1,908
Views
52
CrossRef citations to date
0
Altmetric
Original Research

Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma

, , , , , , , , , , , , & show all
Article: e1008805 | Received 14 Oct 2014, Accepted 12 Jan 2015, Published online: 22 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger & Simon Jasinski-Bergner. (2023) Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p. OncoImmunology 12:1.
Read now
Simon Jasinski-Bergner, Juliane Blümke, Marcus Bauer, Saskia Luise Skiebe, Ofer Mandelboim, Claudia Wickenhauser & Barbara Seliger. (2022) Novel approach to identify putative Epstein–Barr–virus microRNAs regulating host cell genes with relevance in tumor biology and immunology. OncoImmunology 11:1.
Read now

Articles from other publishers (50)

Juanjuan Li, Hong RanXiaoxia Zeng, Dunhui YangXianhai Zeng & Peng Zhang. (2023) Identification of HOXB9 based on comprehensive bioinformatics analysis for predicting prognosis of head and neck squamous cell carcinoma. Medicine 102:35, pages e35035.
Crossref
Ming Zhang, Linfeng Cao, Gouxin Hou, Xiaodong Lv & Jingjing Deng. (2022) Investigation of the Potential Correlation Between RNA-Binding Proteins in the Evolutionarily Conserved MEX3 Family and Non-small-Cell Lung Cancer. Molecular Biotechnology 65:8, pages 1263-1274.
Crossref
Yuan Wang, Simon Jasinski-Bergner, Claudia Wickenhauser & Barbara Seliger. (2023) Cancer Immunology: Immune Escape of Tumors—Expression and Regulation of HLA Class I Molecules and Its Role in Immunotherapies. Advances in Anatomic Pathology 30:3, pages 148-159.
Crossref
Antonino A. Pane, Theresa Kordaß, Agnes Hotz‐Wagenblatt, Elke Dickes, Annette Kopp‐Schneider, Rainer Will, Barbara Seliger, Wolfram Osen & Stefan B. Eichmüller. (2023) MicroRNAs affecting the susceptibility of melanoma cells to CD8 + T cell‐mediated cytolysis . Clinical and Translational Medicine 13:2.
Crossref
Barbara Seliger, Simon Jasinski-Bergner, Chiara Massa, Anja Mueller, Katharina Biehl, Bo Yang, Michael Bachmann, Danny Jonigk, Philip Eichhorn, Arndt Hartmann, Claudia Wickenhauser & Marcus Bauer. (2022) Induction of pulmonary HLA-G expression by SARS-CoV-2 infection. Cellular and Molecular Life Sciences 79:11.
Crossref
Timothy Su, Shuyang Wang, Shuya Huang, Hui Cai, Eliot T. McKinley, Alicia Beeghly-Fadiel, Wei Zheng, Xiao-Ou Shu & Qiuyin Cai. (2022) Multiplex immunohistochemistry and high-throughput image analysis for evaluation of spatial tumor immune cell markers in human breast cancer. Cancer Biomarkers 35:2, pages 193-206.
Crossref
Levent Emirzeoglu, Ozgur Olmez, Fatma Mustafayev, Ufuk Berber, Ismail Yilmaz, Serkan Celik, Bala Oven & Mehmet Ozgun. (2022) Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer. Oncology Letters 24:1.
Crossref
Saife N. Lone, Ajaz A. Bhat, Nissar A. Wani, Thasni Karedath, Sheema Hashem, Sabah Nisar, Mayank Singh, Puneet Bagga, Bhudev Chandra Das, Davide Bedognetti, Ravinder Reddy, Michael P. Frenneaux, Wael El-Rifai, Mushtaq A. Siddiqi, Mohammad Haris & Muzafar A. Macha. (2022) miRNAs as novel immunoregulators in cancer. Seminars in Cell & Developmental Biology 124, pages 3-14.
Crossref
Priya Mondal, Bhavjot Kaur, Jagadish Natesh & Syed Musthapa Meeran. (2022) The emerging role of miRNA in the perturbation of tumor immune microenvironment in chemoresistance: Therapeutic implications. Seminars in Cell & Developmental Biology 124, pages 99-113.
Crossref
Johanna Protze, Stephanie Naas, René Krüger, Christine Stöhr, Andre Kraus, Steffen Grampp, Michael Wiesener, Mario Schiffer, Arndt Hartmann, Bernd Wullich & Johannes Schödel. (2022) The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. Journal of Biological Chemistry 298:3, pages 101699.
Crossref
Simon Jasinski-Bergner, Markus Eckstein, Helge Taubert, Sven Wach, Christian Fiebig, Reiner Strick, Arndt Hartmann & Barbara Seliger. (2022) The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors. Frontiers in Immunology 13.
Crossref
Hajar Alemohammad, Basira Najafzadeh, Zahra Asadzadeh, Amir Baghbanzadeh, Farid Ghorbaninezhad, Arezoo Najafzadeh, Hossein Safarpour, Renato Bernardini, Oronzo Brunetti, Margherita Sonnessa, Rossella Fasano, Nicola Silvestris & Behzad Baradaran. (2022) The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer. Biomedicine & Pharmacotherapy 146, pages 112516.
Crossref
Javaid Ahmed Wani, Sadaf Ali, Ishfaq Shafi Khan, Mosin Saleem Khan, Shafat Ali, Sabhiya Majid & Muneeb U. Rehman. 2022. A Molecular Approach to Immunogenetics. A Molecular Approach to Immunogenetics 193 225 .
E Hui Clarissa Lee, Darren Chen Pei Wong & Jeak Ling Ding. (2021) NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton. Frontiers in Immunology 12.
Crossref
Zahra Souri, Annemijn P. A. Wierenga, Emine Kiliç, Erwin Brosens, Stefan Böhringer, Wilma G. M. Kroes, Robert M. Verdijk, Pieter A. van der Velden, Gregorius P. M. Luyten & Martine J. Jager. (2021) MiRNAs Correlate with HLA Expression in Uveal Melanoma: Both Up- and Downregulation Are Related to Monosomy 3. Cancers 13:16, pages 4020.
Crossref
Veronika Weyerer, Pamela L. Strissel, Christine Stöhr, Markus Eckstein, Sven Wach, Helge Taubert, Lisa Brandl, Carol I. Geppert, Bernd Wullich, Holger Cynis, Matthias W. Beckmann, Barbara Seliger, Arndt Hartmann & Reiner Strick. (2021) Endogenous Retroviral–K Envelope Is a Novel Tumor Antigen and Prognostic Indicator of Renal Cell Carcinoma. Frontiers in Oncology 11.
Crossref
Sarah Nersesian, Sarah L. Schwartz, Stephanie R. Grantham, Leah K. MacLean, Stacey N. Lee, Morgan Pugh-Toole & Jeanette E. Boudreau. (2021) NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis. Translational Oncology 14:1, pages 100930.
Crossref
Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven & Barbara Seliger. (2020) Characterization of the expression and immunological impact of the transcriptional activator CREB in renal cell carcinoma. Journal of Translational Medicine 18:1.
Crossref
Marcus Bauer, Christoforos Vaxevanis, Nadine Heimer, Haifa Kathrin Al-Ali, Nadja Jaekel, Michael Bachmann, Claudia Wickenhauser & Barbara Seliger. (2020) Expression, Regulation and Function of microRNA as Important Players in the Transition of MDS to Secondary AML and Their Cross Talk to RNA-Binding Proteins. International Journal of Molecular Sciences 21:19, pages 7140.
Crossref
Maria-Filothei Lazaridou, Chiara Massa, Diana Handke, Anja Mueller, Michael Friedrich, Karthikeyan Subbarayan, Sandy Tretbar, Reinhard Dummer, Peter Koelblinger & Barbara Seliger. (2020) Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma. Journal of Clinical Medicine 9:9, pages 2690.
Crossref
Simon Jasinski-Bergner, André Steven & Barbara Seliger. (2020) The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. International Journal of Molecular Sciences 21:15, pages 5209.
Crossref
Simon Jasinski-Bergner, Ofer Mandelboim & Barbara Seliger. (2020) Molecular mechanisms of human herpes viruses inferring with host immune surveillance. Journal for ImmunoTherapy of Cancer 8:2, pages e000841.
Crossref
Daniëlle Krijgsman, Jessica Roelands, Wouter Hendrickx, Davide Bedognetti & Peter J. K. Kuppen. (2020) HLA-G: A New Immune Checkpoint in Cancer?. International Journal of Molecular Sciences 21:12, pages 4528.
Crossref
Michael Friedrich, Nadine Heimer, Christine Stoehr, André Steven, Sven Wach, Helge Taubert, Arndt Hartmann & Barbara Seliger. (2020) CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma. Scientific Reports 10:1.
Crossref
Simon Jasinski-Bergner, Christoforos Vaxevanis, Nadine Heimer, Maria-Filothei Lazaridou, Michael Friedrich & Barbara Seliger. 2020. Tumor Immunology and Immunotherapy – Integrated Methods Part B. Tumor Immunology and Immunotherapy – Integrated Methods Part B 323 337 .
Johannes Fänder, Heike Kielstein, Maximilian Büttner, Peter Koelblinger, Reinhard Dummer, Marcus Bauer, Diana Handke, Claudia Wickenhauser, Barbara Seliger & Simon Jasinski-Bergner. (2019) Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma. Oncotarget 10:60, pages 6509-6525.
Crossref
Michael Friedrich, Simon Jasinski-Bergner, Maria-Filothei Lazaridou, Karthikeyan Subbarayan, Chiara Massa, Sandy Tretbar, Anja Mueller, Diana Handke, Katharina Biehl, Jürgen Bukur, Marco Donia, Ofer Mandelboim & Barbara Seliger. (2019) Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy. Cancer Immunology, Immunotherapy 68:10, pages 1689-1700.
Crossref
Hany A. Omar, Ahmed T. El‐Serafi, Fatema Hersi, El‐Shaimaa A. Arafa, Dana M. Zaher, Mohamed Madkour, Hany H. Arab & Mai F. Tolba. (2019) Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment. The FEBS Journal 286:18, pages 3540-3557.
Crossref
Andreas Kahlmeyer, Christine Stöhr, Arndt Hartmann, Peter Goebell, Bernd Wullich, Sven Wach, Helge Taubert & Franziska Erlmeier. (2019) Expression of PD-1 and CTLA-4 Are Negative Prognostic Markers in Renal Cell Carcinoma. Journal of Clinical Medicine 8:5, pages 743.
Crossref
Eleonora A. Braga, Marina V. Fridman, Vitaly I. Loginov, Alexey A. Dmitriev & Sergey G. Morozov. (2019) Molecular Mechanisms in Clear Cell Renal Cell Carcinoma: Role of miRNAs and Hypermethylated miRNA Genes in Crucial Oncogenic Pathways and Processes. Frontiers in Genetics 10.
Crossref
Esther Schwich, Vera Rebmann, Rafael Tomoya Michita, Hana Rohn, Jan Willem Voncken, Peter A. Horn, Rainer Kimmig, Sabine Kasimir-Bauer & Paul Buderath. (2019) HLA-G 3′ untranslated region variants +3187G/G, +3196G/G and +3035T define diametrical clinical status and disease outcome in epithelial ovarian cancer. Scientific Reports 9:1.
Crossref
Uta Sandy Tretbar, Michael Friedrich, Maria-Filothei Lazaridou & Barbara Seliger. 2019. Immune Checkpoint Blockade. Immune Checkpoint Blockade 81 101 .
Mengkai Shieh, Nilesh Chitnis & Dimitri Monos. (2018) Human Leukocyte Antigen and Disease Associations. Clinics in Laboratory Medicine 38:4, pages 679-693.
Crossref
Renan Garcia Gomes, Carlos Alexandre Antunes de Brito, Valéria Ferreira Martinelli, Rossana Nascimento dos Santos, Fabiana Oliveira dos Santos Gomes, Christina Alves Peixoto, Janaína Oliveira Crispim, George Tadeu Nunes Diniz, Eduardo Antônio Donadi & Norma Lucena-Silva. (2018) HLA-G is expressed in intestinal samples of ulcerative colitis and Crohn’s disease patients and HLA-G5 expression is differentially correlated with TNF and IL-10 cytokine expression. Human Immunology 79:6, pages 477-484.
Crossref
Patrick Maschmeyer, Georg Petkau, Francesco Siracusa, Jakob Zimmermann, Franziska Zügel, Anja Andrea Kühl, Katrin Lehmann, Sarah Schimmelpfennig, Melanie Weber, Claudia Haftmann, René Riedel, Markus Bardua, Gitta Anne Heinz, Cam Loan Tran, Bimba Franziska Hoyer, Falk Hiepe, Sebastian Herzog, Jürgen Wittmann, Nikolaus Rajewsky, Fritz Georg Melchers, Hyun-Dong Chang, Andreas Radbruch & Mir-Farzin Mashreghi. (2018) Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. Journal of Autoimmunity 89, pages 41-52.
Crossref
Haichong Wu, Kangfeng Jiang, Shuai Guo, Jing Yang, Gan Zhao, Changwei Qiu & Ganzhen Deng. (2018) IFN-τ Mediated Control of Bovine Major Histocompatibility Complex Class I Expression and Function via the Regulation of bta-miR-148b/152 in Bovine Endometrial Epithelial Cells. Frontiers in Immunology 9.
Crossref
Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald & Bruce R. Blazar. (2018) Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease. Frontiers in Immunology 9.
Crossref
Stefano Regis, Fabio Caliendo, Alessandra Dondero, Francesca Bellora, Beatrice Casu, Cristina Bottino & Roberta Castriconi. (2018) Main NK cell receptors and their ligands: regulation by microRNAs. AIMS Allergy and Immunology 2:2, pages 98-112.
Crossref
Michael Friedrich, Katharina Pracht, Mir-Farzin Mashreghi, Hans-Martin Jäck, Andreas Radbruch & Barbara Seliger. (2017) The role of the miR-148/-152 family in physiology and disease. European Journal of Immunology 47:12, pages 2026-2038.
Crossref
Stefan B. Eichmüller, Wolfram Osen, Ofer Mandelboim & Barbara Seliger. (2017) Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape. JNCI: Journal of the National Cancer Institute 109:10.
Crossref
Barbara Seliger. (2017) Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors. Cytokine & Growth Factor Reviews 36, pages 49-56.
Crossref
Simon Jasinski-Bergner, Maximilian Büttner, Dagmar Quandt, Barbara Seliger & Heike Kielstein. (2017) Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin. Obesity Facts 10:6, pages 569-583.
Crossref
B. Seliger. (2016) Molecular mechanisms of HLA class I-mediated immune evasion of human tumors and their role in resistance to immunotherapies. HLA 88:5, pages 213-220.
Crossref
Steffen Grampp, James L. Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K. Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J. Ratcliffe, David R. Mole & Johannes Schödel. (2016) Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nature Communications 7:1.
Crossref
Barbara Seliger, Simon Jasinski-Bergner, Dagmar Quandt, Christine Stoehr, Juergen Bukur, Sven Wach, Wolfgang Legal, Helge Taubert, Bernd Wullich & Arndt Hartmann. (2016) HLA-E expression and its clinical relevance in human renal cell carcinoma. Oncotarget 7:41, pages 67360-67372.
Crossref
Yunjie Lu, Keli L. HippenAmanda L. LemireJian GuWeizhi WangXuhao NiParvathi RanganathanBruce L. LevineJames L. RileyCarl H. JuneLaurence A. Turka, David H. Munn, Ramiro GarzonLing LuBruce R. Blazar. (2016) miR-146b antagomir–treated human Tregs acquire increased GVHD inhibitory potency. Blood 128:10, pages 1424-1435.
Crossref
Barbara Seliger. (2016) Role of microRNAs on HLA-G expression in human tumors. Human Immunology 77:9, pages 760-763.
Crossref
Simon Jasinski-Bergner, Adi Reches, Christine Stoehr, Chiara Massa, Evamaria Gonschorek, Stefan Huettelmaier, Juliane Braun, Sven Wach, Bernd Wullich, Verena Spath, Ena Wang, Francesco M. Marincola, Ofer Mandelboim, Arndt Hartmann & Barbara Seliger. (2016) Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. Oncotarget 7:18, pages 26866-26878.
Crossref
Fabio Morandi, Roberta Rizzo, Enrico Fainardi, Nathalie Rouas-Freiss & Vito Pistoia. (2016) Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases. Journal of Immunology Research 2016, pages 1-14.
Crossref
Aifen Lin & Wei-Hua Yan. (2015) Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy. Molecular Medicine 21:1, pages 782-791.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.