OncoImmunology, Volume 6, Issue 11 (2017)

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OncoImmunology, Volume 6, Issue 11 (2017)

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Author's View

Opinion
The JAK2V617F and CALR exon 9 mutations are shared immunogenic neoantigens in hematological malignancy
Morten Orebo Holmström, Hans Carl Hasselbalch & Mads Hald Andersen
Article: e1358334
Published online: 21 Aug 2017
AbstractforThe JAK2V617F and CALR exon 9 mutations are shared immunogenic neoantigens in hematological malignancy | Full Text | References | PDF (465.2 KB)
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Opinion
Tissue-resident memory T cells play a key role in the efficacy of cancer vaccines
C. Granier, C. Blanc, S. Karaki, T. Tran, H. Roussel & E. Tartour
Article: e1358841
Published online: 25 Aug 2017
AbstractforTissue-resident memory T cells play a key role in the efficacy of cancer vaccines | Full Text | References | PDF (386.5 KB)
  • 1083 Views
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Editorial

Editorial
CD103+ cells at the forefront of anticancer immunity
Claire Vanpouille-Box & Lorenzo Galluzzi
Article: e1356154
Published online: 21 Aug 2017
CitationforCD103+ cells at the forefront of anticancer immunity | Full Text | References | PDF (259.3 KB)
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Editorial
Blinatumomab bridges the gap between leukemia and immunity
Takahiro Yamazaki & Lorenzo Galluzzi
Article: e1358335
Published online: 22 Aug 2017
First Page PreviewforBlinatumomab bridges the gap between leukemia and immunity | Full Text | References | PDF (351.9 KB)
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Original Research

Article
Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer
Jieti Wang, Chao Lin, He Li, Ruochen Li, Yifan Wu, Hao Liu, Heng Zhang, Hongyong He, Weijuan Zhang & Jiejie Xu
Article: e1353858
Published online: 17 Aug 2017
AbstractforTumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer | Full Text | References | PDF (934 KB) | Supplemental
  • 1464 Views
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Article
GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC
Chengzhong Lin, Wei Cao, Zhenhu Ren, Yu Tang, Chunye Zhang, Rong Yang, Yiming Chen, Zheqi Liu, Canbang Peng, Lizhen Wang, Xu Wang & Tong Ji
Article: e1353860
Published online: 17 Aug 2017
AbstractforGDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC | Full Text | References | PDF (1.7 MB) | Supplemental
  • 1707 Views
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Article
Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue
David A. Quigley, Andliena Tahiri, Torben Lüders, Margit H. Riis, Allan Balmain, Anne-Lise Børresen-Dale, Ida Bukholm & Vessela Kristensen
Article: e1356142
Published online: 14 Sep 2017
AbstractforAge, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1956 Views
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Open Access
Article
TAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer
Agnes Ling, Anna Löfgren-Burström, Pär Larsson, Xingru Li, Maria L. Wikberg, Åke Öberg, Roger Stenling, Sofia Edin & Richard Palmqvist
Article: e1356143
Published online: 12 Sep 2017
AbstractforTAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer | Full Text | References | PDF (741.3 KB) | Supplemental
  • 2300 Views
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Article
EGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer
Zhong-Yi Dong, Jia-Tao Zhang, Si-Yang Liu, Jian Su, Chao Zhang, Zhi Xie, Qing Zhou, Hai-Yan Tu, Chong-Rui Xu, Li-Xu Yan, Yu-Fa Li, Wen-Zhao Zhong & Yi-Long Wu
Article: e1356145
Published online: 21 Aug 2017
AbstractforEGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer | Full Text | References | PDF (1.3 MB) | Supplemental
  • 5821 Views
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Article
Temporal and spatial heterogeneity of programmed cell death 1-Ligand 1 expression in malignant mesothelioma
Simone B. S. P. Terra, Aaron S. Mansfield, Haidong Dong, Tobias Peikert & Anja C. Roden MD
Article: e1356146
Published online: 21 Aug 2017
AbstractforTemporal and spatial heterogeneity of programmed cell death 1-Ligand 1 expression in malignant mesothelioma | Full Text | References | PDF (837.7 KB)
  • 928 Views
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Article
Immune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma
Yuan Li, Zhiliang Lu, Yun Che, Jingnan Wang, Shouguo Sun, Jianbing Huang, Shuangshuang Mao, Yuanyuan Lei, Zhaoli Chen & Jie He
Article: e1356147
Published online: 21 Aug 2017
AbstractforImmune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2675 Views
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Article
Host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity
Charny Park, Junhun Cho, Jeeyun Lee, So Young Kang, Ji Yeong An, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Won Ki Kang, Insuk Sohn, Sin Ho Jung, Myung-Soo Kang & Kyoung-Mee Kim
Article: e1356150
Published online: 31 Aug 2017
AbstractforHost immune response index in gastric cancer identified by comprehensive analyses of tumor immunity | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1876 Views
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Article
Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice
L. Masuelli, M. Granato, M. Benvenuto, R. Mattera, R. Bernardini, M. Mattei, G. d'Amati, G. D'Orazi, A. Faggioni, R. Bei & M. Cirone
Article: e1356151
Published online: 21 Aug 2017
AbstractforChloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice | Full Text | References | PDF (985.2 KB)
  • 1582 Views
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Article
Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes
Yu Wang, Ying-Jun Chang, Lu Chen, Lan-Ping Xu, Zhi-Lei Bian, Xiao-Hui Zhang, Chen-Hua Yan, Kai-Yan Liu & Xiao-Jun Huang
Article: e1356152
Published online: 25 Sep 2017
AbstractforLow-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes | Full Text | References | PDF (734.9 KB)
  • 1817 Views
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Article
Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy
B. Montico, C. Lapenta, M. Ravo, D. Martorelli, E. Muraro, B. Zeng, E. Comaro, M. Spada, S. Donati, S. M. Santini, R. Tarallo, G. Giurato, F. Rizzo, A. Weisz, F. Belardelli, R. Dolcetti & J. Dal Col
Article: e1356964
Published online: 24 Aug 2017
AbstractforExploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2432 Views
  • 36 CrossRef citations
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Article
Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment
Janna Michaeli, Merav E. Shaul, Inbal Mishalian, Avi-Hai Hovav, Liran Levy, Lidia Zolotriov, Zvi Granot & Zvi G. Fridlender
Article: e1356965
Published online: 05 Sep 2017
AbstractforTumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2522 Views
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Article
mRNA Expression levels of genes involved in antitumor immunity: Identification of a 3-gene signature associated with prognosis of muscle-invasive bladder cancer
Constance Le Goux, Sophie Vacher, Géraldine Pignot, Mathilde Sibony, Nicolas Barry Delongchamps, Benoit Terris, Eliane Piaggio, Marc Zerbib, Diane Damotte & Ivan Bieche
Article: e1358330
Published online: 21 Sep 2017
AbstractformRNA Expression levels of genes involved in antitumor immunity: Identification of a 3-gene signature associated with prognosis of muscle-invasive bladder cancer | Full Text | References | PDF (704.9 KB) | Supplemental
  • 1039 Views
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Article
Phase I trial of anti-GD2 monoclonal antibody hu3F8 plus GM-CSF: Impact of body weight, immunogenicity and anti-GD2 response on pharmacokinetics and survival
Irene Y. Cheung, Brian H. Kushner, Shakeel Modak, Ellen M. Basu, Stephen S. Roberts & Nai-Kong V. Cheung
Article: e1358331
Published online: 24 Aug 2017
AbstractforPhase I trial of anti-GD2 monoclonal antibody hu3F8 plus GM-CSF: Impact of body weight, immunogenicity and anti-GD2 response on pharmacokinetics and survival | Full Text | References | PDF (760 KB)
  • 1621 Views
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Article
Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior
David J. Pinato, James R. Black, Sebastian Trousil, Roberto E. Dina, Pritesh Trivedi, Francesco A. Mauri & Rohini Sharma
Article: e1358332
Published online: 24 Aug 2017
AbstractforProgrammed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior | Full Text | References | PDF (950.3 KB) | Supplemental
  • 2042 Views
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Open Access
Article
In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment
Guranda Chitadze, Charlotte Flüh, Elgar Susanne Quabius, Sandra Freitag-Wolf, Christian Peters, Marcus Lettau, Jaydeep Bhat, Daniela Wesch, Hans-Heinrich Oberg, Stefanie Luecke, Ottmar Janssen, Michael Synowitz, Janka Held-Feindt & Dieter Kabelitz
Article: e1358839
Published online: 05 Sep 2017
AbstractforIn-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1596 Views
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Article
High CXC chemokine receptor 1 level represents an independent negative prognosticator in non-metastatic clear-cell renal cell carcinoma patients
Yu Zhu, Zheng Liu, Yiwei Wang, Hangcheng Fu, Zewei Wang, Huyang Xie, Junyu Zhang, Gaoxiang Li, Bo Dai, Dingwei Ye & Jiejie Xu
Article: e1359450
Published online: 05 Sep 2017
AbstractforHigh CXC chemokine receptor 1 level represents an independent negative prognosticator in non-metastatic clear-cell renal cell carcinoma patients | Full Text | References | PDF (1.1 MB) | Supplemental
  • 936 Views
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Article
Functional T cells targeting tumor-associated antigens are predictive for recurrence-free survival of patients with radically operated non-small cell lung cancer
Seyer Safi, Yoshikane Yamauchi, Anchana Rathinasamy, Slava Stamova, Martin Eichhorn, Arne Warth, Geraldine Rauch, Hendrik Dienemann, Hans Hoffmann & Philipp Beckhove
Article: e1360458
Published online: 14 Sep 2017
AbstractforFunctional T cells targeting tumor-associated antigens are predictive for recurrence-free survival of patients with radically operated non-small cell lung cancer | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1249 Views
  • 9 CrossRef citations
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Article
A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers
Eun-A Ko, Kenton M. Sanders & Tong Zhou
Article: e1360457
Published online: 25 Aug 2017
AbstractforA transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers | Full Text | References | PDF (936.3 KB) | Supplemental
  • 1258 Views
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Article
STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade
Sanjay Varikuti, Steve Oghumu, Mohamad Elbaz, Greta Volpedo, Dinesh K. Ahirwar, Pablo C. Alarcon, Rachel H. Sperling, Ellen Moretti, Marissa S. Pioso, Jennifer Kimble, Mohd W. Nasser, Ramesh K. Ganju, Cesar Terrazas & Abhay R. Satoskar
Article: e1361088
Published online: 20 Oct 2017
AbstractforSTAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2144 Views
  • 28 CrossRef citations
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Open Access

Review

Review
The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis
Emma J. de Ruiter MD, Marc L. Ooft, Lot A. Devriese & Stefan M. Willems
Article: e1356148
Published online: 06 Sep 2017
AbstractforThe prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis | Full Text | References | PDF (1.2 MB) | Supplemental
  • 5095 Views
  • 193 CrossRef citations
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Review
Tumor Immunology meets…Immunology: Modified cancer cells as professional APC for priming naïve tumor-specific CD4+ T cells
Farah Bou Nasser Eddine, Elise Ramia, Giovanna Tosi, Greta Forlani & Roberto S. Accolla
Article: e1356149
Published online: 21 Sep 2017
AbstractforTumor Immunology meets…Immunology: Modified cancer cells as professional APC for priming naïve tumor-specific CD4+ T cells | Full Text | References | PDF (650.5 KB)
  • 1119 Views
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Review
Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression
Juan L. Iovanna & Daniel Closa
Article: e1358840
Published online: 05 Sep 2017
AbstractforFactors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression | Full Text | References | PDF (607.3 KB)
  • 1129 Views
  • 8 CrossRef citations
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Review
Trial Watch: Adoptively transferred cells for anticancer immunotherapy
Carole Fournier, François Martin, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Lionel Apetoh
Article: e1363139
Published online: 30 Aug 2017
AbstractforTrial Watch: Adoptively transferred cells for anticancer immunotherapy | Full Text | References | PDF (623.4 KB)
  • 3814 Views
  • 51 CrossRef citations
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Review
Trial watch: Immune checkpoint blockers for cancer therapy
Claire Vanpouille-Box, Claire Lhuillier, Lucillia Bezu, Fernando Aranda, Takahiro Yamazaki, Oliver Kepp, Jitka Fucikova, Radek Spisek, Sandra Demaria, Silvia C. Formenti, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Article: e1373237
Published online: 21 Sep 2017
AbstractforTrial watch: Immune checkpoint blockers for cancer therapy | Full Text | References | PDF (882.3 KB) | Supplemental
  • 4588 Views
  • 56 CrossRef citations
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