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Original Research

Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis

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Article: e1123366 | Received 06 Jul 2015, Accepted 18 Nov 2015, Published online: 11 May 2016

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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