1,117
Views
500
CrossRef citations to date
0
Altmetric
Invited Review

PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance

, , , , , , , , , , & show all
Pages 655-780 | Published online: 29 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (39)

Jane Kasten-Jolly & David A. Lawrence. (2022) Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) modify in vitro mitogen- and antigen-induced human peripheral blood mononuclear cell (PBMC) responses. Journal of Toxicology and Environmental Health, Part A 85:17, pages 715-737.
Read now
Tomoya Yamada, Brian G. Lake & Samuel M. Cohen. (2022) Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action. Critical Reviews in Toxicology 52:1, pages 1-31.
Read now
Adam Barsouk, Krishna Chaitanya Thandra, Kalyan Saginala, Prashanth Rawla & Alexander Barsouk. (2020) Chemical Risk Factors of Primary Liver Cancer: An Update. Hepatic Medicine: Evidence and Research 12, pages 179-188.
Read now
Harm Heusinkveld, Hedwig Braakhuis, Robin Gommans, Phil Botham, Marco Corvaro, Jan Willem van der Laan, Dick Lewis, Federica Madia, Irene Manou, Frédéric Schorsch, Gerrit Wolterink, Ruud Woutersen, Raffaella Corvi, Jyotigna Mehta & Mirjam Luijten. (2020) Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals. Critical Reviews in Toxicology 50:9, pages 725-739.
Read now
Alan Boobis, Paul Brown, Mark Timothy David Cronin, James Edwards, Corrado Lodovico Galli, Jay Goodman, Abigail Jacobs, David Kirkland, Mirjam Luijten, Cyril Marsaux, Matthew Martin, Chihae Yang & Heli Miriam Hollnagel. (2017) Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation. Critical Reviews in Toxicology 47:8, pages 710-732.
Read now
M. K. Manibusan & L. W. Touart. (2017) A comprehensive review of regulatory test methods for endocrine adverse health effects. Critical Reviews in Toxicology 47:6, pages 440-488.
Read now
Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, H. James Wedner & Jack S. Mandel. (2016) A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans. Critical Reviews in Toxicology 46:4, pages 279-331.
Read now
Lisa M. Sweeney, Janet E. Kester, Christopher R. Kirman, P. Robinan Gentry, Marcy I. Banton, James S. Bus & Michael L. Gargas. (2015) Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4). Critical Reviews in Toxicology 45:8, pages 662-726.
Read now
Hong Sik Yoo, Blair U. Bradford, Oksana Kosyk, Svitlana Shymonyak, Takeki Uehara, Leonard B. Collins, Wanda M. Bodnar, Louise M. Ball, Avram Gold & Ivan Rusyn. (2015) Comparative Analysis of the Relationship Between Trichloroethylene Metabolism and Tissue-Specific Toxicity Among Inbred Mouse Strains: Liver Effects. Journal of Toxicology and Environmental Health, Part A 78:1, pages 15-31.
Read now
Pınar Erkekoglu & Belma Kocer-Gumusel. (2014) Genotoxicity of phthalates. Toxicology Mechanisms and Methods 24:9, pages 616-626.
Read now
Ellen T. Chang, Hans-Olov Adami, Paolo Boffetta, Philip Cole, Thomas B. Starr & Jack S. Mandel. (2014) A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans. Critical Reviews in Toxicology 44:sup1, pages 1-81.
Read now
Virunya S. Bhat, Jennifer L. Durham, Gwendolyn L. Ball & J. Caroline English. (2014) Derivation of an Oral Reference Dose (RfD) for the Nonphthalate Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid, Di-Isononyl Ester (DINCH). Journal of Toxicology and Environmental Health, Part B 17:2, pages 63-94.
Read now
Clifford R. Elcombe, Richard C. Peffer, Douglas C. Wolf, Jason Bailey, Remi Bars, David Bell, Russell C. Cattley, Stephen S. Ferguson, David Geter, Amber Goetz, Jay I. Goodman, Susan Hester, Abigail Jacobs, Curtis J. Omiecinski, Rita Schoeny, Wen Xie & Brian G. Lake. (2014) Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Critical Reviews in Toxicology 44:1, pages 64-82.
Read now
J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed & James E. Klaunig. (2014) Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology 44:1, pages 1-49.
Read now
CHIN-HSIAO TSENG & FARN-HSUAN TSENG. (2012) Peroxisome Proliferator-Activated Receptor Agonists and Bladder Cancer: Lessons from Animal Studies. Journal of Environmental Science and Health, Part C 30:4, pages 368-402.
Read now
Laia Salvadó, Lucía Serrano-Marco, Emma Barroso, Xavier Palomer & Manuel Vázquez-Carrera. (2012) Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus. Expert Opinion on Therapeutic Targets 16:2, pages 209-223.
Read now
P. Robinan Gentry, Harvey J. Clewell$suffix/text()$suffix/text(), Rebecca Clewell, Jerry Campbell, Cynthia Van Landingham & Annette M. Shipp. (2011) Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate. Critical Reviews in Toxicology 41:sup2, pages 1-72.
Read now
Vicki Dellarco, Tala Henry, Phil Sayre, Jennifer Seed & Steven Bradbury. (2010) Meeting The Common Needs of a More Effective and Efficient Testing and Assessment Paradigm for Chemical Risk Management. Journal of Toxicology and Environmental Health, Part B 13:2-4, pages 347-360.
Read now
Joseph V. Rodricks, James A. Swenberg, Joseph F. Borzelleca, Robert R. Maronpot & Annette M. Shipp. (2010) Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Critical Reviews in Toxicology 40:5, pages 422-484.
Read now
Douglas McGregor, Alan Boobis, Marco Binaglia, Phil Botham, Laurence Hoffstadt, Sue Hubbard, Thomas Petry, Anthony Riley, Dirk Schwartz & Christa Hennes. (2010) Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). Critical Reviews in Toxicology 40:3, pages 245-285.
Read now
Richard Billington, Richard W. Lewis, Jyotigna M. Mehta & Ian Dewhurst. (2010) The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides. Critical Reviews in Toxicology 40:1, pages 35-49.
Read now
David J. Jollow, James V. Bruckner, David C. McMillan, Jeffrey W. Fisher, David G. Hoel & Lawrence C. Mohr. (2009) Trichloroethylene risk assessment: A review and commentary. Critical Reviews in Toxicology 39:9, pages 782-797.
Read now
Elizabeth Julien , AlanR. Boobis, StephenS. Olin & The ILSI Research Foundation Threshold Working Group. (2009) The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds. Critical Reviews in Food Science and Nutrition 49:8, pages 682-689.
Read now
Thomas G. Osimitz & Brian G. Lake. (2009) Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk. Critical Reviews in Toxicology 39:6, pages 501-511.
Read now
A. Liu, Y. Chen, Z. Yang, Y. Feng, W. Rui, W. Luo, Y. Liu, F. J. Gonzalez & R. Dai. (2009) New metabolites of fenofibrate in Sprague–Dawley rats by UPLC-ESI-QTOF-MS-based metabolomics coupled with LC-MS/MS. Xenobiotica 39:4, pages 345-354.
Read now
MichaelA. Kamrin. (2009) Phthalate Risks, Phthalate Regulation, and Public Health: A Review. Journal of Toxicology and Environmental Health, Part B 12:2, pages 157-174.
Read now
D. Hattis, M. Chu, N. Rahmioglu, R. Goble, P. Verma, K. Hartman & M. Kozlak. (2009) A Preliminary Operational Classification System for Nonmutagenic Modes of Action for Carcinogenesis. Critical Reviews in Toxicology 39:2, pages 97-138.
Read now
LynnM. Crosby, Jane Ellen Simmons, WilliamO. Ward, TanyaM. Moore, KevinT. Morgan & AnthonyB. DeAngelo. (2008) Integrated Disinfection By-Products (DBP) Mixtures Research: Gene Expression Alterations in Primary Rat Hepatocyte Cultures Exposed to DBP Mixtures Formed by Chlorination and Ozonation/Postchlorination. Journal of Toxicology and Environmental Health, Part A 71:17, pages 1195-1215.
Read now
Jennifer Bethsass & Mae Wu. (2007) Budget Cuts to the U.S. EPA Will Reduce Government Data on Pollutants, and Increase Reliance on Industry Data. International Journal of Occupational and Environmental Health 13:2, pages 244-246.
Read now
James Huff. (2007) Industry Influence on Occupational and Environmental Public Health. International Journal of Occupational and Environmental Health 13:1, pages 107-117.
Read now
William B Mattes. (2006) Cross-species comparative toxicogenomics as an aid to safety assessment. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 859-874.
Read now
AntoniaM. Calafat, ManoriJ. Silva, JohnA. Reidy, L. Earl Gray, Ella Samandar, JamesL. Preau$suffix/text()$suffix/text(), ArnetraR. Herbert & LarryL. Needham. (2006) Mono-(3-Carboxypropyl) Phthalate, A Metabolite of Di-n-Octyl Phthalate. Journal of Toxicology and Environmental Health, Part A 69:3, pages 215-227.
Read now
Ivan Rusyn, Jeffrey M. Peters & Michael L. Cunningham. (2006) Modes of Action and Species-Specific Effects of Di-(2-ethylhexyl)Phthalate in the Liver. Critical Reviews in Toxicology 36:5, pages 459-479.
Read now
Andrew Parkinson, Neda Leonard, Alison Draper & Brian W. Ogilvie. (2006) On the Mechanism of Hepatocarcinogenesis of Benzodiazepines: Evidence that Diazepam and Oxazepam are CYP2B Inducers in Rats, and both CYP2B and CYP4A Inducers in Mice. Drug Metabolism Reviews 38:1-2, pages 235-259.
Read now
Michael S. Piepenbrink, Irshad Hussain, James A. Marsh & Rodney R. Dietert. (2005) Developmental Immunotoxicology of Di-(2-Ethylhexyl)phthalate (DEHP): Age-Based Assessment in the Female Rat. Journal of Immunotoxicology 2:1, pages 21-31.
Read now
David Y. Lai. (2004) Rodent Carcinogenicity of Peroxisome Proliferators and Issues on Human Relevance. Journal of Environmental Science and Health, Part C 22:1, pages 37-55.
Read now
Gerald L. Kennedy, John L. Butenhoff, Geary W. Olsen, John C. O'Connor, Andrew M. Seacat, Roger G. Perkins, Lisa B. Biegel, Sandra R. Murphy & David G. Farrar. (2004) The Toxicology of Perfluorooctanoate. Critical Reviews in Toxicology 34:4, pages 351-384.
Read now

Articles from other publishers (461)

Peter Schumann, Claudia Rivetti, Jade Houghton, Bruno Campos, Geoff Hodges & Carlie LaLone. (2024) Combination of computational new approach methodologies for enhancing evidence of biological pathway conservation across species. Science of The Total Environment 912, pages 168573.
Crossref
Dakota R. Robarts, Jiayin Dai, Christopher Lau, Udayan Apte & J. Christopher Corton. (2023) Hepatic Transcriptome Comparative In Silico Analysis Reveals Similar Pathways and Targets Altered by Legacy and Alternative Per- and Polyfluoroalkyl Substances in Mice. Toxics 11:12, pages 963.
Crossref
Zhaonan Zou, Yuka Yoshimura, Yoshihiro Yamanishi & Shinya Oki. (2023) Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data. Epigenetics & Chromatin 16:1.
Crossref
Christian Strupp, Marco Corvaro, Samuel M. Cohen, J. Christopher Corton, Kumiko Ogawa, Lysiane Richert & Miriam N. Jacobs. (2023) Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis. International Journal of Molecular Sciences 24:17, pages 13246.
Crossref
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez & Jeffrey M. Peters. (2023) Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice. Metabolites 13:8, pages 936.
Crossref
Mark Lafranconi, Janet Anderson, Robert Budinsky, Lisa Corey, Norman Forsberg, Joanna Klapacz & Matthew J. LeBaron. (2023) An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents. Regulatory Toxicology and Pharmacology 142, pages 105428.
Crossref
Helmut Greim. 2003. Patty's Toxicology. Patty's Toxicology 1 74 .
Shu‐xuan Li, Lanlan Chen, Ming‐qian Li & Guo‐yue Lv. (2022) Pharmacological agents for defatting livers by normothermic machine perfusion. Artificial Organs 47:6, pages 925-933.
Crossref
Shuangshuang Chen, Yufeng Gong, Yun Luo, Rong Cao, Jiajia Yang, Lin Cheng, Yuan Gao, Haijun Zhang, Jiping Chen & Ningbo Geng. (2023) Toxic Effects and Toxicological Mechanisms of Chlorinated Paraffins: A Review for Insight into Species Sensitivity and Toxicity Difference. Environment International, pages 108020.
Crossref
Manasi Kotulkar, Dakota R. Robarts & Udayan Apte. (2023) HNF4α in Hepatocyte Health and Disease. Seminars in Liver Disease 43:02, pages 234-244.
Crossref
Marta Eide, Anders Goksøyr, Fekadu Yadetie, Alejandra Gilabert, Zdenka Bartosova, Håvard G. Frøysa, Shirin Fallahi, Xiaokang Zhang, Nello Blaser, Inge Jonassen, Per Bruheim, Guttorm Alendal, Morten Brun, Cinta Porte & Odd André Karlsen. (2023) Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod. Frontiers in Physiology 14.
Crossref
Annamaria Colacci, Raffaella Corvi, Kyomi Ohmori, Martin Paparella, Stefania Serra, Iris Da Rocha Carrico, Paule Vasseur & Miriam Naomi Jacobs. (2023) The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens. International Journal of Molecular Sciences 24:6, pages 5659.
Crossref
Dongge Liu, Shuqi Yan, Pingwei Wang, Qianqian Chen, Yanping Liu, Jiajing Cui, Yujun Liang, Shuping Ren & Ying Gao. (2023) Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature. Frontiers in Physiology 14.
Crossref
Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 363 394 .
Melissa M Heintz, Laurie C Haws, James E Klaunig, John M Cullen & Chad M Thompson. (2023) Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans. Toxicological Sciences.
Crossref
Chad M. Thompson, Melissa M. Heintz, Jeffrey C. Wolf, Roza Cheru, Laurie C. Haws & John M. Cullen. (2023) Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death. Toxicologic Pathology 51:1-2, pages 4-14.
Crossref
Shengde Wu, George Daston, Jane Rose, Karen Blackburn, Joan Fisher, Allison Reis, Bastian Selman & Jorge Naciff. (2023) Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across. Current Research in Toxicology 5, pages 100108.
Crossref
George Wypych. 2023. Handbook of Plasticizers. Handbook of Plasticizers 693 752 .
Satoki Fukunaga, Keiko Ogata, Ayumi Eguchi, Kohei Matsunaga, Kengo Sakurai, Jun Abe, Samuel M. Cohen & Hiroyuki Asano. (2022) Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil. Regulatory Toxicology and Pharmacology 136, pages 105268.
Crossref
Mathias Brugel, Claire Carlier, Gabriela Reyes-Castellanos, Sidonie Callon, Alice Carrier & Olivier Bouché. (2022) Pesticides and pancreatic adenocarcinoma: A transversal epidemiological, environmental and mechanistic narrative review. Digestive and Liver Disease 54:12, pages 1605-1613.
Crossref
Archana Vijayakumar, Ayse Okesli‐Armlovich, Ting Wang, Isabel Olson, Minji Seung, Saritha Kusam, David Hollenback, Sangeetha Mahadevan, Bruno Marchand, Maria Toteva, David G. Breckenridge, James L. Trevaskis & Jamie Bates. (2022) Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis. Hepatology Communications 6:9, pages 2298-2309.
Crossref
Akash Bachhuka, Tara Chand Yadav, Abel Santos, Lluis F. Marsal, Süleyman Ergün & Srikanth Karnati. (2022) Emerging nanomaterials for targeting peroxisomes. Materials Today Advances 15, pages 100265.
Crossref
Kouichi Yoshinari & Ryota Shizu. (2022) Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. Drug Metabolism and Disposition 50:7, pages 1019-1026.
Crossref
J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Patricia A Escobar, Roland Froetschl, Alison H Harrill, Kamin Johnson, James E Klaunig, Arun R Pandiri, Alexei A Podtelezhnikov, Julia E Rager, Keith Q Tanis, Jan Willem van der Laan, Alisa Vespa, Carole L Yauk, Syril D Pettit & Frank D Sistare. (2022) A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies. Toxicological Sciences 188:1, pages 4-16.
Crossref
Patrick Harmon & Rainer Otter. (2022) A review of common non-ortho-phthalate plasticizers for use in food contact materials. Food and Chemical Toxicology 164, pages 112984.
Crossref
Shengzhong Su, Laura J. Billy, Sue Chang, Frank J. Gonzalez, Andrew D. Patterson & Jeffrey M. Peters. (2022) The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice. Toxicology 465, pages 153056.
Crossref
Lei Ding, Shiwen Zhang, Yuting Zhu, Nan Zhao, Wenbao Yan & Yahui Li. (2021) Overlooked long-chain chlorinated paraffin (LCCP) contamination in foodstuff from China. Science of The Total Environment 801, pages 149775.
Crossref
Franz Oesch, Daniela Fruth, Jan G. Hengstler, Eric Fabian, Franz Ingo Berger & Robert Landsiedel. (2021) Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat. Archives of Toxicology 95:12, pages 3717-3744.
Crossref
Min Xu, Fangyu Zhou, Ola Ahmed, Gundumi A. Upadhya, Jianluo Jia, Choonghee Lee, Jianwei Xing, Li Ye, So Hee Shim, Zhengyan Zhang, Kathleen Byrnes, Brian Wong, Jae-Sung Kim, Yiing Lin & William C. Chapman. (2021) A Novel Multidrug Combination Mitigates Rat Liver Steatosis Through Activating AMPK Pathway During Normothermic Machine Perfusion. Transplantation 105:11, pages e215-e225.
Crossref
Zhao Yang, Katherine Roth, Manisha Agarwal, Wanqing Liu & Michael C. Petriello. (2021) The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. The Journal of Nutritional Biochemistry 95, pages 108633.
Crossref
Jennifer E Foreman, Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M Cohen, Laura J Billy, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Ivan Rusyn & Jeffrey M Peters. (2021) Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice. Toxicological Sciences 183:1, pages 81-92.
Crossref
Jennifer E Foreman, Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M Cohen, Laura J Billy, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Ivan Rusyn & Jeffrey M Peters. (2021) Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA -Humanized Mice . Toxicological Sciences 183:1, pages 70-80.
Crossref
Mounia Tahri-Joutey, Pierre Andreoletti, Sailesh Surapureddi, Boubker Nasser, Mustapha Cherkaoui-Malki & Norbert Latruffe. (2021) Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα. International Journal of Molecular Sciences 22:16, pages 8969.
Crossref
Ruth F. Menger, Emily Funk, Charles S. Henry & Thomas Borch. (2021) Sensors for detecting per- and polyfluoroalkyl substances (PFAS): A critical review of development challenges, current sensors, and commercialization obstacles. Chemical Engineering Journal 417, pages 129133.
Crossref
B Li, H-Y Jiang, Z-H Wang, Y-C Ma, Y-N Bao & Y Jin. (2021) Effect of fenofibrate on proliferation of SMMC-7721 cells via regulating cell cycle. Human & Experimental Toxicology 40:7, pages 1208-1221.
Crossref
Keith A. Houck, Grace Patlewicz, Ann M. Richard, Antony J. Williams, Mahmoud A. Shobair, Marci Smeltz, M. Scott Clifton, Barbara Wetmore, Alex Medvedev & Sergei Makarov. (2021) Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure. Toxicology 457, pages 152789.
Crossref
Yufeng Gong, Ningbo Geng, Haijun Zhang, Yun Luo, John P. Giesy, Shuai Sun, Ping Wu, Zhengkun Yu & Jiping Chen. (2021) Exposure to short-chain chlorinated paraffins inhibited PPARα-mediated fatty acid oxidation and stimulated aerobic glycolysis in vitro in human cells. Science of The Total Environment 772, pages 144957.
Crossref
Mark Lafranconi, Robert Budinsky, Lisa Corey, Joanna Klapacz, James Crissman, Matthew LeBaron, Rachel Golden & Richard Pleus. (2021) A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane. Regulatory Toxicology and Pharmacology 119, pages 104819.
Crossref
Richard A. Brase, Elizabeth J. Mullin & David C. Spink. (2021) Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects. International Journal of Molecular Sciences 22:3, pages 995.
Crossref
Chengfei Jiang, Ping Li, Xiangbo Ruan, Yonghe Ma, Kenji Kawai, Hiroshi Suemizu & Haiming Cao. (2020) Comparative Transcriptomics Analyses in Livers of Mice, Humans, and Humanized Mice Define Human-Specific Gene Networks. Cells 9:12, pages 2566.
Crossref
Marco Bonato, Francesca Corrà, Marta Bellio, Laura Guidolin, Laura Tallandini, Paola Irato & Gianfranco Santovito. (2020) PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field. International Journal of Environmental Research and Public Health 17:21, pages 8020.
Crossref
Eman A Toraih, Manal S Fawzy, Abdelrahman I Abushouk, Sameerah Shaheen, Yahya H Hobani, Abdulmohsen M Alruwetei, Omniah A Mansouri, Emad Kandil & Dahlia I Badran. (2020) Prognostic value of the miRNA-27a and PPAR/RXRα signaling axis in patients with thyroid carcinoma. Epigenomics 12:20, pages 1825-1843.
Crossref
Bevin E. Blake & Suzanne E. Fenton. (2020) Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects. Toxicology 443, pages 152565.
Crossref
Rebecca A. Clewell, Jeremy A. Leonard, Chantel I. Nicolas, Jerry L. Campbell, Miyoung Yoon, Alina Y. Efremenko, Patrick D. McMullen, Melvin E. Andersen, Harvey J. ClewellIIIIII, Katherine A. Phillips & Yu-Mei Tan. (2020) Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates. Toxicology in Vitro 66, pages 104855.
Crossref
Nuanyuan Luo, Qunqun Chang, Xiaohu Ren, Peiwu Huang, Wei Liu, Li Zhou, Yungang Liu & Jianjun Liu. (2020) Trichloroethylene injures rat liver and elevates the level of peroxisomal bifunctional enzyme (Ehhadh). Molecular & Cellular Toxicology 16:3, pages 331-345.
Crossref
Fei Ren, Jin Wang, Stanley Aniagu, Jianxiang Li, Yan Jiang & Tao Chen. (2020) Effects of Trichloroethylene on the Expression of Long Intergenic Noncoding RNAs in B6C3F1 Mouse Liver. Chemical Research in Toxicology 33:6, pages 1356-1363.
Crossref
Miwa Kondo, Hiroko Kikumoto, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2020) An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicological Sciences 175:1, pages 50-63.
Crossref
Grace A. Chappell, Chad M. Thompson, Jeffrey C. Wolf, John M. Cullen, James E. Klaunig & Laurie C. Haws. (2020) Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. Toxicologic Pathology 48:3, pages 494-508.
Crossref
James E. Klaunig, Luma Melo & Karen Tilmant. (2020) Mechanisms of hepatic cancer by persistent organic pollutants. Current Opinion in Toxicology 19, pages 105-111.
Crossref
Sameena, Riyes Un Aziz & Aubid Bashir. 2020. Innovations in Global Maternal Health. Innovations in Global Maternal Health 296 328 .
Sameena, Riyes Un Aziz & Aubid Bashir. 2020. Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution. Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution 314 339 .
Irfan Ashraf Badroo, Ashiq Hussain Khanday, Zainab Kalimuddin Ali & Suriya Ashraf Badroo. 2020. Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution. Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution 288 313 .
Brian N. Chorley, Gleta K. Carswell, Gail Nelson, Virunya S. Bhat & Charles E. Wood. (2020) Early microRNA indicators of PPARα pathway activation in the liver. Toxicology Reports 7, pages 805-815.
Crossref
Michael S. Malamas, Shrouq I. Farah, Manjunath Lamani, Dimitrios N. Pelekoudas, Nicholas Thomas Perry, Girija Rajarshi, Christina Yume Miyabe, Honrao Chandrashekhar, Jay West, Spiro Pavlopoulos & Alexandros Makriyannis. (2020) Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorganic & Medicinal Chemistry 28:1, pages 115195.
Crossref
Joseph A. Cichocki. 2020. Information Resources in Toxicology. Information Resources in Toxicology 565 568 .
James E. Klaunig. 2020. An Introduction to Interdisciplinary Toxicology. An Introduction to Interdisciplinary Toxicology 97 110 .
Ellen Fritsche, Julia Tigges, Julia Hartmann, Julia Kapr, Melania Maria Serafini & Barbara Viviani. 2021. Organotypic Models in Drug Development. Organotypic Models in Drug Development 111 141 .
E. Gorowska-Wojtowicz, M. Duliban, M. Kudrycka, P. Dutka, P. Pawlicki, A. Milon, M. Zarzycka, W. Placha, M. Kotula-Balak, A. Ptak, J.K. Wolski & B. Bilinska. (2019) Leydig cell tumorigenesis - implication of G-protein coupled membrane estrogen receptor, peroxisome proliferator-activated receptor and xenoestrogen exposure. In vivo and in vitro appraisal. Tissue and Cell 61, pages 51-60.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1802 1874 .
Jonathan M. Ali, Stephen M. Roberts, David S. Gordon & Leah D. Stuchal. (2019) Derivation of a chronic reference dose for perfluorohexane sulfonate (PFHxS) for reproductive toxicity in mice. Regulatory Toxicology and Pharmacology 108, pages 104452.
Crossref
Britta Laube, Sandra Michaelsen, Veronika Meischner, Andrea Hartwig, Bernd Epe & Michael Schwarz. (2019) Classification or non-classification of substances with positive tumor findings in animal studies: Guidance by the German MAK commission. Regulatory Toxicology and Pharmacology 108, pages 104444.
Crossref
Ragavi Ravichandran, S. Viswanathan, V. M. Berlin Grace, Lucia Bonati & Jini Narayanan. (2019) Ameliorating effect of lipo-ATRA treatment on the expression of TIG3 and its suppressing effect on PPARγ gene expression in lung cancer animal model. Molecular and Cellular Biochemistry 460:1-2, pages 105-112.
Crossref
Jeffrey M. Peters, Dae J. Kim, Moses T. Bility, Michael G. Borland, Bokai Zhu & Frank J. Gonzalez. (2019) Regulatory mechanisms mediated by peroxisome proliferator‐activated receptor‐β/δ in skin cancer. Molecular Carcinogenesis 58:9, pages 1612-1622.
Crossref
Chad M. Thompson, Seneca E. Fitch, Caroline Ring, William Rish, John M. Cullen & Laurie C. Haws. (2019) Development of an oral reference dose for the perfluorinated compound GenX. Journal of Applied Toxicology 39:9, pages 1267-1282.
Crossref
Miwa Kondo, Kaori Miyata, Hirohisa Nagahori, Kayo Sumida, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2019) Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse. Toxicological Sciences 168:2, pages 572-596.
Crossref
Adam E. Kurtz, Jessica L. Reiner, Kristi L. West & Brenda A. Jensen. (2019) Perfluorinated Alkyl Acids in Hawaiian Cetaceans and Potential Biomarkers of Effect: Peroxisome Proliferator-Activated Receptor Alpha and Cytochrome P450 4A. Environmental Science & Technology 53:5, pages 2830-2839.
Crossref
Xilin Li, Zemin Wang & James E. Klaunig. (2019) The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice. Toxicology 416, pages 1-14.
Crossref
Carolina Donat-Vargas, Ingvar A. Bergdahl, Andreas Tornevi, Maria Wennberg, Johan Sommar, Jani Koponen, Hannu Kiviranta & Agneta Åkesson. (2019) Associations between repeated measure of plasma perfluoroalkyl substances and cardiometabolic risk factors. Environment International 124, pages 58-65.
Crossref
Alexander W. Auner, Kazi M. Tasneem, Dmitry A. Markov, Lisa J. McCawley & M. Shane Hutson. (2019) Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices. Lab on a Chip 19:5, pages 864-874.
Crossref
Karl Theo von der Trenck, Rainer Konietzka, Annegret Biegel-Engler, Jan Brodsky, Andrea Hädicke, Arnold Quadflieg, Rudolf Stockerl & Thorsten Stahl. (2018) Significance thresholds for the assessment of contaminated groundwater: perfluorinated and polyfluorinated chemicals. Environmental Sciences Europe 30:1.
Crossref
Xilin Li, Zemin Wang & James E. Klaunig. (2018) Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. Toxicology 410, pages 199-213.
Crossref
Hung Su, Min-Zong Huang, Jo-Han Chou, Ting-Hao Chang, Yu-Min Jiang, Yi-Tzu Cho, Sy-Chyi Cheng, Ming-Tsang Wu & Jentaie Shiea. (2018) High-throughput screening of phthalate-containing objects in the kindergartens by ambient mass spectrometry. Analytica Chimica Acta 1039, pages 65-73.
Crossref
Yangshun Tang, Michelle M. Vanlandingham, Yuanfeng Wu, Frederick A. Beland, Greg R. Olson & Jia-Long Fang. (2018) Role of peroxisome proliferator-activated receptor alpha (PPARα) and PPARα-mediated species differences in triclosan-induced liver toxicity. Archives of Toxicology 92:11, pages 3391-3402.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1195 1271 .
James E. Klaunig, Xilin Li & Zemin Wang. (2018) Role of xenobiotics in the induction and progression of fatty liver disease. Toxicology Research 7:4, pages 664-680.
Crossref
Robert L. Smith, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, F. Peter Guengerich, Ivonne M. C. M. Rietjens, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2018) The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research 7:4, pages 618-646.
Crossref
Christian Strupp, Werner H. Bomann, François Spézia, Frédéric Gervais, Roy Forster, Lysiane Richert & Pramila Singh. (2018) A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats. Regulatory Toxicology and Pharmacology 95, pages 348-361.
Crossref
Daqian Yang, Huijie Jiang, Jingjing Lu, Yueying Lv, Ruiqi Baiyun, Siyu Li, Biying Liu, Zhanjun Lv & Zhigang Zhang. (2018) Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway. Environmental Pollution 237, pages 377-387.
Crossref
Richard C Peffer, David E Cowie, Richard A Currie & Daniel J Minnema. (2018) Sedaxane—Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors. Toxicological Sciences 162:2, pages 582-598.
Crossref
Chuan-Hai Li, Xiao-Min Ren, Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo & Guibin Jiang. (2018) Chlorinated Polyfluorinated Ether Sulfonates Exhibit Higher Activity toward Peroxisome Proliferator-Activated Receptors Signaling Pathways than Perfluorooctanesulfonate. Environmental Science & Technology 52:5, pages 3232-3239.
Crossref
Susan P. Felter, Jennifer E. Foreman, Alan Boobis, J. Christopher Corton, Adriana M. Doi, Lynn Flowers, Jay Goodman, Lynne T. Haber, Abigail Jacobs, James E. Klaunig, Angela M. Lynch, Jonathan Moggs & Arun Pandiri. (2018) Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action. Regulatory Toxicology and Pharmacology 92, pages 1-7.
Crossref
Tzutzuy Ramirez, Alexander Strigun, Andreas Verlohner, Hans-Albrecht Huener, Erik Peter, Michael Herold, Natalie Bordag, Werner Mellert, Tilmann Walk, Michael Spitzer, Xiaoqi Jiang, Saskia Sperber, Thomas Hofmann, Thomas Hartung, Hennicke Kamp & Ben van Ravenzwaay. (2017) Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells. Archives of Toxicology 92:2, pages 893-906.
Crossref
Sai Sandeep Singh Rowdhwal & Jiaxiang Chen. (2018) Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview. BioMed Research International 2018, pages 1-10.
Crossref
S.M. Cohen. 2018. Comprehensive Toxicology. Comprehensive Toxicology 226 247 .
M.K. Manibusan & L.W. Touart. 2018. Comprehensive Toxicology. Comprehensive Toxicology 136 171 .
T Kobets & GM. Williams. 2018. Comprehensive Toxicology. Comprehensive Toxicology 409 442 .
J.E. Klaunig & Z. Wang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 233 254 .
J. Christopher Corton, Jeffrey M. Peters & James E. Klaunig. (2017) The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. Archives of Toxicology 92:1, pages 83-119.
Crossref
Yanjie Cheng, Zhuying Wei, Shengsong Xie, You Peng, Yi Yan, Dan Qin, Shenghui Liu, Yanling Xu, Guangpeng Li & Lisheng Zhang. (2017) Alleviation of Toxicity Caused by Overactivation of Pparα through Pparα-Inducible miR-181a2. Molecular Therapy - Nucleic Acids 9, pages 195-206.
Crossref
Min Luo, Manyun Dai, Hante Lin, Minzhu Xie, Jiao Lin, Aiming Liu & Julin Yang. (2017) Species-related exposure of phase II metabolite gemfibrozil 1-O-β-glucuronide between human and mice: A net induction of mouse P450 activity was revealed. Biopharmaceutics & Drug Disposition 38:9, pages 535-542.
Crossref
Wolfgang Dekant, James Bridges & Anthony R. Scialli. (2017) A quantitative weight of evidence assessment of confidence in modes-of-action and their human relevance. Regulatory Toxicology and Pharmacology 90, pages 51-71.
Crossref
Isabel Forner-Piquer, Francesca Maradonna, Giorgia Gioacchini, Stefania Santangeli, Marco Allarà, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo & Oliana Carnevali. (2017) Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. Endocrinology 158:10, pages 3462-3476.
Crossref
Taehyeong Kim, Lilik Duwi Wahyudi, Frank J. Gonzalez & Jung-Hwan Kim. (2017) Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice. Biomolecules & Therapeutics 25:5, pages 504-510.
Crossref
Yu Okuda, Masahiko Kushida, Kayo Sumida, Hirohisa Nagahori, Yoshimasa Nakamura, Hashihiro Higuchi, Satoshi Kawamura, Brian G. Lake, Samuel M. Cohen & Tomoya Yamada. (2017) Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. Toxicological Sciences 158:2, pages 412-430.
Crossref
Dana Loomis, Kathryn Z. Guyton, Kurt Straif & Christopher P. Wild. (2017) Classification schemes for carcinogenicity based on hazard identification serve science and society. Regulatory Toxicology and Pharmacology 88, pages 356-357.
Crossref
Hui Liu, Jianshe Wang, Nan Sheng, Ruina Cui, Yitao Pan & Jiayin Dai. (2017) Acot1 is a sensitive indicator for PPARα activation after perfluorooctanoic acid exposure in primary hepatocytes of Sprague-Dawley rats. Toxicology in Vitro 42, pages 299-307.
Crossref
Alistair C. Leitch, Philip M.E. Probert, James A. Shayman, Stephanie K. Meyer, George E.N. Kass & Matthew C. Wright. (2017) B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals. Toxicology 386, pages 120-132.
Crossref
Mitchell B. Rosen, Kaberi P. Das, John Rooney, Barbara Abbott, Christopher Lau & J. Christopher Corton. (2017) PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. Toxicology 387, pages 95-107.
Crossref
Irena Brčić Karačonji, Sonja Anić Jurica, Dario Lasić & Karlo Jurica. (2017) Facts about phthalate toxicity in humans and their occurrence in alcoholic beverages. Archives of Industrial Hygiene and Toxicology 68:2, pages 81-92.
Crossref
Martin Bopst & Elke-Astrid Atzpodien. (2017) Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite. Regulatory Toxicology and Pharmacology 86, pages 107-116.
Crossref
Zemin Wang, Xilin Li & James E. Klaunig. (2017) Investigation of the mechanism of triclosan induced mouse liver tumors. Regulatory Toxicology and Pharmacology 86, pages 137-147.
Crossref
Richard A. Becker, Vicki Dellarco, Jennifer Seed, Joel M. Kronenberg, Bette Meek, Jennifer Foreman, Christine Palermo, Chris Kirman, Igor Linkov, Rita Schoeny, Michael Dourson, Lynn H. Pottenger & Mary K. Manibusan. (2017) Quantitative weight of evidence to assess confidence in potential modes of action. Regulatory Toxicology and Pharmacology 86, pages 205-220.
Crossref
Yukiko Fujii, Kouji H. Harada, Koichi Haraguchi & Akio Koizumi. (2017) Long-term trends in dietary intake of perfluoroalkyl carboxylic acids in relation to their serum concentration in two regions in Japan from 1979 to 2011. Chemosphere 176, pages 165-174.
Crossref
Timothy M. Coskran, Zhijie Jiang, James E. Klaunig, Dixie L. Mager, Leslie Obert, Andrew Robertson, Nicholas Tsinoremas, Zemin Wang & Mark Gosink. (2017) Induction of endogenous retroelements as a potential mechanism for mouse-specific drug-induced carcinogenicity. PLOS ONE 12:5, pages e0176768.
Crossref
Hsin-Pao Chen, Min-Hsiung Pan, Yuan-Yi Chou, Chieh Sung, Kuo-Hsin Lee, Chung-Man Leung & Ping-Chi Hsu. (2017) Effects of di(2-ethylhexyl)phthalate exposure on 1,2-dimethyhydrazine-induced colon tumor promotion in rats. Food and Chemical Toxicology 103, pages 157-167.
Crossref
Sander Kersten & Rinke Stienstra. (2017) The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. Biochimie 136, pages 75-84.
Crossref
Janice K. Britt & Robert C. James. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology 1 53 .
Caterina Ledda, Carla Loreto, Christian Zammit, Andrea Marconi, Lucrezia Fago, Serena Matera, Valentina Costanzo, Giovanni Fuccio Sanzà, Stefano Palmucci, Margherita Ferrante, Chiara Costa, Concettina Fenga, Antonio Biondi, Cristoforo Pomara & Venerando Rapisarda. (2017) Non-infective occupational risk factors for hepatocellular carcinoma: A review. Molecular Medicine Reports 15:2, pages 511-533.
Crossref
Franziska Boess, Barbara Lenz, Juergen Funk, Urs Niederhauser, Simon Bassett, Jitao David Zhang, Thomas Singer & Adrian B. Roth. (2017) Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro. Toxicology 379, pages 48-61.
Crossref
. (2017) Fortschreibung der vorl?ufigen Bewertung von per- und polyfluorierten Chemikalien (PFC) im Trinkwasser. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 60:3, pages 350-352.
Crossref
Yan Li, Hongmei Mao, Yanfeng Xu, Xiaocen Li, Lishan Pan, Xin Wu, Yang Li, Yi Li & Jun He. (2017) Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil. Toxicology Research 6:1, pages 98-104.
Crossref
Yan Jiang, Yufei Dai & Tao Chen. 2017. 51 79 .
Ruud A. Woutersen, Ans E.M.F. Soffers, E. Dinant Kroese, Cyrille A.M. Krul, Jan Willem van der Laan, Jan van Benthem & Mirjam Luijten. (2016) Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data. Regulatory Toxicology and Pharmacology 81, pages 242-249.
Crossref
Hugo F. Olivares-Rubio & Armando Vega-López. (2016) Fatty acid metabolism in fish species as a biomarker for environmental monitoring. Environmental Pollution 218, pages 297-312.
Crossref
Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation 321 350 .
Jan Willem van der Laan, Wenny H. W. Buitenhuis, Laura Wagenaar, Ans E. M. F. Soffers, Eugene P. van Someren, Cyrille A. M. Krul & Ruud A. Woutersen. (2016) Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties. Frontiers in Medicine 3.
Crossref
Reyna Cristina Collí-Dulá, Christopher J. Martyniuk, Summer Streets, Nancy D. Denslow & Randy Lehr. (2016) Molecular impacts of perfluorinated chemicals (PFASs) in the liver and testis of male largemouth bass (Micropterus salmoides) in Minnesota Lakes. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 19, pages 129-139.
Crossref
Valeria Marasco & David Costantini. (2016) Signaling in a Polluted World: Oxidative Stress as an Overlooked Mechanism Linking Contaminants to Animal Communication. Frontiers in Ecology and Evolution 4.
Crossref
Kevin M. Beggs, Steven R. McGreal, Alex McCarthy, Sumedha Gunewardena, Jed N. Lampe, Christoper Lau & Udayan Apte. (2016) The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicology and Applied Pharmacology 304, pages 18-29.
Crossref
Jung-Hwan Kim, Lilik Duwi Wahyudi, Kee K. Kim & Frank J. Gonzalez. (2016) PPARα activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver. Biochemical and Biophysical Research Communications 476:4, pages 293-298.
Crossref
Kathryn Z. Guyton & Michael D. Waters. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 247 279 .
Russell S. Thomas & Michael D. Waters. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 154 184 .
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1955 1996 .
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1743 1790 .
Kazunori Kuwata, Kaoru Inoue, Ryohei Ichimura, Miwa Takahashi, Yukio Kodama, Makoto Shibutani & Midori Yoshida. (2016) Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicological Sciences 151:2, pages 271-285.
Crossref
Zsuzsanna Ament, James A. West, Elizabeth Stanley, Tom Ashmore, Lee D. Roberts, Jayne Wright, Andrew W. Nicholls & Julian L. Griffin. (2016) PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling. Free Radical Biology and Medicine 95, pages 357-368.
Crossref
Mi-Kyung Song, Yoon Cho, Seung-Chan Jeong & Jae-Chun Ryu. (2016) Analysis of gene expression changes in relation to hepatotoxicity induced by perfluorinated chemicals in a human hepatoma cell line. Toxicology and Environmental Health Sciences 8:2, pages 114-127.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1067 1110 .
Ann E. Bradley, Joanna L. Shoenfelt & Judi L. Durda. (2016) Carcinogenicity and mode of action evaluation for alpha-hexachlorocyclohexane: Implications for human health risk assessment. Regulatory Toxicology and Pharmacology 76, pages 152-173.
Crossref
Kazunori Kuwata, Kaoru Inoue, Ryohei Ichimura, Miwa Takahashi, Yukio Kodama & Midori Yoshida. (2016) Constitutive active/androstane receptor, peroxisome proliferator-activated receptor α, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice. Food and Chemical Toxicology 88, pages 75-86.
Crossref
Shuji Tsuda. (2016) Differential toxicity between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). The Journal of Toxicological Sciences 41:Special, pages SP27-SP36.
Crossref
Yvonne P. Dragan. 2016. Hepatocellular Carcinoma. Hepatocellular Carcinoma 65 92 .
Rebecca A. Clewell, Patrick D. McMullen, Yeyejide Adeleye, Paul L. Carmichael & Melvin E. Andersen. 2016. Validation of Alternative Methods for Toxicity Testing. Validation of Alternative Methods for Toxicity Testing 205 230 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 58 .
Brian G. Lake & Roger J. Price. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 309 332 .
Hong Sik Yoo, Joseph A. Cichocki, Sungkyoon Kim, Abhishek Venkatratnam, Yasuhiro Iwata, Oksana Kosyk, Wanda Bodnar, Stephen Sweet, Anthony Knap, Terry Wade, Jerry Campbell, Harvey J. Clewell, Stepan B. Melnyk, Weihsueh A. Chiu & Ivan Rusyn. (2015) The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene. Toxicological Sciences 147:2, pages 339-349.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 44 .
Reza J. Rasoulpour, Amanda K. Andrus, M. Sue Marty, Fagen Zhang, Johnson Thomas, Matthew J. LeBaron, Sabitha Papineni, Lynn H. Pottenger & David L. Eisenbrandt. (2015) Pronamide: Human relevance of liver-mediated rat leydig cell tumors. Regulatory Toxicology and Pharmacology 72:2, pages 394-404.
Crossref
Kannan Badri Narayanan, Manaf Ali, Barry J. Barclay, Qiang (Shawn) Cheng, Leandro D’Abronzo, Rita Dornetshuber-Fleiss, Paramita M. Ghosh, Michael J. Gonzalez Guzman, Tae-Jin Lee, Po Sing Leung, Lin Li, Suidjit Luanpitpong, Edward Ratovitski, Yon Rojanasakul, Maria Fiammetta Romano, Simona Romano, Ranjeet K. Sinha, Clement Yedjou, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Dustin G. Brown, Elizabeth P. Ryan, Anna Maria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Hosni K. Salem, Jordan Woodrick, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Seo Yun Kim, William H. Bisson, Leroy Lowe & Hyun Ho Park. (2015) Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis 36:Suppl 1, pages S89-S110.
Crossref
Wilhelm Engström, Philippa Darbre, Staffan Eriksson, Linda Gulliver, Tove Hultman, Michalis V. Karamouzis, James E. Klaunig, Rekha Mehta, Kim Moorwood, Thomas Sanderson, Hideko Sone, Pankaj Vadgama, Gerard Wagemaker, Andrew Ward, Neetu Singh, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A.Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth Ryan, Dustin G. Brown & William H. Bisson. (2015) The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis 36:Suppl 1, pages S38-S60.
Crossref
Maria Wiels?e, Manhai Long, Mandana Ghisari & Eva C. Bonefeld-J?rgensen. (2015) Perfluoroalkylated substances (PFAS) affect oxidative stress biomarkers in vitro. Chemosphere 129, pages 239-245.
Crossref
Ling Niu, Xiu-hua He, Qing-wen Wang, Ming-yu Fu, Feng Xu, Ying Xue, Zhen-zhou Wang & Xin-jiang An. (2015) Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases. Cell Biochemistry and Biophysics 72:2, pages 485-494.
Crossref
Brian G Lake, Roger J Price & Thomas G Osimitz. (2014) Mode of action analysis for pesticide‐induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk. Pest Management Science 71:6, pages 829-834.
Crossref
Hui-Xin Liu, Ying Hu, Samuel W. French, Frank J. Gonzalez & Yu-Jui Yvonne Wan. (2015) Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARαPAC mice due to dysregulated bile acid synthesis. Oncotarget 6:12, pages 9686-9700.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 56 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 45 .
Jie Liu, Kamel Mansouri, Richard S. Judson, Matthew T. Martin, Huixiao Hong, Minjun Chen, Xiaowei Xu, Russell S. Thomas & Imran Shah. (2015) Predicting Hepatotoxicity Using ToxCast in Vitro Bioactivity and Chemical Structure . Chemical Research in Toxicology 28:4, pages 738-751.
Crossref
Jason S. Garcia & Raymond D. Harbison. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 689 718 .
Thomas J. Steinbach, Robert. R. Maronpot & Jerry F. Hardisty. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 1189 1196 .
Nikki Gillum Posnack, Rabia Idrees, Hao Ding, Rafael Jaimes III, Gulnaz Stybayeva, Zaruhi Karabekian, Michael A. Laflamme & Narine Sarvazyan. (2015) Exposure to Phthalates Affects Calcium Handling and Intercellular Connectivity of Human Stem Cell-Derived Cardiomyocytes. PLOS ONE 10:3, pages e0121927.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 38 .
James V. Bruckner. 2015. Mammalian Toxicology. Mammalian Toxicology 187 218 .
Shayne C. Gad, Charles B. Spainhour & Samantha E. Gad. 2015. Mammalian Toxicology. Mammalian Toxicology 341 393 .
Tomoya Yamada, Hiroko Kikumoto, Brian G. Lake & Satoshi Kawamura. (2015) Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes. Toxicology Research 4:4, pages 901-913.
Crossref
J.M. Caverly Rae, Lisa Craig, Theodore W. Slone, Steven R. Frame, L.William Buxton & Gerald L. Kennedy. (2015) Evaluation of chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague–Dawley rats. Toxicology Reports 2, pages 939-949.
Crossref
Meenu Varshney, Abhijit Chandra, Rajeev Jain, Riaz Ahmad, Vipin Bihari, C. Keshava Chandran, Mohana K.R. Mudiam, Satykam Patnaik & S.K. Goel. (2015) Occupational health hazards of trichloroethylene among workers in relation to altered mRNA expression of cell cycle regulating genes (p53, p21, bax and bcl-2) and PPARA. Toxicology Reports 2, pages 748-757.
Crossref
Deborah Meltzer, Daniel B. Martinez–Arguelles, Enrico Campioli, Sunghoon Lee & Vassilios Papadopoulos. (2015) In utero exposure to the endocrine disruptor di(2-ethylhexyl) phthalate targets ovarian theca cells and steroidogenesis in the adult female rat. Reproductive Toxicology 51, pages 47-56.
Crossref
Pinar Erkekoglu, Josiane Arnaud, Walid Rachidi, Belma Kocer-Gumusel, Alain Favier & Filiz Hincal. (2015) The effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats. Journal of Trace Elements in Medicine and Biology 29, pages 296-302.
Crossref
Sloane K. Tilley & Rebecca C. Fry. 2015. Systems Biology in Toxicology and Environmental Health. Systems Biology in Toxicology and Environmental Health 117 169 .
Marc Rigden, Guillaume Pelletier, Raymond Poon, Jiping Zhu, Christiane Auray-Blais, René Gagnon, Cariton Kubwabo, Ivana Kosarac, Kaela Lalonde, Sabit Cakmak, Bin Xiao, Karen Leingartner, Ka Lei Ku, Ranjan Bose & Jianli Jiao. (2014) Assessment of Urinary Metabolite Excretion After Rat Acute Exposure to Perfluorooctanoic Acid and Other Peroxisomal Proliferators. Archives of Environmental Contamination and Toxicology 68:1, pages 148-158.
Crossref
Yan Jiang, Jiahong Chen, Jian Tong & Tao Chen. (2014) Trichloroethylene-Induced Gene Expression and DNA Methylation Changes in B6C3F1 Mouse Liver. PLoS ONE 9:12, pages e116179.
Crossref

Displaying 200 of 500 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.