Advanced search
Publication Cover
OncoImmunology Volume 6, 2017 - Issue 2
Submit an article Journal homepage
2,736
Views
45
CrossRef citations to date
0
Altmetric
Original Research

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

Eva M. PutzImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Camille GuillereyImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia
,
Kevin KosImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Kimberley StannardImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Kim MilesImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
,
Rebecca B. DelconteThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Biology, The University of Melbourne, Victoria, Australia
,
Kazuyoshi TakedaDepartment of Immunology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, JapanORCID Iconhttp://orcid.org/0000-0002-5539-310X
ORCID Icon,
Sandra E. NicholsonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Biology, The University of Melbourne, Victoria, Australia
,
Nicholas D. HuntingtonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Biology, The University of Melbourne, Victoria, Australia
&
Mark J. SmythImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, AustraliaCorrespondence[email protected]
 show all
Article: e1267892 | Received 02 Sep 2016, Accepted 24 Nov 2016, Published online: 07 Feb 2017

Citations (45)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Zhe Ge, Shan Wu, Zhe Zhang & Shuzhe Ding. (2020) Mechanism of tumor cells escaping from immune surveillance of NK cells. Immunopharmacology and Immunotoxicology 42:3, pages 187-198.
Read now
Alexandre Ivagnès, Meriem Messaoudene, Gautier Stoll, Bertrand Routy, Aurélie Fluckiger, Takahiro Yamazaki, Kristina Iribarren, Connie P. M. Duong, Laetitia Fend, Anne Caignard, Isabelle Cremer, Axel LeCesne, Julien Adam, Charles Honoré, Olivier Mir, Loïc Chaigneau, Anne Berger, Pierre Validire, Christos Christidis, Valérie Le Brun-Ly, Mark J. Smyth, Xavier Mariette, Benoît L. Salomon, Guido Kroemer, Sylvie Rusakiewicz & Laurence Zitvogel. (2018) TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer. OncoImmunology 7:12.
Read now
Edmond M. Linossi, Dale J. Calleja & Sandra E. Nicholson. (2018) Understanding SOCS protein specificity. Growth Factors 36:3-4, pages 104-117.
Read now
Jing Liu, Xinyu Qu, Liwei Shao, Yuan Hu, Xin Yu, Peixiang Lan, Qie Guo, Qiuju Han, Jian Zhang & Cai Zhang. (2018) Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation. Cancer Biology & Therapy 19:3, pages 160-168.
Read now

Articles from other publishers (41)

Zhi-Guang Huang, Yi Chen, Tong Wu, Bin-Tong Yin, Xiao Feng, Sheng-Hua Li, Dong-Ming Li, Gang Chen, Ji-Wen Cheng & Juan He. (2023) What should be the future direction of development in the field of prostate cancer with lung metastasis?. World Journal of Clinical Oncology 14:10, pages 420-439.
Crossref
Mona M. Elanany, Dina Mostafa & Nadia M. Hamdy. (2023) Remodeled tumor immune microenvironment (TIME) parade via natural killer cells reprogramming in breast cancer. Life Sciences 330, pages 121997.
Crossref
Harrison Sudholz, Rebecca B Delconte & Nicholas D Huntington. (2023) Interleukin-15 cytokine checkpoints in natural killer cell anti-tumor immunity. Current Opinion in Immunology 84, pages 102364.
Crossref
Pamela Wong, Jennifer A. Foltz, Lily Chang, Carly C. Neal, Tony Yao, Celia C. Cubitt, Jennifer Tran, Samantha Kersting-Schadek, Sathvik Palakurty, Natalia Jaeger, David A. Russler-Germain, Nancy D. Marin, Margery Gang, Julia A. Wagner, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Lynne Marsala, Ethan McClain, Patrick Pence, Michelle Becker-Hapak, Bryan Fisk, Allegra A. Petti, Obi L. Griffith, Malachi Griffith, Melissa M. Berrien-Elliott & Todd A. Fehniger. (2023) T-BET and EOMES sustain mature human NK cell identity and antitumor function. Journal of Clinical Investigation 133:13.
Crossref
Yanlin Yu. (2023) The Function of NK Cells in Tumor Metastasis and NK Cell-Based Immunotherapy. Cancers 15:8, pages 2323.
Crossref
Yuqing Yang, Lin Chen, Bohao Zheng & Shengtao Zhou. (2022) Metabolic hallmarks of natural killer cells in the tumor microenvironment and implications in cancer immunotherapy. Oncogene 42:1, pages 1-10.
Crossref
Shoubao Ma, Michael A. Caligiuri & Jianhua Yu. (2022) Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy. Trends in Immunology 43:10, pages 833-847.
Crossref
Buyue Niu, Zhihua Chen, Diwen Yao, Mingxing Kou, Xiaowen Gao, Yuan Sun, Xiuqin Yang, Xibiao Wang, Shengwei Di, Jiancheng Cai & Dongchun Guo. (2022) A 12-bp indel in the 3’UTR of porcine CISH gene associated with Landrace piglet diarrhea score. Research in Veterinary Science 146, pages 53-59.
Crossref
Laurys Boudin, Alexandre De Nonneville, Pascal Finetti, Geoffrey Guittard, Jacques A. Nunes, Daniel Birnbaum, Emilie Mamessier & François Bertucci. (2022) CISH Expression Is Associated with Metastasis-Free Interval in Triple-Negative Breast Cancer and Refines the Prognostic Value of PDL1 Expression. Cancers 14:14, pages 3356.
Crossref
Benjamin H. Goldenson, Pooja Hor & Dan S. Kaufman. (2022) iPSC-Derived Natural Killer Cell Therapies - Expansion and Targeting. Frontiers in Immunology 13.
Crossref
Mohamed Luban Sobah, Clifford Liongue & Alister C. Ward. (2021) SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer. Frontiers in Medicine 8.
Crossref
Nawen Du, Feifei Guo, Yufeng Wang & Jiuwei Cui. (2021) NK Cell Therapy: A Rising Star in Cancer Treatment. Cancers 13:16, pages 4129.
Crossref
Damien J. Zanker, Katie L. Owen, Nikola Baschuk, Alex J. Spurling & Belinda S. Parker. (2021) Loss of type I IFN responsiveness impairs natural killer cell antitumor activity in breast cancer. Cancer Immunology, Immunotherapy 70:8, pages 2125-2138.
Crossref
Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A. de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L. Nutt, Viktor Umansky, Bogoljub Ciric, Joanna R. Groom, Paul S. Foster, Philip M. Hansbro, Andrew N. J. McKenzie, Daniel H. D. Gray, Andreas Behren, Jonathan Cebon, Eric Vivier, Ian P. Wicks, Joseph A. Trapani, Ariel Munitz, Melissa J. Davis, Wei Shi, Paul J. Neeson & Gabrielle T. Belz. (2021) Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology 22:7, pages 851-864.
Crossref
Sunil Kumar, Ravinder Nagpal, Amit Kumar, Muhammad Umer Ashraf & Yong-Soo Bae. (2021) Immunotherapeutic Potential of m6A-Modifiers and MicroRNAs in Controlling Acute Myeloid Leukaemia. Biomedicines 9:6, pages 690.
Crossref
Rasa Islam, Aleta Pupovac, Vera Evtimov, Nicholas Boyd, Runzhe Shu, Richard Boyd & Alan Trounson. (2021) Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy. Cells 10:5, pages 1058.
Crossref
May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif KerbauyPinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul MohantyYifei ShenHila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin XiXinhai Wan, Duncan MakEnli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing WangShahram Kordasti, Nedyalko Petrov, Navin VaradarajanDavid Marin, Lorenzo Brunetti, Richard J. SkinnerShangrong LyuLeiser SilvaRolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin KurganMark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall & Katayoun Rezvani. (2021) Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. Blood 137:5, pages 624-636.
Crossref
Camille Guillerey, Kimberley Stannard, Jason Chen, Sophie Krumeich, Kim Miles, Kyohei Nakamura, Jessica Smith, Yuan Yu, Susanna Ng, Heidi Harjunpää, Michele WL Teng, Christian Engwerda, Gabrielle T Belz & Mark J Smyth. (2020) Systemic administration of IL‐33 induces a population of circulating KLRG1 hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma . Immunology & Cell Biology 99:1, pages 65-83.
Crossref
Luke Riggan, Siya Shah & Timothy E O’Sullivan. (2021) Arrested development: suppression of NK cell function in the tumor microenvironment. Clinical & Translational Immunology 10:1.
Crossref
Tamara Laskowski & Katayoun Rezvani. (2020) Adoptive cell therapy: Living drugs against cancer. Journal of Experimental Medicine 217:12.
Crossref
Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G. Lima, Lizeth G. Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, Sebastien Jacquelin, Maike Effern, Brodie Quine, Lambros T. Koufariotis, Mika Casey, Kyohei Nakamura, Eun Y. Seo, Michael Hölzel, Matthias Geyer, Glen Kristiansen, Touraj Taheri, Elizabeth Ahern, Brett G.M. Hughes, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Martin D. Batstone, Jennifer Landsberg, Dimo Dietrich, Oltin T. Pop, Lukas Flatz, William C. Dougall, André Veillette, Sandra E. Nicholson, Andreas Möller, Robert J. Johnston, Ludovic Martinet, Mark J. Smyth & Tobias Bald. (2020) CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells. Immunity 53:4, pages 805-823.e15.
Crossref
Jai Rautela, Elliot Surgenor & Nicholas D. Huntington. (2020) Drug target validation in primary human natural killer cells using CRISPR RNP. Journal of Leukocyte Biology 108:4, pages 1397-1408.
Crossref
Huang Zhu, Robert H. Blum, Davide Bernareggi, Eivind Heggernes Ask, Zhengming Wu, Hanna Julie Hoel, Zhipeng Meng, Chengsheng Wu, Kun-Liang Guan, Karl-Johan Malmberg & Dan S. Kaufman. (2020) Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell 27:2, pages 224-237.e6.
Crossref
Jiao Wang & Sandro Matosevic. (2020) Functional and metabolic targeting of natural killer cells to solid tumors. Cellular Oncology 43:4, pages 577-600.
Crossref
Christian Sordo-Bahamonde, Massimo Vitale, Seila Lorenzo-Herrero, Alejandro López-Soto & Segundo Gonzalez. (2020) Mechanisms of Resistance to NK Cell Immunotherapy. Cancers 12:4, pages 893.
Crossref
Xiaoyue Yang, Zhiming Ma, Ying Zhang, Jingcheng Wu, Jin Huang, Wenyi Zhao, Fan Mo, Zhiwei Lin, Yingchun Xu, Zhan Zhou & Shuqing Chen. (2020) Anti-tumor immune response varies among individuals: A gene expression profiling of mouse melanoma. International Immunopharmacology 80, pages 106211.
Crossref
Katie L. Owen, Natasha K. Brockwell & Belinda S. Parker. (2019) JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression. Cancers 11:12, pages 2002.
Crossref
Dagmar Gotthardt, Jana Trifinopoulos, Veronika Sexl & Eva Maria Putz. (2019) JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation. Frontiers in Immunology 10.
Crossref
Giuseppe Sciumè, Cinzia Fionda, Helena Stabile, Angela Gismondi & Angela Santoni. (2019) Negative regulation of innate lymphoid cell responses in inflammation and cancer. Immunology Letters 215, pages 28-34.
Crossref
Gianluca Scarno, Giuseppe Pietropaolo, Chiara Di Censo, Massimo Gadina, Angela Santoni & Giuseppe Sciumè. (2019) Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells. Frontiers in Immunology 10.
Crossref
Andrew J. Freeman, Stephin J. Vervoort, Kelly M. Ramsbottom, Madison J. Kelly, Jessica Michie, Lizzy Pijpers, Ricky W. Johnstone, Conor J. Kearney & Jane Oliaro. (2019) Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion. Cell Reports 28:11, pages 2784-2794.e5.
Crossref
Jiacheng Bi & Zhigang Tian. (2019) NK Cell Dysfunction and Checkpoint Immunotherapy. Frontiers in Immunology 10.
Crossref
Ziqing Chen, Ying Yang, Lisa L. Liu & Andreas Lundqvist. (2019) Strategies to Augment Natural Killer (NK) Cell Activity against Solid Tumors. Cancers 11:7, pages 1040.
Crossref
Narelle Keating & Sandra E. Nicholson. (2019) SOCS-mediated immunomodulation of natural killer cells. Cytokine 118, pages 64-70.
Crossref
Robert J Hennessy, Kim Pham, Rebecca Delconte, Jai Rautela, Philip D Hodgkin & Nicholas D Huntington. (2019) Quantifying NK cell growth and survival changes in response to cytokines and regulatory checkpoint blockade helps identify optimal culture and expansion conditions. Journal of Leukocyte Biology 105:6, pages 1341-1354.
Crossref
S. Mathia, L. J. Rudigier, M. Kasim, K. M. Kirschner, P. B. Persson, K.-U. Eckardt, C. Rosenberger & M. Fähling. (2018) A dual role of miR-22 in rhabdomyolysis-induced acute kidney injury. Acta Physiologica 224:3, pages e13102.
Crossref
Subburaj Ilangumaran, Bryan R.G. Williams & Dhan V. Kalvakolanu. (2018) Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer. Cytokine 108, pages 225-231.
Crossref
Adriana Albini, Antonino Bruno, Douglas M. Noonan & Lorenzo Mortara. (2018) Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy. Frontiers in Immunology 9.
Crossref
Geoffrey Guittard, Ana Dios-Esponera, Douglas C. Palmer, Itoro Akpan, Valarie A. Barr, Asit Manna, Nicholas P. Restifo & Lawrence E. Samelson. (2018) The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells. Scientific Reports 8:1.
Crossref
Kimberly Mayes, Zeinab Elsayed, Aiman Alhazmi, Michael Waters, Suehyb G. Alkhatib, Mark Roberts, Carolyn Song, Kristen Peterson, Vivian Chan, Nikhil Ailaney, Pumoli Malapati, Tana Blevins, Berislav Lisnić, Catherine I. Dumur & Joseph W. Landry. (2017) BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands. Oncotarget 8:38, pages 64344-64357.
Crossref
Alejandro López-Soto, Segundo Gonzalez, Mark J. Smyth & Lorenzo Galluzzi. (2017) Control of Metastasis by NK Cells. Cancer Cell 32:2, pages 135-154.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.