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Virulence Volume 9, 2018 - Issue 1
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Research Paper

PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target

Yuebang YinDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Wen DangDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Xinying ZhouDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Lei XuDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Wenshi WangDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Wanlu CaoDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Sunrui ChenDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
,
Junhong SuMedical Faculty, Kunming University of Science and Technology, Kunming, P. R. China
,
Xuepeng CaiState Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou, P. R. China
,
Shaobo XiaoState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China
,
Maikel P. PeppelenboschDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
&
Qiuwei PanDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The NetherlandsCorrespondence[email protected]
 show all
Pages 83-98 | Received 17 Jan 2017, Accepted 29 Apr 2017, Published online: 01 Jun 2017

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Kirstan A Vessey, Andrew I Jobling, Mai X. Tran, Anna Y. Wang, Ursula Greferath & Erica L. Fletcher. (2022) Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E). Autophagy 18:10, pages 2368-2384.
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Upayan Patra, Urbi Mukhopadhyay, Arpita Mukherjee, Shanta Dutta & Mamta Chawla-Sarkar. (2021) Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions. Virulence 12:1, pages 1022-1062.
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Bo Yang, Qinghong Xue, Xuefeng Qi, Xueping Wang, Peilong Jia, Shuying Chen, Ting Wang, Tianxia Xue & Jingyu Wang. (2018) Autophagy enhances the replication of Peste des petits ruminants virus and inhibits caspase-dependent apoptosis in vitro. Virulence 9:1, pages 1176-1194.
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Jason Kindrachuk. (2018) Selective inhibition of host cell signaling for rotavirus antivirals: PI3K/Akt/mTOR-mediated rotavirus pathogenesis. Virulence 9:1, pages 5-8.
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