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OncoImmunology Volume 8, 2019 - Issue 9
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Original Research

High tumoral PD-L1 expression and low PD-1+ or CD8+ tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system

Sehui KimDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;Cancer Research Institute, Seoul National University, Seoul, Republic of KoreaView further author information
,
Soo Jeong NamDepartment of Pathology, Asan Medical Center, Seoul, Republic of KoreaView further author information
,
Changhee ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of KoreaView further author information
,
Dohee KwonDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;Cancer Research Institute, Seoul National University, Seoul, Republic of KoreaORCID Iconhttps://orcid.org/0000-0002-4725-3852View further author information
ORCID Icon,
Jeemin YimDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of KoreaView further author information
,
Seung Geun SongDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of KoreaView further author information
,
Chan-Young OckDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of KoreaView further author information
,
Young A KimDepartment of Pathology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, SeoulRepublic of KoreaView further author information
,
Sung Hye ParkDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of KoreaView further author information
,
Tae Min KimCancer Research Institute, Seoul National University, Seoul, Republic of Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of KoreaView further author information
&
Yoon Kyung JeonDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;Cancer Research Institute, Seoul National University, Seoul, Republic of KoreaCorrespondence[email protected]
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Article: e1626653 | Received 10 Jan 2019, Accepted 29 May 2019, Published online: 10 Jun 2019

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Jingbo Zhang, Yiwei Guo, Huiying Fang, Xiuchen Guo & Lina Zhao. (2023) Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment. Autoimmunity 56:1.
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Maysaa Abdulla, Andrei Alexsson, Christer Sundström, Claes Ladenvall, Larry Mansouri, Cecilia Lindskog, Mattias Berglund, Lucia Cavelier, Gunilla Enblad, Peter Hollander & Rose-Marie Amini. (2021) PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS. Acta Oncologica 60:4, pages 531-538.
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Articles from other publishers (18)

Yanjie Ruan, Jiyu Wang, Qiuye Zhang, Huiping Wang, Cong Li, Xuanxuan Xu & Zhimin Zhai. (2023) Clinical implications of aberrant PD-1 expression for acute leukemia prognosis. European Journal of Medical Research 28:1.
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Junnan Li, Xiaoqiong Tang, Xiaohua Luo, Lin Liu, Dan Li & Li Yang. (2023) Clinicopathological analysis and specific discriminating markers of interleukin detection in cerebrospinal fluid with primary central nervous system lymphoma: results from a retrospective study. Annals of Hematology 102:8, pages 2153-2163.
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Isaias Hernández-Verdin, Andrea Morales-Martínez, Khê Hoang-Xuan & Agustí Alentorn. (2022) Primary central nervous system lymphoma: advances in its pathogenesis, molecular markers and targeted therapies. Current Opinion in Neurology 35:6, pages 779-786.
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Bo Liu, Shufang Yan, Sijing Li, Qian Zhang, Meihong Yang, Liuqing Yang, Jiajia Ma & Xinxia Li. (2022) Correlation study of PD-L1, CD4, CD8, and PD-1 in primary diffuse large B-cell lymphoma of the central nervous system. Pathology - Research and Practice 239, pages 154008.
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Shufang Yan, Qinyu Shang, Zhaopu Fan, Yuping Yang, Yanping Liu, Hongliang Gao, Ken Chen, Fei Liang, Xinxia Li, Qian Zhang & Huifang Yan. (2022) Expression of PD-L1 and YWHAZ in Patients with Diffuse Large B Cell Lymphoma: A Possible Association with the Prognosis of Lymphoma. Journal of Immunology Research 2022, pages 1-18.
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Shoichi Kimura, Yumi Oshiro, Hiromi Iwasaki, Masanori Kadowaki, Yasuhito Mihashi, Toshifumi Sakata, Shigeto Kawauchi, Ziyao Wang, Yasushi Takamatsu & Morishige Takeshita. (2021) Programmed cell death-ligand 1 (PD-L1)+ tumour cells and low-reacting programmed cell death 1 (PD1)+ tumour-infiltrating lymphocytes predict poor prognosis in Epstein–Barr virus+ diffuse large B-cell lymphoma. Clinical and Experimental Medicine 22:3, pages 411-419.
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Shufang Yan, Qinyu Shang, Haipeng Zhu, Ken Chen, Xinxia Li, Hongliang Gao, Bo Liu, Mei Feng & Lixia Gao. (2022) Effects of hsa-miR-28-5p on Adriamycin Sensitivity in Diffuse Large B-Cell Lymphoma. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-14.
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Tasuku Kawano, Yuta Tsuyuki, Yuka Suzuki, Kazuyuki Shimada, Seiichi Kato, Taishi Takahara, Mayuko Mori, Masato Nakaguro, Ayako Sakakibara, Shigeo Nakamura & Akira Satou. (2021) Clinicopathologic Analysis of Primary Adrenal Diffuse Large B-Cell Lymphoma. American Journal of Surgical Pathology 45:12, pages 1606-1615.
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Georgia Karpathiou, Silvia-Maria Babiuc, Florian Camy, Elise Ferrand, Alexandra Papoudou-Bai, Jean Marc Dumollard, Jerome Cornillon & Michel Peoc’h. (2021) Primary central nervous system lymphomas express immunohistochemical factors of autophagy. Scientific Reports 11:1.
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Shidai Mu, Deyao Shi, Lisha Ai, Fengjuan Fan, Fei Peng, Chunyan Sun & Yu Hu. (2021) International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma. Frontiers in Immunology 12.
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Le Ge, Shan Lu, Lixia Xu & Hua Yan. (2021) MYC, BCL2, and BCL6 expression as prognostic indicators in primary central nervous system lymphoma: A systematic review and meta-analysis. Clinical Neurology and Neurosurgery 208, pages 106838.
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Liang Shao, Chengshi Xu, Huijing Wu, Muhammad Jamal, Shan Pan, Sirui Li, Fei Chen, Ding Yu, Kui Liu & Yongchang Wei. (2021) Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside. Frontiers in Oncology 11.
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Yan Yuan, Tianling Ding, Shu Wang, Hong Chen, Ying Mao & Tong Chen. (2021) Current and emerging therapies for primary central nervous system lymphoma. Biomarker Research 9:1.
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Georgia Karpathiou, Elise Ferrand, Florian Camy, Silvia-Maria Babiuc, Alexandra Papoudou-Bai, Jean Marc Dumollard, Jerome Cornillon & Michel Peoc’h. (2021) Expression of STAT6 and Phosphorylated STAT6 in Primary Central Nervous System Lymphomas. Journal of Neuropathology & Experimental Neurology 80:9, pages 830-834.
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Tongjuan Li, Lei Zhao, Yuanyuan Zhang, Yi Xiao, Di Wang, Liang Huang, Liya Ma, Liting Chen, Songya Liu, Xiaolu Long, Fankai Meng, Xiaojian Zhu, Jia Wei, Bin Xu, Jianfeng Zhou & Xiaoxi Zhou. (2020) CAR T-Cell Therapy Is Effective but Not Long-Lasting in B-Cell Lymphoma of the Brain. Frontiers in Oncology 10.
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Sehui Kim, Dohee Kwon, Jiwon Koh, Soo Jeong Nam, Young A Kim, Tae Min Kim, Chul Woo Kim & Yoon Kyung Jeon. (2020) Clinicopathological features of programmed cell death-1 and programmed cell death-ligand-1 expression in the tumor cells and tumor microenvironment of angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma not otherwise specified. Virchows Archiv 477:1, pages 131-142.
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Shuzhen Tan, Dongpei Li & Xiao Zhu. (2020) Cancer immunotherapy: Pros, cons and beyond. Biomedicine & Pharmacotherapy 124, pages 109821.
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Eduardo Cambruzzi. (2020) Primary Intra-Axial Diffuse Large B-Cell Lymphoma in Immunocompetent Patients: Clinical Impact of Molecular Analysis and Histogenetic Evaluation. World Neurosurgery 134, pages 215-220.
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