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany;b Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyView further author information
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Han Byul Yooa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany;c Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
,
Lukas Pekara Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
,
Christian Schröterd ADCs & Targeted NBE Therapeutics, Merck KGaA, Darmstadt, GermanyView further author information
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Thomas Clarkee Bioinformatics, EMD Serono, Billerica, MA, USAView further author information
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Simon Kraha Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
,
Daniel Klewinghausc Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
,
Vanessa Siegmundc Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
,
Andreas Eversa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, GermanyCorrespondence[email protected]
View further author information
&
Stefan Zielonkaa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany;b Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4649-2843View further author information
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Article: 2261149 | Received 27 May 2023, Accepted 15 Sep 2023, Published online: 27 Sep 2023

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Lukas Pekar, Simon Krah & Stefan Zielonka. (2024) Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics. Expert Opinion on Biological Therapy 24:3, pages 115-118.
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Articles from other publishers (3)

Gemma L. Gordon, Matthew I. J. Raybould, Ashley Wong & Charlotte M. Deane. (2024) Prospects for the computational humanization of antibodies and nanobodies. Frontiers in Immunology 15.
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Paul Arras, Jasmin Zimmermann, Britta Lipinski, Bernhard Valldorf, Andreas Evers, Desislava Elter, Simon Krah, Achim Doerner, Enrico Guarnera, Vanessa Siegmund, Harald Kolmar, Lukas Pekar & Stefan Zielonka. (2024) Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features. Biological Chemistry 0:0.
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Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich, Christian Schröter, Jennifer Schanz, Jason Tonillo, Vanessa Siegmund, Achim Doerner, Simon Krah, Enrico Guarnera, Stefan Zielonka & Andreas Evers. (2023) AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study. Frontiers in Molecular Biosciences 10.
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