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Gut Microbes Volume 7, 2016 - Issue 3: Gut Microbiota Metabolites in Health and Disease
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Research Paper/Report

The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy

Canaan M. Whitfield-CargileDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA
,
Noah D. CohenDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USACorrespondence[email protected]
,
Robert S. ChapkinDepartment of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA;Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USA
,
Brad R. WeeksDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA
,
Laurie A. DavidsonDepartment of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA
,
Jennifer S. GoldsbyDepartment of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA
,
Carrie L. HuntDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USA
,
Shelby H. SteinmeyerDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USA
,
Rani MenonDepartment of Chemical Engineering, College of Engineering, Texas A&M University, College Station, Texas, USA
,
Jan S. SuchodolskiDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA
,
Arul JayaramanDepartment of Chemical Engineering, College of Engineering, Texas A&M University, College Station, Texas, USA
&
Robert C. AlanizDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USACorrespondence[email protected]
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Pages 246-261 | Received 23 Oct 2015, Accepted 15 Feb 2016, Published online: 14 Apr 2016

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Jennifer AA DeLuca, Kimberly F Allred, Rani Menon, Rebekah Riordan, Brad R Weeks, Arul Jayaraman & Clinton D Allred. (2018) Bisphenol-A alters microbiota metabolites derived from aromatic amino acids and worsens disease activity during colitis. Experimental Biology and Medicine 243:10, pages 864-875.
Crossref
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Crossref
M. Jennis, C. R. Cavanaugh, G. C. Leo, J. R. Mabus, J. Lenhard & P. J. Hornby. (2018) Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo. Neurogastroenterology & Motility 30:2, pages e13178.
Crossref
Canaan M. Whitfield-Cargile, Noah D. Cohen, Kejun He, Ivan Ivanov, Jennifer S. Goldsby, Ana Chamoun-Emanuelli, Brad R. Weeks, Laurie A. Davidson & Robert S. Chapkin. (2017) The non-invasive exfoliated transcriptome (exfoliome) reflects the tissue-level transcriptome in a mouse model of NSAID enteropathy. Scientific Reports 7:1.
Crossref
Páraic Ó Cuív, Sriti Burman, Sian Pottenger & Mark Morrison. 2016. Microbial Metabolomics. Microbial Metabolomics 49 82 .

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