Advanced search
Publication Cover
Gut Microbes Volume 12, 2020 - Issue 1
Submit an article Journal homepage
8,586
Views
38
CrossRef citations to date
0
Altmetric
Research Paper

A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

Le Duc Huy Taa Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeView further author information
,
James Chun Yip Chanb Skin Research Institute of Singapore, A*STAR, Singapore;c Innovations in Food & Chemical Safety Programme, A*STARORCID Iconhttps://orcid.org/0000-0003-3162-8389View further author information
ORCID Icon,
Gaik Chin Yapa Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeView further author information
,
Rikky W. Purbojatid Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, SingaporeORCID Iconhttps://orcid.org/0000-0002-2790-4056View further author information
ORCID Icon,
Daniela I. Drautz-Mosesd Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, SingaporeORCID Iconhttps://orcid.org/0000-0002-3739-0917View further author information
ORCID Icon,
Yanqing Michelle Kohd Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, SingaporeView further author information
,
Carina Jing Xuan Taya Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeView further author information
,
Chiung-Hui Huanga Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeView further author information
,
Dorinda Yan Qin Kiohe Department of Pharmacy, Faculty of Science, National University of Singapore, SingaporeView further author information
,
Jia Yun Woone Department of Pharmacy, Faculty of Science, National University of Singapore, SingaporeView further author information
,
Elizabeth Huiwen Thama Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;f Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, SingaporeORCID Iconhttps://orcid.org/0000-0003-1037-6143View further author information
ORCID Icon,
Evelyn Xiu Ling Loog Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeView further author information
,
Lynette P.C. Sheka Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;f Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, SingaporeView further author information
,
Neerja Karnanig Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeView further author information
,
Anne Gohh Department of Paediatrics, KK Women’s and Children’s Hospital, SingaporeView further author information
,
Hugo P.S. Van Bevera Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;f Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, SingaporeView further author information
,
Oon Hoe Teohh Department of Paediatrics, KK Women’s and Children’s Hospital, SingaporeORCID Iconhttps://orcid.org/0000-0002-5100-1543View further author information
ORCID Icon,
Yiong Huak Chani Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeView further author information
,
Christophe Laya Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;j Danone Nutricia Research, SingaporeView further author information
,
Jan Knolk Danone Nutricia Research, Utrecht, The Netherlands;l Laboratory of Microbiology, Wageningen University, Wageningen, The NetherlandsView further author information
,
Fabian Yaph Department of Paediatrics, KK Women’s and Children’s Hospital, SingaporeView further author information
,
Kok Hian Tanh Department of Paediatrics, KK Women’s and Children’s Hospital, SingaporeView further author information
,
Yap-Seng Chongg Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore;m Department of Obstetrics & Gynaecology, National University of Singapore, SingaporeView further author information
,
Keith M. Godfreyn MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UKView further author information
,
Staffan Kjellebergd Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, SingaporeView further author information
,
Stephan C. Schusterd Singapore Centre For Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, SingaporeView further author information
,
Eric Chun Yong Chanc Innovations in Food & Chemical Safety Programme, A*STAR;e Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore;g Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeCorrespondence[email protected]
View further author information
&
Bee Wah Leea Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeCorrespondence[email protected]
View further author information
 show all
Article: 1801964 | Received 17 Apr 2020, Accepted 15 Jul 2020, Published online: 06 Oct 2020

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Min Tian, Qihui Li, Tenghui Zheng, Siwang Yang, Fang Chen, Wutai Guan & Shihai Zhang. (2023) Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation. Gut Microbes 15:1.
Read now
Min-Jung Lee, Yoon Mee Park, Byunghyun Kim, in Hwan Tae, Nam-Eun Kim, Marina Pranata, Taewon Kim, Sungho Won, Nam Joo Kang, Yun Kyung Lee, Dong-Woo Lee, Myung Hee Nam, Soo-Jong Hong & Bong-Soo Kim. (2022) Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis. Gut Microbes 14:1.
Read now
Zhifeng Fang, Tong Pan, Lingzhi Li, Hongchao Wang, Jinlin Zhu, Hao Zhang, Jianxin Zhao, Wei Chen & Wenwei Lu. (2022) Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis. Gut Microbes 14:1.
Read now
Larissa Koidl & Eva Untersmayr. (2021) The clinical implications of the microbiome in the development of allergy diseases. Expert Review of Clinical Immunology 17:2, pages 115-126.
Read now

Articles from other publishers (34)

Yun Zhou, Yun Jie Sheng, Cheng Yan Li, Li Zou, Chao Ying Tong, Yang Zhang, Gang Cao & Dan Shou. (2023) Beneficial effect and mechanism of natural resourced polysaccharides on regulating bone metabolism through intestinal flora: A review. International Journal of Biological Macromolecules 253, pages 127428.
Crossref
Man Kit Cheung, Ting Fan Leung, Wing Hung Tam, Agnes S. Y. Leung, Oi Man Chan, Rita W. Y. Ng, Jennifer W. K. Yau, Lai-yuk Yuen, Sylvia L. Y. Tong, Wendy C. S. Ho, Apple C. M. Yeung, Zigui Chen & Paul K. S. Chan. (2023) Development of the early-life gut microbiome and associations with eczema in a prospective Chinese cohort. mSystems 8:5.
Crossref
Noor H.A. Suaini, Hugo Van Bever & Elizabeth Huiwen Tham. (2023) Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts. Allergology International.
Crossref
Holly Steininger, Jacqueline Moltzau-Anderson & Susan V. Lynch. (2023) Contributions of the early-life microbiome to childhood atopy and asthma development. Seminars in Immunology 69, pages 101795.
Crossref
Laura Bonzano, Francesco Borgia, Rossella Casella, Andrea Miniello, Eustachio Nettis & Sebastiano Gangemi. (2023) Microbiota and IL-33/31 Axis Linkage: Implications and Therapeutic Perspectives in Atopic Dermatitis and Psoriasis. Biomolecules 13:7, pages 1100.
Crossref
Heidi K. Leftwich, Daniela Vargas-Robles, Mayra Rojas-Correa, Yan Rou Yap, Shakti Bhattarai, Doyle V. Ward, Gavin Fujimori, Catherine S. Forconi, Tracy Yeboah, Acara Carter, Alyssa Kastrinakis, Alison M. Asirwatham, Vanni Bucci, Ann M. Moormann & Ana Maldonado-Contreras. (2023) The microbiota of pregnant women with SARS-CoV-2 and their infants. Microbiome 11:1.
Crossref
Alexandru Cosmin Pantazi, Cristina Maria Mihai, Adriana Luminita Balasa, Tatiana Chisnoiu, Ancuta Lupu, Corina Elena Frecus, Larisia Mihai, Adina Ungureanu, Mustafa Ali Kassim Kassim, Antonio Andrusca, Maria Nicolae, Viviana Cuzic, Vasile Valeriu Lupu & Simona Claudia Cambrea. (2023) Relationship between Gut Microbiota and Allergies in Children: A Literature Review. Nutrients 15:11, pages 2529.
Crossref
Yanan Chu, Qingren Meng, Jun Yu, Juan Zhang, Jing Chen & Yu Kang. (2023) Strain-Level Dynamics Reveal Regulatory Roles in Atopic Eczema by Gut Bacterial Phages. Microbiology Spectrum 11:2.
Crossref
Trisha Rahman, Prioty F. Sarwar, Cassie Potter, Sarah S. Comstock & Vanja Klepac-Ceraj. (2023) Role of human milk oligosaccharide metabolizing bacteria in the development of atopic dermatitis/eczema. Frontiers in Pediatrics 11.
Crossref
Stefano Leo, Omer Faruk Cetiner, Laure F. Pittet, Nicole L. Messina, William Jakob, Laurent Falquet, Nigel Curtis & Petra Zimmermann. (2023) The association between the composition of the early-life intestinal microbiome and eczema in the first year of life. Frontiers in Microbiomes 2.
Crossref
Lishan Zhang, Yueping Zeng & Jinlyu Sun. (2023) Fortschritte bei der Metabolomik der atopischen Dermatitis: eine systematische Übersicht. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 21:3, pages 229-238.
Crossref
Le Duc Huy Ta, James Chun Yip Chan, Gaik Chin Yap, Chiung‐Hui Huang, Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Noor H. A. Suaini, Lynette P. Shek, Neerja Karnani, Anne Eng Neo Goh, Hugo P. S. Van Bever, Oon Hoe Teoh, Yiong Huak Chan, Christophe Lay, Jan Knol, Fabian Yap, Kok Hian Tan, Yap‐Seng Chong, Mary Foong‐Fong Chong, Shiao Yng Chan, Johan Gunnar Eriksson, Keith M. Godfrey, Eric Chun Yong Chan & Bee Wah Lee. (2022) Prenatal diet, plasma micronutrients/metabolome and inflammatory status influence the development of atopic eczema in early childhood. Allergy 78:3, pages 867-871.
Crossref
Lijuan Wang, Yihui Wang, Xi E. Wang, Bin Chen, Lei Zhang & Xixue Lu. (2022) Causal association between atopic eczema and inflammatory bowel disease: A two‐sample bidirectional Mendelian randomization study of the East Asian population . The Journal of Dermatology 50:3, pages 327-336.
Crossref
Aurélien Trompette & Niki D. Ubags. (2023) Skin barrier immunology from early life to adulthood. Mucosal Immunology.
Crossref
Lishan Zhang, Yueping Zeng & Jinlyu Sun. (2023) Progress of metabolomics in atopic dermatitis: a systematic review. JDDG: Journal der Deutschen Dermatologischen Gesellschaft.
Crossref
Xianjun Xiao, Xiaoshen Hu, Junpeng Yao, Wei Cao, Zihao Zou, Lu Wang, Haiyan Qin, Dongling Zhong, Yuxi Li, Peiwen Xue, Rongjiang Jin, Ying Li, Yunzhou Shi & Juan Li. (2023) The role of short-chain fatty acids in inflammatory skin diseases. Frontiers in Microbiology 13.
Crossref
Pernilla Lif Holgerson, Anders Esberg, Christina E. West & Ingegerd Johansson. (2022) The breast milk and childhood gastrointestinal microbiotas and disease outcomes: a longitudinal study. Pediatric Research 93:3, pages 570-578.
Crossref
Mwenya Mubanga, Cecilia Lundholm, Elin S. Rohlin, Gustaf Rejnö, Bronwyn K. Brew & Catarina Almqvist. (2023) Mode of delivery and offspring atopic dermatitis in a Swedish nationwide study. Pediatric Allergy and Immunology 34:1.
Crossref
Mari Sasaki, Clarissa Schwab, Alejandro Ramirez Garcia, Qing Li, Ruth Ferstl, Eugen Bersuch, Cezmi A. Akdis, Roger Lauener, Remo Frei & Caroline Roduit. (2022) The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy . Allergy 77:12, pages 3629-3640.
Crossref
Erin C. Davis, Vanessa P. Castagna, David A. Sela, Margaret A. Hillard, Samantha Lindberg, Nicholas J. Mantis, Antti E. Seppo & Kirsi M. Järvinen. (2022) Gut microbiome and breast-feeding: Implications for early immune development. Journal of Allergy and Clinical Immunology 150:3, pages 523-534.
Crossref
Hui-Yuan Chong, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Kar-Wai Hong, Vanassa Ratnasingam, Nurul-Syakima Ab Mutalib, Learn-Han Lee & Vengadesh Letchumanan. (2022) Exploring the Potential of Human Milk and Formula Milk on Infants’ Gut and Health. Nutrients 14:17, pages 3554.
Crossref
Jamie Afghani, Claudia Traidl-Hoffmann, Philippe Schmitt-Kopplin, Matthias Reiger & Constanze Mueller. (2022) An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study. International Journal of Molecular Sciences 23:15, pages 8791.
Crossref
Aurélien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A. Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C. Wong, Alexandra C. Kendall, Andreas Wiederkehr, Laurent P. Nicod, Anna Nicolaou, Christophe von Garnier, Niki D.J. Ubags & Benjamin J. Marsland. (2022) Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation. Mucosal Immunology 15:5, pages 908-926.
Crossref
Igor Łoniewski, Karolina Skonieczna-Żydecka, Laura Stachowska, Magdalena Fraszczyk-Tousty, Piotr Tousty & Beata Łoniewska. (2022) Breastfeeding Affects Concentration of Faecal Short Chain Fatty Acids During the First Year of Life: Results of the Systematic Review and Meta-Analysis. Frontiers in Nutrition 9.
Crossref
Hsin Yue Cheng, James Chun Yip Chan, Gaik Chin Yap, Chiung-Hui Huang, Dorinda Yan Qin Kioh, Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Lynette P. C. Shek, Neerja Karnani, Anne Goh, Hugo P. S. Van Bever, Oon Hoe Teoh, Yiong Huak Chan, Christophe Lay, Jan Knol, Fabian Yap, Kok Hian Tan, Yap-Seng Chong, Keith M. Godfrey, Eric Chun Yong Chan, Bee Wah Lee & Le Duc Huy Ta. (2022) Evaluation of Stool Short Chain Fatty Acids Profiles in the First Year of Life With Childhood Atopy-Related Outcomes. Frontiers in Allergy 3.
Crossref
Amrita Vijay & Ana M. Valdes. (2021) Role of the gut microbiome in chronic diseases: a narrative review. European Journal of Clinical Nutrition 76:4, pages 489-501.
Crossref
Emanuele Ugo Garzarella, Beatriz Navajas-Porras, Sergio Pérez-Burillo, Hammad Ullah, Cristina Esposito, Cristina Santarcangelo, Daniel Hinojosa-Nogueira, Silvia Pastoriza, Vincenzo Zaccaria, Jianbo Xiao, José Ángel Rufián-Henares & Maria Daglia. (2022) Evaluating the effects of a standardized polyphenol mixture extracted from poplar-type propolis on healthy and diseased human gut microbiota. Biomedicine & Pharmacotherapy 148, pages 112759.
Crossref
Qingrong Ni, Ping Zhang, Qiang Li & Zheyi Han. (2022) Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases. Frontiers in Cell and Developmental Biology 10.
Crossref
Christine LM Joseph, Alexandra R. Sitarik, Haejin Kim, Gary Huffnagle, Kei Fujimura, Germaine Jia Min Yong, Albert M. Levin, Edward Zoratti, Susan Lynch, Dennis R. Ownby, Nicholas W. Lukacs, Brent Davidson, Charles Barone & Christine Cole Johnson. (2021) Infant gut bacterial community composition and food‐related manifestation of atopy in early childhood. Pediatric Allergy and Immunology 33:1.
Crossref
Christophe Lay, Collins Wenhan Chu, Rikky Wenang Purbojati, Enzo Acerbi, Daniela I. Drautz-Moses, Paola Florez de Sessions, Song Jie, Eliza Ho, Yee Jiun Kok, Xuezhi Bi, Shuwen Chen, Shi Ya Mak, Mei Chien Chua, Anne E. N. Goh, Wen Chin Chiang, Rajeshwar Rao, Surasith Chaithongwongwatthana, Nipon Khemapech, Voranush Chongsrisawat, Rocio Martin, Yanqing Koh, Sachin R. Lohar, Ivan Chin Hin Tan, Wong Anng Anng, Chen Jie, Nana Bartke, Kaouther Ben-Amor, Ingrid B. Renes, Fiona Wong, Guus Roeselers, Ying Swan Ho, Martin L. Hibberd, Stephan C. Schuster & Jan Knol. (2021) A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants. BMC Microbiology 21:1.
Crossref
Noor Hidayatul Aini Suaini, Kewin Tien Ho Siah & Elizabeth Huiwen Tham. (2021) Role of the gut–skin axis in IgE-mediated food allergy and atopic diseases. Current Opinion in Gastroenterology 37:6, pages 557-564.
Crossref
Harri Alenius, Hanna Sinkko, Lucas Moitinho‐Silva, Elke Rodriguez, Conor Broderick, Helen Alexander, Matthias Reiger, Mathis Hjort Hjelmsø, Nanna Fyhrquist, Peter Olah, Paul Bryce, Catherine Smith, Frits Koning, Kilian Eyerich, Dario Greco, Ellen H. van den Bogaard, Avidan U. Neumann, Claudia Traidl‐Hoffmann, Bernhard Homey, Carsten Flohr, Klaus Bønnelykke, Jakob Stokholm & Stephan Weidinger. (2021) The power and potential of BIOMAP to elucidate host‐microbiome interplay in skin inflammatory diseases. Experimental Dermatology 30:10, pages 1517-1531.
Crossref
Emily A. Troyer, Jordan N. Kohn, Gertrude Ecklu-Mensah, Gajender Aleti, David R. Rosenberg & Suzi Hong. (2021) Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions. Neuroscience & Biobehavioral Reviews 125, pages 517-534.
Crossref
Lucas André Cavalcanti Brandão, Paola Maura Tricarico, Rossella Gratton, Almerinda Agrelli, Luisa Zupin, Haissam Abou-Saleh, Ronald Moura & Sergio Crovella. (2021) Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment. International Journal of Molecular Sciences 22:4, pages 1523.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.