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OncoImmunology Volume 7, 2018 - Issue 7
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Original Research

Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells

Pei XiaoCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. China;Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. ChinaORCID Iconhttp://orcid.org/0000-0003-3419-0335 http://orcid.org/0000-0003-3419-0335View further author information
ORCID Icon ORCID Icon,
Xinxin LongDepartment of Oncology, Tengzhou Central People's Hospital, Tengzhou, Shandong, P.R. ChinaView further author information
,
Lijie ZhangCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. China;Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. ChinaView further author information
,
Yingnan YeCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. ChinaView further author information
,
Jincheng GuoBioinformatics Research Group & Health Big-Data, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, P.R. China.ORCID Iconhttp://orcid.org/0000-0002-8321-1676View further author information
ORCID Icon,
Pengpeng LiuCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. ChinaView further author information
,
Rui ZhangCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. ChinaView further author information
,
Junya NingCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. China;Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. ChinaView further author information
,
Wenwen YuDepartment of Immunology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. ChinaView further author information
,
Feng WeiDepartment of Immunology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. ChinaView further author information
&
Jinpu YuCancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. China;Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P. R. ChinaCorrespondence[email protected]
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Article: e1440166 | Received 16 Aug 2017, Accepted 06 Feb 2018, Published online: 13 Mar 2018

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Liang Deng, Shan Huang, Bin Chen, Yajun Tang, Fei Huang, Dong Li & Di Tang. (2020) Tumor-Linked Macrophages Promote HCC Development by Mediating the CCAT1/Let-7b/HMGA2 Signaling Pathway. OncoTargets and Therapy 13, pages 12829-12843.
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Bei Zhou, Yun Yang & Cuiping Li. (2019) SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway. OncoTargets and Therapy 12, pages 2519-2529.
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Mingyan Huang, Huamin Wang, Xiang Hu & Xuetao Cao. (2019) lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression. OncoImmunology 8:1.
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