Advanced search
Publication Cover
OncoImmunology Volume 5, 2016 - Issue 6
Submit an article Journal homepage
1,230
Views
19
CrossRef citations to date
0
Altmetric
Original Research

Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses

Dàlia Raïch-ReguéStarzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USCorrespondence[email protected]
,
Kellsye P. FabianDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
,
Alicia R. WatsonStarzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
,
Ronald J. FecekDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
,
Walter J. StorkusDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US;Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
&
Angus W. ThomsonStarzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, US;Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Article: e1146841 | Received 17 Jul 2015, Accepted 21 Jan 2016, Published online: 07 Jun 2016

Citations (19)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Sjoerd Klarenbeek, Chris W. Doornebal, Sjors M. Kas, Nicola Bonzanni, Jinhyuk Bhin, Tanya M. Braumuller, Ingrid van der Heijden, Mark Opdam, Philip C. Schouten, Kelly Kersten, Roebi de Bruijn, Daniel Zingg, Julia Yemelyanenko, Lodewyk F.A. Wessels, Karin E. de Visser & Jos Jonkers. (2020) Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system. OncoImmunology 9:1.
Read now
Sophie Langdon, Adina Hughes, Molly A. Taylor, Elizabeth A. Kuczynski, Deanna A. Mele, Oona Delpuech, Laura Jarvis, Anna Staniszewska, Sabina Cosulich, Larissa S. Carnevalli & Charles Sinclair. (2018) Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity. OncoImmunology 7:8.
Read now

Articles from other publishers (17)

Ipsita Volety, Chandrashekhar D. Patil & Deepak Shukla. 2024. Stress: Immunology and Inflammation. Stress: Immunology and Inflammation 173 182 .
Sahar Mafi, Behzad Mansoori, Shahram Taeb, Hossein Sadeghi, Reza Abbasi, William C. Cho & Davoud Rostamzadeh. (2022) mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment. Frontiers in Immunology 12.
Crossref
Alexandre el Hage & Olivier Dormond. (2021) Combining mTOR Inhibitors and T Cell-Based Immunotherapies in Cancer Treatment. Cancers 13:6, pages 1359.
Crossref
Qile Dai, Weimiao Wu, Amei Amei, Xiting Yan, Lingeng Lu & Zuoheng Wang. (2021) Regulation and characterization of tumor-infiltrating immune cells in breast cancer. International Immunopharmacology 90, pages 107167.
Crossref
Shi-Yong Sun. (2020) Searching for the real function of mTOR signaling in the regulation of PD-L1 expression. Translational Oncology 13:12, pages 100847.
Crossref
Alicia R. Watson, Helong Dai, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe & Angus W. Thomson. (2019) mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells. Frontiers in Immunology 10.
Crossref
Helong Dai & Angus W. Thomson. (2019) The “other” mTOR complex: New insights into mTORC 2 immunobiology and their implications . American Journal of Transplantation 19:6, pages 1614-1621.
Crossref
Alicia R. Watson, Helong Dai, Julio A. Diaz‐Perez, Meaghan E. Killeen, Alicia R. Mathers & Angus W. Thomson. (2018) mTORC2 deficiency in cutaneous dendritic cells potentiates CD8 + effector T cell responses and accelerates skin graft rejection . American Journal of Transplantation 19:3, pages 646-661.
Crossref
Miquel Lozano, Joan Cid, Daniel Benitez-Ribas & Manel Juan Otero. (2019) Technical Challenges in the Manufacture of Dendritic Cell Cancer Therapies. European Oncology & Haematology 15:1, pages 22.
Crossref
Helong Dai, Alicia R. Watson, Daniel Fantus, Longkai Peng, Angus W. Thomson & Natasha M. Rogers. (2018) Rictor deficiency in dendritic cells exacerbates acute kidney injury. Kidney International 94:5, pages 951-963.
Crossref
Yakir Guri, Thierry M. Nordmann & Jason Roszik. (2018) mTOR at the Transmitting and Receiving Ends in Tumor Immunity. Frontiers in Immunology 9.
Crossref
A.R. Sánchez-Paulete, A. Teijeira, F.J. Cueto, S. Garasa, J.L. Pérez-Gracia, A. Sánchez-Arráez, D. Sancho & I. Melero. (2017) Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy. Annals of Oncology 28, pages xii44-xii55.
Crossref
Kristian M. Hargadon. (2017) Strategies to Improve the Efficacy of Dendritic Cell-Based Immunotherapy for Melanoma. Frontiers in Immunology 8.
Crossref
David A. Fruman, Honyin Chiu, Benjamin D. Hopkins, Shubha Bagrodia, Lewis C. Cantley & Robert T. Abraham. (2017) The PI3K Pathway in Human Disease. Cell 170:4, pages 605-635.
Crossref
Russell G. Jones & Edward J. Pearce. (2017) MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells. Immunity 46:5, pages 730-742.
Crossref
Nyamdelger Sukhbaatar, Markus Hengstschläger & Thomas Weichhart. (2016) mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function. Trends in Immunology 37:11, pages 778-789.
Crossref
Daniel Fantus, Natasha M. Rogers, Florian Grahammer, Tobias B. Huber & Angus W. Thomson. (2016) Roles of mTOR complexes in the kidney: implications for renal disease and transplantation. Nature Reviews Nephrology 12:10, pages 587-609.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.