70
Views
105
CrossRef citations to date
0
Altmetric
Article

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

, , , &
Pages 3903-3912 | Received 24 Feb 2012, Accepted 17 Jul 2012, Published online: 20 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Penghui Wang & Xiaodong He. (2017) Current research on circular RNAs associated with colorectal cancer. Scandinavian Journal of Gastroenterology 52:11, pages 1203-1210.
Read now
Cong Fei, Zhenfei Li, Chen Li, Yuelei Chen, Zhangcheng Chen, Xiaoli He, Li Mao, Xin Wang, Rong Zeng & Lin Li. (2013) Smurf1-Mediated Lys29-Linked Nonproteolytic Polyubiquitination of Axin Negatively Regulates Wnt/β-Catenin Signaling. Molecular and Cellular Biology 33:20, pages 4095-4105.
Read now
Kenyi Saito-Diaz, Tony W. Chen, Xiaoxi Wang, Curtis A. Thorne, Heather A. Wallace, Andrea Page-McCaw & Ethan Lee. (2013) The way Wnt works: Components and mechanism. Growth Factors 31:1, pages 1-31.
Read now
Justine T. Tigno-Aranjuez, Xiaodong Bai & Derek W. Abbott. (2013) A Discrete Ubiquitin-Mediated Network Regulates the Strength of NOD2 Signaling. Molecular and Cellular Biology 33:1, pages 146-158.
Read now

Articles from other publishers (101)

Khatere Mokhtari, Maryam Peymani, Mohsen Rashidi, Kiavash Hushmandi, Kamran Ghaedi, Afshin Taheriazam & Mehrdad Hashemi. (2023) Colon cancer transcriptome. Progress in Biophysics and Molecular Biology 180-181, pages 49-82.
Crossref
Rafael M. Ioris, Katherine Ferris & Vincenzo D'Angiolella. 2023. Inducing Targeted Protein Degradation. Inducing Targeted Protein Degradation 63 106 .
Fathia Zaky El Sharkawi, Mamdouh El-Sherbiny, Sahar Abdel Mohsen Ali & Walaa M.H. Nassif. (2023) The potential value of plasma Circ-ITCH in hepatocellular carcinoma patients with current hepatitis C virus infection. Gastroenterología y Hepatología 46:1, pages 17-27.
Crossref
Fathia Zaky El Sharkawi, Mamdouh El-Sherbiny, Sahar Abdel Mohsen Ali & Walaa M.H. Nassif. (2023) The potential value of plasma Circ-ITCH in hepatocellular carcinoma patients with current hepatitis C virus infection. Gastroenterología y Hepatología (English Edition) 46:1, pages 17-27.
Crossref
Vaishna Vamadevan, Neelam Chaudhary & Subbareddy Maddika. (2022) Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling. Journal of Cell Science 135:24.
Crossref
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin & Haifeng Zhang. (2022) CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling. Journal of Translational Medicine 20:1.
Crossref
Geetha Priya Boligala, Mingxiao V. Yang, Jenna C. van Wunnik & Kevin Pruitt. (2022) Nuclear Dishevelled: An enigmatic role in governing cell fate and Wnt signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:10, pages 119305.
Crossref
Qian Sun, Bi‐Bo Wang, Wei Wei, Gui‐Chun Huang, Lei‐Lei Liu, Wei‐Wei Chen, Jing Wang, Xiao‐Yue Zhao, Lu Lu, Rong Fang, Chun‐Yan Zhu & Xiao‐Yuan Chu. (2022) ITCH facilitates proteasomal degradation of TXNIP in hypoxia‐ induced lung cancer cells . Thoracic Cancer 13:15, pages 2235-2247.
Crossref
Tong Liu, Tao Huang, Mei Shang & Gang Han. (2022) CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases. Frontiers in Genetics 13.
Crossref
Kaixin Su, Qiao Yi, Xiaohan Dai & Ousheng Liu. (2022) Circular RNA ITCH: An Emerging Multifunctional Regulator. Biomolecules 12:3, pages 359.
Crossref
Anita V. Kumar, Joslyn Mills & Louis R. Lapierre. (2022) Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging. Frontiers in Cell and Developmental Biology 10.
Crossref
Qiaoni Shi & Ye-Guang Chen. (2021) Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy. Trends in Biochemical Sciences 46:12, pages 1003-1016.
Crossref
Ileana Cristea, Ove Bruland, Ingvild Aukrust, Eyvind Rødahl & Cecilie Bredrup. (2021) Pellino‐2 in nonimmune cells: novel interaction partners and intracellular localization. FEBS Letters 595:23, pages 2909-2921.
Crossref
Monica Sharma, Isabel Castro-Piedras, Fahmida Rasha, Sabarish Ramachandran, Souad R. Sennoune, Kathryn Furr, Sharilyn Almodovar, Vadivel Ganapathy, Matthew B. Grisham, Rakhshanda Layeequr Rahman & Kevin Pruitt. (2021) Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling. Oncotarget 12:22, pages 2234-2251.
Crossref
Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao & Zhaocai Zhou. (2021) An MST4‐p β ‐Catenin Thr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis . Advanced Science 8:17, pages 2004850.
Crossref
Dingsheng ZhaoGuohui ZhongJianwei LiJunjie PanYinlong ZhaoHailin SongWeijia SunXiaoyan JinYuheng LiRuikai DuJielin NieTong LiuJunmeng ZhengYixin JiaZifan LiuWei LiuXinxin YuanZizhong LiuJinping SongGuanghan KanYouyou LiCaizhi LiuXingcheng GaoWenjuan XingYan-Zhong Chang, Yingxian LiShukuan Ling. (2021) Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination. Circulation 144:9, pages 694-711.
Crossref
Sun-Ok Kim, Kyoung Sang Cho, Bo Yeon Kim & Kyung Ho Lee. (2021) Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. International Journal of Molecular Sciences 22:14, pages 7572.
Crossref
Lorena Verduci, Emilio Tarcitano, Sabrina Strano, Yosef Yarden & Giovanni Blandino. (2021) CircRNAs: role in human diseases and potential use as biomarkers. Cell Death & Disease 12:5.
Crossref
Cong Wang, Hongyan Li, Lei Wu, Xueli Jiao, Zihui Jin, Yujie Zhu, Ziling Fang, Xiaodong Zhang, Haishan Huang & Lingling Zhao. (2021) Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation. Frontiers in Oncology 11.
Crossref
Adnan Shami Shah, Xiaofu Cao, Andrew C. White & Jeremy M. Baskin. (2021) PLEKHA4 Promotes Wnt/β-Catenin Signaling–Mediated G1–S Transition and Proliferation in Melanoma. Cancer Research 81:8, pages 2029-2043.
Crossref
Toni Li, Wei Cen Wang, Vivian McAlister, Qinfeng Zhou & Xiufen Zheng. (2021) Circular RNA in colorectal cancer. Journal of Cellular and Molecular Medicine 25:8, pages 3667-3679.
Crossref
Ke Li, Ting-ting Zhang, Chen-xi Zhao, Feng WangBing CuiZhao-na YangXiao-xi LvZaiwuli Yeerjiang, Yu-fen YuanJin-mei Yu, Zhen-he WangXiao-wei Zhang, Jiao-jiao YuShan-shan Liu, Shuang Shang, Bo Huang, Fang Hua & Zhuo-wei Hu. (2021) Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability. Science Translational Medicine 13:586.
Crossref
Manni Sun, Jinlan Gao, Tao Meng, Shenghuan Liu, Haiying Chen, Qi Liu, Xuesha Xing, Chenyang Zhao & Yang Luo. (2020) Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia. The FASEB Journal 35:2.
Crossref
Miroslav Micka & Vítězslav Bryja. 2021. Pharmacology of the WNT Signaling System. Pharmacology of the WNT Signaling System 117 135 .
Jun GotoYoichiro Otaki, Tetsu WatanabeYuta KobayashiTomonori AonoKen WatanabeMasahiro WanezakiDaisuke KutsuzawaShigehiko KatoHarutoshi TamuraSatoshi NishiyamaTakanori ArimotoHiroki TakahashiTetsuro ShishidoMasafumi Watanabe. (2020) HECT (Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/β-Catenin Signaling Pathway. Hypertension 76:6, pages 1868-1878.
Crossref
Qing Yin, Clayton J. Wyatt, Tao Han, Keiran S.M. Smalley & Lixin Wan. (2020) ITCH as a potential therapeutic target in human cancers. Seminars in Cancer Biology 67, pages 117-130.
Crossref
Yaohua Zhang, Yajuan Li, Qingsong Hu, Yutao Xi, Zhen Xing, Zhao Zhang, Lisa Huang, Jianbo Wu, Ke Liang, Tina K. Nguyen, Sergey D. Egranov, Chengcao Sun, Zilong Zhao, David H. Hawke, Jin Li, Deqiang Sun, Jean J. Kim, Ping Zhang, Jie Cheng, Abid Farida, Mien-Chie Hung, Leng Han, Radbod Darabi, Chunru Lin & Liuqing Yang. (2020) The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nature Cell Biology 22:11, pages 1332-1345.
Crossref
Léa Lescouzères & Pascale Bomont. (2020) E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy. Frontiers in Physiology 11.
Crossref
Yang Peng & Hong Hong Wang. (2020) Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/β-catenin pathway. Scientific Reports 10:1.
Crossref
Melissa V Gammons, Miha Renko, Joshua E Flack, Juliusz Mieszczanek & Mariann Bienz. (2020) Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin. eLife 9.
Crossref
Jiansen Du, Lin Fu, Yingli Sui & Lingqiang Zhang. (2019) The function and regulation of OTU deubiquitinases. Frontiers of Medicine 14:5, pages 542-563.
Crossref
Zhuoyao Chen, Gregory A. Wasney, Sarah Picaud, Panagis Filippakopoulos, Masoud Vedadi, Vincenzo D'Angiolella & Alex N. Bullock. (2020) Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. Open Biology 10:6.
Crossref
Hong-Beom Park, Ju-Won Kim & Kwang-Hyun Baek. (2020) Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers. International Journal of Molecular Sciences 21:11, pages 3904.
Crossref
Ondrej Bernatik, Petra Paclikova, Ranjani Sri Ganji & Vitezslav Bryja. (2020) Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled. Cells 9:5, pages 1147.
Crossref
Maryam Kohansal, Hailin Tang, Xiaoming Xie, Ali Taghinezhad & Ali Ghanbariasad. (2020) Circular RNAs as miRNA sponges in triple-negative breast cancer: a systematic review. Minerva Biotecnologica 32:2.
Crossref
Yaya Wang, Diana Argiles-Castillo, Emma I. Kane, Anning Zhou & Donald E. Spratt. (2020) HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance. Journal of Cell Science 133:7.
Crossref
Annegien T. Kenter, Eveline Rentmeester, Job Riet, Ruben Boers, Joachim Boers, Mehrnaz Ghazvini, Vanessa J. Xavier, Geert J.L.H. Leenders, Paul C.M.S. Verhagen, Marjan E. Til, Bert Eussen, Monique Losekoot, Annelies Klein, Dorien J.M. Peters, Wilfred F.J. IJcken, Harmen J.G. Werken, Robert Zietse, Ewout J. Hoorn, Gert Jansen & Joost H. Gribnau. (2020) Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients. Stem Cells Translational Medicine 9:4, pages 478-490.
Crossref
Lu Deng, Tong Meng, Lei Chen, Wenyi Wei & Ping Wang. (2020) The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduction and Targeted Therapy 5:1.
Crossref
Bing-Qing Shang, Min-Le Li, Hao-yu Quan, Ping-Fu Hou, Zhong-Wei Li, Su-Fang Chu, Jun-Nian Zheng & Jin Bai. (2019) Functional roles of circular RNAs during epithelial-to-mesenchymal transition. Molecular Cancer 18:1.
Crossref
Nikol Baloghova, Tomas Lidak & Lukas Cermak. (2019) Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis. Genes 10:10, pages 815.
Crossref
Shengqiang Wang, Yi Wu, Yan Xu & Xianjun Tang. (2019) miR-10b promoted melanoma progression through Wnt/β-catenin pathway by repressing ITCH expression. Gene 710, pages 39-47.
Crossref
Casey P. Nielsen, Kristin K. Jernigan, Nicole L. Diggins, Donna J. Webb & Jason A. MacGurn. (2019) USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification. Cell Reports 28:4, pages 1074-1089.e5.
Crossref
Luoyan Ai, Yimeng Ren, Yiting Li, Haoyan Chen, Yun Qian, Shiyuan Lu, Antao Xu, Linlin Ren, Shuliang Zhao, Zhaofei Chen, Ying‐Xuan Chen, Jie Xu & Jing‐Yuan Fang. (2019) Synbindin deficiency inhibits colon carcinogenesis by attenuating Wnt cascade and balancing gut microbiome. International Journal of Cancer 145:1, pages 206-220.
Crossref
Shifan Ma, Insiya Y. Attarwala & Xiang-Qun Xie. (2019) SQSTM1/p62: A Potential Target for Neurodegenerative Disease. ACS Chemical Neuroscience 10:5, pages 2094-2114.
Crossref
Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka & Jeremy M. Baskin. (2019) PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Cell Reports 27:7, pages 2157-2170.e8.
Crossref
Yun-Feng Li, Jian Zhang & Lei Yu. (2019) Circular RNAs Regulate Cancer Onset and Progression via Wnt/β-Catenin Signaling Pathway. Yonsei Medical Journal 60:12, pages 1117.
Crossref
Yuan Yuan, Xiaogang Chen & Enying Huang. (2019) Upregulation of Circular RNA Itchy E3 Ubiquitin Protein Ligase Inhibits Cell Proliferation and Promotes Cell Apoptosis Through Targeting MiR-197 in Prostate Cancer. Technology in Cancer Research & Treatment 18, pages 153303381988686.
Crossref
Xianwen Meng, Dahui Hu, Peijing Zhang, Qi Chen & Ming Chen. (2019) CircFunBase: a database for functional circular RNAs. Database 2019.
Crossref
Juan Wang, Yuki Shibayama, Anqi Zhang, Hiroyuki Ohsaki, Eisuke Asano, Yasuyuki Suzuki, Yoshio Kushida, Hideki Kobara, Tsutomu Masaki, Zhiyu Wang & Akira Nishiyama. (2018) (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations. British Journal of Cancer 120:2, pages 229-237.
Crossref
Ling Luo, Yuqiang Gao & Xiaofeng Sun. (2018) Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged overall survival, and it inhibits cells proliferation while promotes cells apoptosis in epithelial ovarian cancer. Cancer Biomarkers 23:4, pages 505-513.
Crossref
Yaxian Zhong, Yajun Du, Xue Yang, Yongzhen Mo, Chunmei Fan, Fang Xiong, Daixi Ren, Xin Ye, Chunwei Li, Yumin Wang, Fang Wei, Can Guo, Xu Wu, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng & Wei Xiong. (2018) Circular RNAs function as ceRNAs to regulate and control human cancer progression. Molecular Cancer 17:1.
Crossref
Xiao-yue Xu, Lei-lei Zhou, Chen Yu, Bo Shen, Ji-feng Feng & Shao-rong Yu. (2018) Advances of circular RNAs in carcinoma. Biomedicine & Pharmacotherapy 107, pages 59-71.
Crossref
Xiaoxiang Cheng, Jun Zheng, Gang Li, Verena GöbelHongjie Zhang. (2018) Degradation for better survival? Role of ubiquitination in epithelial morphogenesis. Biological Reviews 93:3, pages 1438-1460.
Crossref
Daisuke Aki, Hui Li, Wen Zhang, Mingke Zheng, Chris Elly, Jee H. Lee, Weiguo Zou & Yun-Cai Liu. (2018) The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR. Nature Immunology 19:7, pages 766-775.
Crossref
Monica Sharma, Isabel Castro-Piedras, Glenn E. SimmonsJrJr & Kevin Pruitt. (2018) Dishevelled: A masterful conductor of complex Wnt signals. Cellular Signalling 47, pages 52-64.
Crossref
Eun-Bee Cho, Wonjin Yoo, Sungjoo Kim Yoon & Jong-Bok Yoon. (2018) β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:6, pages 2199-2213.
Crossref
Jianlei Xie, Meng Han, Miaojun Zhang, Haiteng Deng & Wei Wu. (2018) PP5 (PPP5C) is a phosphatase of Dvl2. Scientific Reports 8:1.
Crossref
Sung Noh Hong. (2018) Genetic and epigenetic alterations of colorectal cancer. Intestinal Research 16:3, pages 327.
Crossref
Jessica M. Perez, Yinghua Chen, Tsan S. Xiao & Derek W. Abbott. (2018) Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. Journal of Biological Chemistry 293:3, pages 1100-1105.
Crossref
Zhaohui Chen, Lijie Zhou, Longwang Wang, Gallina Kazobinka, Xiaoping Zhang, Xiaomin Han, Bin Li & Teng Hou. (2018) HBO1 promotes cell proliferation in bladder cancer via activation of Wnt/β-catenin signaling. Molecular Carcinogenesis 57:1, pages 12-21.
Crossref
Shujuan Meng, Hecheng Zhou, Ziyang Feng, Zihao Xu, Ying Tang, Peiyao Li & Minghua Wu. (2017) CircRNA: functions and properties of a novel potential biomarker for cancer. Molecular Cancer 16:1.
Crossref
Nishi Kumari, Patrick William Jaynes, Azad Saei, Prasanna Vasudevan Iyengar, John Lalith Charles Richard & Pieter Johan Adam Eichhorn. (2017) The roles of ubiquitin modifying enzymes in neoplastic disease. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:2, pages 456-483.
Crossref
Xiaoxia Ren, Yongxing Du, Lei You & Yupei Zhao. (2017) Potential functions and implications of circular RNA in gastrointestinal cancer (Review). Oncology Letters.
Crossref
Chao Han, Nicole A. Seebacher, Francis J. Hornicek, Quancheng Kan & Zhenfeng Duan. (2017) Regulation of microRNAs function by circular RNAs in human cancer. Oncotarget 8:38, pages 64622-64637.
Crossref
Li Liu, Xiao-Ming Zhou, Fang-Fei Yang, Yuan Miao, Yan Yin, Xue-Jun Hu, Gang Hou, Qiu-Yue Wang & Jian Kang. (2017) TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT/GSK3β/β-catenin signaling in non-small cell lung cancer. Oncotarget 8:37, pages 62069-62080.
Crossref
Susitha Premarathne, Mariyam Murtaza, Nicholas Matigian, Lachlan A. Jolly & Stephen A. Wood. (2017) Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Scientific Reports 7:1.
Crossref
Sapna Vijayakumar, Guizhong Liu, Huei-Chi Wen, Yaa Abu, Robert Chong, Horacio Nastri, Gadi G. Bornstein, Zhen-Qiang Pan & Stuart A. Aaronson. (2017) Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase. Genes & Cancer 8:7-8, pages 613-627.
Crossref
Yu-Man Tsui, Karen Man-Fong Sze, Edmund Kwok-Kwan Tung, Daniel Wai-Hung Ho, Terence Kin-Wah Lee & Irene Oi-Lin Ng. (2017) Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. Oncotarget 8:24, pages 39430-39442.
Crossref
Shen Kiat Lim, Ssu Yi Lu, Shin-Ae Kang, Hock Jin Tan, Zilin Li, Zhen Ning Adrian Wee, Jye Swei Guan, Vishnu Priyanka Reddy Chichili, J. Sivaraman, Thomas Putti, Aye Aye Thike, Puay Hoon Tan, Marius Sudol, David M. Virshup, Siew Wee Chan, Wanjin Hong & Yoon Pin Lim. (2016) Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Cancer Research 76:21, pages 6278-6289.
Crossref
Minzhang Cheng, Hua Xue, Weipeng Cao, Wenxia Li, Hua Chen, Bofeng Liu, Benyu Ma, Xiaohua Yan & Ye-Guang Chen. (2016) Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling. Journal of Biological Chemistry 291:24, pages 12871-12879.
Crossref
Babita MadanMatthew P. WalkerRobert YoungLaura QuickKelly A. OrgelMeagan RyanPriti GuptaIan C. HenrichMarc FerrerShane MarineBrian S. RobertsWilliam T. ArthurJason D. BerndtAndre M. Oliveira, Randall T. MoonDavid M. Virshup, Margaret M. ChouMichael B. Major. (2016) USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proceedings of the National Academy of Sciences 113:21.
Crossref
Maria Antonella Burza, Benedetta Maria Motta, Rosellina Margherita Mancina, Piero Pingitore, Carlo Pirazzi, Saverio Massimo Lepore, Rocco Spagnuolo, Patrizia Doldo, Cristina Russo, Veronica Lazzaro, Janett Fischer, Thomas Berg, Alessio Aghemo, Cristina Cheroni, Raffaele De Francesco, Silvia Fargion, Massimo Colombo, Christian Datz, Felix Stickel, Luca Valenti & Stefano Romeo. (2015) DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection. Hepatology 63:2, pages 418-427.
Crossref
Li Wan, Lin Zhang, Kai Fan, Zai-Xing Cheng, Quan-Chao Sun & Jian-Jun Wang. (2016) Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/ β -Catenin Pathway . BioMed Research International 2016, pages 1-11.
Crossref
Thomas Mund, Michael Graeb, Juliusz Mieszczanek, Melissa Gammons, Hugh R. B. Pelham & Mariann Bienz. (2015) Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled. Open Biology 5:12, pages 150185.
Crossref
Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra & Amit Mishra. (2015) Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing. Ageing Research Reviews 24, pages 138-159.
Crossref
Daisuke Aki, Wen Zhang & Yun-Cai Liu. (2015) The E3 ligase Itch in immune regulation and beyond. Immunological Reviews 266:1, pages 6-26.
Crossref
Jessica M. Perez, Steven M. Chirieleison & Derek W. Abbott. (2015) An IκB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Cell Reports 12:4, pages 537-544.
Crossref
Guanli Huang, Hua Zhu, Yixiong Shi, Wenzhi Wu, Huajie Cai & Xiangjian Chen. (2015) cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway. PLOS ONE 10:6, pages e0131225.
Crossref
Mateusz Cyryl Ambrozkiewicz & Hiroshi Kawabe. (2015) HECT-type E3 ubiquitin ligases in nerve cell development and synapse physiology. FEBS Letters 589:14, pages 1635-1643.
Crossref
S Wang, Y Dong, Y Zhang, X Wang, L Xu, S Yang, X Li, H Dong, L Xu, L Su, S S M Ng, Z Chang, J J Sung, X Zhang & J Yu. (2014) DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer. Oncogene 34:20, pages 2575-2585.
Crossref
Kieran J. Bunn, Phil Daniel, Heleen S. Rösken, Adam C. O’Neill, Sophia R. Cameron-Christie, Tim Morgan, Han G. Brunner, Angeline Lai, Henricus P.M. Kunst, David M. Markie & Stephen P. Robertson. (2015) Mutations in DVL1 Cause an Osteosclerotic Form of Robinow Syndrome. The American Journal of Human Genetics 96:4, pages 623-630.
Crossref
Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao & Lei Zhang. (2015) Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications 6:1.
Crossref
Fang Li, Liyuan Zhang, Wei Li, Jieqiong Deng, Jian Zheng, Mingxing An, Jiachun Lu & Yifeng Zhou. (2015) Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. Oncotarget 6:8, pages 6001-6013.
Crossref
Yongsheng Huang, Peng Wang, Hua Chen, Yi Ding & Ye-Guang Chen. (2015) Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation. Biochemical Journal 466:3, pages 499-509.
Crossref
Su-hyun Park, Eun-Ho Jung, Geun-Young Kim, Byung-Chul Kim, Jae Hyang Lim & Chang-Hoon Woo. (2015) Itch E3 Ubiquitin Ligase Positively Regulates TGF-β Signaling to EMT via Smad7 Ubiquitination. Molecules and Cells 38:1, pages 20-25.
Crossref
Chenxi Gao, Gutian Xiao & Jing Hu. (2014) Regulation of Wnt/β-catenin signaling by posttranslational modifications. Cell & Bioscience 4:1.
Crossref
Thomas Mund, Michael J. Lewis, Sarah Maslen & Hugh R. Pelham. (2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proceedings of the National Academy of Sciences 111:47, pages 16736-16741.
Crossref
Annie Angers & Pierre Drapeau. (2014) Itch Is Required for Lateral Line Development in Zebrafish. PLoS ONE 9:11, pages e111799.
Crossref
Mariann Bienz. (2014) Signalosome assembly by domains undergoing dynamic head-to-tail polymerization. Trends in Biochemical Sciences 39:10, pages 487-495.
Crossref
Nobuyuki Shimizu, Shizuka Ishitani, Atsushi Sato, Hiroshi Shibuya & Tohru Ishitani. (2014) Hipk2 and PP1c Cooperate to Maintain Dvl Protein Levels Required for Wnt Signal Transduction. Cell Reports 8:5, pages 1391-1404.
Crossref
Vítězslav Bryja & Ondřej Bernatík. 2014. Wnt Signaling in Development and Disease. Wnt Signaling in Development and Disease 207 216 .
Cong Fei, Xiaoli He, Sichun Xie, Haofei Miao, Zhilei Zhou & Lin Li. (2014) Smurf1-mediated Axin Ubiquitination Requires Smurf1 C2 Domain and Is Cell Cycle-dependent. Journal of Biological Chemistry 289:20, pages 14170-14177.
Crossref
Ying Zhou, Hanqiao Shang, Chunli Zhang, Yan Liu, Yantao Zhao, Feng Shuang, Hongbin Zhong, Jiaguang Tang & Shuxun Hou. (2014) The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation. Biochemical and Biophysical Research Communications 447:3, pages 431-436.
Crossref
Yongtao Geng, Yanfang Ju, Fangli Ren, Ying Qiu, Yasuhiko Tomita, Miki Tomoeda, Mioka Kishida, Yinyin Wang, Lian Jin, Fuqin Su, Chunhong Wei, Baoqing Jia, Yi Li & Zhijie Chang. (2014) Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2. Journal of Biological Chemistry 289:16, pages 11230-11241.
Crossref
Reinoud E. A. de GrootRanjani S. GanjiOndrej BernatikBethan Lloyd-LewisKatja SeipelKateřina ŠedováZbyněk ZdráhalVishnu M. DhopleTrevor C. DaleHendrik C. KorswagenVitezslav Bryja. (2014) Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway. Science Signaling 7:317.
Crossref
Xiaomin Song, Sheng Wang & Lin Li. (2014) New insights into the regulation of Axin function in canonical Wnt signaling pathway. Protein & Cell 5:3, pages 186-193.
Crossref
Hengwei Zhang & Lianping Xing. (2013) Ubiquitin E3 Ligase Itch Negatively Regulates Osteoblast Differentiation from Mesenchymal Progenitor Cells. Stem Cells 31:8, pages 1574-1583.
Crossref
Claus Schertel, Dashun Huang, Mikael Björklund, Johannes Bischof, Dingzi Yin, Rongxia Li, Yi Wu, Rong Zeng, Jiarui Wu, Jussi Taipale, Haiyun Song & Konrad Basler. (2013) Systematic Screening of a Drosophila ORF Library In Vivo Uncovers Wnt/Wg Pathway Components. Developmental Cell 25:2, pages 207-219.
Crossref
Kevin A. Maupin, Casey J. Droscha & Bart O. Williams. (2013) A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Research 1:1, pages 27-71.
Crossref
Yi Ding, Yan Zhang, Chao Xu, Qing-Hua Tao & Ye-Guang Chen. (2013) HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation. Journal of Biological Chemistry 288:12, pages 8289-8298.
Crossref
Wantae Kim, Minseong Kim & Eek-hoon Jho. (2013) Wnt/β-catenin signalling: from plasma membrane to nucleus. Biochemical Journal 450:1, pages 9-21.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.