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Article

Chromatin Profiling Reveals Regulatory Network Shifts and a Protective Role for Hepatocyte Nuclear Factor 4α during Colitis

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Pages 3291-3304 | Received 13 Mar 2014, Accepted 19 Jun 2014, Published online: 20 Mar 2023

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M.P.G. Barnett & L.R. Ferguson. 2017. Molecular Diagnostics. Molecular Diagnostics 305 326 .
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Berta N Vazquez, Joshua K Thackray, Nicolas G Simonet, Noriko Kane‐Goldsmith, Paloma Martinez‐Redondo, Trang Nguyen, Samuel Bunting, Alejandro Vaquero, Jay A Tischfield & Lourdes Serrano. (2016) SIRT 7 promotes genome integrity and modulates non‐homologous end joining DNA repair . The EMBO Journal 35:14, pages 1488-1503.
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