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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 47, 2019 - Issue 1
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Research Article

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

Yongkang Liua Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Xing Kanga Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Geng Niua Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Senlin Hea Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Tingting Zhanga Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Yuwei Baia Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Yi Lid School of Computer Science, Xi’an Polytechnic University, Xi’an, ChinaView further author information
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Houyan Haoa Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, ChinaView further author information
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Chao Chenb School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaView further author information
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Zhexing Shoue Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorrespondence[email protected]
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Bin Lia Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Xi'an, China;b School of Life Sciences, Northwest University, Xi'an, Shaanxi, China;c National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, ChinaCorrespondence[email protected]
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Pages 626-635 | Received 19 Sep 2018, Accepted 27 Nov 2018, Published online: 15 Mar 2019

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Chunmei Yan, Qiuxia Li, Qiang Sun, Lu Yang, Xing Liu, Yuxin Zhao, Mingyi Shi, Xiaofang Li & Kaipei Luo. (2023) Promising Nanomedicines of Shikonin for Cancer Therapy. International Journal of Nanomedicine 18, pages 1195-1218.
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Yang Yang, Zhen-Zhen Ren, Wu-Jun Wei, Zhi-Long He, You-Lin Deng, Zhuan Wang, Yu-Chun Fan, Jie Zhou & Li-He Jiang. (2022) Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro. Pharmaceutical Biology 60:1, pages 1566-1577.
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Junli Zhang, Ling Shang, Wendi Jiang & Wenjuan Wu. (2022) Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells. Bioengineered 13:3, pages 7904-7918.
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Tong Liu, Sainan Li, Liwei Wu, Qiang Yu, Jingjing Li, Jiao Feng, Jie Zhang, Jiaojiao Chen, Yuting Zhou, Jie Ji, Kan Chen, Yuqing Mao, Fan Wang, Weiqi Dai, Xiaoming Fan, Jianye Wu & Chuanyong Guo. (2020) Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2. Journal of Hepatocellular Carcinoma 7, pages 19-31.
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Qing Tang, Lihua Liu, Hongyan Zhang, Jing Xiao & Swei Sunny Hann. (2020) Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells. Drug Design, Development and Therapy 14, pages 577-589.
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Xu Liu & JiKui Liu. (2020) Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53/DRAM-mediated autophagy in human hepatocellular carcinoma. Artificial Cells, Nanomedicine, and Biotechnology 48:1, pages 488-497.
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Xiao-bao Shen, Yang Wang, Xuan-zhen Han, Liang-quan Sheng, Fu-fang Wu & Xinhua Liu. (2020) Design, synthesis and anticancer activity of naphthoquinone derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 773-785.
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