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OncoImmunology Volume 9, 2020 - Issue 1
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Original Research

Identification of a costimulatory molecule-based signature for predicting prognosis risk and immunotherapy response in patients with lung adenocarcinoma

Chaoqi Zhanga Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Zhihui Zhanga Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Nan Suna Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Zhen Zhangb Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
,
Guochao Zhanga Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Feng Wanga Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Yuejun Luoa Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Yun Chea Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
&
Jie Hea Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCorrespondence[email protected]
View further author information
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Article: 1824641 | Received 24 Apr 2020, Accepted 14 Sep 2020, Published online: 29 Sep 2020

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Chao Wu, Jingyue Yang, Rui Ding, Xiao Li, Zhi Yang, Min Zhu & Zhengcai Liu. (2022) Identification of a costimulatory molecule-based signature to predict prognostic risk of pancreatic adenocarcinoma. All Life 15:1, pages 808-819.
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Chunxiao Wu, Qiquan Yu, Weizhen Shou, Kun Zhang, Yang Li, Wentao Guo & Qi Bao. (2022) Co-stimulatory molecule clusters correlate with survival, immune infiltration, and tumor mutation burden in non-small cell lung cancer. All Life 15:1, pages 760-770.
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Articles from other publishers (31)

Weiyi Zhang. (2023) Big data analysis identified a telomere-related signature predicting the prognosis and drug sensitivity in lung adenocarcinoma. Medicine 102:46, pages e35526.
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Zuwei Li, Minzhang Guo, Wanli Lin & Peiyuan Huang. (2023) Machine Learning-Based Integration Develops a Macrophage-Related Index for Predicting Prognosis and Immunotherapy Response in Lung Adenocarcinoma. Archives of Medical Research 54:7, pages 102897.
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Dong Zhang, Yingnan Wang, Faming Zhao & Qifeng Yang. (2023) Integrated multiomics analyses unveil the implication of a costimulatory molecule score on tumor aggressiveness and immune evasion in breast cancer: A large-scale study through over 8,000 patients. Computers in Biology and Medicine 159, pages 106866.
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Peng Wu, Zhihui Zhang, Zhaoyang Yang, Chaoqi Zhang, Yuejun Luo, Guochao Zhang, Lide Wang, Qi Xue, Nan Sun & Jie He. (2022) Costimulatory molecule expression profile as a biomarker to predict prognosis and chemotherapy response for patients with small cell lung cancer. Cancer Immunology, Immunotherapy 72:3, pages 617-631.
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Wanze Huang, Duntao Su, Xin Liao, Tongtong Yang, Yan Lu & Zhejia Zhang. (2023) Prognostic costimulatory molecule-related signature risk model correlates with immunotherapy response in colon cancer. Scientific Reports 13:1.
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Hui Jia, Wen-Jin Tang, Lei Sun, Chong Wan, Yun Zhou & Wei-Zhong Shen. (2023) Pan-cancer analysis identifies proteasome 26S subunit, ATPase (PSMC) family genes, and related signatures associated with prognosis, immune profile, and therapeutic response in lung adenocarcinoma. Frontiers in Genetics 13.
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Fangfang Duan, Weisen Wang, Wenyu Zhai, Junye Wang, Zerui Zhao, Lie Zheng, Bingyu Rao, Yuheng Zhou, Hao Long & Yaobin Lin. (2022) A novel diagnostic model for predicting immune microenvironment subclass based on costimulatory molecules in lung squamous carcinoma. Frontiers in Genetics 13.
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Zhen Chen, Xinhuai Dong, Genglong Liu, Yangpeng Ou, Chuangang Lu, Ben Yang, Xuelian Zhu & Liuer Zuo. (2022) Comprehensive characterization of costimulatory molecule gene for diagnosis, prognosis and recognition of immune microenvironment features in sepsis. Clinical Immunology 245, pages 109179.
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Ji Wang, Zi Wang, Wenxue Jia, Wei Gong, Bokai Dong, Zhuangzhuang Wang, Meng Zhou & Chunlei Tian. (2022) The role of costimulatory molecules in glioma biology and immune microenvironment. Frontiers in Genetics 13.
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Hao Rong, Jun Peng, Ke Ma, Jiang Zhu & Jin-Tao He. (2022) Ttc39c is a potential target for the treatment of lung cancer. BMC Pulmonary Medicine 22:1.
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Xue Zhan, Shihan Feng, Xutao Zhou, Wei Liao, Bin Zhao, Qian Yang, Qi Tan & Jian Shen. (2022) Immunotherapy response and microenvironment provide biomarkers of immunotherapy options for patients with lung adenocarcinoma. Frontiers in Genetics 13.
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Hongxiang Feng, Chaoyang Liang, Yuhui Shi, Deruo Liu, Jin Zhang & Zhenrong Zhang. (2022) Comprehensive Analysis of a Novel Immune-Related Gene Signature in Lung Adenocarcinoma. Journal of Clinical Medicine 11:20, pages 6154.
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Wen-Yu Zhai, Fang-Fang Duan, Yi-Zhi Wang, Jun-Ye Wang, Ze-Rui Zhao, Yao-Bin Lin, Bing-Yu Rao, Si Chen, Lie Zheng & Hao Long. (2022) Integrative Analysis of Bioinformatics and Machine Learning Algorithms Identifies a Novel Diagnostic Model Based on Costimulatory Molecule for Predicting Immune Microenvironment Status in Lung Adenocarcinoma. The American Journal of Pathology 192:10, pages 1433-1447.
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Shihao Huang, Shiyu Chen, Di Zhang, Jiamei Gao & Linhua Liu. (2022) Enhancer-associated regulatory network and gene signature based on transcriptome and methylation data to predict the survival of patients with lung adenocarcinoma. Frontiers in Genetics 13.
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Yang Liu, Mingyang Yu, Xuechao Cheng, Xingshu Zhang, Qian Luo, Sijin Liao, Zhongzheng Chen, Jianhao Zheng, Kaijun Long, Xingwei Wu, Wendong Qu, Ming Gong & Yongxiang Song. (2022) A novel LUAD prognosis prediction model based on immune checkpoint-related lncRNAs. Frontiers in Genetics 13.
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Congkuan Song, Shize Pan, Donghang Li, Bo Hao, Zilong Lu, Kai Lai, Ning Li & Qing Geng. (2022) Comprehensive analysis reveals the potential value of inflammatory response genes in the prognosis, immunity, and drug sensitivity of lung adenocarcinoma. BMC Medical Genomics 15:1.
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Yongjie Zhou, Xin Zhou, Qingxin Liu, Zihan Zhang, Wen Zhang, Jingqin Ma, Minjie Yang, Jiaze Yu, Jianjun Luo & Zhiping Yan. (2022) Development of a Costimulatory Molecule Signature to Predict Prognosis, Immune Landscape, and Response to Immune Therapy for Hepatocellular Carcinoma. Disease Markers 2022, pages 1-15.
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Yan Mao, Zhengyun Hu, Xuejiao Xu, Jinwen Xu, Chuyan Wu, Feng Jiang & Guoping Zhou. (2022) Identification of a prognostic model based on costimulatory molecule-related subtypes and characterization of tumor microenvironment infiltration in acute myeloid leukemia. Frontiers in Genetics 13.
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Jinfeng Ning, Fengjiao Wang, Jianlong Bu, Kaibin Zhu & Wei Liu. (2022) Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma. Cell Death Discovery 8:1.
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Bangjie Chen, Yong Yao, Deshen Mao, Conghan Li, Xingyu Wang, Shuyan Sheng, Lizhi Zhang, Xinyi Wang, Sanwei Chen, Wentao Xu, Jianyi Deng, Chenyu Sun, Qin Zhou, Scott Lowe, Rachel Bentley, Wei Shao & Haiwen Li. (2022) A Signature Based on Costimulatory Molecules for the Assessment of Prognosis and Immune Characteristics in Patients With Stomach Adenocarcinoma. Frontiers in Immunology 13.
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Congkuan Song, Zilong Lu, Kai Lai, Donghang Li, Bo Hao, Chenzhen Xu, Shize Pan, Ning Li & Qing Geng. (2022) Identification of an inflammatory response signature associated with prognostic stratification and drug sensitivity in lung adenocarcinoma. Scientific Reports 12:1.
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Qi Wang, Qiong Fang, Yanping Huang, Jin Zhou & Meimei Liu. (2022) Identification of a novel prognostic signature for HCC and analysis of costimulatory molecule-related lncRNA AC099850.3. Scientific Reports 12:1.
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Yueli Shi, Yun Xu, Zhiyong Xu, Huan Wang, Jingnan Zhang, Yuan Wu, Bufu Tang, Shenfei Zheng & Kai Wang. (2022) TKI resistant-based prognostic immune related gene signature in LUAD, in which FSCN1 contributes to tumor progression. Cancer Letters 532, pages 215583.
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Yan Ma, Xiaoyan Zhang, Jiancheng Yang, Yanping Jin, Ying Xu & Jianping Qiu. (2022) Comprehensive Molecular Analyses of a TNF Family-Based Gene Signature as a Potentially Novel Prognostic Biomarker for Cervical Cancer. Frontiers in Oncology 12.
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Carlo Genova, Chiara Dellepiane, Paolo Carrega, Sara Sommariva, Guido Ferlazzo, Paolo Pronzato, Rosaria Gangemi, Gilberto Filaci, Simona Coco & Michela Croce. (2022) Therapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade. Frontiers in Immunology 12.
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Wen-Yu Zhai, Fang-Fang Duan, Si Chen, Jun-Ye Wang, Yao-Bin Lin, Yi-Zhi Wang, Bing-Yu Rao, Ze-Rui Zhao & Hao Long. (2022) A Novel Inflammatory-Related Gene Signature Based Model for Risk Stratification and Prognosis Prediction in Lung Adenocarcinoma. Frontiers in Genetics 12.
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Xin Cheng, Yucheng Cao, Xiaowei Wang, Lin Cheng, Yaqiong Liu, Jun Lei, Weijun Peng & Dazun Shi. (2022) Systematic Pan-Cancer Analysis of KLRB1 with Prognostic Value and Immunological Activity across Human Tumors. Journal of Immunology Research 2022, pages 1-21.
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Wenchang Lv, Chongru Zhao, Yufang Tan, Weijie Hu, Honghao Yu, Ning Zeng, Qi Zhang & Yiping Wu. (2021) Identification of an Aging-Related Gene Signature in Predicting Prognosis and Indicating Tumor Immune Microenvironment in Breast Cancer. Frontiers in Oncology 11.
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Zhihui Zhang, Chaoqi Zhang, Yuejun Luo, Peng Wu, Guochao Zhang, Qingpeng Zeng, Lide Wang, Zhaoyang Yang, Liyan Xue, Bo Zheng, Hua Zeng, Fengwei Tan, Qi Xue, Shugeng Gao, Nan Sun & Jie He. (2021) m6A regulator expression profile predicts the prognosis, benefit of adjuvant chemotherapy, and response to anti-PD-1 immunotherapy in patients with small-cell lung cancer. BMC Medicine 19:1.
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Xiaoliang Hua, Shengdong Ge, Jiong Zhang, Haibing Xiao, Sheng Tai, Cheng Yang, Li Zhang & Chaozhao Liang. (2021) A costimulatory molecule-related signature in regard to evaluation of prognosis and immune features for clear cell renal cell carcinoma. Cell Death Discovery 7:1.
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Long‐Qing Li, Liang‐Hao Zhang, Yao‐bo Yuan, Xin‐Chang Lu, Yi Zhang, Yong‐Kui Liu, Jia Wen, Manhas Abdul Khader, Tao Liu, Jia‐Zhen Li & Yan Zhang. (2021) Signature based on metabolic‐related gene pairs can predict overall survival of osteosarcoma patients. Cancer Medicine 10:13, pages 4493-4509.
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