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Molecular and Cellular Biology Volume 35, 2015 - Issue 22
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Article

PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation

Swapna Aravind GudipatyDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Ryan P. McNamaraDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Emily L. MortonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
&
Iván D'OrsoDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USACorrespondence[email protected]
Pages 3810-3828 | Received 27 Feb 2015, Accepted 19 Aug 2015, Published online: 20 Mar 2023

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Curtis W. Bacon & Iván D’Orso. (2019) CDK9: a signaling hub for transcriptional control. Transcription 10:2, pages 57-75.
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Annemieke A. Michels & Olivier Bensaude. (2018) Hexim1, an RNA-controlled protein hub. Transcription 9:4, pages 262-271.
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You Li, Min Liu, Lin-Feng Chen & Ruichuan Chen. (2018) P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II. Transcription 9:2, pages 88-94.
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Ali M. Yazbeck, Kifah R. Tout & Peter F. Stadler. (2018) Detailed secondary structure models of invertebrate 7SK RNAs. RNA Biology 15:2, pages 158-164.
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Andrew P. Rice. (2016) Cyclin-dependent kinases as therapeutic targets for HIV-1 infection. Expert Opinion on Therapeutic Targets 20:12, pages 1453-1461.
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Ryan P. McNamara, Curtis W. Bacon & Iván D'Orso. (2016) Transcription elongation control by the 7SK snRNP complex: Releasing the pause. Cell Cycle 15:16, pages 2115-2123.
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Iván D'Orso. (2016) 7SKiing on chromatin: Move globally, act locally. RNA Biology 13:6, pages 545-553.
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Articles from other publishers (27)

Momodou B. Camara, Amr M. Sobeh & Catherine D. Eichhorn. (2023) Progress in 7SK ribonucleoprotein structural biology. Frontiers in Molecular Biosciences 10.
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Yue Jiang, Chengda Zhang, Yang Chen, Shiyu Zhao, Yipeng He & Jun He. (2022) Prognostic risk assessment model for alternative splicing events and splicing factors in malignant pleural mesothelioma. Cancer Medicine 12:4, pages 4895-4906.
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Amr M. Sobeh & Catherine D. Eichhorn. (2023) C-terminal determinants for RNA binding motif 7 protein stability and RNA recognition. Biophysical Chemistry 292, pages 106928.
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Nora Tula Detering, Tobias Schüning, Niko Hensel & Peter Claus. (2022) The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA). Cellular and Molecular Life Sciences 79:9.
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Megumi Ikeura, Hiroto Tashiro, Yuka Yamagata, Hikaru Saito, Tamaki Kobayashi, Masataka Mizunuma, Kazuki Yamazaki, Keisuke Baba, Kazuhiro Furukawa & Yoshiro Chuman. (2022) Development of Antibody-like Proteins Targeting the Oncogenic Ser/Thr Protein Phosphatase PPM1D. Processes 10:8, pages 1501.
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Qingyu Xiao, Zhen Cheng, Wenbin Kuang, Haijun Wu, Xi Luo & Renling Wang. (2022) Clinical Value of PPM1G Gene in Survival Prognosis and Immune Infiltration of Hepatocellular Carcinoma. Applied Bionics and Biomechanics 2022, pages 1-7.
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Dawei Chen, Zhenguo Zhao, Lu Chen, Qinghua Li, Jixue Zou & Shuanghai Liu. (2021) PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3. Cell Death & Disease 12:8.
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Cécilia Studniarek, Michael Tellier, Pascal G.P. Martin, Shona Murphy, Tamás Kiss & Sylvain Egloff. (2021) The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming. Cell Reports 35:2, pages 108965.
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Usman Hyder, Jennifer L. McCannJinli Wang, Victor FungJuan Bayo & Iván D’Orso. (2020) The ARF tumor suppressor targets PPM1G/PP2Cγ to counteract NF-κB transcription tuning cell survival and the inflammatory response. Proceedings of the National Academy of Sciences 117:51, pages 32594-32605.
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Antoine Dutilleul, Anthony Rodari & Carine Van Lint. (2020) Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know. Viruses 12:12, pages 1385.
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Vikas Sharma & Monica M. Montano. (2020) Non-epigenetic induction of HEXIM1 by DNMT1 inhibitors and functional relevance. Scientific Reports 10:1.
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Kuai Yu, Huabin Tian & Hongyu Deng. (2020) PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion. Science Advances 6:47.
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Rui Kamada, Fuki Kudoh, Shogo Ito, Itsumi Tani, Jose Isagani B. Janairo, James G. Omichinski & Kazuyasu Sakaguchi. (2020) Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors. Pharmacology & Therapeutics 215, pages 107622.
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Curtis W. Bacon, Ashwini Challa, Usman Hyder, Ashutosh Shukla, Aditi N. Borkar, Juan Bayo, Jiuyang Liu, Shwu-Yuan Wu, Cheng-Ming Chiang, Tatiana G. Kutateladze & Iván D’Orso. (2020) KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs. Molecular Cell 78:6, pages 1133-1151.e14.
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Koh Fujinaga. (2020) P-TEFb as A Promising Therapeutic Target. Molecules 25:4, pages 838.
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Andrii Bugai, Alexandre J.C. Quaresma, Caroline C. Friedel, Tina Lenasi, Robert Düster, Christopher R. Sibley, Koh Fujinaga, Petra Kukanja, Thomas Hennig, Melanie Blasius, Matthias Geyer, Jernej Ule, Lars Dölken & Matjaž Barborič. (2019) P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress. Molecular Cell 74:2, pages 254-267.e10.
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Anna Georges, Edyta Marcon, Jack Greenblatt & Lori Frappier. (2018) Identification and Characterization of USP7 Targets in Cancer Cells. Scientific Reports 8:1.
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Jaehyuk Pyo, Jaewook Ryu, Wootae Kim, Jae-Sun Choi, Joo-Won Jeong & Ja-Eun Kim. (2018) The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression. International Journal of Molecular Sciences 19:8, pages 2297.
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Catherine D. Eichhorn, Yuan Yang, Lucas Repeta & Juli Feigon. (2018) Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7. Proceedings of the National Academy of Sciences 115:28.
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Uri Mbonye, Benlian Wang, Giridharan Gokulrangan, Wuxian Shi, Sichun Yang & Jonathan Karn. (2018) Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. Journal of Biological Chemistry 293:26, pages 10009-10025.
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Mark D. BensonQiong YangDebby NgoYineng ZhuDongxiao ShenLaurie A. FarrellSumita SinhaMichelle J. KeyesRamachandran S. VasanMartin G. LarsonJ. Gustav SmithThomas J. WangRobert E. Gerszten. (2018) Genetic Architecture of the Cardiovascular Risk Proteome. Circulation 137:11, pages 1158-1172.
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Oliver J. Gruss, Rajyalakshmi Meduri, Maximilian Schilling & Utz Fischer. (2017) UsnRNP biogenesis: mechanisms and regulation. Chromosoma 126:5, pages 577-593.
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Uri MbonyeJonathan Karn. (2017) The Molecular Basis for Human Immunodeficiency Virus Latency. Annual Review of Virology 4:1, pages 261-285.
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John E. Brogie & David H. Price. (2017) Reconstitution of a functional 7SK snRNP. Nucleic Acids Research 45:11, pages 6864-6880.
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Sarah Bourbigot, Anne-Catherine Dock-Bregeon, Pascal Eberling, Jérôme Coutant, Bruno Kieffer & Isabelle Lebars. (2016) Solution structure of the 5′-terminal hairpin of the 7SK small nuclear RNA. RNA 22:12, pages 1844-1858.
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Catherine D. Eichhorn, Rahul Chug & Juli Feigon. (2016) hLARP7 C-terminal domain contains an xRRM that binds the 3′ hairpin of 7SK RNA. Nucleic Acids Research, pages gkw833.
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Alexandre J. C. Quaresma, Andrii Bugai & Matjaz Barboric. (2016) Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb. Nucleic Acids Research 44:16, pages 7527-7539.
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