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OncoImmunology Volume 5, 2016 - Issue 6
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Original Research

CD8+ Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4+ Tregs in mice

Jessica HeinrichsDepartment of Pathology and Cell biology, University of South Florida, Tampa, FL, USA;Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
Jun LiDepartment of Hematology, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Hung NguyenDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
Yongxia WuDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
David BastianDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
Anusara DaethanasanmakDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
M-Hanief SofiDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
Steven SchuttDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
,
Chen LiuPathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA
,
Junfei JinDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA;Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, ChinaCorrespondence[email protected] [email protected]
,
Brian BettsDepartment of Pathology and Cell biology, University of South Florida, Tampa, FL, USA
,
Claudio AnasettiDepartment of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL, USA
&
Xue-Zhong YuDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA;Department of Medicine, Medical University of South Carolina, Charleston, SC, USACorrespondence[email protected] [email protected]
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Article: e1146842 | Received 18 Dec 2015, Accepted 22 Jan 2016, Published online: 23 May 2016

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Yue Hu, Gan-Lin He, Xiang-Yu Zhao, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xue-Zhong Yu, Kai-Yan Liu, Ying-Jun Chang & Xiao-Jun Huang. (2017) Regulatory B cells promote graft-versus-host disease prevention and maintain graft-versus-leukemia activity following allogeneic bone marrow transplantation. OncoImmunology 6:3.
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Articles from other publishers (42)

Haowen Jiang & Wenmei Fan. (2023) Research progress on CD8+ T cell immune regulation in allogenic transplantation. Transplant Immunology 81, pages 101945.
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Govindarajan Thangavelu, Sara Bolivar-Wagers, Ethan G. Aguilar, Stephanie Y. Rhee, Brent H. Koehn, Keli L. Hippen & Bruce R. Blazar. 2023. Translational Autoimmunity. Translational Autoimmunity 329 360 .
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Adrian Liston & Meryem Aloulou. (2022) A fresh look at a neglected regulatory lineage: CD8+Foxp3+ Regulatory T cells. Immunology Letters 247, pages 22-26.
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Yongxia Wu, Corey MealerSteven SchuttCarole L. Wilson, David BastianM. Hanief SofiMengmeng ZhangZhenwu LuoHee-Jin Choi, Kaipo Yang, Linlu TianHung Nguyen, Kris HelkeLynn M. Schnapp, Honglin WangXue-Zhong Yu. (2022) MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice. Blood Advances 6:10, pages 3036-3052.
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Qingxiao Song, Ubaydah Nasri, Ryotaro Nakamura, Paul J. Martin & Defu Zeng. (2022) Retention of Donor T Cells in Lymphohematopoietic Tissue and Augmentation of Tissue PD-L1 Protection for Prevention of GVHD While Preserving GVL Activity. Frontiers in Immunology 13.
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Sara Bolivar-Wagers, Jemma H. Larson, Sujeong Jin & Bruce R. Blazar. (2022) Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease. Frontiers in Immunology 13.
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Weihao Wang, Tao Hong, Xiaoqi Wang, Rui Wang, Yuxuan Du, Qiangguo Gao, Shijie Yang & Xi Zhang. (2021) Newly Found Peacekeeper: Potential of CD8+ Tregs for Graft-Versus-Host Disease. Frontiers in Immunology 12.
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Chunxu Gao, Debra Gardner, Marie-Clare Theobalds, Shannon Hitchcock, Heather Deutsch, Chidozie Amuzie, Matteo Cesaroni, Davit Sargsyan, Tadimeti S Rao & Ravi Malaviya. (2021) Cytotoxic T lymphocyte antigen-4 regulates development of xenogenic graft versus host disease in mice via modulation of host immune responses induced by changes in human T cell engraftment and gene expression. Clinical and Experimental Immunology 206:3, pages 422-438.
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Mehrdad Hefazi, Sara Bolivar-Wagers & Bruce R. Blazar. (2021) Regulatory T Cell Therapy of Graft-versus-Host Disease: Advances and Challenges. International Journal of Molecular Sciences 22:18, pages 9676.
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Wen-wen Guo, Xiu-hua Su, Ming-yang Wang, Ming-zhe Han, Xiao-ming Feng & Er-lie Jiang. (2021) Regulatory T Cells in GVHD Therapy. Frontiers in Immunology 12.
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Geoffrey R. Hill, Brian C. Betts, Victor Tkachev, Leslie S. Kean & Bruce R. Blazar. (2021) Current Concepts and Advances in Graft-Versus-Host Disease Immunology. Annual Review of Immunology 39:1, pages 19-49.
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Qianqian Yu, Han Wang, Lingling Zhang & Wei Wei. (2021) Advances in the treatment of graft-versus-host disease with immunomodulatory cells. International Immunopharmacology 92, pages 107349.
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Bruce R. Blazar, Geoffrey R. Hill & William J. Murphy. (2020) Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nature Reviews Clinical Oncology 17:8, pages 475-492.
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Léa Flippe, Séverine Bézie, Ignacio Anegon & Carole Guillonneau. (2019) Future prospects for CD8 + regulatory T cells in immune tolerance . Immunological Reviews 292:1, pages 209-224.
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Zhi‐Gang Yang, Rui‐Ting Wen, Jin‐Shan Feng, Pei‐Jie Cao, Hai‐Tao Zhou & Wen‐Xin Liu. (2018) Recipient‐Derived Allo‐iTregs Induced by Donor DCs Effectively Inhibit the Proliferation of Donor T Cells and Reduce GVHD. The Anatomical Record 302:5, pages 825-836.
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