Advanced search
Publication Cover
OncoImmunology Volume 8, 2019 - Issue 11
Submit an article Journal homepage
2,260
Views
16
CrossRef citations to date
0
Altmetric
Original Research

The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients

Arjun KhungerDepartment of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USAView further author information
,
Julie A. RytlewskiAdaptive Biotechnologies, Seattle, WA, USAView further author information
,
Paul FieldsAdaptive Biotechnologies, Seattle, WA, USAView further author information
,
Erik C. YuskoAdaptive Biotechnologies, Seattle, WA, USAView further author information
&
Ahmad A. TarhiniDepartment of Cutaneous Oncology, Moffitt Comprehensive Cancer Center, Tampa, Florida, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3193-9702View further author information
ORCID Icon
Article: e1652538 | Received 28 Mar 2019, Accepted 31 Jul 2019, Published online: 20 Aug 2019

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Mariam Saad, Ella Castellano & Ahmad A. Tarhini. (2023) Clinical updates in neoadjuvant immunotherapy for melanoma before surgery. Expert Review of Clinical Immunology 0:0, pages 1-17.
Read now
Julie Le Naour, Laurence Zitvogel, Lorenzo Galluzzi, Erika Vacchelli & Guido Kroemer. (2020) Trial watch: STING agonists in cancer therapy. OncoImmunology 9:1.
Read now

Articles from other publishers (14)

A. Abed, A.B. Beasley, A.L. Reid, N. Law, L. Calapre, M. Millward, J. Lo & E.S. Gray. (2023) Circulating pre-treatment T-cell receptor repertoire as a predictive biomarker in advanced or metastatic non-small-cell lung cancer patients treated with pembrolizumab alone or in combination with chemotherapy. ESMO Open 8:6, pages 102066.
Crossref
Mariam Saad & Ahmad A. Tarhini. (2023) Neoadjuvant Therapy in Melanoma: Where Are We Now?. Current Oncology Reports 25:4, pages 325-339.
Crossref
Firas Hamdan & Vincenzo Cerullo. (2023) Cancer immunotherapies: A hope for the uncurable?. Frontiers in Molecular Medicine 3.
Crossref
Wei Wang, Liu-Fang Ye, Hua Bao, Ming-Tao Hu, Ming Han, Hai-Meng Tang, Chao Ren, Xue Wu, Yang Shao, Feng-Hua Wang, Zhi-Wei Zhou, Yu-Hong Li, Rui-Hua Xu & De-Shen Wang. (2022) Heterogeneity and evolution of tumour immune microenvironment in metastatic gastroesophageal adenocarcinoma. Gastric Cancer 25:6, pages 1017-1030.
Crossref
Ahmad A Tarhini, Jennifer R Eads, Kathleen N Moore, Valerie Tatard-Leitman, John Wright, Patrick M Forde & Robert L Ferris. (2022) Neoadjuvant immunotherapy of locoregionally advanced solid tumors. Journal for ImmunoTherapy of Cancer 10:8, pages e005036.
Crossref
Adrienne M. Luoma, Shengbao Suo, Yifan Wang, Lauren Gunasti, Caroline B.M. Porter, Nancy Nabilsi, Jenny Tadros, Andrew P. Ferretti, Sida Liao, Cagan Gurer, Yu-Hui Chen, Shana Criscitiello, Cora A. Ricker, Danielle Dionne, Orit Rozenblatt-Rosen, Ravindra Uppaluri, Robert I. Haddad, Orr Ashenberg, Aviv Regev, Eliezer M. Van Allen, Gavin MacBeath, Jonathan D. Schoenfeld & Kai W. Wucherpfennig. (2022) Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. Cell 185:16, pages 2918-2935.e29.
Crossref
Yi Zhou, Qi Shu, Zailin Fu, Chen Wang, Jianrong Gu, Jianbo Li, Yifang Chen & Minghua Xie. (2022) A novel risk model based on cuproptosis-related lncRNAs predicted prognosis and indicated immune microenvironment landscape of patients with cutaneous melanoma. Frontiers in Genetics 13.
Crossref
Andrea Aran, Laia Garrigós, Giuseppe Curigliano, Javier Cortés & Mercè Martí. (2022) Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?. Cancers 14:7, pages 1771.
Crossref
Noah A. Kaitz, Cindy L. Zuleger, Peng Yu, Michael A. Newton, Richard J. Albertini & Mark R. Albertini. (2022) Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cells. Mutation Research/Reviews in Mutation Research 789, pages 108414.
Crossref
Huakan Zhao, Lei Wu, Guifang Yan, Yu Chen, Mingyue Zhou, Yongzhong Wu & Yongsheng Li. (2021) Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduction and Targeted Therapy 6:1.
Crossref
Mitra Ghasemi‐Chaleshtari, Seyed Hossein Kiaie, Mahzad Irandoust, Hadis Karami, Mohsen Nabi Afjadi, Sepideh Ghani, Nasimeh Aghaei Vanda, Mohammad Javad Ghaderi Sede, Armin Ahmadi, Ali Masjedi, Hadi Hassannia, Fatemeh Atyabi, Mohammad Hojjat‐Farsangi, Afshin Namdar, Ghasem Ghalamfarsa & Farhad Jadidi‐Niaragh. (2020) Concomitant blockade of A2AR and CTLA‐4 by siRNA‐loaded polyethylene glycol‐chitosan‐alginate nanoparticles synergistically enhances antitumor T‐cell responses. Journal of Cellular Physiology 235:12, pages 10068-10080.
Crossref
Johanna Chiffelle, Raphael Genolet, Marta AS Perez, George Coukos, Vincent Zoete & Alexandre Harari. (2020) T-cell repertoire analysis and metrics of diversity and clonality. Current Opinion in Biotechnology 65, pages 284-295.
Crossref
Ilenia Aversa, Donatella Malanga, Giuseppe Fiume & Camillo Palmieri. (2020) Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy. International Journal of Molecular Sciences 21:7, pages 2378.
Crossref
Bhavneet Bhinder & Olivier Elemento. 2020. Tumor Immunology and Immunotherapy – Integrated Methods Part B. Tumor Immunology and Immunotherapy – Integrated Methods Part B 209 259 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.