Advanced search
Publication Cover
Molecular and Cellular Biology Volume 27, 2007 - Issue 21
Submit an article Journal homepage
38
Views
42
CrossRef citations to date
0
Altmetric
Article

FADD Negatively Regulates Lipopolysaccharide Signaling by Impairing Interleukin-1 Receptor-Associated Kinase 1-MyD88 Interaction

Rachel Zhande1 Department of Medical Biophysics, British Columbia Cancer Agency;2 Department of Pathology and Laboratory Medicine, University of British Columbia
,
Shauna M. Dauphinee1 Department of Medical Biophysics, British Columbia Cancer Agency;4 Experimental Medicine Program, University of British Columbia, Vancouver, BC, Canada
,
James A. Thomas5 Departments of Pediatrics, Molecular Biology, and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas
,
Masahiro Yamamoto6 Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, Osaka, Japan
,
Shizuo Akira6 Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, Osaka, Japan
&
Aly Karsan1 Department of Medical Biophysics, British Columbia Cancer Agency;2 Department of Pathology and Laboratory Medicine, University of British Columbia;3 Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency;4 Experimental Medicine Program, University of British Columbia, Vancouver, BC, CanadaCorrespondence[email protected]
Pages 7394-7404 | Received 05 Apr 2007, Accepted 25 Aug 2007, Published online: 27 Mar 2023

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Theodore J. Standiford & Venkateshwar G. Keshamouni. (2012) Breaking the tolerance for tumor. OncoImmunology 1:3, pages 340-345.
Read now
Ryan J. Arsenault, Shakiba Jalal, Lorne A. Babiuk, Andrew Potter, Philip J. Griebel & Scott Napper. (2009) Kinome analysis of Toll-like receptor signaling in bovine monocytes. Journal of Receptors and Signal Transduction 29:6, pages 299-311.
Read now

Articles from other publishers (40)

Xuerui Zhang, Banghui Zhu, Lin Li, Jiahong Xu, Yuheng Han, Jing Zhang & Zichun Hua. (2022) The dephosphorylation of FADD at S191 induces an excessive expansion of TCRαβ + IELs in the intestinal mucosa . Immunology 167:2, pages 233-246.
Crossref
Yankai Wang, Jing Diao, Bei Wang, Xi Xu, Minjie Gui, Chenghua Li & Ming Guo. (2022) A second FADD mediates coelomocyte apoptosis response to Vibrio splendidus infection in sea cucumber Apostichopus japonicus. Fish & Shellfish Immunology 127, pages 396-404.
Crossref
Arash Heidari, Niloufar Yazdanpanah & Nima Rezaei. (2022) The role of Toll-like receptors and neuroinflammation in Parkinson’s disease. Journal of Neuroinflammation 19:1.
Crossref
Zhijie Lu, Meizhen Tang, Yanan Li, Fei Shi, Fanbin Zhan, Menglan Zhang, Lijuan Zhao, Jun Li, Li Lin & Zhendong Qin. (2021) Molecular cloning and characterization of FADD from the grass carp (Ctenopharyngodon idellus) in response to bacterial infection. Aquaculture 542, pages 736829.
Crossref
Haipeng Li, Ting Chen, Hongyan Sun, Xiaofen Wu, Xiao Jiang & Chunhua Ren. (2019) Functional characterisation of Holothuria leucospilota Fas-associated death domain in the innate immune-related signalling pathways . Innate Immunity 26:2, pages 138-145.
Crossref
Patrick Coulombe, Grigorios N. Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H. Kyle, Andrew I. Minchinton, R. Keith Humphries, Pamela A. Hoodless, Jeremy D.K. Parker, Joanne L. Wright & Aly Karsan. (2019) Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Reports 27:6, pages 1769-1780.e4.
Crossref
Kiva Brennan, Caitriona Lyons, Philana Fernandes, Sarah Doyle, Aileen Houston & Elizabeth Brint. (2018) Engagement of Fas differentially regulates the production of LPS ‐induced proinflammatory cytokines and type I interferons . The FEBS Journal 286:3, pages 523-535.
Crossref
Xin Zhang, Shaoqing Zang, Chen Li, Jingguang Wei & Qiwei Qin. (2018) Molecular cloning and characterization of FADD from the orange-spotted grouper (Epinephelus coioides). Fish & Shellfish Immunology 74, pages 517-529.
Crossref
Eboni Chambers, Sharon Rounds & Qing Lu. 2018. Molecular and Functional Insights Into the Pulmonary Vasculature. Molecular and Functional Insights Into the Pulmonary Vasculature 63 86 .
Chiung‐Ya Chen, Hsin‐Yu Liu & Yi‐Ping Hsueh. (2016) TLR 3 downregulates expression of schizophrenia gene Disc1 via MYD 88 to control neuronal morphology . EMBO reports 18:1, pages 169-183.
Crossref
Hua Zhou, Erin Harberts, Rita Fishelevich & Anthony A. Gaspari. (2016) TLR4 acts as a death receptor for ultraviolet radiation (UVR) through IRAK-independent and FADD-dependent pathway in macrophages. Experimental Dermatology 25:12, pages 949-955.
Crossref
Hongqin Zhuang, Xueshi Wang, Daolong Zha, Ziyi Gan, Fangfang Cai, Pan Du, Yunwen Yang, Bingya Yang, Xiangyu Zhang, Chun Yao, Yuqiang Zhou, Chizhou Jiang, Shengwen Guan, Xuerui Zhang, Jing Zhang, Wenhui Jiang, Qingang Hu & Zi‐Chun Hua. (2016) FADD is a key regulator of lipid metabolism . EMBO Molecular Medicine 8:8, pages 895-918.
Crossref
Amir I. Tukhvatulin, Alina S. Dzharullaeva, Natalia M. Tukhvatulina, Dmitry V. Shcheblyakov, Maxim M. Shmarov, Inna V. Dolzhikova, Patricia Stanhope-Baker, Boris S. Naroditsky, Andrei V. Gudkov, Denis Y. Logunov & Alexander L. Gintsburg. (2016) Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses. PLOS ONE 11:5, pages e0155650.
Crossref
Caitriona Lyons, Philana Fernandes, Liam J. Fanning, Aileen Houston & Elizabeth Brint. (2015) Engagement of Fas on Macrophages Modulates Poly I:C Induced Cytokine Production with Specific Enhancement of IP-10. PLOS ONE 10:4, pages e0123635.
Crossref
Guanghong Liu, Peijie Du & Zhanxin Zhang. (2014) Myeloid Differentiation Factor 88 Promotes Cisplatin Chemoresistance in Ovarian Cancer. Cell Biochemistry and Biophysics 71:2, pages 963-969.
Crossref
Philana Fernandes, Charlotte O’Donnell, Caitriona Lyons, Jonathan Keane, Tim Regan, Stephen O’Brien, Padraic Fallon, Elizabeth Brint & Aileen Houston. (2014) Intestinal Expression of Fas and Fas Ligand Is Upregulated by Bacterial Signaling through TLR4 and TLR5, with Activation of Fas Modulating Intestinal TLR-Mediated Inflammation. The Journal of Immunology 193:12, pages 6103-6113.
Crossref
Chih-Ching Yang, Chien-An Yao, Jyh-Chin Yang & Chiang-Ting Chien. (2014) Sialic Acid Rescues Repurified Lipopolysaccharide-Induced Acute Renal Failure via Inhibiting TLR4/PKC/gp91-Mediated Endoplasmic Reticulum Stress, Apoptosis, Autophagy, and Pyroptosis Signaling. Toxicological Sciences 141:1, pages 155-165.
Crossref
Yu‐Ling Chang, Tzu‐Hui Chen, Yi‐Hsiu Wu, Guann‐An Chen, Tzu‐Huei Weng, Ping‐Hui Tseng, Shie‐Liang Hsieh, Shu‐Ling Fu, Chi‐Hung Lin, Chun‐Jen Chen, Ching‐Liang Chu, Iok In Christine Chio, Tak Wah Mak & Nien‐Jung Chen. (2014) A novel TLR 2‐triggered signalling crosstalk synergistically intensifies TNF ‐mediated IL ‐6 induction . Journal of Cellular and Molecular Medicine 18:7, pages 1344-1357.
Crossref
Mufadhal Al-Kuhlani, James Rothchild, Sukumar Pal, Luis M. de la Maza, Sander Ouburg, Servaas A. Morré, Deborah Dean & David M. Ojcius. (2014) TRAIL-R1 Is a Negative Regulator of Pro-Inflammatory Responses and Modulates Long-Term Sequelae Resulting from Chlamydia trachomatis Infections in Humans. PLoS ONE 9:4, pages e93939.
Crossref
BAO-GUO XIE, SONG JIN & WEI-JIE ZHU. (2014) Expression of toll-like receptor 4 in maternal monocytes of patients with gestational diabetes mellitus. Experimental and Therapeutic Medicine 7:1, pages 236-240.
Crossref
Elizabeth Brint, Grace O’Callaghan & Aileen Houston. (2013) Life in the Fas lane: differential outcomes of Fas signaling. Cellular and Molecular Life Sciences 70:21, pages 4085-4099.
Crossref
Chun Yao, Hongqin Zhuang, Pan Du, Wei Cheng, Bingya Yang, Shengwen Guan, Yun Hu, Dalong Zhu, Miller Christine, Lv Shi & Zi-Chun Hua. (2013) Role of Fas-Associated Death Domain-containing Protein (FADD) Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation. Molecular & Cellular Proteomics 12:10, pages 2689-2700.
Crossref
Shauna M. Dauphinee, Ashley Clayton, Angela Hussainkhel, Cindy Yang, Yoo-Jin Park, Megan E. Fuller, Josip Blonder, Timothy D. Veenstra & Aly Karsan. (2013) SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling. The Journal of Immunology 191:2, pages 892-901.
Crossref
Lincoln S. Smith, Jerry J. Zimmerman & Thomas R. Martin. (2013) Mechanisms of Acute Respiratory Distress Syndrome in Children and Adults. Pediatric Critical Care Medicine 14:6, pages 631-643.
Crossref
Durairaj M. Kumar, Vikas Patil, Bini Ramachandran, Murugesan V. Nila, Kuppamuthu Dharmalingam & Kumaravel Somasundaram. (2013) Temozolomide-modulated glioma proteome: Role of interleukin-1 receptor-associated kinase-4 (IRAK4) in chemosensitivity. PROTEOMICS 13:14, pages 2113-2124.
Crossref
Kazuhiro Sakamaki, Chiyo Takagi, Atsushi Kitayama, Tomoko Kurata, Takamasa S. Yamamoto, Kumiko Chiba, Katsuya Kominami, Sang-Kee Jung, Katsuya Okawa, Masami Nozaki, Hiroshi Y. Kubota & Naoto Ueno. (2012) Multiple functions of FADD in apoptosis, NF-κB-related signaling, and heart development in Xenopus embryos . Genes to Cells 17:11, pages 875-896.
Crossref
V. Vilmont, L. Tourneur & G. Chiocchia. (2012) Fas-associated death domain protein and adenosine partnership: fad in RA. Rheumatology 51:6, pages 964-975.
Crossref
M-S Jang, S-J Lee, C-J Kim, C-W Lee & E Kim. (2010) Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD. Oncogene 30:4, pages 471-481.
Crossref
Meiyu Ren, Li Gao & Xinyi Wu. (2010) TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines . Immunology & Cell Biology 88:5, pages 529-536.
Crossref
Léa Tourneur & Gilles Chiocchia. (2010) FADD: a regulator of life and death. Trends in Immunology 31:7, pages 260-269.
Crossref
Ruyun Du, Jing Long, Jun Yao, Yun Dong, Xiaoli Yang, Siwei Tang, Shuai Zuo, Yufei He & Xian Chen. (2010) Subcellular Quantitative Proteomics Reveals Multiple Pathway Cross-Talk That Coordinates Specific Signaling and Transcriptional Regulation for the Early Host Response to LPS. Journal of Proteome Research 9:4, pages 1805-1821.
Crossref
Elizabeth A. Cates, Erin E. Connor, David M. Mosser & Douglas D. Bannerman. (2009) Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-κB activation and apoptosis. Comparative Immunology, Microbiology and Infectious Diseases 32:6, pages 477-490.
Crossref
Adeeb H. Rahman, Devon K. Taylor & Laurence A. Turka. (2009) The contribution of direct TLR signaling to T cell responses. Immunologic Research 45:1, pages 25-36.
Crossref
Jie H. Li, Alessio D'Alessio & Jordan S. Pober. (2009) Lipopolysaccharide Can Trigger a Cathepsin B-Dependent Programmed Death Response in Human Endothelial Cells. The American Journal of Pathology 175:3, pages 1124-1135.
Crossref
Precious G. Motshwene, Martin C. Moncrieffe, J. Günter Grossmann, Cheng Kao, Murali Ayaluru, Alan M. Sandercock, Carol V. Robinson, Eicke Latz & Nicholas J. Gay. (2009) An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4. Journal of Biological Chemistry 284:37, pages 25404-25411.
Crossref
Brianna Lyttle, Jinghua Chai, Juan M. Gonzalez, Hua Xu, Mary Sammel & Michal A. Elovitz. (2009) The negative regulators of the host immune response: an unexplored pathway in preterm birth. American Journal of Obstetrics and Gynecology 201:3, pages 284.e1-284.e7.
Crossref
Jin Hou, Pin Wang, Li Lin, Xingguang Liu, Feng Ma, Huazhang An, Zhugang Wang & Xuetao Cao. (2009) MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2. The Journal of Immunology 183:3, pages 2150-2158.
Crossref
A. C. Wang, Q. B. Su, F. X. Wu, X. L. Zhang & P. S. Liu. (2009) Role of TLR4 for paclitaxel chemotherapy in human epithelial ovarian cancer cells. European Journal of Clinical Investigation 39:2, pages 157-164.
Crossref
Steven C. Gribar, Chhinder P. Sodhi, Ward M. Richardson, Rahul J. Anand, George K. Gittes, Maria F. Branca, Adam Jakub, Xia-hua Shi, Sohail Shah, John A. Ozolek & David J. Hackam. (2009) Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis. The Journal of Immunology 182:1, pages 636-646.
Crossref
Huazhang An, Jin Hou, Jun Zhou, Wei Zhao, Hongmei Xu, Yuejuan Zheng, Yizhi Yu, Shuxun Liu & Xuetao Cao. (2008) Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nature Immunology 9:5, pages 542-550.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.