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OncoImmunology Volume 8, 2019 - Issue 2
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Original Research

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

Fiamma SalernoDepartment of Hematopoiesis, Sanquin Research/AMC Landsteiner Laboratory, Amsterdam, The NetherlandsORCID Iconhttp://orcid.org/0000-0002-8595-4051View further author information
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Aurelie GuislainDepartment of Hematopoiesis, Sanquin Research/AMC Landsteiner Laboratory, Amsterdam, The NetherlandsORCID Iconhttp://orcid.org/0000-0002-3999-6648View further author information
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Julian J. Freen-Van HeerenDepartment of Hematopoiesis, Sanquin Research/AMC Landsteiner Laboratory, Amsterdam, The NetherlandsORCID Iconhttp://orcid.org/0000-0003-0506-2756View further author information
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Benoit P. NicoletDepartment of Hematopoiesis, Sanquin Research/AMC Landsteiner Laboratory, Amsterdam, The NetherlandsORCID Iconhttp://orcid.org/0000-0002-0065-7729View further author information
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Howard A. YoungLaboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, MD, USAORCID Iconhttp://orcid.org/0000-0002-3118-5111View further author information
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Monika C. WolkersDepartment of Hematopoiesis, Sanquin Research/AMC Landsteiner Laboratory, Amsterdam, The NetherlandsCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3242-1363View further author information
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Article: e1532762 | Received 20 Jun 2018, Accepted 26 Sep 2018, Published online: 22 Oct 2018

Citations (26)

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Burcu Temizoz & Ken J. Ishii. (2021) Type I and II interferons toward ideal vaccine and immunotherapy. Expert Review of Vaccines 20:5, pages 527-544.
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Mick J. M. van Eijs, Rik J. Verheijden, Stefanie A. van der Wees, Stefan Nierkens, Anne S. R. van Lindert, Karijn P. M. Suijkerbuijk, Femke van Wijk, Linde Meyaard, Jürgen H. E. Kuball, Bas Oldenburg & Jeanette H. W. Leusen. (2023) Toxicity-specific peripheral blood T and B cell dynamics in anti-PD-1 and combined immune checkpoint inhibition. Cancer Immunology, Immunotherapy 72:12, pages 4049-4064.
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Iosifina P. Foskolou, Pedro P. Cunha, Elena Sánchez-López, Eleanor A. Minogue, Benoît P. Nicolet, Aurélie Guislain, Christian Jorgensen, Sarantos Kostidis, Nordin D. Zandhuis, Laura Barbieri, David Bargiela, Demitris Nathanael, Petros A. Tyrakis, Asis Palazon, Martin Giera, Monika C. Wolkers & Randall S. Johnson. (2023) The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function. Cell Reports 42:9, pages 113013.
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Yueyue Chen, Ningning Niu & Jing Xue. (2023) Double-edged roles of IFNγ in tumor elimination and immune escape. Journal of Pancreatology 6:1, pages 8-17.
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Sung Won Lee, Hyun Jung Park, Luc Van Kaer & Seokmann Hong. (2022) Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25+CD4+ T Cells during IFNγ-Driven Colitis. International Journal of Molecular Sciences 23:23, pages 15316.
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Zhanghui Yue, Jianfang Sun & Liqing Shi. (2022) Construction and Validation of a 6-Ferroptosis Related Gene Signature for Prognosis and Immune Landscape Prediction in Melanoma. Frontiers in Genetics 13.
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Mary Philip & Andrea Schietinger. (2021) CD8+ T cell differentiation and dysfunction in cancer. Nature Reviews Immunology 22:4, pages 209-223.
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Katia Beider, Orit Itzhaki, Jacob Schachter, Ania Hava Grushchenko-Polaq, Valeria Voevoda-Dimenshtein, Evgenia Rosenberg, Olga Ostrovsky, Olivia Devillers, Ronnie Shapira Frommer, Li-at Zeltzer, Amos Toren, Elad Jacoby, Avichai Shimoni, Abraham Avigdor, Arnon Nagler & Michal J. Besser. (2022) Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies. Cells 11:7, pages 1140.
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Wan Du, Timothy L. Frankel, Michael Green & Weiping Zou. (2021) IFNγ signaling integrity in colorectal cancer immunity and immunotherapy. Cellular & Molecular Immunology 19:1, pages 23-32.
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Benoit P. Nicolet, Nordin D. Zandhuis, V. Maria Lattanzio & Monika C. Wolkers. (2021) Sequence determinants as key regulators in gene expression of T cells. Immunological Reviews 304:1, pages 10-29.
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Xiufen Chen, Brendan W. MacNabb, Blake Flood, Bruce R. Blazar & Justin Kline. (2021) Divergent fates of antigen-specific CD8+ T cell clones in mice with acute leukemia. Cell Reports 37:6, pages 109991.
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Olga Trofimova, Ksenija Korotkaja, Dace Skrastina, Juris Jansons, Karina Spunde, Maria Isaguliants & Anna Zajakina. (2021) Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model. Vaccines 9:11, pages 1247.
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Julian J. Freen‐van Heeren. (2021) Post‐transcriptional control of T‐cell cytokine production: Implications for cancer therapy. Immunology 164:1, pages 57-72.
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Sasan Ghaffari, Nastaran Khalili & Nima Rezaei. (2021) CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapy. Journal of Experimental & Clinical Cancer Research 40:1.
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Julian J. Freen‐van Heeren. (2021) Harnessing high‐throughput flow cytometric protein and RNA detection to enhance TIL therapy . Cytometry Part A 99:8, pages 766-768.
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Ning Wang, Guiqiang Zhang, Haifeng Sun, Yuan Tian, Jingcheng Hao & Jiwei Cui. (2021) Vaccine Nanoparticles Derived from Mung Beans for Cancer Immunotherapy. Chemistry of Materials 33:11, pages 4057-4066.
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Julian J. Freen‐van Heeren. (2021) Toll‐like receptor‐2/7‐mediated T cell activation: An innate potential to augment CD8 + T cell cytokine production . Scandinavian Journal of Immunology 93:5.
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Sarah E. Fenton, Diana Saleiro & Leonidas C. Platanias. (2021) Type I and II Interferons in the Anti-Tumor Immune Response. Cancers 13:5, pages 1037.
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Angel K. Kongsomboonvech, Felipe Rodriguez, Anh L. Diep, Brandon M. Justice, Brayan E. Castallanos, Ana Camejo, Debanjan Mukhopadhyay, Gregory A. Taylor, Masahiro Yamamoto, Jeroen P. J. Saeij, Michael L. Reese & Kirk D. C. Jensen. (2020) Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. PLOS Pathogens 16:8, pages e1008327.
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Julian J. Freen‐van Heeren, Branka Popović, Aurélie Guislain & Monika C. Wolkers. (2020) Human T cells employ conserved AU‐rich elements to fine‐tune IFN‐γ production. European Journal of Immunology 50:7, pages 949-958.
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Zeyneb Hadjidj, Rabia Messali & Mourad Aribi. (2020) Lack of cell movement impairs survival of peripheral blood IL-2-stimulated natural killer cells originating from solid cancer and promotes red blood cells to induce their switch toward a regulatory phenotype. Immunology Letters 221, pages 6-17.
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Anne M. van der Leun, Daniela S. Thommen & Ton N. Schumacher. (2020) CD8+ T cell states in human cancer: insights from single-cell analysis. Nature Reviews Cancer 20:4, pages 218-232.
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Fiamma Salerno, Martin Turner & Monika C. Wolkers. (2020) Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function. Trends in Immunology 41:3, pages 240-254.
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Julian J. Freen-van Heeren, Benoit P. Nicolet & Monika C. Wolkers. 2020. Immune Mediators in Cancer. Immune Mediators in Cancer 259 271 .
Fiamma Salerno, Julian J. Freen-van Heeren, Aurelie Guislain, Benoit P. Nicolet & Monika C. Wolkers. (2019) Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses. The Journal of Immunology 202:3, pages 714-723.
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