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Research Article

Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway

Yi Xiaoa Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Fang Liuc College of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Sanhua Lia Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Nian Jianga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Changyan Yua Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Xinting Zhua Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;c College of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Ying Qina Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Jing Huia Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Lingjie Menga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Changwei Songa Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaORCID Iconhttps://orcid.org/0000-0003-4114-5786View further author information
ORCID Icon,
Xiao-Fei Lia Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;c College of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaCorrespondence[email protected]
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Yun Liua Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8615-4710View further author information
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Pages 39-48 | Received 08 Jun 2019, Accepted 24 Oct 2019, Published online: 28 Dec 2019

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Ruibin Wang, Yuchen Li, Yanjie Zhao, Feng Shi, Quan Zhou, Jiangping Wu, Shuzhen Lyu & Qingkun Song. (2022) Metformin Inducing the Change of Functional and Exhausted Phenotypic Tumor-Infiltrated Lymphocytes and the Correlation with JNK Signal Pathway in Triple-Negative Breast Cancer. Breast Cancer: Targets and Therapy 14, pages 391-403.
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Majed M Masadeh, Karem H Alzoubi, Majd M Masadeh & Zainah O Aburashed. (2021) Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria. Clinical Pharmacology: Advances and Applications 13, pages 83-90.
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Wenjiao Xia, Xin Qi, Mingfeng Li, Yu Wu, Lulu Sun, Xinglong Fan, Yuan Yuan & Jing Li. (2021) Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner. OncoImmunology 10:1.
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Articles from other publishers (24)

Fang Liu, Hongjiao Zhang, Haijuan Wang, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu & Yi Xiao. (2023) The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1. Cellular and Molecular Life Sciences 80:11.
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Amirhossein Malaekeh-Nikouei, Sina Shokri-Naei, Sobhan Karbasforoushan, Hossein Bahari, Vafa Baradaran Rahimi, Reza Heidari & Vahid Reza Askari. (2023) Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins. Biomedicine & Pharmacotherapy 165, pages 115263.
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Yi Xiao, Fang Liu, Qinyi Wu, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li & Yun Liu. (2023) Dioscin Activates Endoplasmic Reticulum Unfolded Protein Response for Defense Against Pathogenic Bacteria in Caenorhabditis elegans via IRE-1/XBP-1 Pathway . The Journal of Infectious Diseases.
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Lucas Mergan, Brecht Driesschaert & Liesbet Temmerman. (2023) Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction. PLOS ONE 18:6, pages e0287933.
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Turab Mohammed, Michael Bowe, Alexandria Plant, Mario Perez, Carlos A Alvarez & Eric M Mortensen. (2023) Metformin Use Is Associated With Lower Mortality in Veterans With Diabetes Hospitalized With Pneumonia. Clinical Infectious Diseases 76:7, pages 1237-1244.
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JA Ruiz-Pacheco, LA Castillo-Díaz, R. Arreola-Torres, S. Fonseca-Coronado & B. Gómez-Navarro. (2023) Diabetes mellitus: Lessons from COVID-19 for monkeypox infection. Primary Care Diabetes 17:2, pages 113-118.
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Rodrigo Jiménez-Escutia, Donovan Vargas-Alcantar, Pilar Flores-Espinosa, Addy Cecilia Helguera-Repetto, Oscar Villavicencio-Carrisoza, Ismael Mancilla-Herrera, Claudine Irles, Yessica Dorin Torres-Ramos, María Yolotzin Valdespino-Vazquez, Pilar Velázquez-Sánchez, Rodrigo Zamora-Escudero, Marcela Islas-López, Caridad Carranco-Salinas, Lorenza Díaz, Verónica Zaga-Clavellina & Andrea Olmos-Ortiz. (2023) High Glucose Promotes Inflammation and Weakens Placental Defenses against E. coli and S. agalactiae Infection: Protective Role of Insulin and Metformin. International Journal of Molecular Sciences 24:6, pages 5243.
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Yi Xiao, Li Zhang, Xinting Zhu, Ying Qin, Changyan Yu, Nian Jiang, Sanhua Li, Fang Liu & Yun Liu. (2023) Luteolin promotes pathogen resistance in Caenorhabditis elegans via DAF-2/DAF-16 insulin-like signaling pathway. International Immunopharmacology 115, pages 109679.
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Yang Du, Ya-Juan Zhu, Yi-Xin Zhou, Jing Ding & Ji-Yan Liu. (2022) Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study. Molecular Biomedicine 3:1.
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Samaneh Mostafavi, Hamidreza Zalpoor & Zuhair Mohammad Hassan. (2022) The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors. Cellular & Molecular Biology Letters 27:1.
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Xinting Zhu, Fang Liu, Qinyi Wu, Sanhua Li, Guoyong Ruan, Jianbo Yang, Changyan Yu, Nian Jiang, Yi Xiao & Yun Liu. (2022) Brevilin A enhances innate immunity and the resistance of oxidative stress in Caenorhabditis elegans via p38 MAPK pathway. International Immunopharmacology 113, pages 109385.
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Vincenzo Sorrenti, Francesca Benedetti, Alessandro Buriani, Stefano Fortinguerra, Giada Caudullo, Sergio Davinelli, Davide Zella & Giovanni Scapagnini. (2022) Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks. Pharmaceuticals 15:8, pages 912.
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Fa Dai, Ming Guo, Yina Shao & Chenghua Li. (2022) Vibrio splendidus flagellin C binds tropomodulin to induce p38 MAPK-mediated p53-dependent coelomocyte apoptosis in Echinodermata. Journal of Biological Chemistry 298:7, pages 102091.
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Salwa E. Gomaa, Ghada H. Shaker, Farag M. Mosallam & Hisham A. Abbas. (2022) Knocking down Pseudomonas aeruginosa virulence by oral hypoglycemic metformin nano emulsion. World Journal of Microbiology and Biotechnology 38:7.
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Mengyao Liu, Nana Li, Shan Shan, Yudong Shi, Yuanbing Zhu & Weihong Lu. (2022) Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response. International Journal of Molecular Sciences 23:9, pages 5034.
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Grace C. Lee, Alvaro G. Moreira, Cecilia Hinojosa, Raymond Benavides, Caitlyn Winter, Audrey C. Anderson, Chang-Jui Chen, Noemi Borsa, Gabrielyd Hastings, Cody A. Black, Sarah M. Bandy, Alexander Shaffer, Marcos I. Restrepo & Sunil K. Ahuja. (2022) Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae. Frontiers in Aging 3.
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Yuchen Ge, Min Zhou, Cui Chen, Xiaojian Wu & Xiaobo Wang. (2022) Role of AMPK mediated pathways in autophagy and aging. Biochimie 195, pages 100-113.
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Jeffrey A. Tomalka, Mehul S. Suthar, Steven G. Deeks & Rafick Pierre Sekaly. (2022) Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses. Nature Immunology 23:3, pages 360-370.
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Jamie N. Justice, Sriram Gubbi, Ameya S. Kulkarni, Jenna M. Bartley, George A. Kuchel & Nir Barzilai. (2020) A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin. GeroScience 43:3, pages 1093-1112.
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Qi-You Huang, Fei Yao, Chuan-Ren Zhou, Xiao-Ying Huang, Qiang Wang, Hui Long & Qing-Ming Wu. (2020) Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes. World Journal of Clinical Cases 8:24, pages 6213-6228.
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Flavio A. Cadegiani. (2020) Repurposing existing drugs for COVID-19: an endocrinology perspective. BMC Endocrine Disorders 20:1.
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Pool Marcos-Carbajal, Christian Allca-Muñoz, Ángel Urbano-Niño & Alberto Salazar-Granara. (2020) Exploración de la actividad antibacteriana de Metformina frente a Escherichia coli, Staphylococcus aureus y Pseudomonas aeruginosa. Bionatura 5:4, pages 1335-1339.
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Hanako Nakajima, Fumie Takewaki, Yoshitaka Hashimoto, Shizuo Kajiyama, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Masahiro Yamazaki, Yoshiki Tanaka, Yousuke Oikawa, Shunji Nakajima, Hiroshi Ohno & Michiaki Fukui. (2020) The Effects of Metformin on the Gut Microbiota of Patients with Type 2 Diabetes: A Two-Center, Quasi-Experimental Study. Life 10:9, pages 195.
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Turab Mohammed, Michael Bowe, Alexandria Plant, Mario Perez, Carlos Alvarez & Eric M. Mortensen. (2022) Metformin Use is Associated with Lower Mortality in Veterans with Diabetes Hospitalized with Pneumonia. SSRN Electronic Journal.
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