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Research Article

Porcine Insulin Biodegradable Polyester Microspheres: Stability and In Vitro Release Characteristics

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Pages 1-9 | Received 05 Jun 1998, Accepted 03 May 1999, Published online: 18 Jan 2000

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Jahanzeb Mudassir, Yusrida Darwis, Suriani Muhamad & Arshad Ali Khan. (2019) Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: characterization, lyophilization and in-vivo evaluation. International Journal of Nanomedicine 14, pages 4895-4909.
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C. Presmanes, L. de Miguel, R. Espada, C. Álvarez, E. Morales & J.J. Torrado. (2011) Effect of PLGA hydrophilia on the drug release and the hypoglucemic activity of different insulin-loaded PLGA microspheres. Journal of Microencapsulation 28:8, pages 791-798.
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Christopher F van der Walle, Gaurav Sharma & MNV Ravi Kumar. (2009) Current approaches to stabilising and analysing proteins during microencapsulation in PLGA. Expert Opinion on Drug Delivery 6:2, pages 177-186.
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R. L. Graves, M. C. Makoid & S. Jonnalagadda. (2005) The effect of coencapsulation of bovine insulin with cyclodextrins in ethylcellulose microcapsules. Journal of Microencapsulation 22:6, pages 661-670.
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Dinesh B. Shenoy, Reshma J. D'Souza, Sandip B. Tiwari & N. Udupa. (2003) Potential Applications of Polymeric Microsphere Suspension as Subcutaneous Depot for Insulin. Drug Development and Industrial Pharmacy 29:5, pages 555-563.
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Andreas Bernkop-Schnürch. (2000) The use of multifunctional polymers for non-invasive peptide and protein application. Expert Opinion on Therapeutic Patents 10:9, pages 1357-1366.
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Parker W. Lee & Jonathan K. Pokorski. (2018) Poly(lactic‐co‐glycolic acid) devices: Production and applications for sustained protein delivery. WIREs Nanomedicine and Nanobiotechnology 10:5.
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G. Sharma, C.F. van der Walle & M.N.V. Ravi Kumar. (2013) Antacid co-encapsulated polyester nanoparticles for peroral delivery of insulin: Development, pharmacokinetics, biodistribution and pharmacodynamics. International Journal of Pharmaceutics 440:1, pages 99-110.
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Bing‐Cang Li, Shu‐Sheng Jiao, Chuan Xu, Hua You & Jian‐Mei Chen. (2010) PLGA conduit seeded with olfactory ensheathing cells for bridging sciatic nerve defect of rats. Journal of Biomedical Materials Research Part A 94A:3, pages 769-780.
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Shayne Cox GadShunmugaperumal Tamilvanan. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Chandrasekar Manoharan & Jagdish Singh. (2009) Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats. Journal of Pharmaceutical Sciences 98:11, pages 4237-4250.
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Hyun Jung Yang, In Suh Park & Kun Na. (2009) Biocompatible microspheres based on acetylated polysaccharide prepared from water-in-oil-in-water (W1/O/W2) double-emulsion method for delivery of type II diabetic drug (exenatide). Colloids and Surfaces A: Physicochemical and Engineering Aspects 340:1-3, pages 115-120.
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Jaber Emami, Hamed Hamishehkar, Abdolhossien Rouholamini Najafabadi, Kambiz Gilani, Mohsen Minaiyan, Hamid Mahdavi & Ali Nokhodchi. (2009) A Novel Approach to Prepare Insulin-Loaded Poly (Lactic-Co-Glycolic Acid) Microcapsules and the Protein Stability Study. Journal of Pharmaceutical Sciences 98:5, pages 1712-1731.
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Chandrasekar Manoharan & Jagdish Singh. (2009) Insulin Loaded PLGA Microspheres: Effect of Zinc Salts on Encapsulation, Release, and Stability. Journal of Pharmaceutical Sciences 98:2, pages 529-542.
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Sherif I. Farag Badawy & Munir A. Hussain. (2007) Microenvironmental pH Modulation in Solid Dosage Forms. Journal of Pharmaceutical Sciences 96:5, pages 948-959.
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Angelika Maschke, Christian Becker, Daniela Eyrich, Josef Kiermaier, Torsten Blunk & Achim Göpferich. (2007) Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof. European Journal of Pharmaceutics and Biopharmaceutics 65:2, pages 175-187.
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Ajay Taluja, Yu Seok Youn & You Han Bae. (2007) Novel approaches in microparticulate PLGA delivery systems encapsulating proteins. Journal of Materials Chemistry 17:38, pages 4002.
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Xiongliang Xu, Yao Fu, Haiyan Hu, Yourong Duan & Zhirong Zhang. (2006) Quantitative determination of insulin entrapment efficiency in triblock copolymeric nanoparticles by high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 41:1, pages 266-273.
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Ugo Bilati, Eric Allémann & Eric Doelker. (2005) Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues. AAPS PharmSciTech 6:4, pages E594-E604.
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Mohamed Abbas Ibrahim, Ahmed Ismail, Mohamed Ihab Fetouh & Achim Göpferich. (2005) Stability of insulin during the erosion of poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres. Journal of Controlled Release 106:3, pages 241-252.
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Kinam Park & Yoon Yeo. 2003. Tissue Engineering And Novel Delivery Systems. Tissue Engineering And Novel Delivery Systems.
Shao-Qiong Liu, Yi-Yan Yang, Xue-Ming Liu & Yen-Wah Tong. (2003) Preparation and Characterization of Temperature-Sensitive Poly( N -isopropylacrylamide)- b -poly( d , l -lactide) Microspheres for Protein Delivery . Biomacromolecules 4:6, pages 1784-1793.
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Dong Hee Na, Yu Seok Youn, Sang Deuk Lee, Mi-Won Son, Won-Bae Kim, Patrick P. DeLuca & Kang Choon Lee. (2003) Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry. Journal of Controlled Release 92:3, pages 291-299.
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Lin Yang & Paschalis Alexandridis. (2000) Physicochemical aspects of drug delivery and release from polymer-based colloids. Current Opinion in Colloid & Interface Science 5:1-2, pages 132-143.
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Purnendu Kumar Nayak, Karthikan Rajagopal & Debby Chang. (2022) Hydroxypropyl Methyl Cellulose Derivatives Stabilize Fragment Antibody Against Aggregation in Spray Dried Formulations at Elevated Temperature and Resist Ph Changes. SSRN Electronic Journal.
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