Advanced search
Publication Cover
Emerging Microbes & Infections Volume 8, 2019 - Issue 1
Submit an article Journal homepage
5,611
Views
32
CrossRef citations to date
0
Altmetric
Original Articles

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection

Wenxu Jiaa Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Rudragouda Channappanavarb Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, USA;c Department of Acute and Tertiary Care, and the Institute for the Study of Host–Pathogen Systems, University of Tennessee Health Science Center, Memphis, TN, USAView further author information
,
Chao Zhangd School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China;e Key Laboratory of Molecular Virology & Immunology, Vaccine Research Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaView further author information
,
Mingxi Lia Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Haixia Zhouf The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Shuyuan Zhangf The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Panpan Zhoua Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Jiuyang Xua Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-1906-5918View further author information
ORCID Icon,
Sisi Shana Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Xuanling Shia Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Xinquan Wangf The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, People’s Republic of ChinaView further author information
,
Jincun Zhaog State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaView further author information
,
Dongming Zhoue Key Laboratory of Molecular Virology & Immunology, Vaccine Research Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Stanley Perlmanb Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, USA;g State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4213-2354View further author information
ORCID Icon &
Linqi Zhanga Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4931-509XView further author information
ORCID Icon show all
Pages 760-772 | Received 21 Feb 2019, Accepted 09 May 2019, Published online: 25 May 2019

Citations (32)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Rajat Mudgal, Sanketkumar Nehul & Shailly Tomar. (2020) Prospects for mucosal vaccine: shutting the door on SARS-CoV-2. Human Vaccines & Immunotherapeutics 16:12, pages 2921-2931.
Read now
Naru Zhang, Jian Shang, Chaoqun Li, Kehui Zhou & Lanying Du. (2020) An overview of Middle East respiratory syndrome coronavirus vaccines in preclinical studies. Expert Review of Vaccines 19:9, pages 817-829.
Read now
Jiuyang Xu, Wenxu Jia, Pengfei Wang, Senyan Zhang, Xuanling Shi, Xinquan Wang & Linqi Zhang. (2019) Antibodies and vaccines against Middle East respiratory syndrome coronavirus. Emerging Microbes & Infections 8:1, pages 841-856.
Read now

Articles from other publishers (29)

Panli Zhang, Shengxue Luo, Peng Zou, Qitao Deng, Cong Wang, Jinfeng Li, Peiqiao Cai, Ling Zhang, Chengyao Li & Tingting Li. (2023) A novel simian adenovirus-vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens. Microbiology Spectrum 11:6.
Crossref
Mingqing Lu, Yanfeng Yao, Xuekai Zhang, Hang Liu, Ge Gao, Yun Peng, Miaoyu Chen, Jiaxuan Zhao, XiaoYu Zhang, Chunhong Yin, Weiwei Guo, Peipei Yang, Xue Hu, Juhong Rao, Entao Li, Tong Chen, Sandra Chiu, Gary Wong, Zhiming Yuan, Jiaming Lan & Chao Shan. (2023) Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection. npj Vaccines 8:1.
Crossref
Shen Wang, Bo Liang, Weiqi Wang, Ling Li, Na Feng, Yongkun Zhao, Tiecheng Wang, Feihu Yan, Songtao Yang & Xianzhu Xia. (2023) Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases. Signal Transduction and Targeted Therapy 8:1.
Crossref
Ting Wang, Lilan Zheng, Qiujian Zhao, Yazhou Yao, Feng Zhou, Fang Wei & Qiliang Cai. (2023) Parainfluenza virus 5 is a next‐generation vaccine vector for human infectious pathogens. Journal of Medical Virology 95:3.
Crossref
Tatianna Travieso, Jenny Li, Sneha Mahesh, Juliana Da Fonzeca Redenze E. Mello & Maria Blasi. (2022) The use of viral vectors in vaccine development. npj Vaccines 7:1.
Crossref
Zhen Zhuang, Donglan Liu, Jing Sun, Fang Li & Jincun Zhao. (2022) Immune responses to human respiratory coronaviruses infection in mouse models. Current Opinion in Virology 52, pages 102-111.
Crossref
Natália Meneses Araújo, Ileana Gabriela Sanchez Rubio, Nicholas Pietro Agulha Toneto, Mirian Galliote Morale & Rodrigo Esaki Tamura. (2022) The use of adenoviral vectors in gene therapy and vaccine approaches. Genetics and Molecular Biology 45:3 suppl 1.
Crossref
Khursheed Ul Islam, Thoraya Mohamed Elhassan A-Elgadir, Sarah Afaq, Tanveer Ahmad & Jawed Iqbal. (2021) Molecular and Clinical Aspects of COVID-19 Vaccines and Other Therapeutic Interventions Apropos Emerging Variants of Concern. Frontiers in Pharmacology 12.
Crossref
Jiaojiao Liu, Kun Xu, Man Xing, Yue Zhuo, Jingao Guo, Meng Du, Qi Wang, Yaling An, Jinhe Li, Ping Gao, Yihan Wang, Furong He, Yingying Guo, Mingxi Li, Yuchao Zhang, Linqi Zhang, George F. Gao, Lianpan Dai & Dongming Zhou. (2021) Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection. Cell Discovery 7:1.
Crossref
Marvin J. Sklar, Santina Maiolatesi, Noelle Patterson, Martha Sedegah, Keith Limbach, Nimfa Teneza-Mora, Ilin Chuang, K. Monique Hollis-Perry, Jo Glenna Banania, Ivelese Guzman, Harini Ganeshan, Sharina Reyes, Michael R. Hollingdale, Mimi Wong, Ashley Lindstrom, Anatalio Reyes, Yolanda Alcorta, Lindsey Garver, Kelli Bankard, Arnel Belmonte, Maria Belmonte, Jun Huang, Kalpana Gowda, Sandra Inoue, Rachel Velasco, Elke Bergmann-Leitner, Jack Hutter, Tida Lee, Nehkonti Adams, Sidhartha Chaudhury, Devin Hunt, Cindy Tamminga, Eleanor Berrie, Duncan Bellamy, Mustapha Bittaye, Katie Ewer, Carter Diggs, Lorraine A. Soisson, Alison Lawrie, Adrian Hill, Thomas L. Richie, Eileen Villasante, Judith E. Epstein & Christopher A. Duplessis. (2021) A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults. PLOS ONE 16:9, pages e0256980.
Crossref
Julien Lemaitre, Thibaut Naninck, Benoît Delache, Justina Creppy, Philippe Huber, Marion Holzapfel, Camille Bouillier, Vanessa Contreras, Frédéric Martinon, Nidhal Kahlaoui, Quentin Pascal, Sabine Tricot, Frédéric Ducancel, Laurent Vecellio, Roger Le Grand & Pauline Maisonnasse. (2021) Non-human primate models of human respiratory infections. Molecular Immunology 135, pages 147-164.
Crossref
Traci L. Bricker, Tamarand L. Darling, Ahmed O. Hassan, Houda H. Harastani, Allison Soung, Xiaoping Jiang, Ya-Nan Dai, Haiyan Zhao, Lucas J. Adams, Michael J. Holtzman, Adam L. Bailey, James Brett Case, Daved H. Fremont, Robyn Klein, Michael S. Diamond & Adrianus C.M. Boon. (2021) A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters. Cell Reports 36:3, pages 109400.
Crossref
Mingxi Li, Jingao Guo, Shuaiyao Lu, Runhong Zhou, Hongyang Shi, Xuanling Shi, Lin Cheng, Qingtai Liang, Hongqi Liu, Pui Wang, Nan Wang, Yifeng Wang, Lili Fu, Man Xing, Ruoke Wang, Bin Ju, Li Liu, Siu-Ying Lau, Wenxu Jia, Xin Tong, Lin Yuan, Yong Guo, Hai Qi, Qi Zhang, Zhen Huang, Honglin Chen, Zheng Zhang, Zhiwei Chen, Xiaozhong Peng, Dongming Zhou & Linqi Zhang. (2021) Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection. Frontiers in Immunology 12.
Crossref
Ahmed Elkashif, Marwa Alhashimi, Ekramy E Sayedahmed, Suryaprakash Sambhara & Suresh K Mittal. (2021) Adenoviral vector‐based platforms for developing effective vaccines to combat respiratory viral infections. Clinical & Translational Immunology 10:10.
Crossref
Luis Jiménez-Cabello, Sergio Utrilla-Trigo, Eva Calvo-Pinilla, Sandra Moreno, Aitor Nogales, Javier Ortego & Alejandro Marín-López. (2020) Viral Vector Vaccines against Bluetongue Virus. Microorganisms 9:1, pages 42.
Crossref
Jing Zhao, Shan Zhao, Junxian Ou, Jing Zhang, Wendong Lan, Wenyi Guan, Xiaowei Wu, Yuqian Yan, Wei Zhao, Jianguo Wu, James Chodosh & Qiwei Zhang. (2020) COVID-19: Coronavirus Vaccine Development Updates. Frontiers in Immunology 11.
Crossref
Bin Ju, Qi Zhang, Jiwan Ge, Ruoke Wang, Jing Sun, Xiangyang Ge, Jiazhen Yu, Sisi Shan, Bing Zhou, Shuo Song, Xian Tang, Jinfang Yu, Jun Lan, Jing Yuan, Haiyan Wang, Juanjuan Zhao, Shuye Zhang, Youchun Wang, Xuanling Shi, Lei Liu, Jincun Zhao, Xinquan Wang, Zheng Zhang & Linqi Zhang. (2020) Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 584:7819, pages 115-119.
Crossref
Helena F. Florindo, Ron Kleiner, Daniella Vaskovich-Koubi, Rita C. Acúrcio, Barbara Carreira, Eilam Yeini, Galia Tiram, Yulia Liubomirski & Ronit Satchi-Fainaro. (2020) Immune-mediated approaches against COVID-19. Nature Nanotechnology 15:8, pages 630-645.
Crossref
Alan Sariol & Stanley Perlman. (2020) Lessons for COVID-19 Immunity from Other Coronavirus Infections. Immunity 53:2, pages 248-263.
Crossref
Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Ruymán Alonso-Ravelo, Eva Calvo-Pinilla, Alejandro Marín-López, Sandra Moreno, Gema Lorenzo, Julio Benavides, Sarah Gilbert, Aitor Nogales & Javier Ortego. (2020) Heterologous Combination of ChAdOx1 and MVA Vectors Expressing Protein NS1 as Vaccination Strategy to Induce Durable and Cross-Protective CD8+ T Cell Immunity to Bluetongue Virus. Vaccines 8:3, pages 346.
Crossref
Mariangela Garofalo, Monika Staniszewska, Stefano Salmaso, Paolo Caliceti, Katarzyna Wanda Pancer, Magdalena Wieczorek & Lukasz Kuryk. (2020) Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2. Vaccines 8:2, pages 293.
Crossref
Nicolas Vabret, Graham J. Britton, Conor Gruber, Samarth Hegde, Joel Kim, Maria Kuksin, Rachel Levantovsky, Louise Malle, Alvaro Moreira, Matthew D. Park, Luisanna Pia, Emma Risson, Miriam Saffern, Bérengère Salomé, Myvizhi Esai Selvan, Matthew P. Spindler, Jessica Tan, Verena van der Heide, Jill K. Gregory, Konstantina Alexandropoulos, Nina Bhardwaj, Brian D. Brown, Benjamin Greenbaum, Zeynep H. Gümüş, Dirk Homann, Amir Horowitz, Alice O. Kamphorst, Maria A. Curotto de Lafaille, Saurabh Mehandru, Miriam Merad, Robert M. Samstein, Manasi Agrawal, Mark Aleynick, Meriem Belabed, Matthew Brown, Maria Casanova-Acebes, Jovani Catalan, Monica Centa, Andrew Charap, Andrew Chan, Steven T. Chen, Jonathan Chung, Cansu Cimen Bozkus, Evan Cody, Francesca Cossarini, Erica Dalla, Nicolas Fernandez, John Grout, Dan Fu Ruan, Pauline Hamon, Etienne Humblin, Divya Jha, Julia Kodysh, Andrew Leader, Matthew Lin, Katherine Lindblad, Daniel Lozano-Ojalvo, Gabrielle Lubitz, Assaf Magen, Zafar Mahmood, Gustavo Martinez-Delgado, Jaime Mateus-Tique, Elliot Meritt, Chang Moon, Justine Noel, Tim O’Donnell, Miyo Ota, Tamar Plitt, Venu Pothula, Jamie Redes, Ivan Reyes Torres, Mark Roberto, Alfonso R. Sanchez-Paulete, Joan Shang, Alessandra Soares Schanoski, Maria Suprun, Michelle Tran, Natalie Vaninov, C. Matthias Wilk, Julio Aguirre-Ghiso, Dusan Bogunovic, Judy Cho, Jeremiah Faith, Emilie Grasset, Peter Heeger, Ephraim Kenigsberg, Florian Krammer & Uri Laserson. (2020) Immunology of COVID-19: Current State of the Science. Immunity 52:6, pages 910-941.
Crossref
Ana Ricobaraza, Manuela Gonzalez-Aparicio, Lucia Mora-Jimenez, Sara Lumbreras & Ruben Hernandez-Alcoceba. (2020) High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy. International Journal of Molecular Sciences 21:10, pages 3643.
Crossref
Lynda Coughlan. (2020) Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines. Frontiers in Immunology 11.
Crossref
Kun Li, Zhuo Li, Christine Wohlford-Lenane, David K. Meyerholz, Rudragouda Channappanavar, Dong An, Stanley Perlman, Paul B. McCrayJr.Jr. & Biao He. (2020) Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection. mBio 11:2.
Crossref
Entao Li, Feihu Yan, Pei Huang, Hang Chi, Shengnan Xu, Guohua Li, Chuanyu Liu, Na Feng, Hualei Wang, Yongkun Zhao, Songtao Yang & Xianzhu Xia. (2020) Characterization of the Immune Response of MERS-CoV Vaccine Candidates Derived from Two Different Vectors in Mice. Viruses 12:1, pages 125.
Crossref
Maged Gomaa Hemida. 2020. Animal-Origin Viral Zoonoses. Animal-Origin Viral Zoonoses 241 254 .
Mustafa AbabnehMu'men AlrwashdehMohammad Khalifeh. (2019) Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice. Veterinary World 12:10, pages 1554-1562.
Crossref
Li, Chi, Huang, Yan, Zhang, Liu, Wang, Li, Zhang, Mo, Jin, Wang, Feng, Wang, Bi, Wang, Sun, Gao, Zhao, Yang & Xia. (2019) A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice. Viruses 11:9, pages 799.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.