2,758
Views
46
CrossRef citations to date
0
Altmetric
Original Research

Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients

ORCID Icon, , , , , , , , , , , , , , , , , , , ORCID Icon, & ORCID Icon show all
Article: e1537581 | Received 22 Mar 2018, Accepted 13 Oct 2018, Published online: 31 Oct 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Kerry A. Whalen, Kavya Rakhra, Naveen K. Mehta, Alexander Steinle, Jennifer S. Michaelson & Patrick A. Baeuerle. (2023) Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors. mAbs 15:1.
Read now
Florencia Secchiari, Sol Yanel Nuñez, Jessica Mariel Sierra, Andrea Ziblat, María Victoria Regge, Ximena Lucía Raffo Iraolagoitia, Agustín Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolás Richards, Hernando Ríos Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolás Bonanno, Leandro Blas, Aldana Trotta, Adrián David Friedrich, Mercedes Beatriz Fuertes, Carolina Inés Domaica & Norberto Walter Zwirner. (2022) The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology. OncoImmunology 11:1.
Read now
Barbara Oliviero, Stefania Varchetta, Dalila Mele, Greta Pessino, Roberta Maiello, Monica Falleni, Delfina Tosi, Matteo Donadon, Cristiana Soldani, Barbara Franceschini, Guido Torzilli, Gaetano Piccolo, Matteo Barabino, Enrico Opocher, Marcello Maestri, Stefano Bernuzzi, Kai W. Wucherpfennig, Mario U. Mondelli & Stefania Mantovani. (2022) MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma. OncoImmunology 11:1.
Read now

Articles from other publishers (43)

Azadeh Rahimi, Zahra Malakoutikhah, Ilnaz Rahimmanesh, Gordon A. Ferns, Reza Nedaeinia, Sayed Mohammad Matin Ishaghi, Nasim Dana & Shaghayegh Haghjooy Javanmard. (2023) The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies. Cancer Cell International 23:1.
Crossref
Samuel X. Tan, Sharene Chong, Casey Rowe, Magdalena Claeson, James Dight, Chenhao Zhou, Mathieu P. Rodero, Maryrose Malt, B. Mark Smithers, Adele C. Green & Kiarash Khosrotehrani. (2023) pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma. Melanoma Research 33:6, pages 506-513.
Crossref
Ming Yi, Tianye Li, Mengke Niu, Qi Mei, Bin Zhao, Qian Chu, Zhijun Dai & Kongming Wu. (2023) Exploiting innate immunity for cancer immunotherapy. Molecular Cancer 22:1.
Crossref
Keren Rouvinov, Gal Mazor, Ella Kozlener, Amichay Meirovitz, Noa Shani Shrem, Omar Abu Saleh, Sondos Shalata, Alexander Yakobson & Walid Shalata. (2023) Cemiplimab as First Line Therapy in Advanced Penile Squamous Cell Carcinoma: A Real-World Experience. Journal of Personalized Medicine 13:11, pages 1623.
Crossref
Xintao Cen, Mengna Li, Amin Yao, Yue Zheng & Wei Lai. (2023) Immune infiltration and clinical significance analyses of the cancer‐associated fibroblast‐related signature in skin cutaneous melanoma. The Journal of Gene Medicine.
Crossref
Nurudeen A Adegoke, Tuba N Gide, Yizhe Mao, Camelia Quek, Ellis Patrick, Matteo S Carlino, Serigne N Lo, Alexander Maxwell Menzies, Ines Pires da Silva, Ismael A Vergara, Georgina Long, Richard A Scolyer & James S Wilmott. (2023) Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapies. Journal for ImmunoTherapy of Cancer 11:10, pages e007144.
Crossref
Ishita Gupta, Ola Hussein, Konduru Seetharama Sastry, Salim Bougarn, Neha Gopinath, Evonne Chin-Smith, Yashi Sinha, Hesham Mohamed Korashy & Cristina Maccalli. (2023) Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications. Advances in Cancer Biology - Metastasis 8, pages 100107.
Crossref
Alexander Yakobson, Ashraf Abu Jama, Omar Abu Saleh, Regina Michlin & Walid Shalata. (2023) PD-1 Inhibitors in Elderly and Immunocompromised Patients with Advanced or Metastatic Cutaneous Squamous Cell Carcinoma. Cancers 15:16, pages 4041.
Crossref
Hobin Seo, Amisha Verma, Megan Kinzel, Qiutong Huang, Douglas J. Mahoney & Nicolas Jacquelot. (2023) Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers. Pharmaceutics 15:7, pages 2001.
Crossref
Hansol Lee, Angela L. Ferguson, Camelia Quek, Ismael A. Vergara, Ines Pires daSilva, Ruth Allen, Tuba Nur Gide, Jordan W. Conway, Lambros T. Koufariotis, Nicholas K. Hayward, Nicola Waddell, Matteo S. Carlino, Alexander M. Menzies, Robyn P.M. Saw, Elena Shklovskaya, Helen Rizos, Serigne Lo, Richard A. Scolyer, Georgina V. Long, Umaimainthan Palendira & James S. Wilmott. (2023) Intratumoral CD16+ Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy. Clinical Cancer Research 29:13, pages 2513-2524.
Crossref
Chengbin Guo, Yuqin Tang, Qizhuo Li, Zhao Yang, Yuqi Guo, Chuanliang Chen & Yongqiang Zhang. (2023) Deciphering the immune heterogeneity dominated by natural killer cells with prognostic and therapeutic implications in hepatocellular carcinoma. Computers in Biology and Medicine 158, pages 106872.
Crossref
Man Yao, Shufang Liang & Binbin Cheng. (2023) Role of exosomes in hepatocellular carcinoma and the regulation of traditional Chinese medicine. Frontiers in Pharmacology 14.
Crossref
Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin & Hsing-Chen Tsai. (2023) Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities. Journal of Biomedical Science 30:1.
Crossref
Arailym Sarsembayeva, Melanie Kienzl, Eva Gruden, Dusica Ristic, Kathrin Maitz, Paulina Valadez-Cosmes, Ana Santiso, Carina Hasenoehrl, Luka Brcic, Jörg Lindenmann, Julia Kargl & Rudolf Schicho. (2023) Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells. Frontiers in Immunology 13.
Crossref
Pedro L. Valenzuela, Gonzalo Saco-Ledo, Alejandro Santos-Lozano, Javier S. Morales, Adrián Castillo-García, Richard J. Simpson, Alejandro Lucia & Carmen Fiuza-Luces. (2022) Exercise Training and Natural Killer Cells in Cancer Survivors: Current Evidence and Research Gaps Based on a Systematic Review and Meta-analysis. Sports Medicine - Open 8:1.
Crossref
Xuewen Deng & Hiroshi Terunuma. (2022) Harnessing NK Cells to Control Metastasis. Vaccines 10:12, pages 2018.
Crossref
Xin Chen, Lei Jiang & Xuesong Liu. (2022) Natural killer cells: the next wave in cancer immunotherapy. Frontiers in Immunology 13.
Crossref
Guang he Ran, Yu qing Lin, Lei Tian, Tao Zhang, Dong mei Yan, Jian hua Yu & You cai Deng. (2022) Natural killer cell homing and trafficking in tissues and tumors: from biology to application. Signal Transduction and Targeted Therapy 7:1.
Crossref
Fiorella Rossi, Nathaniel Fredericks, Andrew Snowden, Michael J. Allegrezza & Uriel Y. Moreno-Nieves. (2022) Next Generation Natural Killer Cells for Cancer Immunotherapy. Frontiers in Immunology 13.
Crossref
Ariel Ramírez-Labrada, Cecilia Pesini, Llipsy Santiago, Sandra Hidalgo, Adanays Calvo-Pérez, Carmen Oñate, Alejandro Andrés-Tovar, Marcela Garzón-Tituaña, Iratxe Uranga-Murillo, Maykel A. Arias, Eva M. Galvez & Julián Pardo. (2022) All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity. Frontiers in Immunology 13.
Crossref
Jiannong LiInna Smalley, Zhihua ChenJheng-Yu WuManali S. PhadkeJamie K. Teer, Thanh NguyenFlorian A. Karreth, John M. Koomen, Amod A. SarnaikJonathan S. Zager, Nikhil I. KhushalaniAhmad A. Tarhini, Vernon K. Sondak, Paulo C. Rodriguez, Jane L. Messina, Y. Ann Chen & Keiran S.M. Smalley. (2022) Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy. Clinical Cancer Research 28:10, pages 2131-2146.
Crossref
Hailey K. Carroll, Austin G. Duffy & Cliona O'Farrelly. (2022) Liver Immunology, Immunotherapy, and Liver Cancers: Time for a Rethink?. Seminars in Liver Disease 42:02, pages 212-224.
Crossref
Qing Wu, Yangzhi Hu, Qinghui Ma, Shanglin Yang, Junpeng Chen, Shunqian Wen & Guanqun Liao. (2022) Comprehensive Analysis of RAPGEF2 for Predicting Prognosis and Immunotherapy Response in Patients with Hepatocellular Carcinoma. Journal of Oncology 2022, pages 1-11.
Crossref
Andrea Ladányi, Barbara Hegyi, Tímea Balatoni, Gabriella Liszkay, Raphael Rohregger, Christoph Waldnig, József Dudás & Soldano Ferrone. (2022) HLA Class I Downregulation in Progressing Metastases of Melanoma Patients Treated With Ipilimumab. Pathology and Oncology Research 28.
Crossref
Ridwan Dwi Saputro, Hanggoro Tri Rinonce, Yayuk Iramawasita, Muhammad Rasyid Ridho, Maria Fransiska Pudjohartono, Sumadi Lukman Anwar, Kunto Setiaji & Teguh Aryandono. (2021) Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma. BMC Research Notes 14:1.
Crossref
Pankaj Ahluwalia, Meenakshi Ahluwalia, Ashis K. Mondal, Nikhil S. Sahajpal, Vamsi Kota, Mumtaz V. Rojiani & Ravindra Kolhe. (2021) Natural Killer Cells and Dendritic Cells: Expanding Clinical Relevance in the Non-Small Cell Lung Cancer (NSCLC) Tumor Microenvironment. Cancers 13:16, pages 4037.
Crossref
Mercedes Beatriz Fuertes, Carolina Inés Domaica & Norberto Walter Zwirner. (2021) Leveraging NKG2D Ligands in Immuno-Oncology. Frontiers in Immunology 12.
Crossref
Quentin Wright, Jazmina L. Gonzalez Cruz, James W. Wells & Graham R. Leggatt. (2021) PD-1 and beyond to Activate T Cells in Cutaneous Squamous Cell Cancers: The Case for 4-1BB and VISTA Antibodies in Combination Therapy. Cancers 13:13, pages 3310.
Crossref
Elena Shklovskaya & Helen Rizos. (2021) MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It. International Journal of Molecular Sciences 22:13, pages 6741.
Crossref
Grace H. Attrill, Peter M. Ferguson, Umaimainthan Palendira, Georgina V. Long, James S. Wilmott & Richard A. Scolyer. (2020) The tumour immune landscape and its implications in cutaneous melanoma. Pigment Cell & Melanoma Research 34:3, pages 529-549.
Crossref
Kari A. Shaver, Tayler J. Croom-Perez & Alicja J. Copik. (2021) Natural Killer Cells: The Linchpin for Successful Cancer Immunotherapy. Frontiers in Immunology 12.
Crossref
Hansol Lee, Inês Pires Da Silva, Umaimainthan Palendira, Richard A. Scolyer, Georgina V. Long & James S. Wilmott. (2021) Targeting NK Cells to Enhance Melanoma Response to Immunotherapies. Cancers 13:6, pages 1363.
Crossref
Ziqing Chen, Ying Yang, Shi Y Neo, Hao Shi, Yi Chen, Arnika K Wagner, Karin Larsson, Le Tong, Per‐Johan Jakobsson, Evren Alici, Jing Wu, Yihai Cao, Kai Wang, Lisa L Liu, Yumeng Mao, Dhifaf Sarhan & Andreas Lundqvist. (2021) Phosphodiesterase 4A confers resistance to PGE2‐mediated suppression in CD25 + /CD54 + NK cells . EMBO reports 22:3.
Crossref
Fahmin Basher, Payal Dhar, Xin Wang, Derek A. Wainwright, Bin Zhang, Jeffrey Sosman, Zhe Ji & Jennifer D. Wu. (2020) Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy. Journal of Hematology & Oncology 13:1.
Crossref
Peng-Fei Zhang, Chao Gao, Xiao-Yong Huang, Jia-Cheng Lu, Xiao-Jun Guo, Guo-Ming Shi, Jia-Bin Cai & Ai-Wu Ke. (2020) Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. Molecular Cancer 19:1.
Crossref
Aintzane Apraiz, Aitor Benedicto, Joana Marquez, Andrea Agüera-Lorente, Aintzane Asumendi, Elvira Olaso & Beatriz Arteta. (2020) Innate Lymphoid Cells in the Malignant Melanoma Microenvironment. Cancers 12:11, pages 3177.
Crossref
Kishore Kumar Jella, Tahseen H. Nasti, Zhentian Li, David H. Lawson, Jeffrey M. Switchenko, Rafi Ahmed, William S. Dynan & Mohammad K. Khan. (2020) Exosome-Containing Preparations From Postirradiated Mouse Melanoma Cells Delay Melanoma Growth In Vivo by a Natural Killer Cell–Dependent Mechanism. International Journal of Radiation Oncology*Biology*Physics 108:1, pages 104-114.
Crossref
Lujun Shen, Han Qi, Shuanggang Chen, Fei Cao, Lin Xie, Ying Wu, Weimei Ma, Ze Song, Hui Yuan, Tao Zhang, Dandan Li, Xizhi Wen, Qifeng Chen, Wang Li, Xiaoshi Zhang & Weijun Fan. (2020) Cryoablation combined with transarterial infusion of pembrolizumab (CATAP) for liver metastases of melanoma: an ambispective, proof-of-concept cohort study. Cancer Immunology, Immunotherapy 69:9, pages 1713-1724.
Crossref
Zuzana Strizova, Martin Snajdauf, Dmitry Stakheev, Pavla Taborska, Jiri VachtenheimJrJr, Jan Biskup, Robert Lischke, Jirina Bartunkova & Daniel Smrz. (2020) The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients. Journal of Cancer Research and Clinical Oncology 146:8, pages 1979-1992.
Crossref
Rui Teng, Yanmeng Wang, Nan Lv, Dan Zhang, Ramone A. Williamson, Lei Lei, Ping Chen, Li Lei, Baiyan Wang, Jiaqi Fu, Xuna Liu, Aili He, Michael O’Dwyer & Jinsong Hu. (2020) Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways. Journal of Immunology Research 2020, pages 1-14.
Crossref
Jules Russick, Carine Torset, Edouard Hemery & Isabelle Cremer. (2020) NK cells in the tumor microenvironment: Prognostic and theranostic impact. Recent advances and trends. Seminars in Immunology 48, pages 101407.
Crossref
Mehdi R. Pirozyan, Helen M. McGuire, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Jenny H. Lee, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, Barbara Fazekas de St Groth & Peter Hersey. (2020) Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients. Frontiers in Immunology 11.
Crossref
Maite Alvarez, Federico Simonetta, Jeanette Baker, Alyssa R. Morrison, Arielle S. Wenokur, Antonio Pierini, Pedro Berraondo & Robert S. Negrin. (2020) Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion. Frontiers in Immunology 11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.