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Original Research

Correlation between previous treatment with BRAF inhibitors and clinical response to pembrolizumab in patients with advanced melanoma

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Article: e1283462 | Received 31 Oct 2016, Accepted 12 Jan 2017, Published online: 03 Mar 2017

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Maximilian Haist, Henner Stege, Ronja Ebner, Maria Isabel Fleischer, Carmen Loquai & Stephan Grabbe. (2022) The Role of Treatment Sequencing with Immune-Checkpoint Inhibitors and BRAF/MEK Inhibitors for Response and Survival of Patients with BRAFV600-Mutant Metastatic Melanoma—A Retrospective, Real-World Cohort Study. Cancers 14:9, pages 2082.
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Paweł Rogala, Anna M. Czarnecka, Bożena Cybulska-Stopa, Krzysztof Ostaszewski, Karolina Piejko, Marcin Ziętek, Robert Dziura, Ewa Rutkowska, Łukasz Galus, Natasza Kempa-Kamińska, Jacek Calik, Agata Sałek-Zań, Tomasz Zemełka, Wiesław Bal, Agnieszka Kamycka, Tomasz Świtaj, Grażyna Kamińska-Winciorek, Rafał Suwiński, Jacek Mackiewicz & Piotr Rutkowski. (2022) Long-Term Outcomes of Targeted Therapy after First-Line Immunotherapy in BRAF-Mutated Advanced Cutaneous Melanoma Patients—Real-World Evidence. Journal of Clinical Medicine 11:8, pages 2239.
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Adrian Barreno & Jose L. Orgaz. (2022) Cytoskeletal Remodelling as an Achilles’ Heel for Therapy Resistance in Melanoma. Cells 11:3, pages 518.
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Yujue Wang, Sixue Liu, Zhentao Yang, Alain P. Algazi, Shirley H. Lomeli, Yan Wang, Megan Othus, Aayoung Hong, Xiaoyan Wang, Chris E. Randolph, Alexis M. Jones, Marcus W. Bosenberg, Stephanie D. Byrum, Alan J. Tackett, Henry Lopez, Clayton Yates, David B. Solit, Antoni Ribas, Marco Piva, Gatien Moriceau & Roger S. Lo. (2021) Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Cancer Cell 39:10, pages 1375-1387.e6.
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X. Bai & K.T. Flaherty. (2020) Targeted and immunotherapies in BRAF mutant melanoma: where we stand and what to expect . British Journal of Dermatology 185:2, pages 253-262.
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Emily J. Lelliott, Grant A. McArthur, Jane Oliaro & Karen E. Sheppard. (2021) Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma. Frontiers in Immunology 12.
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Paolo A. Ascierto, Antoni Ribas, James Larkin, Grant A. McArthur, Karl D. Lewis, Axel Hauschild, Keith T. Flaherty, Edward McKenna, Qian Zhu, Yong Mun & Brigitte Dréno. (2020) Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: a pooled analysis of four clinical trials. Journal of Translational Medicine 18:1.
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Patryk Górniak, Maja Wasylecka‐Juszczyńska, Iwona Ługowska, Piotr Rutkowski, Anna Polak, Maciej Szydłowski & Przemysław Juszczyński. (2020) BRAF inhibition curtails IFN‐gamma‐inducible PD‐L1 expression and upregulates the immunoregulatory protein galectin‐1 in melanoma cells. Molecular Oncology 14:8, pages 1817-1832.
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Igor Puzanov, Antoni Ribas, Caroline Robert, Jacob Schachter, Marta Nyakas, Adil Daud, Ana Arance, Matteo S. Carlino, Steven J. O’Day, Georgina V. Long, Kim A. Margolin, Reinhard Dummer, Dirk Schadendorf, Jose Lutzky, Paolo A. Ascierto, Ahmad Tarhini, Jianxin Lin, Robin Mogg, Blanca Homet Moreno, Nageatte Ibrahim & Omid Hamid. (2020) Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition With Pembrolizumab Outcomes in Advanced Melanoma . JAMA Oncology 6:8, pages 1256.
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Irene L. M. Reijers, Elisa A. Rozeman, Sofie Wilgenhof, Johannes V. Thienen, John B. A. G. Haanen & Christian U. Blank. (2019) Switch to checkpoint inhibition after targeted therapy at time of progression or during ongoing response: A retrospective single‐centre experience in patients with BRAF‐mutated melanoma. Pigment Cell & Melanoma Research 33:3, pages 498-506.
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Pauline Tétu, Barouyr Baroudjian & Céleste Lebbe. (2020) Targeting BRAF and MEK inhibitors in melanoma in the metastatic, neoadjuvant and adjuvant setting. Current Opinion in Oncology 32:2, pages 85-90.
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Paolo A. Ascierto & Michael B. Atkins. 2020. Cutaneous Melanoma. Cutaneous Melanoma 1215 1241 .
Vito Vanella, Lucia Festino, Claudia Trojaniello, Maria Grazia Vitale, Antonio Sorrentino, Miriam Paone & Paolo A. Ascierto. (2019) The Role of BRAF-Targeted Therapy for Advanced Melanoma in the Immunotherapy Era. Current Oncology Reports 21:9.
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Sophia Kreft, Anja Gesierich, Thomas Eigentler, Cindy Franklin, Sara Valpione, Selma Ugurel, Jochen Utikal, Sebastian Haferkamp, Christian Blank, James Larkin, Claus Garbe, Dirk Schadendorf, Paul Lorigan & Bastian Schilling. (2019) Efficacy of PD-1–based immunotherapy after radiologic progression on targeted therapy in stage IV melanoma. European Journal of Cancer 116, pages 207-215.
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Meredith S. Pelster & Rodabe N. Amaria. (2019) Combined targeted therapy and immunotherapy in melanoma: a review of the impact on the tumor microenvironment and outcomes of early clinical trials. Therapeutic Advances in Medical Oncology 11, pages 175883591983082.
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Svenja Meierjohann & Bastian Schilling. 2019. Oncogenomics. Oncogenomics 655 668 .
Paolo A. Ascierto & Michael B. Atkins. 2018. Cutaneous Melanoma. Cutaneous Melanoma 1 27 .
M. Amini-Adle, N. Khanafer, M. Le-Bouar, G. Duru, S. Dalle & L. Thomas. (2018) Ineffective anti PD-1 therapy after BRAF inhibitor failure in advanced melanoma. BMC Cancer 18:1.
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