Advanced search
Publication Cover
OncoImmunology Volume 9, 2020 - Issue 1
Submit an article Journal homepage
3,726
Views
22
CrossRef citations to date
0
Altmetric
Original Research

Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation

Mark A. J. M. Hendriksa Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-7276-4622View further author information
ORCID Icon,
Emily M. Ploega Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-0735-2020View further author information
ORCID Icon,
Iris Koopmansa Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-9976-6510View further author information
ORCID Icon,
Isabel Britscha Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-4772-9889View further author information
ORCID Icon,
Xiurong Kea Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands;b Department of Immunotherapy and Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, ChinaORCID Iconhttps://orcid.org/0000-0002-0640-4466View further author information
ORCID Icon,
Douwe F. Samploniusa Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-0613-7150View further author information
ORCID Icon &
Wijnand Helfricha Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7004-3995View further author information
ORCID Icon show all
Article: 1824323 | Received 03 Jun 2020, Accepted 02 Sep 2020, Published online: 29 Sep 2020

Citations (22)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Celine A.N. Sewnath, Leonie M. Behrens & Marjolein van Egmond. (2022) Targeting myeloid cells with bispecific antibodies as novel immunotherapies of cancer. Expert Opinion on Biological Therapy 22:8, pages 983-995.
Read now
Mark A.J.M. Hendriks, Isabel Britsch, Xiurong Ke, Anne P. van Wijngarden, Douwe F. Samplonius, Emily M. Ploeg & Wijnand Helfrich. (2021) Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis. OncoImmunology 10:1.
Read now

Articles from other publishers (20)

Xiaotong Liu, Huarong Zhang, Chaohu Wang, Zhiyong Li, Qianchao Zhu, Yiwen Feng, Jun Fan, Songtao Qi, Zhiyong Wu & Yi Liu. (2023) Tumor-selective Blockade of CD47 Signaling with CD47 Antibody for Enhanced Anti-tumor Activity in Malignant Meningioma. Current Neuropharmacology 21:10, pages 2159-2173.
Crossref
Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Hao Zhang & Wijnand Helfrich. (2023) Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR. Journal for ImmunoTherapy of Cancer 11:9, pages e006837.
Crossref
Jacqueline Aparecida Torres, Angelo Borsarelli Carvalho Brito, Virgilio Souza e Silva, Iara Monique Messias, Alexcia Camila Braun, Anna Paula Carreta Ruano, Marcilei E. C. Buim, Dirce Maria Carraro & Ludmilla Thomé Domingos Chinen. (2023) CD47 Expression in Circulating Tumor Cells and Circulating Tumor Microemboli from Non-Small Cell Lung Cancer Patients Is a Poor Prognosis Factor. International Journal of Molecular Sciences 24:15, pages 11958.
Crossref
Vinicio Melo, Levi Collin Nelemans, Martijn Vlaming, Harm Jan Lourens, Valerie R. Wiersma, Vrouyr Bilemjian, Gerwin Huls, Marco de Bruyn & Edwin Bremer. (2023) EGFR-selective activation of CD27 co-stimulatory signaling by a bispecific antibody enhances anti-tumor activity of T cells. Frontiers in Immunology 14.
Crossref
Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius & Wijnand Helfrich. (2023) A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer. Cancers 15:14, pages 3651.
Crossref
Yu Hao, Xinxuan Zhou, Yiling Li, Bolei Li & Lei Cheng. (2023) The CD47-SIRPα axis is a promising target for cancer immunotherapies. International Immunopharmacology 120, pages 110255.
Crossref
Zhihong Wang, Naijing Hu, Haitao Wang, Yuanyu Wu, Guiqi Quan, Yahui Wu, Xinying Li, Jiannan Feng & Longlong Luo. (2023) High-affinity decoy protein, nFD164, with an inactive Fc region as a potential therapeutic drug targeting CD47. Biomedicine & Pharmacotherapy 162, pages 114618.
Crossref
Zi-Han Ye, Wei-Bang Yu, Mu-Yang Huang, Jun Chen & Jin-Jian Lu. (2023) Building on the backbone of CD47-based therapy in cancer: Combination strategies, mechanisms, and future perspectives. Acta Pharmaceutica Sinica B 13:4, pages 1467-1487.
Crossref
Leonie M. Behrens, Marjolein van Egmond & Timo K. van den Berg. (2022) Neutrophils as immune effector cells in antibody therapy in cancer. Immunological Reviews 314:1, pages 280-301.
Crossref
Mengmeng Liu, Lina Liu, Yongping Song, Wei Li & Linping Xu. (2022) Targeting macrophages: a novel treatment strategy in solid tumors. Journal of Translational Medicine 20:1.
Crossref
Xavier Chauchet, Laura Cons, Laurence Chatel, Bruno Daubeuf, Gérard Didelot, Valéry Moine, Didier Chollet, Pauline Malinge, Guillemette Pontini, Krzysztof Masternak, Walter Ferlin, Vanessa Buatois & Limin Shang. (2022) CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model. Experimental Hematology & Oncology 11:1.
Crossref
Alberto Mantovani, Paola Allavena, Federica Marchesi & Cecilia Garlanda. (2022) Macrophages as tools and targets in cancer therapy. Nature Reviews Drug Discovery 21:11, pages 799-820.
Crossref
Marion Cannac, Jovan Nikolic & Philippe Benaroch. (2022) Cancer Immunotherapies Based on Genetically Engineered Macrophages. Cancer Immunology Research 10:10, pages 1156-1166.
Crossref
Binglei Zhang, Wei Li, Dandan Fan, Wenzhi Tian, Jian Zhou, Zhenyu Ji & Yongping Song. (2022) Advances in the study of CD47 ‐based bispecific antibody in cancer immunotherapy . Immunology 167:1, pages 15-27.
Crossref
Renée Bouwstra, Tom van Meerten & Edwin Bremer. (2022) CD47‐SIRPα blocking‐based immunotherapy: Current and prospective therapeutic strategies. Clinical and Translational Medicine 12:8.
Crossref
Leonie M. Behrens, Timo K. van den Berg & Marjolein van Egmond. (2022) Targeting the CD47-SIRPα Innate Immune Checkpoint to Potentiate Antibody Therapy in Cancer by Neutrophils. Cancers 14:14, pages 3366.
Crossref
Anneloes van Duijn, Sjoerd H Van der Burg & Ferenc A Scheeren. (2022) CD47/SIRPα axis: bridging innate and adaptive immunity. Journal for ImmunoTherapy of Cancer 10:7, pages e004589.
Crossref
Won Lee, Song Kim, Jae An, Tae-Koon Kim, Hee Cha, Hyo Chang, Sang Kim, Seong Kim & Myung Han. (2022) Tristetraprolin regulates phagocytosis through interaction with CD47 in head and neck cancer. Experimental and Therapeutic Medicine 24:3.
Crossref
Vinicio Melo, Edwin Bremer & John D. Martin. (2022) Towards Immunotherapy-Induced Normalization of the Tumor Microenvironment. Frontiers in Cell and Developmental Biology 10.
Crossref
Emily M. Ploeg, Xiurong Ke, Isabel Britsch, Mark A.J.M. Hendriks, Femke A. Van der Zant, Schelto Kruijff, Douwe F. Samplonius, Hao Zhang & Wijnand Helfrich. (2021) Bispecific antibody CD73xEpCAM selectively inhibits the adenosine-mediated immunosuppressive activity of carcinoma-derived extracellular vesicles. Cancer Letters 521, pages 109-118.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.