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OncoImmunology Volume 4, 2015 - Issue 8
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Original Research

Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions

Claire GermainInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France;Laboratory “Cancer, Immune control and Escape,”, Cordeliers Research Center; UMRS1138; Paris, France
,
Thierry GuillaudeuxUniversité de Rennes 1; INSERM, Unité 917; EFS Bretagne; UMS 3480CNRS 018INSERM Biosit; Rennes, France
,
Elisabeth D GalsgaardBiopharmaceutical Research Unit, Novo Nordisk A/S, DK-2760; Måløv, Denmark
,
Catherine HervouetInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Nedra TekayaInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Anne-Sophie GallouetUniversité de Rennes 1; INSERM, Unité 917; EFS Bretagne; UMS 3480CNRS 018INSERM Biosit; Rennes, France
,
Julien FassyInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Franck BihlInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Gwenola PouponInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Anne LazzariInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Pieter SpeeBiopharmaceutical Research Unit, Novo Nordisk A/S, DK-2760; Måløv, Denmark
,
Fabienne AnjuèreInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, France
,
Céline PangaultUniversité de Rennes 1; INSERM, Unité 917, EFS Bretagne; CHU de Rennes, Service d'Hématologie, UMS 3480CNRS 018INSERM Biosit; Rennes, France
,
Karin TarteUniversité de Rennes 1; INSERM, Unité 917, EFS Bretagne; CHU de Rennes, Service d'Hématologie, UMS 3480CNRS 018INSERM Biosit; Rennes, France
,
Patrick TasUniversité de Rennes 1; INSERM, Unité 917, EFS Bretagne; CHU de Rennes, Service d'Hématologie, UMS 3480CNRS 018INSERM Biosit; Rennes, France
,
Luc XerriDépartement d'Oncologie Moléculaire; Centre de Recherche en Cancérologie de Marseille; INSERM UMR89, IFR137; Marseille, France
&
Veronique M BraudInstitut de Pharmacologie Moléculaire et Cellulaire; CNRS UMR7275; Valbonne, France; Université de Nice-Sophia Antipolis; Valbonne, FranceCorrespondence[email protected]
 show all
Article: e1026503 | Received 13 Nov 2014, Accepted 27 Feb 2015, Published online: 30 Jun 2015

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Véronique M. Braud, Jérôme Biton, Etienne Becht, Samantha Knockaert, Audrey Mansuet-Lupo, Estelle Cosson, Diane Damotte, Marco Alifano, Pierre Validire, Fabienne Anjuère, Isabelle Cremer, Nicolas Girard, Dominique Gossot, Agathe Seguin-Givelet, Marie-Caroline Dieu-Nosjean & Claire Germain. (2018) Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome. OncoImmunology 7:5.
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Margherita Boieri, Aina Ulvmoen, Amanda Sudworth, Clare Lendrem, Matthew Collin, Anne M. Dickinson, Lise Kveberg & Marit Inngjerdingen. (2017) IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo. OncoImmunology 6:3.
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Marie Tosolini, Christelle Algans, Frédéric Pont, Bernard Ycart & Jean-Jacques Fournié. (2016) Large-scale microarray profiling reveals four stages of immune escape in non-Hodgkin lymphomas. OncoImmunology 5:7.
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Oleksandr KyrysyukKai W. Wucherpfennig. (2023) Designing Cancer Immunotherapies That Engage T Cells and NK Cells. Annual Review of Immunology 41:1, pages 17-38.
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Sheila B. Powers, Nourhan G. Ahmed, Roslin Jose, Marissa Brezgiel, Subhash Aryal, W. Paul Bowman, Porunelloor A. Mathew & Stephen O. Mathew. (2023) Differential Expression of LLT1, SLAM Receptors CS1 and 2B4 and NCR Receptors NKp46 and NKp30 in Pediatric Acute Lymphoblastic Leukemia (ALL). International Journal of Molecular Sciences 24:4, pages 3860.
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Veronique M. Braud, Aïda Meghraoui-Kheddar, Roxane Elaldi, Luciana Petti, Claire Germain & Fabienne Anjuère. (2022) LLT1-CD161 Interaction in Cancer: Promises and Challenges. Frontiers in Immunology 13.
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Nathan D. Mathewson, Orr Ashenberg, Itay Tirosh, Simon Gritsch, Elizabeth M. Perez, Sascha Marx, Livnat Jerby-Arnon, Rony Chanoch-Myers, Toshiro Hara, Alyssa R. Richman, Yoshinaga Ito, Jason Pyrdol, Mirco Friedrich, Kathrin Schumann, Michael J. Poitras, Prafulla C. Gokhale, L. Nicolas Gonzalez Castro, Marni E. Shore, Christine M. Hebert, Brian Shaw, Heather L. Cahill, Matthew Drummond, Wubing Zhang, Olamide Olawoyin, Hiroaki Wakimoto, Orit Rozenblatt-Rosen, Priscilla K. Brastianos, X. Shirley Liu, Pamela S. Jones, Daniel P. Cahill, Matthew P. Frosch, David N. Louis, Gordon J. Freeman, Keith L. Ligon, Alexander Marson, E. Antonio Chiocca, David A. Reardon, Aviv Regev, Mario L. Suvà & Kai W. Wucherpfennig. (2021) Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell 184:5, pages 1281-1298.e26.
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Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt & William K. Decker. (2021) CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential. Frontiers in Immunology 11.
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Pierre Milpied, Anita K. Gandhi, Guillaume Cartron, Laura Pasqualucci, Karin Tarte, Bertrand Nadel & Sandrine Roulland. 2021. 43 103 .
Casey W. Buller, Porunelloor A. Mathew & Stephen O. Mathew. (2020) Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 (CLEC2D) in Cancer. Cancers 12:7, pages 1755.
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Massimo Giuliani & Alessandro Poggi. (2020) Checkpoint Inhibitors and Engineered Cells: New Weapons for Natural Killer Cell Arsenal Against Hematological Malignancies. Cells 9:7, pages 1578.
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James C. Romero-Masters, Makoto Ohashi, Reza Djavadian, Mark R. Eichelberg, Mitchell Hayes, Nicholas A. Zumwalde, Jillian A. Bristol, Scott E. Nelson, Shidong Ma, Erik A. Ranheim, Jenny E. Gumperz, Eric C. Johannsen & Shannon C. Kenney. (2020) An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model. Journal of Virology 94:10.
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Arushi Khurana & Stephen M. Ansell. (2020) Role of Microenvironment in Non-Hodgkin Lymphoma. The Cancer Journal 26:3, pages 206-216.
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Ondřej Vaněk, Petra Celadova, Ondřej Skořepa, Jan Bláha, Barbora Kalousková, Anna Dvorská, Edita Poláchová, Helena Pucholtová, Daniel Kavan, Petr Pompach, Kateřina Hofbauerová, Vladimír KopeckýJr.Jr., Aruz Mesci, Sebastian Voigt & James R. Carlyle. (2019) Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells. Scientific Reports 9:1.
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Simona Sivori, Raffaella Meazza, Concetta Quintarelli, Simona Carlomagno, Mariella Della Chiesa, Michela Falco, Lorenzo Moretta, Franco Locatelli & Daniela Pende. (2019) NK Cell-Based Immunotherapy for Hematological Malignancies. Journal of Clinical Medicine 8:10, pages 1702.
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Léa Verdière, Frédéric Mourcin & Karin Tarte. (2018) Microenvironment signaling driving lymphomagenesis. Current Opinion in Hematology 25:4, pages 335-345.
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Karin Tarte. (2017) Role of the microenvironment across histological subtypes of NHL. Hematology 2017:1, pages 610-617.
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Jan Bláha, Barbora Kalousková, Ondřej Skořepa, Samuel Pažický, Petr Novák & Ondřej Vaněk. (2017) High-level expression and purification of soluble form of human natural killer cell receptor NKR-P1 in HEK293S GnTI− cells. Protein Expression and Purification 140, pages 36-43.
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Fengyuan Che, Xueyuan Heng, Haiyan Zhang, Quanping Su, Baoxue Zhang, Yanying Chen, Zhaohong Zhang, Yifeng Du & Lijuan Wang. (2017) Novel B7-H4-mediated crosstalk between human non-Hodgkin lymphoma cells and tumor-associated macrophages leads to immune evasion via secretion of IL-6 and IL-10. Cancer Immunology, Immunotherapy 66:6, pages 717-729.
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Stephen O. Mathew, Pankaj Chaudhary, Sheila B. Powers, Jamboor K. Vishwanatha & Porunelloor A. Mathew. (2016) Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction. Oncotarget 7:42, pages 68650-68661.
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Alba Llibre, Paul Klenerman & Christian B Willberg. (2016) Multi-functional lectin-like transcript-1: A new player in human immune regulation. Immunology Letters 177, pages 62-69.
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Alba Llibre, Constantino López-Macías, Teresa Marafioti, Hema Mehta, Amy Partridge, Carina Kanzig, Felice Rivellese, Jacob D. Galson, Lucy J. Walker, Paul Milne, Rodney E. Phillips, Dominic F. Kelly, Gordon J. Freeman, Mohey Eldin El Shikh, Paul Klenerman & Christian B. Willberg. (2016) LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation. The Journal of Immunology 196:5, pages 2085-2094.
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Luc Xerri, Stephan Dirnhofer, Leticia Quintanilla-Martinez, Birgitta Sander, John K.C. Chan, Elias Campo, Steven H. Swerdlow & German Ott. (2015) The heterogeneity of follicular lymphomas: from early development to transformation. Virchows Archiv 468:2, pages 127-139.
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Alba Llibre, Lucy Garner, Amy Partridge, Gordon J. Freeman, Paul Klenerman & Chris B. Willberg. (2016) Expression of lectin-like transcript-1 in human tissues. F1000Research 5, pages 2929.
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