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Commentary

Is there a role for therapeutic cancer vaccines in the age of checkpoint inhibitors?

Pages 528-532 | Received 07 Sep 2016, Accepted 29 Sep 2016, Published online: 23 Dec 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Robert O. Dillman, Gabriel I. Nistor & Hans S. Keirstead. (2023) Autologous dendritic cells loaded with antigens from self-renewing autologous tumor cells as patient-specific therapeutic cancer vaccines. Human Vaccines & Immunotherapeutics 19:1.
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Robert O. Dillman, Gabriel I. Nistor & Aleksandra J. Poole. (2020) Genomic, proteomic, and immunologic associations with a durable complete remission of measurable metastatic melanoma induced by a patient-specific dendritic cell vaccine. Human Vaccines & Immunotherapeutics 16:4, pages 742-755.
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Gaetano Donofrio, Giulia Tebaldi, Stefania Lanzardo, Roberto Ruiu, Elisabetta Bolli, Andrea Ballatore, Valeria Rolih, Francesca Macchi, Laura Conti & Federica Cavallo. (2018) Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells. OncoImmunology 7:12.
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Margaret E. Gatti-Mays, Jason M. Redman, Julie M. Collins & Marijo Bilusic. (2017) Cancer vaccines: Enhanced immunogenic modulation through therapeutic combinations. Human Vaccines & Immunotherapeutics 13:11, pages 2561-2574.
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Deepti Katiyar. (2023) Applications of intelligent biomaterials in cancer immunotherapy: A review. Materials Today: Proceedings.
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Qiuyu Wu, Yuanhang Xia, Xiaohe Xiong, Xinxing Duan, Xiaoxiao Pang, Fugui Zhang, Song Tang, Junlei Su, Shuqiong Wen, Li Mei, Richard D. Cannon, Ping Ji & Zhanpeng Ou. (2023) Focused ultrasound-mediated small-molecule delivery to potentiate immune checkpoint blockade in solid tumors. Frontiers in Pharmacology 14.
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Pei Huang & Hongzhang Deng. 2023. Immune Checkpoint Inhibitors - New Insights and Recent Progress. Immune Checkpoint Inhibitors - New Insights and Recent Progress.
Dalil Hannani, Estelle Leplus, Karine Laulagnier, Laurence Chaperot & Joël Plumas. (2023) Leveraging a powerful allogeneic dendritic cell line towards neoantigen-based cancer vaccines. Genes & Cancer 14, pages 3-11.
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Natacha Jugniot, Jeremy J. Dahl & Ramasamy Paulmurugan. (2022) Immunotheranostic microbubbles (iMBs) - a modular platform for dendritic cell vaccine delivery applied to breast cancer immunotherapy. Journal of Experimental & Clinical Cancer Research 41:1.
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Mahnaz Rezaei, Natalia D. Danilova, Mojdeh Soltani, Lyudmila V. Savvateeva, Vadim V. Tarasov, Mazdak Ganjalikhani-Hakemi, Alexandr V. Bazhin & Andrey A. Zamyatnin. (2022) Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities. Current Cancer Drug Targets 22:6, pages 437-453.
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Juliana Sitta, Pier Paolo Claudio & Candace M. Howard. (2022) Virus-Based Immuno-Oncology Models. Biomedicines 10:6, pages 1441.
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Reza Bayat Mokhtari, Manpreet Sambi, Bessi Qorri, Narges Baluch, Neda Ashayeri, Sushil Kumar, Hai-Ling Margaret Cheng, Herman Yeger, Bikul Das & Myron R. Szewczuk. (2021) The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy. Cancers 13:14, pages 3596.
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Patrick Santos & Fausto Almeida. (2021) Exosome-Based Vaccines: History, Current State, and Clinical Trials. Frontiers in Immunology 12.
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Mengying He, Tao Yang, Yuhan Wang, Mengyuan Wang, Xingye Chen, Dawei Ding, Yiran Zheng & Huabing Chen. (2021) Immune Checkpoint Inhibitor‐Based Strategies for Synergistic Cancer Therapy. Advanced Healthcare Materials 10:9, pages 2002104.
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Roza Nurieva, Margarita Divenko & Sang Kim. 2021. Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy. Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy 3 29 .
Gabriel I. Nistor & Robert O. Dillman. (2020) Cytokine network analysis of immune responses before and after autologous dendritic cell and tumor cell vaccine immunotherapies in a randomized trial. Journal of Translational Medicine 18:1.
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Fan Yang, Kun Shi, Yan-peng Jia, Ying Hao, Jin-rong Peng & Zhi-yong Qian. (2020) Advanced biomaterials for cancer immunotherapy. Acta Pharmacologica Sinica 41:7, pages 911-927.
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Pierre Rosenbaum, Cécile Artaud, Sylvie Bay, Christelle Ganneau, Mario Campone, Suzette Delaloge, Carole Gourmelon, Delphine Loirat, Jacques Medioni, François Pein, Marie-Paule Sablin, Olivier Tredan, Andrea Varga & Claude Leclerc. (2020) The fully synthetic glycopeptide MAG-Tn3 therapeutic vaccine induces tumor-specific cytotoxic antibodies in breast cancer patients. Cancer Immunology, Immunotherapy 69:5, pages 703-716.
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Livia Neves Borgheti-Cardoso, Juliana Santos Rosa Viegas, Ana Vitoria Pupo Silvestrini, Angelo Luis Caron, Fabiola Garcia Praça, Marcelo Kravicz & Maria Vitória Lopes Badra Bentley. (2020) Nanotechnology approaches in the current therapy of skin cancer. Advanced Drug Delivery Reviews 153, pages 109-136.
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Robert Owen Dillman & Candace Hsieh. (2019) Survival Comparison between Melanoma Patients Treated with Patient-Specific Dendritic Cell Vaccines and Other Immunotherapies Based on Extent of Disease at the Time of Treatment. Biomedicines 7:4, pages 80.
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Jing Zhao, Ye Chen, Zhen-Yu Ding & Ji-Yan Liu. (2019) Safety and Efficacy of Therapeutic Cancer Vaccines Alone or in Combination With Immune Checkpoint Inhibitors in Cancer Treatment. Frontiers in Pharmacology 10.
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Robert O. Dillman, Gabriel I. Nistor, Bryce T. McLelland, Candace Hsieh, Aleksandra J. Poole, Andrew N. Cornforth & Hans S. Keirstead. (2019) Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines. Oncotarget 10:51, pages 5359-5371.
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Robert O Dillman, Andrew N Cornforth, Edward F McClay & Carol Depriest. (2019) Patient-specific dendritic cell vaccines with autologous tumor antigens in 72 patients with metastatic melanoma. Melanoma Management 6:2, pages MMT20.
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Rachel S. Riley, Carl H. June, Robert Langer & Michael J. Mitchell. (2019) Delivery technologies for cancer immunotherapy. Nature Reviews Drug Discovery 18:3, pages 175-196.
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Robert O. Dillman, Andrew N. Cornforth, Gabriel I. Nistor, Edward F. McClay, Thomas T. Amatruda & Carol Depriest. (2018) Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses. Journal for ImmunoTherapy of Cancer 6:1.
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Robert O. Dillman & Carol Depriest. (2018) Dendritic Cell Vaccines Presenting Autologous Tumor Antigens from Self-renewing Cancer Cells in Metastatic Renal Cell Carcinoma. Journal of Exploratory Research in Pharmacology 3:4, pages 93-101.
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Fang Zheng, Jianzhong Dang, Hongyu Zhang, Fangzhou Xu, Diandian Ba, Bingyu Zhang, Fanjun Cheng, Alfred E. Chang, Max S. Wicha & Qiao Li. (2018) Cancer Stem Cell Vaccination With PD-L1 and CTLA-4 Blockades Enhances the Eradication of Melanoma Stem Cells in a Mouse Tumor Model. Journal of Immunotherapy 41:8, pages 361-368.
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Robert O Dillman. (2017) An update on the relevance of vaccine research for the treatment of metastatic melanoma. Melanoma Management 4:4, pages 203-215.
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Qiuju Han, Yaqun Wang, Min Pang & Jian Zhang. (2017) STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC. Journal of Experimental & Clinical Cancer Research 36:1.
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Abhishek D. Garg, Pierre G. Coulie, Benoit J. Van den Eynde & Patrizia Agostinis. (2017) Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape. Trends in Immunology 38:8, pages 577-593.
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