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Molecular and Cellular Biology Volume 33, 2013 - Issue 2
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Article

RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression

Jung-Chun Lina Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;b School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan
,
Yu-Ting Yana Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
,
Wen-Kou Hsieha Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
,
Pey-Jey Penga Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
,
Chun-Hao Sua Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;c Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
&
Woan-Yuh Tarna Institute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanCorrespondence[email protected]
Pages 319-327 | Received 16 Sep 2012, Accepted 31 Oct 2012, Published online: 20 Mar 2023

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Yishu Wang, Yu Yu, Yidan Pang, Haojun Yu, Wenqi Zhang, Xian Zhao & Jianxiu Yu. (2021) The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism. RNA Biology 18:12, pages 2107-2126.
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Dhananjaya D, Kuan-Yang Hung & Woan-Yuh Tarn. (2018) RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Molecular and Cellular Biology 38:12.
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Chun-Hao Su, Kuan-Yang Hung, Shih-Chieh Hung & Woan-Yuh Tarn. (2017) RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M. Molecular and Cellular Biology 37:3.
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Jung-Chun Lin. (2015) RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes. RNA Biology 12:2, pages 208-220.
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Articles from other publishers (28)

Yadanar Than Naing & Lei Sun. (2023) The Role of Splicing Factors in Adipogenesis and Thermogenesis. Molecules and Cells 46:5, pages 268-277.
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Wengang Jian, Wei Xue, Tengda Wang, Yongchun Yu, Licheng Cai, Yuyang Meng, Zhinan Xia & Cheng Zhang. (2022) RBM4 inhibits the growth of clear cell renal cell carcinoma by enhancing the stability of p53 mRNA. Molecular Carcinogenesis 62:4, pages 464-478.
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Benoît Soubise, Yan Jiang, Nathalie Douet-Guilbert & Marie-Bérengère Troadec. (2022) RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer. Cancers 14:3, pages 643.
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Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Masafumi Matsuo, Fumihiko Hakuno, Naoyuki Kataoka & Shin-Ichiro Takahashi. (2021) Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells. Biochimie 187, pages 25-32.
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Emily J. Gallagher & Derek LeRoith. (2020) Hyperinsulinaemia in cancer. Nature Reviews Cancer 20:11, pages 629-644.
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Nicole D. Moss & Lori Sussel. (2020) mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic β Cell Function. Frontiers in Genetics 11.
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Austin L. Good & Doris A. Stoffers. (2020) Stress-Induced Translational Regulation Mediated by RNA Binding Proteins: Key Links to β-Cell Failure in Diabetes. Diabetes 69:4, pages 499-507.
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Ching-Sheng Hung & Jung-Chun Lin. (2020) Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1863:1, pages 194437.
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Wei-Yang Wang, Weili Quan, Fan Yang, Ya-Xun Wei, Jia-Jun Chen, Han Yu, Jie Xie, Yi Zhang & Zhan-Fei Li. (2019) RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells. Molecular Genetics and Genomics 295:1, pages 95-106.
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Veronica Vella, Roberta Malaguarnera, Maria Luisa Nicolosi, Andrea Morrione & Antonino Belfiore. (2019) Insulin/IGF signaling and discoidin domain receptors: An emerging functional connection. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:11, pages 118522.
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Yi-Lin Chi & Jung-Chun Lin. (2018) RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:11, pages 1515-1525.
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Hui-Yu Peng, Yu-Chih Liang, Tse-Hua Tan, Huai-Chia Chuang, Ying-Ju Lin & Jung-Chun Lin. (2018) RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis. International Journal of Molecular Sciences 19:9, pages 2646.
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Antonino Belfiore, Roberta Malaguarnera, Veronica Vella, Michael C Lawrence, Laura Sciacca, Francesco Frasca, Andrea Morrione & Riccardo Vigneri. (2017) Insulin Receptor Isoforms in Physiology and Disease: An Updated View. Endocrine Reviews 38:5, pages 379-431.
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Francisco E. Baralle & Jimena Giudice. (2017) Alternative splicing as a regulator of development and tissue identity. Nature Reviews Molecular Cell Biology 18:7, pages 437-451.
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Hongmei Yong, Huijun Zhu, Shu Zhang, Wei Zhao, Wei Wang, Chen Chen, Guipeng Ding, Lun Zhu, Ziyuan Zhu, Huaidong Liu, Yongjie Zhang, Jinbo Wen, Xing Kang, Jin Zhu, Zhenqing Feng & Baorui Liu. (2016) Prognostic value of decreased expression of RBM4 in human gastric cancer. Scientific Reports 6:1.
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Woan-Yuh Tarn, Hung-Che Kuo, Hsin-I. Yu, Shin-Wu Liu, Ching-Tzu Tseng, Dodda Dhananjaya, Kuan-Yang Hung, Chi-Chiang Tu, Shuo-Hsiu Chang, Guo-Jen Huang & Ing-Ming Chiu. (2016) RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Molecular Biology of the Cell 27:10, pages 1676-1683.
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Jung-Chun Lin, Yi-Han Lu, Yun-Ru Liu & Ying-Ju Lin. (2016) RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes. Scientific Reports 6:1.
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Jung-Chun Lin. (2015) Impacts of Alternative Splicing Events on the Differentiation of Adipocytes. International Journal of Molecular Sciences 16:9, pages 22169-22189.
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Lucie Baillon, Fabien Pierron, Raphaël Coudret, Eric Normendeau, Antoine Caron, Laurent Peluhet, Pierre Labadie, Hélène Budzinski, Gilles Durrieu, Jérôme Sarraco, Pierre Elie, Patrice Couture, Magalie Baudrimont & Louis Bernatchez. (2014) Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels. Ecotoxicology 24:1, pages 71-84.
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Aminetou Mint Mohamed, Morgan Thénoz, Françoise Solly, Marie Balsat, Franck Mortreux & Eric Wattel. (2014) How mRNA is misspliced in acute myelogenous leukemia (AML)?. Oncotarget 5:20, pages 9534-9545.
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Yang Wang, Dan Chen, Haili Qian, Yihsuan S. Tsai, Shujuan Shao, Quentin Liu, Daniel Dominguez & Zefeng Wang. (2014) The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression. Cancer Cell 26:3, pages 374-389.
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Samantha Maragh, Ronald A. Miller, Seneca L. Bessling, Guangliang Wang, Paul W. Hook & Andrew S. McCallion. (2014) Rbm24a and Rbm24b Are Required for Normal Somitogenesis. PLoS ONE 9:8, pages e105460.
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Virginie Aïello, Alba Moreno-Asso, Joan-Marc Servitja & Mercè Martín. (2014) Thyroid hormones promote endocrine differentiation at expenses of exocrine tissue. Experimental Cell Research 322:2, pages 236-248.
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Jung-Chun Lin, Woan-Yuh Tarn & Wen-Kou Hsieh. (2014) Emerging role for RNA binding motif protein 4 in the development of brown adipocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:4, pages 769-779.
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F. Tang, X. Yao, H. Zhu, H. Mu, Z. Niu, M. Yu, C. Yang, S. Peng, G. Li & J. Hua. (2014) Expression pattern of Ngn3 in dairy goat testis and its function in promoting meiosis by upregulating Stra8. Cell Proliferation 47:1, pages 38-47.
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Maria Grazia Magro & Michele Solimena. (2013) Regulation of β-cell function by RNA-binding proteins. Molecular Metabolism 2:4, pages 348-355.
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Amaresh Panda, Ioannis Grammatikakis, Je-Hyun Yoon & Kotb Abdelmohsen. (2013) Posttranscriptional Regulation of Insulin Family Ligands and Receptors. International Journal of Molecular Sciences 14:9, pages 19202-19229.
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Sarah F. Andres, James G. Simmons, Amanda T. Mah, M. Agostina Santoro, Laurianne Van Landeghem & P. Kay Lund. (2013) Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation. Journal of Cell Science.
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