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Article

ck2-Dependent Phosphorylation of Progesterone Receptors (PR) on Ser81 Regulates PR-B Isoform-Specific Target Gene Expression in Breast Cancer Cells

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Pages 2439-2452 | Received 27 Oct 2010, Accepted 11 Apr 2011, Published online: 20 Mar 2023

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Marisa Cabeza, Yvonne Heuze, Araceli Sánchez, Mariana Garrido & Eugene Bratoeff. (2015) Recent advances in structure of progestins and their binding to progesterone receptors. Journal of Enzyme Inhibition and Medicinal Chemistry 30:1, pages 152-159.
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Caroline Diep, Nathan Charles, C. Blake Gilks, Steve Kalloger, Peter Argenta & Carol A. Lange. (2013) Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle 12:9, pages 1433-1449.
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William H. Walker. (2011) Testosterone signaling and the regulation of spermatogenesis. Spermatogenesis 1:2, pages 116-120.
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Janeen H. Trembley, Betsy T. Kren, Muhammad Afzal, George A. Scaria, Mark A. Klein & Khalil Ahmed. (2022) Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise. Molecular and Cellular Biochemistry 478:4, pages 899-926.
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Yiyang Li, Wei Zhou, Xiangbing Meng, Sarina D. Murray, Long Li, Abby Fronk, Vanessa J. Lazaro-Camp, Kuo-kuang Wen, Meng Wu, Adam Dupuy, Kimberly K. Leslie & Shujie Yang. (2022) Utilizing an Endogenous Progesterone Receptor Reporter Gene for Drug Screening and Mechanistic Study in Endometrial Cancer. Cancers 14:19, pages 4883.
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May-Britt Firnau & Angela Brieger. (2022) CK2 and the Hallmarks of Cancer. Biomedicines 10:8, pages 1987.
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Sailaja Kamaraju, Amy M Fowler, Elizabeth Weil, Kari B Wisinski, Thu H Truong, Martin Lehr, Lubna N Chaudhary, Yee Chung Cheng, Christopher R Chitambar, Hallgeir Rui, Douglas Yee & Carol Lange. (2021) Leveraging Antiprogestins in the Treatment of Metastatic Breast Cancer. Endocrinology 162:8.
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Stefania Salsano, Roberto González-Martín, Alicia Quiñonero, Silvia Pérez-Debén & Francisco Domínguez. (2021) Deciphering the Role of PGRMC1 During Human Decidualization Using an In Vitro Approach. The Journal of Clinical Endocrinology & Metabolism 106:8, pages 2313-2327.
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Hossein Hosseinirad, Marefat Ghaffari Novin, Sedighe Hosseini, Hamid Nazarian, Zahra Safaei, Teibeh Hashemi, Shahrokh Paktinat & Zahra Shams Mofarahe. (2021) Evaluation of Expression and Phosphorylation of Progesterone Receptor in Endometrial Stromal Cells of Patients with Recurrent Implantation Failure Compared to Healthy Fertile Women. Reproductive Sciences 28:5, pages 1457-1465.
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Suryendu Saha, Samya Dey & Somsubhra Nath. (2021) Steroid Hormone Receptors: Links With Cell Cycle Machinery and Breast Cancer Progression. Frontiers in Oncology 11.
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Amy R. Dwyer, Thu H. Truong, Carlos Perez Kerkvliet, Kiran V. Paul, Peter Kabos, Carol A. Sartorius & Carol A. Lange. (2020) Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer. British Journal of Cancer 124:1, pages 217-227.
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Hossein Hosseinirad, Marefat Ghaffari Novin, Sedighe Hosseini, Hamid Nazarian, Fardin Amidi, Shahrokh Paktinat, Elham Azizi & Zahra Shams Mofarahe. (2020) Effect of 1,25(OH)2-vitamin D3 on expression and phosphorylation of progesterone receptor in cultured endometrial stromal cells of patients with repeated implantation failure. Acta Histochemica 122:2, pages 151489.
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Mauro E. Cenciarini & Cecilia J. Proietti. (2019) Molecular mechanisms underlying progesterone receptor action in breast cancer: Insights into cell proliferation and stem cell regulation. Steroids 152, pages 108503.
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Merit L. Goodman, Gloria M. Trinca, Katherine R. Walter, Evangelia K. Papachristou, Clive S. D’Santos, Tianbao Li, Qi Liu, Zhao Lai, Prabhakar Chalise, Rashna Madan, Fang Fan, Mary A. Markiewicz, Victor X. Jin, Jason S. Carroll & Christy R. Hagan. (2019) Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer. The Journal of Immunology 202:10, pages 3076-3086.
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Taylor E. Escher, Asona J. Lui, Eric S. Geanes, Katherine R. Walter, Ossama Tawfik, Christy R. Hagan & Joan Lewis-Wambi. (2019) Interaction Between MUC1 and STAT1 Drives IFITM1 Overexpression in Aromatase Inhibitor–Resistant Breast Cancer Cells and Mediates Estrogen-Induced Apoptosis. Molecular Cancer Research 17:5, pages 1180-1194.
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Thu H Truong, Amy R Dwyer, Caroline H Diep, Hsiangyu Hu, Kyla M Hagen & Carol A Lange. (2019) Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates. Endocrinology 160:2, pages 430-446.
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Cecilia J. Proietti, Mauro E. Cenciarini & Patricia V. Elizalde. (2018) Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions. Steroids 133, pages 75-81.
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Viroj Boonyaratanakornkit, Nalo Hamilton, Diana C. Márquez-Garbán, Prangwan Pateetin, Eileen M. McGowan & Richard J. Pietras. (2018) Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer. Molecular and Cellular Endocrinology 466, pages 51-72.
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Katherine A. Leehy, Thu H. Truong, Laura J. Mauro & Carol A. Lange. (2018) Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models. The Journal of Steroid Biochemistry and Molecular Biology 176, pages 88-93.
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Gloria M. Trinca, Merit L. Goodman, Evangelia K. Papachristou, Clive S. D’Santos, Prabhakar Chalise, Rashna Madan, Chad Slawson & Christy R. Hagan. (2017) O-GlcNAc-Dependent Regulation of Progesterone Receptor Function in Breast Cancer. Hormones and Cancer 9:1, pages 12-21.
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Todd P. Knutson, Thu H. Truong, Shihong Ma, Nicholas J. Brady, Megan E. Sullivan, Ganesh Raj, Kathryn L. Schwertfeger & Carol A. Lange. (2017) Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. Journal of Hematology & Oncology 10:1.
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Qianwen Li, Ke Li, Tianyang Yang, Sheng Zhang, Yu Zhou, Zhenyu Li, Jinrong Xiong, Fangzheng Zhou, Xiaoshu Zhou, Li Liu, Rui Meng & Gang Wu. (2017) Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer. Scientific Reports 7:1.
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Stefanie Ruhs, Nicole Strätz, Katja Quarch, Antonia Masch, Mike Schutkowski, Michael Gekle & Claudia Grossmann. (2017) Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2. Scientific Reports 7:1.
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Katherine R. Walter, Merit L. Goodman, Hari Singhal, Jade A. Hall, Tianbao Li, Sean M. Holloran, Gloria M. Trinca, Katelin A. Gibson, Victor X. Jin, Geoffrey L. Greene & Christy R. Hagan. (2017) Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer. Molecular Cancer Research 15:10, pages 1331-1340.
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Asona J. Lui, Eric S. Geanes, Joshua Ogony, Fariba Behbod, Jordan Marquess, Kelli Valdez, William Jewell, Ossama Tawfik & Joan Lewis-Wambi. (2017) IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT-mediated induction of p21. Cancer Letters 399, pages 29-43.
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Melissa Chua, Charina Ortega, Ayesha Sheikh, Migi Lee, Hussein Abdul-Rassoul, Kevan Hartshorn & Isabel Dominguez. (2017) CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals 10:4, pages 18.
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XIAOFEN PAN, RUI MENG, ZHONGHUA YU, JINGJING MOU, SHA LIU, ZIYI SUN, ZHENWEI ZOU, GANG WU & GANG PENG. (2016) Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression. International Journal of Oncology 48:3, pages 1073-1084.
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Lindsey S. Treviño, Michael J. Bolt, Sandra L. Grimm, Dean P. Edwards, Michael A. Mancini & Nancy L. Weigel. (2016) Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Molecular Endocrinology 30:2, pages 158-172.
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Jacques Bonneterre, Emilie Hutt, Jacques Bosq, J. Dinny Graham, Matthew A. Powell, Eric Leblanc, Keiichi Fujiwara, Thomas J. Herzog, Robert L. Coleman, Christine L. Clarke, Erard M. Gilles, Alexander A. Zukiwski & Bradley J. Monk. (2015) Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus. Gynecologic Oncology 138:3, pages 663-667.
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