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Article

Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels

Renaud LeflochInstitute of Signaling Developmental Biology and Cancer, CNRS UMR 6543, Université de Nice Sophia Antipolis, Centre A. Lacassagne, 33 Avenue de Valombrose, 06189Nice, France
,
Jacques PouysségurInstitute of Signaling Developmental Biology and Cancer, CNRS UMR 6543, Université de Nice Sophia Antipolis, Centre A. Lacassagne, 33 Avenue de Valombrose, 06189Nice, France
&
Philippe LenormandInstitute of Signaling Developmental Biology and Cancer, CNRS UMR 6543, Université de Nice Sophia Antipolis, Centre A. Lacassagne, 33 Avenue de Valombrose, 06189Nice, FranceCorrespondence[email protected]
Pages 511-527 | Received 07 May 2007, Accepted 11 Oct 2007, Published online: 27 Mar 2023

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Zutao Yu, Shiqi Ye, Gaoyun Hu, Meng Lv, Zhijun Tu, Kun Zhou & Qianbin Li. (2015) The RAF-MEK-ERK pathway: targeting ERK to overcome obstacles to effective cancer therapy. Future Medicinal Chemistry 7:3, pages 269-289.
Crossref
Pui–Kei Wu, Seung–Keun Hong, Seung–Hee Yoon & Jong–In Park. (2015) Active ERK 2 is sufficient to mediate growth arrest and differentiation signaling . The FEBS Journal 282:6, pages 1017-1030.
Crossref
Mario Niepel, Marc Hafner, Emily A Pace, Mirra Chung, Diana H Chai, Lili Zhou, Jeremy L Muhlich, Birgit Schoeberl & Peter K Sorger. (2014) Analysis of growth factor signaling in genetically diverse breast cancer lines. BMC Biology 12:1.
Crossref
Bertram Klinger & Nils Blüthgen. (2014) Consequences of feedback in signal transduction for targeted therapies. Biochemical Society Transactions 42:4, pages 770-775.
Crossref
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Crossref
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Crossref
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Crossref
N A Bonito, J Drechsler, S Stoecker, C R Carmo, M J Seckl, H M Hermanns & A P Costa-Pereira. (2013) Control of gp130 expression by the mitogen-activated protein kinase ERK2. Oncogene 33:17, pages 2255-2263.
Crossref
Anneliis Ihermann-Hella, Maria Lume, Ilkka J. Miinalainen, Anniina Pirttiniemi, Yujuan Gui, Johan Peränen, Jean Charron, Mart Saarma, Frank Costantini & Satu Kuure. (2014) Mitogen-Activated Protein Kinase (MAPK) Pathway Regulates Branching by Remodeling Epithelial Cell Adhesion. PLoS Genetics 10:3, pages e1004193.
Crossref
Matthew D. Mazalouskas, Raquel Godoy-Ruiz, David J. Weber, Danna B. Zimmer, Richard E. Honkanen & Brian E. Wadzinski. (2014) Small G Proteins Rac1 and Ras Regulate Serine/Threonine Protein Phosphatase 5 (PP5)·Extracellular Signal-Regulated Kinase (ERK) Complexes Involved in the Feedback Regulation of Raf1. Journal of Biological Chemistry 289:7, pages 4219-4232.
Crossref
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Crossref
Jong-In Park. (2014) Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. Frontiers in Biology 9:2, pages 95-103.
Crossref
Xavier Deschênes-Simard, Filippos Kottakis, Sylvain Meloche & Gerardo Ferbeyre. (2014) ERKs in Cancer: Friends or Foes?. Cancer Research 74:2, pages 412-419.
Crossref
W. Wu, S. Iwata, S. Homma, H. J. Worman & A. Muchir. (2013) Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation. Human Molecular Genetics 23:1, pages 1-11.
Crossref
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Hongliang Dai, Dan Song, Junnan Xu, Baoman Li, Leif Hertz & Liang Peng. (2013) Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling. Neurochemistry International 63:6, pages 610-625.
Crossref
Diana Zamora-Olivares, Tamer S. Kaoud, Kevin N. Dalby & Eric V. Anslyn. (2013) In-Situ Generation of Differential Sensors that Fingerprint Kinases and the Cellular Response to Their Expression. Journal of the American Chemical Society 135:39, pages 14814-14820.
Crossref
Weifeng Shi, Xueling Hou, Xiang Li, Hongjun Peng, Mei Shi, Qingbo Jiang, Xiping Liu, Yun Ji, Yuhua Yao, Caizhen He & Xiangdong Lei. (2013) Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells. The Brazilian Journal of Infectious Diseases 17:4, pages 410-417.
Crossref
Laurent Turchi, David N. Debruyne, Fabien Almairac, Virginie Virolle, Mohamed Fareh, Yasmine Neirijnck, Fanny Burel-Vandenbos, Philippe Paquis, Marie-Pierre Junier, Ellen Van Obberghen-Schilling, Hervé Chneiweiss & Thierry Virolle. (2013) Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling. Stem Cells 31:7, pages 1252-1265.
Crossref
Gregory P. Botta, Maximilian Reichert, Mauricio J. Reginato, Steffen Heeg, Anil K. Rustgi & Peter I. Lelkes. (2013) ERK2-regulated TIMP1 Induces Hyperproliferation of K-RasG12D-Transformed Pancreatic Ductal Cells. Neoplasia 15:4, pages 359-IN1.
Crossref
Melanie Meister, Ana Tomasovic, Antje Banning & Ritva Tikkanen. (2013) Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. International Journal of Molecular Sciences 14:3, pages 4854-4884.
Crossref
Hongjiang Ruan, Shen Liu, Fengfeng Li, Xujun Li & Cunyi Fan. (2013) Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs. International Journal of Molecular Sciences 14:2, pages 4361-4371.
Crossref
Bettina Hahn, Lorenza Alice D’Alessandro, Sofia Depner, Katharina Waldow, Martin E. Boehm, Julie Bachmann, Marcel Schilling, Ursula Klingmüller & Wolf D. Lehmann. (2012) Cellular ERK Phospho-Form Profiles with Conserved Preference for a Switch-Like Pattern. Journal of Proteome Research 12:2, pages 637-646.
Crossref
Simone Radtke, Mina Milanovic, Carine Rossé, Manu de Rycker, Sylvie Lachmann, Andrew Hibbert, Stéphanie Kermorgant & Peter J. Parker. (2013) ERK2 but not ERK1 mediates HGF-induced motility in non small cell lung carcinoma cell lines. Journal of Cell Science.
Crossref
Jean-Philippe Guégan, Frédéric Ezan, Nathalie Théret, Sophie Langouët & Georges Baffet. (2013) MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells. Carcinogenesis 34:1, pages 38-47.
Crossref
Evonne N. Woodson & Dean H. Kedes. (2012) Distinct Roles for Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 in the Structure and Production of a Primate Gammaherpesvirus. Journal of Virology 86:18, pages 9721-9736.
Crossref
Robert RoskoskiJr.Jr.. (2012) ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacological Research 66:2, pages 105-143.
Crossref
S. Krishna-Subramanian, M.L. Hanski, C. Loddenkemper, B. Choudhary, G. Pagès, M. Zeitz & C. Hanski. (2012) UDCA slows down intestinal cell proliferation by inducing high and sustained ERK phosphorylation. International Journal of Cancer 130:12, pages 2771-2782.
Crossref
Heather A Harrington, Michał Komorowski, Mariano Beguerisse-Díaz, Gian Michele Ratto & Michael P H Stumpf. (2012) Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2. Physical Biology 9:3, pages 036001.
Crossref
Gregory P. Botta, Mauricio J. Reginato, Maximilian Reichert, Anil K. Rustgi & Peter I. Lelkes. (2012) Constitutive K - Ras G12D Activation of ERK2 Specifically Regulates 3D Invasion of Human Pancreatic Cancer Cells via MMP-1 . Molecular Cancer Research 10:2, pages 183-196.
Crossref
Maria Elena Hernandez & Michael J. Wilson. (2012) The Role of Prolactin in the Evolution of Prostate Cancer. Open Journal of Urology 02:03, pages 188-197.
Crossref
Anne von Thun, Marc Birtwistle, Gabriela Kalna, Joan Grindlay, David Strachan, Walter Kolch, Alexander von Kriegsheim & Jim C. Norman. (2012) ERK2 drives tumour cell migration in 3D microenvironments by suppressing expression of Rab17 and Liprin-β2. Journal of Cell Science.
Crossref
Jean-Philippe Guégan, Christophe Frémin & Georges Baffet. (2012) The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control. International Journal of Hepatology 2012, pages 1-13.
Crossref
Daniele Vergara, Pasquale Simeone, Daniela Toraldo, Piero Del Boccio, Viviana Vergaro, Stefano Leporatti, Damiana Pieragostino, Andrea Tinelli, Stefania De Domenico, Saverio Alberti, Andrea Urbani, Michel Salzet, Angelo Santino & Michele Maffia. (2012) Resveratrol downregulates Akt/GSK and ERK signalling pathways in OVCAR-3 ovarian cancer cells. Molecular BioSystems 8:4, pages 1078.
Crossref
Christophe Frémin, Frédéric Ezan, Jean-Philippe Guegan, Luc Gailhouste, Maud Trotard, Jacques Le Seyec, Julie Rageul, Nathalie Theret, Sophie Langouët & Georges Baffet. (2012) The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses. Journal of Cellular Physiology 227:1, pages 59-69.
Crossref
Jin-Sung Choi, Jung-Hwa Oh, Han-Jin Park, Mi-Sun Choi, Se-Myo Park, Seung-Jun Kang, Moon-Ju Oh, Seung Jun Kim, Seung Yong Hwang & Seokjoo Yoon. (2011) miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol. Reproductive Biology and Endocrinology 9:1.
Crossref
Juliana Sartori Bonini, Weber Cláudio Da Silva, Clarice Kras Borges Da Silveira, Cristiano André Köhler, Iván Izquierdo & Martín Cammarota. (2011) Histamine facilitates consolidation of fear extinction. The International Journal of Neuropsychopharmacology 14:09, pages 1209-1217.
Crossref
Yasushi Satoh, Shogo Endo, Takahiro Nakata, Yasushi Kobayashi, Kazuyuki Yamada, Toshio Ikeda, Atsuya Takeuchi, Takeshi Hiramoto, Yasuhiro Watanabe & Tomiei Kazama. (2011) ERK2 Contributes to the Control of Social Behaviors in Mice. The Journal of Neuroscience 31:33, pages 11953-11967.
Crossref
Bruno Bernardes de Jesus, Kerstin Schneeberger, Elsa Vera, Agueda Tejera, Calvin B. Harley & Maria A. Blasco. (2011) The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 10:4, pages 604-621.
Crossref
Shu-Tao Zheng, Qi Huo, Aerziguli Tuerxun, Wen-Jing Ma, Guo-Dong Lv, Cong-Gai Huang, Qing Liu, Xing Wang, Ren-Yong Lin, Ilyar Sheyhidin & Xiao-Mei Lu. (2010) The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706. Molecular Biology Reports 38:2, pages 865-872.
Crossref
Raphaela Fritsche‐Guenther, Franziska Witzel, Anja Sieber, Ricarda Herr, Nadine Schmidt, Sandra Braun, Tilman Brummer, Christine Sers & Nils Blüthgen. (2011) Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Molecular Systems Biology 7:1.
Crossref
Wei-Lun Huang, Hsuan-Heng Yeh, Chien-Chung Lin, Wu-Wei Lai, Jang-Yang Chang, Wen-Tsan Chang & Wu-Chou Su. (2010) Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Molecular Cancer 9:1.
Crossref
Reiner Wimmer & Manuela Baccarini. (2010) Partner exchange: protein–protein interactions in the Raf pathway. Trends in Biochemical Sciences 35:12, pages 660-668.
Crossref
Xiang Wang, Fengfeng Li, Cunyi Fan, Chunyang Wang & Hongjiang Ruan. (2010) Analysis of isoform specific ERK signaling on the effects of interleukin-1β on COX-2 expression and PGE2 production in human chondrocytes. Biochemical and Biophysical Research Communications 402:1, pages 23-29.
Crossref
Anatoliy I. Masyuk, Bing Q. Huang, Christopher J. Ward, Sergio A. Gradilone, Jesus M. Banales, Tatyana V. Masyuk, Brynn Radtke, Patrick L. Splinter & Nicholas F. LaRusso. (2010) Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. American Journal of Physiology-Gastrointestinal and Liver Physiology 299:4, pages G990-G999.
Crossref
Osamu Imamura, Gilles Pagès, Jacques Pouysségur, Shogo Endo & Kunio Takishima. (2010) ERK1 and ERK2 are required for radial glial maintenance and cortical lamination. Genes to Cells 15:10, pages 1072-1088.
Crossref
Benedict J. Alter, Chengshui Zhao, Farzana Karim, Gary E. Landreth & Robert W. GereauIVIV. (2010) Genetic Targeting of ERK1 Suggests a Predominant Role for ERK2 in Murine Pain Models. The Journal of Neuroscience 30:34, pages 11537-11547.
Crossref
T. S. Niault & M. Baccarini. (2010) Targets of Raf in tumorigenesis. Carcinogenesis 31:7, pages 1165-1174.
Crossref
Soizic GuihardDenis ClayLaurence CocaultNathalie SaulnierPaule Opolon, Michèle SouyriGilles Pagès, Jacques Pouysségur, Françoise PorteuMurielle Gaudry. (2010) The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 115:18, pages 3686-3694.
Crossref
Ivo Bendix, Caspar F. Pfueller, Tina Leuenberger, Nadezhda Glezeva, Volker Siffrin, Yasmin Müller, Timour Prozorovski, Wiebke Hansen, Ulf Schulze Topphoff, Christoph Loddenkemper, Frauke Zipp & Sonia Waiczies. (2010) MAPK3 deficiency drives autoimmunity via DC arming . European Journal of Immunology 40:5, pages 1486-1495.
Crossref
Sejeong Shin, Christopher A. Dimitri, Sang-Oh Yoon, William Dowdle & John Blenis. (2010) ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events. Molecular Cell 38:1, pages 114-127.
Crossref
Audesh Bhat, Susantha Gomis, Andrew Potter & Suresh K. Tikoo. (2010) Role of Hsp90 in CpG ODN mediated immunostimulation in avian macrophages. Molecular Immunology 47:6, pages 1337-1346.
Crossref
M.M. Tsoory, A. Guterman & G. Richter-Levin. (2010) âJuvenile stressâ alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: Relevance for stress-related psychopathologies. Journal of Neuroscience Research 88:2, pages 369-380.
Crossref
Patrick Martin & Philippe Pognonec. (2010) ERK and cell death: cadmium toxicity, sustained ERK activation and cell death. FEBS Journal 277:1, pages 39-46.
Crossref
Diane S. Lidke, Fang Huang, Janine N. Post, Bernd Rieger, Julie Wilsbacher, James L. Thomas, Jacques Pouysségur, Thomas M. Jovin & Philippe Lenormand. (2010) ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation. Journal of Biological Chemistry 285:5, pages 3092-3102.
Crossref
Eldar Zehorai, Zhong Yao, Alexander Plotnikov & Rony Seger. (2010) The subcellular localization of MEK and ERK—A novel nuclear translocation signal (NTS) paves a way to the nucleus. Molecular and Cellular Endocrinology 314:2, pages 213-220.
Crossref
Fengfeng Li, Hongjiang Ruan, Cunyi Fan, Bingfang Zeng, Chunyang Wang & Xiang Wang. (2010) Efficient inhibition of the formation of joint adhesions by ERK2 small interfering RNAs. Biochemical and Biophysical Research Communications 391:1, pages 795-799.
Crossref
Marzia Indrigo, Alessandro Papale, Daniel Orellana & Riccardo Brambilla. 2010. MAP Kinase Signaling Protocols. MAP Kinase Signaling Protocols 205 220 .
Yonat Keshet & Rony Seger. 2010. MAP Kinase Signaling Protocols. MAP Kinase Signaling Protocols 3 38 .
Kyoung-Won Cho, Jinglei Cai, Hyun-Yi Kim, Akihiro Hosoya, Hayato Ohshima, Kang-Yell Choi & Han-Sung Jung. (2009) ERK activation is involved in tooth development via FGF10 signaling. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 312B:8, pages 901-911.
Crossref
Eftychia Oikonomou, Eleni Makrodouli, Maria Evagelidou, Tobias Joyce, Lesley Probert & Alexander Pintzas. (2009) BRAFV600E Efficient Transformation and Induction of Microsatellite Instability Versus KRASG12V Induction of Senescence Markers in Human Colon Cancer Cells. Neoplasia 11:11, pages 1116-IN2.
Crossref
Seung-Keun Hong, Seunghee Yoon, Cas Moelling, Dumrongkiet Arthan & Jong-In Park. (2009) Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling. Journal of Biological Chemistry 284:48, pages 33006-33018.
Crossref
Manuela Lemoine, Joëlle Dupont, Vanaïque Guillory, Sophie Tesseraud & Elisabeth Blesbois. (2009) Potential Involvement of Several Signaling Pathways in Initiation of the Chicken Acrosome Reaction1. Biology of Reproduction 81:4, pages 657-665.
Crossref
Gita Kumari & S. Mahalingam. (2009) Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2. Experimental Cell Research 315:16, pages 2775-2790.
Crossref
Fengfeng Li, Bingfang Zeng, Yimin Chai, Peihua Cai, Cunyi Fan & Tao Cheng. (2009) The linker region of Smad2 mediates TGF-β-dependent ERK2-induced collagen synthesis. Biochemical and Biophysical Research Communications 386:2, pages 289-293.
Crossref
Dongsoon Bae & Susan Ceryak. (2009) Raf-independent, PP2A-dependent MEK activation in response to ERK silencing. Biochemical and Biophysical Research Communications 385:4, pages 523-527.
Crossref
Lee Campbell, Rosa Nuttall, David Griffiths & Mark Gumbleton. (2009) Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma. Cancer 115:15, pages 3457-3467.
Crossref
Wonshill Koh, Kamakshi Sachidanandam, Amber N. Stratman, Anastasia Sacharidou, Anne M. Mayo, Eric A. Murphy, David A. Cheresh & George E. Davis. (2009) Formation of endothelial lumens requires a coordinated PKCϵ-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. Journal of Cell Science 122:11, pages 1812-1822.
Crossref
Fengfeng Li, Cunyi Fan, Tao Cheng, Chaoyin Jiang & Bingfang Zeng. (2009) Efficient inhibition of fibroblast proliferation and collagen expression by ERK2 siRNAs. Biochemical and Biophysical Research Communications 382:2, pages 259-263.
Crossref
Christophe Frémin, Anne Bessard, Frédéric Ezan, Luc Gailhouste, Morgane Régeard, Jacques Le Seyec, David Gilot, Gilles Pagès, Jacques Pouysségur, Sophie Langouët & Georges Baffet. (2009) Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. Hepatology 49:3, pages 930-939.
Crossref
Marcel Schilling, Thomas Maiwald, Stefan Hengl, Dominic Winter, Clemens Kreutz, Walter Kolch, Wolf D Lehmann, Jens Timmer & Ursula Klingmüller. (2009) Theoretical and experimental analysis links isoform‐ specific ERK signalling to cell fate decisions. Molecular Systems Biology 5:1.
Crossref
Luc Gailhouste, Frédéric Ezan, Anne Bessard, Christophe Frémin, Julie Rageul, Sophie Langouët & Georges Baffet. (2009) RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo . International Journal of Cancer, pages NA-NA.
Crossref
Warren N. D'Souza, Chiung-Fang Chang, April M. Fischer, Manqing Li & Stephen M. Hedrick. (2008) The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival. The Journal of Immunology 181:11, pages 7617-7629.
Crossref
Jason NewbernJian ZhongRasika S. WickramasingheXiaoyan LiYaohong WuIvy Samuels, Natalie Cherosky, J. Colleen Karlo, Brianne O'LoughlinJamie WikenheiserMadhusudhana Gargesha, Yong Qiu DoughmanJean Charron, David D. GintyMichiko WatanabeSulagna C. SaittaWilliam D. SniderGary E. Landreth. (2008) Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proceedings of the National Academy of Sciences 105:44, pages 17115-17120.
Crossref
Nicholette A. Zeliadt, Laura J. Mauro & Elizabeth V. Wattenberg. (2008) Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. Toxicology and Applied Pharmacology 232:3, pages 408-417.
Crossref
Yue Wang, Paul R. Crisostomo, Meijing Wang, Troy A. Markel, Nathan M. Novotny & Daniel R. Meldrum. (2008) TGF-α increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295:4, pages R1115-R1123.
Crossref
Hwangseo Park, Young Jae Bahn, Dae Gwin Jeong, Eui Jeon Woo, Jung Sun Kwon & Seong Eon Ryu. (2008) Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters 18:20, pages 5372-5376.
Crossref
A Bessard, C Frémin, F Ezan, A Fautrel, L Gailhouste & G Baffet. (2008) RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene 27:40, pages 5315-5325.
Crossref
Jessica Shama, Raquel Garcia-Medina, Jacques Pouysségur & Emmanuel Vial. (2008) Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells. Biochemical and Biophysical Research Communications 372:4, pages 845-849.
Crossref
Thomas W. Sturgill. (2008) MAP kinase: It’s been longer than fifteen minutes. Biochemical and Biophysical Research Communications 371:1, pages 1-4.
Crossref

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