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Original Research

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

L. MasuelliDepartment of Experimental Medicine, “Sapienza” University of Rome, Rome, ItalyCorrespondence[email protected] [email protected]

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M. GranatoDepartment of Experimental Medicine, “Sapienza” University of Rome, Rome, ItalyCorrespondence[email protected] [email protected]

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M. BenvenutoDepartment of Clinical Sciences and Traslational Medicine, “Tor Vergata” University of Rome, Rome, Italy

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R. MatteraDepartment of Clinical Sciences and Traslational Medicine, “Tor Vergata” University of Rome, Rome, Italy

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R. BernardiniSTA, “Tor Vergata” University of Rome, Rome, Italy

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M. MatteiSTA, “Tor Vergata” University of Rome, Rome, Italy

http://orcid.org/0000-0002-0814-8873

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G. d'AmatiDepartment of Radiological, Oncological and Pathological Sciences, “Sapienza” University of Rome, Rome, Italy

http://orcid.org/0000-0002-6959-691X

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G. D'OraziDepartment of Research, Advanced Diagnostics, and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy;Department of Medical, Oral and Biotechnological Sciences, Tumor Biology Section, University ‘G. d'Annunzio’, Chieti, Italy

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A. FaggioniDepartment of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy

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R. BeiDepartment of Clinical Sciences and Traslational Medicine, “Tor Vergata” University of Rome, Rome, Italy

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M. CironeDepartment of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy