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OncoImmunology Volume 5, 2016 - Issue 9
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Original Research

Chemo-immunotherapy mediates durable cure of orthotopic KrasG12D/p53−/− pancreatic ductal adenocarcinoma

Vanaja KonduriDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA
,
Dali LiMichael E. Debakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
,
Matthew M. HalpertDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA
,
Dan LiangDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA
,
Zhengdong LiangMichael E. Debakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
,
Yunyu ChenDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA
,
William E. FisherMichael E. Debakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA;Elkins Pancreas Center, Baylor College of Medicine, Houston, TX, USA;Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
,
Silke PaustDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA;Center for Human Immunobiology, Baylor College of Medicine, Houston, TX, USA
,
Jonathan M. LevittDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA;Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA
,
Qizhi Cathy YaoDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;Michael E. Debakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA;Elkins Pancreas Center, Baylor College of Medicine, Houston, TX, USA;Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA;Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX, USACorrespondence[email protected]
&
William K. DeckerDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA;Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USACorrespondence[email protected]
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Article: e1213933 | Received 10 Jun 2016, Accepted 06 Jul 2016, Published online: 10 Sep 2016

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Ying Zhang, Jin-An Ma, Hai-Xia Zhang, Yu-Na Jiang & Wen-Hao Luo. (2020) Cancer vaccines: Targeting KRAS-driven cancers. Expert Review of Vaccines 19:2, pages 163-173.
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Inga Hochnadel, Uta Kossatz-Boehlert, Nils Jedicke, Henrike Lenzen, Michael P. Manns & Tetyana Yevsa. (2017) Cancer vaccines and immunotherapeutic approaches in hepatobiliary and pancreatic cancers. Human Vaccines & Immunotherapeutics 13:12, pages 2931-2952.
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Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene & Lorenzo Galluzzi. (2017) Trial watch: DNA-based vaccines for oncological indications. OncoImmunology 6:12.
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Articles from other publishers (13)

Yongting Liu, Bin Xie & Qiong Chen. (2023) RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment. Journal of Translational Medicine 21:1.
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Hande Asimgil, Utku Ertetik, Nedim Can Çevik, Menar Ekizce, Alper Doğruöz, Muazzez Gökalp, Elif Arık-Sever, Rouzanna Istvanffy, Helmut Friess, Güralp Onur Ceyhan & Ihsan Ekin Demir. (2022) Targeting the undruggable oncogenic KRAS: the dawn of hope. JCI Insight 7:1.
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Vanaja Konduri, Sujith K. Joseph, Tiara T. Byrd, Zeid Nawas, Jonathan Vazquez-Perez, Colby J. Hofferek, Matthew M. Halpert, Dongliang LiuZhengdong Liang, Yunyu Baig, Vita S. SalsmanDamilola Oyewole-Said, Anna TsimelzonBriana A. Burns, Changyi ChenJonathan M. LevittQizhi Yao, Nabil M. Ahmed, Meenakshi HegdeWilliam K. Decker. (2021) A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma. Science Translational Medicine 13:592.
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Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt & William K. Decker. (2021) CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential. Frontiers in Immunology 11.
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Shan-Ming Chen, Wee-Wei Chieng, Szu-Wei Huang, Li-Jin Hsu & Ming-Shiou Jan. (2020) The synergistic tumor growth-inhibitory effect of probiotic Lactobacillus on transgenic mouse model of pancreatic cancer treated with gemcitabine. Scientific Reports 10:1.
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Namrata Khurana, Paarth B. Dodhiawala, Ashenafi Bulle & Kian-Huat Lim. (2020) Deciphering the Role of Innate Immune NF-ĸB Pathway in Pancreatic Cancer. Cancers 12:9, pages 2675.
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Matthew M. Halpert, Vanaja Konduri, Dan Liang, Jonathan Vazquez‐Perez, Colby J. Hofferek, Scott A. Weldon, Yunyu Baig, Indira Vedula, Jonathan M. Levitt & William K. Decker. (2020) MHC class I and II peptide homology regulates the cellular immune response. The FASEB Journal 34:6, pages 8082-8101.
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Claudia Maletzki, Leonie Wiegele, Ingy Nassar, Jan Stenzel & Christian Junghanss. (2019) Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer. Journal for ImmunoTherapy of Cancer 7:1.
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V. Konduri, M. M. Halpert, Y. C. Baig, R. Coronado, J. R. Rodgers, J. M. Levitt, B. Cerroni, S. Piscoya, N. Wilson, L. DiBernardi, Z. Omarbekov, L. Seelhoff, V. Ravi, L. Douglass & W. K. Decker. (2019) Dendritic cell vaccination plus low-dose doxorubicin for the treatment of spontaneous canine hemangiosarcoma. Cancer Gene Therapy 26:9-10, pages 282-291.
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Nahla E. El-Ashmawy, Enas A. El-Zamarany, Mohamed L. Salem, Eman G. Khedr & Amera O. Ibrahim. (2019) A new strategy for enhancing antitumor immune response using dendritic cells loaded with chemo-resistant cancer stem-like cells in experimental mice model. Molecular Immunology 111, pages 106-117.
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Paola Cappello, Claudia Curcio, Giorgia Mandili, Cecilia Roux, Sara Bulfamante & Francesco Novelli. (2018) Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners. Cancers 10:2, pages 51.
Crossref
Dan Liang, Lin Tian, Ran You, Matthew M. Halpert, Vanaja Konduri, Yunyu C. Baig, Silke Paust, Doyeun Kim, Sunghoon Kim, Fuli Jia, Shixia Huang, Xiang Zhang, Farrah Kheradmand, David B. Corry, Brian E. Gilbert, Jonathan M. Levitt & William K. Decker. (2018) AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity. Frontiers in Immunology 8.
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Vanaja Konduri, Matthew M. Halpert, Dan Liang, Jonathan M. Levitt, Julio Vladimir Cruz-Chan, Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Kathryn M. Jones & William K. Decker. (2017) Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infection and Immunity 85:9.
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