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A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization
Paul Arrasa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany;b Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyView further author information
, Han Byul Yooa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany;c Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
, Lukas Pekara Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
, Christian Schröterd ADCs & Targeted NBE Therapeutics, Merck KGaA, Darmstadt, GermanyView further author information
, Thomas Clarkee Bioinformatics, EMD Serono, Billerica, MA, USAView further author information
, Simon Kraha Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
, Daniel Klewinghausc Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
, Vanessa Siegmundc Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, GermanyView further author information
, Andreas Eversa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, GermanyCorrespondence[email protected]
View further author information
& View further author information
Stefan Zielonkaa Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany;b Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyCorrespondence[email protected]
https://orcid.org/0000-0002-4649-2843View further author information
show allhttps://orcid.org/0000-0002-4649-2843View further author information
Article: 2261149
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Received 27 May 2023, Accepted 15 Sep 2023, Published online: 27 Sep 2023
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