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Climacteric Volume 6, 2003 - Issue 2
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(RG) Obstetrics and Gynaecology

Comparison of a novel vaginal ring delivering estradiol acetate versus oral estradiol for relief of vasomotor menopausal symptoms

F. Al-Azzawi Gynaecology Research Unit, Department of Obstetrics and Gynaecology, University of Leicester, Leicester, UK
&
H. M. Buckler Department of Endocrinology, University of Manchester and Salford Royal Hospitals NHS Trust, Manchester, UK
Pages 118-127 | Published online: 03 Jul 2009

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M. L. Hull, B. Stuckey, K. Hartman, N. Zack, A. Thurman & D. R. Friend. (2023) Safety and acceptability of intravaginal rings releasing estradiol and progesterone. Climacteric 26:5, pages 465-471.
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Peter Boyd, Ruth Merkatz, Bruce Variano & R. Karl Malcolm. (2020) The ins and outs of drug-releasing vaginal rings: a literature review of expulsions and removals. Expert Opinion on Drug Delivery 17:11, pages 1519-1540.
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R. J. Santen. (2015) Vaginal administration of estradiol: effects of dose, preparation and timing on plasma estradiol levels. Climacteric 18:2, pages 121-134.
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R Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd & Ian Major. (2012) Vaginal rings for delivery of HIV microbicides. International Journal of Women's Health 4, pages 595-605.
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Vivian Lewis. (2009) Undertreatment of menopausal symptoms and novel options for comprehensive management. Current Medical Research and Opinion 25:11, pages 2689-2698.
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Richard E Hedrick. (2008) Low-dose estradiol gel 0.1% for the treatment of vasomotor symptoms associated with menopause. Expert Review of Obstetrics & Gynecology 3:2, pages 155-162.
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N. N. Sarkar. (2003) Low-dose intravaginal estradiol delivery using a Silastic vaginal ring for estrogen replacement therapy in postmenopausal women: a review. The European Journal of Contraception & Reproductive Health Care 8:4, pages 217-224.
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Articles from other publishers (19)

Ahmed Abdelgader, Mershen Govender, Pradeep Kumar & Yahya E. Choonara. (2023) Intravaginal Drug Delivery Systems to Treat the Genitourinary Syndrome of Menopause: Towards the Design of Safe and Efficacious Estrogen-loaded Prototypes. Journal of Pharmaceutical Sciences 112:6, pages 1566-1585.
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Louise Hull, Bronwyn G. A. Stuckey, Kimberly Hartman, Nadene Zack & David R. Friend. (2023) Evaluation of 28-day estradiol and progesterone vaginal rings in a phase 1 clinical pharmacokinetic study. Menopause 30:4, pages 427-436.
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Eva V. Vodegel, Sandra E. Zwolsman, Astrid Vollebregt, Ruben G. Duijnhoven, Judith E. Bosmans, Leonie Speksnijder, Eveline J. Roos, Wilbert Spaans, Franca Gerards, Albert Adriaanse, Flora Vernooij, Alfredo L. Milani, Marko Sikkema, Mirjam Weemhoff, Marieke Mous, Anne Damoiseaux, Heleen van Dongen, Marinus v/d Ploeg, Joggem Veen, Geerte van de Pol, Bart Broekman, Pieternel Steures, Fernando Tjin-Asjoe, Jolande van der Stege, Ronald Mouw, Carl H. van der Vaart & Jan-Paul W. R. Roovers. (2021) Cost-Effectiveness of perioperative Vaginally Administered estrogen in postmenopausal women undergoing prolapse surgery (EVA trial): study protocol for a multicenter double-blind randomized placebo-controlled trial. BMC Women's Health 21:1.
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Valerie A Flores, Lubna Pal & JoAnn E Manson. (2021) Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment. Endocrine Reviews 42:6, pages 720-752.
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S Iliodromiti, W Wang, MA Lumsden, MS Hunter, R Bell, G Mishra & M Hickey. (2019) Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology 127:3, pages 320-333.
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Herman Weiss, Bridget Martell, Ginger D. Constantine, Sarah M. Davis, Justin D. Vidal, Philip R. Mayer, Martin Doorbar & David R. Friend. (2019) Pharmacokinetics and Tolerability of a Novel 17β-Estradiol and Progesterone Intravaginal Ring in Sheep. Journal of Pharmaceutical Sciences 108:8, pages 2677-2684.
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Ginger D. Constantine, Shelli Graham, Kate Lapane, Kathleen Ohleth, Brian Bernick, James Liu & Sebastian Mirkin. (2019) Endometrial safety of low-dose vaginal estrogens in menopausal women: a systematic evidence review. Menopause 26:7, pages 800-807.
Crossref
Clare F. McCoy, David C. Apperley, Bruce Variano, Heather Sussman, Daniel Loeven, Peter Boyd & R. Karl Malcolm. (2018) Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system. International Journal of Pharmaceutics 548:1, pages 689-697.
Crossref
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 122 151 .
. (2014) Practice Bulletin No. 141. Obstetrics & Gynecology 123:1, pages 202-216.
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Nattawan Promadej‐Lanier, James M. Smith, Priya Srinivasan, Clare F. McCoy, Sal Butera, A. David Woolfson, R. Karl Malcolm & Ron A. Otten. (2009) Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non‐human primates. Journal of Medical Primatology 38:4, pages 263-271.
Crossref
R Malcolm. 2008. Modified-Release Drug Delivery Technology, Second Edition. Modified-Release Drug Delivery Technology, Second Edition 499 510 .
Wulf H Utian, Leon Speroff, Herman Ellman & Clint Dart. (2005) Comparative controlled trial of a novel oral estrogen therapy, estradiol acetate, for relief of menopause symptoms. Menopause 12:6, pages 708-715.
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Farook Al-Azzawi, Belinda Lees, John Thompson & John C Stevenson. (2005) Bone mineral density in postmenopausal women treated with a vaginal ring delivering systemic doses of estradiol acetate. Menopause 12:3, pages 331-339.
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M.N.G. Dukes. 2005. Side Effects of Drugs Annual 28. Side Effects of Drugs Annual 28 480 504 .
Nancy J Alexander, Edward Baker, Marc Kaptein, Ulrich Karck, Leslie Miller & Edio Zampaglione. (2004) Why consider vaginal drug administration?. Fertility and Sterility 82:1, pages 1-12.
Crossref
&NA;. (2004) Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society: Retracted. Menopause 11:1, pages 11-33.
Crossref
Leon Speroff. (2003) Efficacy and Tolerability of a Novel Estradiol Vaginal Ring for Relief of Menopausal Symptoms. Obstetrics & Gynecology 102:4, pages 823-834.
Crossref
Helen Buckler & Farook Al-Azzawi. (2003) The effect of a novel vaginal ring delivering oestradiol acetate on climacteric symptoms in postmenopausal women. BJOG: An International Journal of Obstetrics and Gynaecology 110:8, pages 753-759.
Crossref

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