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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 10
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Original Articles

Microwave‐Assisted Synthesis of 2‐Amino‐thiophene‐3‐Carboxylic Derivatives Under Solvent‐Free Conditions

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Pages 1351-1357 | Received 22 Nov 2004, Published online: 16 Aug 2006

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Mohamed M. Kaddah, Alaa R. I. Morsy, Abdelgawad A. Fahmi, Mustafa M. Kamel, Mounir M. Elsafty, Sameh A. Rizk & Sayed K. Ramadan. (2021) Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide. Synthetic Communications 51:22, pages 3366-3378.
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Jian Li, Deju Ye, Hong Liu, Xiaoming Luo & Hualiang Jiang. (2008) Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol. Synthetic Communications 38:4, pages 567-575.
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Safaa E. Seif, Zeinab Mahmoud, Wagnat W. Wardakhan, Amr M. Abdou & Rasha A. Hassan. (2023) Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐ d ]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of PI3K/AKT/mTOR signaling pathway . Drug Development Research.
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Ehab Abdel‐Latif, Rabia E. Alashhab, Amr El‐Demerdash & Mohamed A. Ismail. (2020) Utilization of 5‐Chloro‐2‐(cyanoacetamido)pyridines in the Synthesis of Biologically Active Heterocyclic Hybrids. ChemistrySelect 5:5, pages 1797-1802.
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Majid Heravi & Vahideh Zadsirjan. 2020. Recent Advances in Applications of Name Reactions in Multicomponent Reactions. Recent Advances in Applications of Name Reactions in Multicomponent Reactions 15 138 .
Ehab Abdel‐Latif, Altaf S. Almatari & Ghada E. Abd‐ElGhani. (2019) Synthesis and Antibacterial Evaluation of Some New Thiazole‐Based Polyheterocyclic Ring Systems. Journal of Heterocyclic Chemistry 56:7, pages 1978-1985.
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Ehab Abdel-Latif, Eman M. Keshk, Abdel-Galil M. Khalil, Ali Saeed & Heba M. Metwally. (2018) Utilization of thioacetanilides in the synthesis of new 4-(4-acetamidophenylazo)thiophene scaffolds and evaluating their anti-oxidant activity. Journal of the Iranian Chemical Society 16:3, pages 629-637.
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Shiv Dev Singh, Arvind Kumar, Firoz Babar, Neetu Sachan & Arun Kumar Sharma. (2019) Synthesis of Novel 3(N,N-dialkylamino)alkyl/phenyl Substituted Thieno [2,3-d]pyrimidinones as H1-Anti-Histaminic and Antimicrobial Agents. Current Bioactive Compounds 15:1, pages 63-70.
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Dipen K. Sureja & Kantilal R. Vadalia. (2018) POCl 3 catalyzed, one-step, solvent-free synthesis of some novel thieno[2,3- d ]pyrimidin-4(3 H )-one derivatives as antimicrobial agent. Journal of Saudi Chemical Society 22:2, pages 248-253.
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L. V. Klyba, N. A. Nedolya, E. R. Sanzheeva & O. A. Tarasova. (2017) Mass spectra of new heterocycles: XVI. Electron impact study of alkyl 5-aminothiophene-2-carboxylates. Russian Journal of Organic Chemistry 53:6, pages 913-919.
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Ram W. Sabnis. (2016) The Gewald reaction in dye chemistry. Coloration Technology 132:1, pages 49-82.
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Ahmed A. Fadda & Ramy Rabie. (2015) Cyanoacetylation of amines: recent advances in preparation methods and their synthetic uses in the formation of biologically active compounds. Research on Chemical Intermediates 42:2, pages 771-811.
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Devulapally Srikrishna & Pramod Kumar Dubey. (2014) Efficient stepwise and one pot three-component synthesis of 2-amino-4-(2-oxo-2H-chromen-3-yl)thiophene-3-carbonitriles. Tetrahedron Letters 55:48, pages 6561-6566.
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Navjeet Kaur. (2013) Microwave-assisted synthesis of five-membered S-heterocycles. Journal of the Iranian Chemical Society 11:2, pages 523-564.
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Hung The Dang, Erik Chorell, Hanna Uvell, Jerome S. Pinkner, Scott J. Hultgren & Fredrik Almqvist. (2014) Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Org. Biomol. Chem. 12:12, pages 1942-1956.
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Kuncha Madhusudana, Boyapati Shireesha, Vegi Ganga Modi Naidu, Sistla Ramakrishna, Banda Narsaiah, Akkinepally Raghuram Rao & Prakash V. Diwan. (2012) Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs. European Journal of Pharmacology 678:1-3, pages 48-54.
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Arif Daştan, Aditya Kulkarni & Béla Török. (2012) Environmentally benign synthesis of heterocyclic compounds by combined microwave-assisted heterogeneous catalytic approaches † . Green Chem. 14:1, pages 17-37.
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Jiangping Lou, Zhen Liu, Yan Li, Mi Zhou, Zhengxi Zhang, Shu Zheng, Renxiao Wang & Jian Li. (2011) Synthesis and anti-tumor activities of N′-benzylidene-2-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives. Bioorganic & Medicinal Chemistry Letters 21:22, pages 6662-6666.
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Farid Moeinpour, Raheleh Omidinia, Nadieh Dorostkar-Ahmadi & Bentalhoda Khoshdeli. (2011) Cesium Carbonate as a Heterogeneous Base Catalyst for Synthesis of 2-Aminothiophenes via Gewald Reaction. Bulletin of the Korean Chemical Society 32:6, pages 2091-2092.
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Deju Ye, Yu Zhang, Fei Wang, Mingfang Zheng, Xu Zhang, Xiaomin Luo, Xu Shen, Hualiang Jiang & Hong Liu. (2010) Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. Bioorganic & Medicinal Chemistry 18:5, pages 1773-1782.
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Kan Wang, Dabin Kim & Alexander Dömling. (2009) Cyanoacetamide MCR (III): Three-Component Gewald Reactions Revisited. Journal of Combinatorial Chemistry 12:1, pages 111-118.
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Jin Zhu, Tong Chen, Jie Liu, Ruoqun Ma, Weiqiang Lu, Jin Huang, Honglin Li, Jian Li & Hualiang Jiang. (2009) 2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation. Molecules 14:2, pages 785-797.
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Matthias Treu, Thomas Karner, Roland Kousek, Helmut Berger, Moriz Mayer, Darryl B. McConnell & Alexander Stadler. (2008) Microwave-Assisted Parallel Synthesis of Fused Heterocycles in a Novel Parallel Multimode Reactor. Journal of Combinatorial Chemistry 10:6, pages 863-868.
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V. D. Dyachenko, R. P. Tkachiov & O. S. Bityukova. (2008) Chemical properties of cyanoacetanilides and synthesis of biologically active compounds around them. Russian Journal of Organic Chemistry 44:11, pages 1565-1579.
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O. Sato & J. Nakayama. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 843 930 .
Stéphanie Hesse, Enrico Perspicace & Gilbert Kirsch. (2007) Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno[2,3-d]pyrimidin-4-one and 4-chlorothieno[2,3-d]pyrimidine. Tetrahedron Letters 48:30, pages 5261-5264.
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M. Raghu Prasad, S. Raziya & D. Pran Kishore. (2019) Microwave Assisted Synthesis of Some Novel Thiadiazolothienopyrimidines. Journal of Chemical Research 2007:3, pages 133-135.
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Mailavaram Raghu Prasad & Deb Pran Kishore. (2007) Multistep, Microwave Assisted, Solvent Free Synthesis and Antibacterial Activity of 6-Substituted-2,3,4-trihydropyrimido[1,2-c]9,10,11,12-tetrahydrobenzo[b]thieno[3,2-e]pyrimidines. CHEMICAL & PHARMACEUTICAL BULLETIN 55:5, pages 776-779.
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Tomasz Janosik & Jan Bergman. 2007. A critical review of the 2005 literature preceded by two chapters on current heterocyclic topics. A critical review of the 2005 literature preceded by two chapters on current heterocyclic topics 126 149 .
Wei Huang, Jian Li, Jing Tang, Hong Liu, Jianhua Shen & Hualiang Jiang. (2005) Microwave‐Assisted Synthesis of 2‐Aminothiophene‐3‐carboxylic Derivatives under Solvent‐Free Conditions.. ChemInform 36:41.
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