78
Views
47
CrossRef citations to date
0
Altmetric
Article

Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation

, , &
Pages 4188-4200 | Received 01 Dec 2008, Accepted 21 May 2009, Published online: 21 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Katia Coulonval, Vincent Vercruysse, Sabine Paternot, Jaime M. Pita, Robert Corman, Eric Raspé & Pierre P. Roger. (2022) Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27. Cell Cycle 21:1, pages 12-32.
Read now
Sabine Paternot, Bianca Colleoni, Xavier Bisteau & Pierre P Roger. (2014) The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes. Cell Cycle 13:18, pages 2879-2888.
Read now
Miriam Merzel Schachter & Robert P Fisher. (2013) The CDK-activating kinase Cdk7. Cell Cycle 12:20, pages 3239-3240.
Read now
Heidelinde Jäkel, Ines Peschel, Clarissa Kunze, Christina Weinl & Ludger Hengst. (2012) Regulation of p27 by mitogen-induced tyrosine phosphorylation. Cell Cycle 11:10, pages 1910-1917.
Read now

Articles from other publishers (43)

Christina G Gangemi, Rahkesh T. Sabapathy & Harald Janovjak. (2023) CDK6 activity in a recurring convergent kinase network motif. The FASEB Journal 37:4.
Crossref
Rawikant Kamolphiwong, Kanyanatt Kanokwiroon, Weerinrada Wongrin, Parunya Chaiyawat, Jeerawan Klangjorhor, Jongkolnee Settakorn, Pimpisa Teeyakasem, Apiwat Sangphukieo & Dumnoensun Pruksakorn. (2023) Potential target identification for osteosarcoma treatment: Gene expression re-analysis and drug repurposing. Gene 856, pages 147106.
Crossref
Sabine Paternot, Eric Raspé, Clément Meiller, Maxime Tarabichi, Jean‐Baptiste Assié, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, Nolwenn Le Stang, Séverine Tabone‐Eglinger, Françoise Galateau‐Sallé, Christophe Blanquart, Jan P. Van Meerbeeck, Thierry Berghmans, Didier Jean & Pierre P. Roger. (2022) Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4 /6 inhibition . Molecular Oncology.
Crossref
Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych & Renata Kontek. (2022) Cyclin-dependent kinases in DNA damage response. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:3, pages 188716.
Crossref
Elisa Ventura, Carmelina Antonella Iannuzzi, Francesca Pentimalli, Antonio Giordano & Andrea Morrione. (2021) RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways. Cancers 13:19, pages 5025.
Crossref
Ni Made Pitri Susanti & Daryono Hadi Tjahjono. (2021) Cyclin-Dependent Kinase 4 and 6 Inhibitors in Cell Cycle Dysregulation for Breast Cancer Treatment. Molecules 26:15, pages 4462.
Crossref
Ceryl Tan, Miriam B. Ginzberg, Rachel Webster, Seshu Iyengar, Shixuan Liu, David Papadopoli, John Concannon, Yuan Wang, Douglas S. Auld, Jeremy L. Jenkins, Hannes Rost, Ivan Topisirovic, Andreas Hilfinger, W. Brent Derry, Nish Patel & Ran Kafri. (2021) Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK. Developmental Cell 56:12, pages 1756-1769.e7.
Crossref
Hye Young Shin, Kyung-Seok Han, Hyung Woo Park, Yun Hwa Hong, Yona Kim, Hyo Eun Moon, Kwang Woo Park, Hye Ran Park, C. Justin Lee, Kiyoung Lee, Sang Jeong Kim, Man Seung Heo, Sung-Hye Park, Dong Gyu Kim & Sun Ha Paek. (2021) Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling. Experimental Neurobiology 30:2, pages 120-143.
Crossref
Xuewei Wu, Xiaobao Yang, Yan Xiong, Ruitong Li, Takahiro Ito, Tamer A. Ahmed, Zoi Karoulia, Christos Adamopoulos, Hong Wang, Li Wang, Ling Xie, Jing Liu, Beatrix Ueberheide, Stuart A. Aaronson, Xian Chen, Sean G. Buchanan, William R. Sellers, Jian Jin & Poulikos I. Poulikakos. (2021) Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Nature Cancer 2:4, pages 429-443.
Crossref
Jordan L Kohlmeyer, David J Gordon, Munir R Tanas, Varun Monga, Rebecca D Dodd & Dawn E Quelle. (2020) CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets. International Journal of Molecular Sciences 21:8, pages 3018.
Crossref
Shang Su, Zimo Yang, Hongying Gao, Haiyan Yang, Songbiao Zhu, Zixuan An, Juanjuan Wang, Qing Li, Sarat Chandarlapaty, Haiteng Deng, Wei Wu & Yu Rao. (2019) Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. Journal of Medicinal Chemistry 62:16, pages 7575-7582.
Crossref
Anja Urbach & Otto W. Witte. (2019) Divide or Commit – Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis. Frontiers in Cell and Developmental Biology 7.
Crossref
Liam Cornell, Seth A. Wander, Tanvi Visal, Nikhil Wagle & Geoffrey I. Shapiro. (2019) MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Reports 26:10, pages 2667-2680.e7.
Crossref
Esra Aydemir Çoban, Didem Tecimel, Fikrettin Şahin & Ayşen Aslı Hızlı Deniz. 2020. Cell Biology and Translational Medicine, Volume 8. Cell Biology and Translational Medicine, Volume 8 125 134 .
Mercedes Ruiz-Estevez, James Staats, Ellen Paatela, Dane Munson, Nobuko Katoku-Kikyo, Ce Yuan, Yoko Asakura, Reilly Hostager, Hiroshi Kobayashi, Atsushi Asakura & Nobuaki Kikyo. (2018) Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization. Cell Reports 25:9, pages 2537-2551.e8.
Crossref
Huan He, Juan Xu, Wen Xie, Qing-Lian Guo, Feng-Lei Jiang & Yi Liu. (2018) Reduced state transition barrier of CDK6 from open to closed state induced by Thr177 phosphorylation and its implication in binding modes of inhibitors. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:3, pages 501-512.
Crossref
Xuelu Li, Yuan Zhang, Jinlei Ding, Min Wang, Na Li, Hui Yang, Kainan Wang, Dandan Wang, Peter Ping Lin, Man Li, Zuowei Zhao & Pixu Liu. (2017) Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis. Oncotarget 9:2, pages 2705-2714.
Crossref
Feng Wei, Xin Jiang, Hao-Yue Gao & Shuo-Hui Gao. (2017) Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. International Journal of Oncology 51:5, pages 1383-1394.
Crossref
Eric Raspé, Katia Coulonval, Jaime M Pita, Sabine Paternot, Françoise Rothé, Laure Twyffels, Sylvain Brohée, Ligia Craciun, Denis Larsimont, Véronique Kruys, Flavienne Sandras, Isabelle Salmon, Steven Van Laere, Martine Piccart, Michail Ignatiadis, Christos Sotiriou & Pierre P Roger. (2017) CDK 4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib . EMBO Molecular Medicine 9:8, pages 1052-1066.
Crossref
Yi HeHuizhi ZengYang YuJiashu ZhangXiaona ZengFengtao GongQi LiuBo Yang. (2017) Resveratrol Improves Cell Cycle Arrest in Chronic Prostatitis Rats, by C-kit/SCF Suppression . DNA and Cell Biology 36:8, pages 709-714.
Crossref
B Colleoni, S Paternot, J M Pita, X Bisteau, K Coulonval, R J Davis, E Raspé & P P Roger. (2017) JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21. Oncogene 36:30, pages 4349-4361.
Crossref
G. M. Verkhivker. (2017) Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms. Molecular BioSystems 13:11, pages 2235-2253.
Crossref
Bekesho Geleta, Eyasu Makonnen & Solomon M. Abay. (2016) Withdrawn: Cyclic Dependent Kinases (CDKs) in Cancer Pathogenesis and Therapeutics. International Journal of Cancer Research 12:2, pages 109-121.
Crossref
Akiyoshi Chikenji, Hitoshi Ando, Megumi Nariyama, Takeo Suga, Ryohei Iida & Kazuhiro Gomi. (2016) <i>MyoD</i> is regulated by the miR-29a-<i>Tet1</i> pathway in C2C12 myoblast cells. Journal of Oral Science 58:2, pages 219-229.
Crossref
Hirotomo Takatsuka, Chikage Umeda‐Hara & Masaaki Umeda. (2015) Cyclin‐dependent kinase‐activating kinases CDKD ;1 and CDKD ;3 are essential for preserving mitotic activity in Arabidopsis thaliana . The Plant Journal 82:6, pages 1004-1017.
Crossref
LONG YUAN, YONGRONG ZHANG, JUAN XIA, BIN LIU, QINGYU ZHANG, JIE LIU, LIMING LUO, ZHOU PENG, ZEQING SONG & RUNZHI ZHU. (2015) Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells. Molecular Medicine Reports 11:4, pages 2459-2464.
Crossref
Y J Choi & L Anders. (2013) Signaling through cyclin D-dependent kinases. Oncogene 33:15, pages 1890-1903.
Crossref
Katja Handschick, Knut Beuerlein, Liane Jurida, Marek Bartkuhn, Helmut Müller, Johanna Soelch, Axel Weber, Oliver Dittrich-Breiholz, Heike Schneider, Maren Scharfe, Michael Jarek, Julia Stellzig, M. Lienhard Schmitz & Michael Kracht. (2014) Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression. Molecular Cell 53:2, pages 193-208.
Crossref
Guozhong Zhao, Yunping Yao, Chunling Wang, Lihua Hou & Xiaohong Cao. (2013) Comparative genomic analysis of Aspergillus oryzae strains 3.042 and RIB40 for soy sauce fermentation. International Journal of Food Microbiology 164:2-3, pages 148-154.
Crossref
Xavier Bisteau, Sabine Paternot, Bianca Colleoni, Karin Ecker, Katia Coulonval, Philippe De Groote, Wim Declercq, Ludger Hengst & Pierre P. Roger. (2013) CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point. PLoS Genetics 9:5, pages e1003546.
Crossref
Miriam Merzel Schachter, Karl A. Merrick, Stéphane Larochelle, Alexander Hirschi, Chao Zhang, Kevan M. Shokat, Seth M. Rubin & Robert P. Fisher. (2013) A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression. Molecular Cell 50:2, pages 250-260.
Crossref
Holger Buss, Katja Handschick, Nadine Jurrmann, Pirita Pekkonen, Knut Beuerlein, Helmut Müller, Robin Wait, Jeremy Saklatvala, Päivi M. Ojala, M. Lienhard Schmitz, Michael Naumann & Michael Kracht. (2012) Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression. PLoS ONE 7:12, pages e51847.
Crossref
Katia Coulonval, Hugues Kooken & Pierre P. Roger. (2011) Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation. Molecular Biology of the Cell 22:21, pages 3971-3985.
Crossref
A. G. Trubitsyn. (2011) The mechanism of phenoptosis: 2. The Hayflick limit is caused by programmed decrease of the bioenergetics level. Advances in Gerontology 1:2, pages 134-139.
Crossref
Satoshi Ishizuka, Ken-ichi Saitoh, Takuya Suzuki, Jae-Sung Lee & Hiroshi Hara. (2011) A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells. Food Chemistry 125:4, pages 1219-1225.
Crossref
Jian-Ying Chuang & Jan-Jong Hung. (2011) Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway. Biochemical and Biophysical Research Communications 407:3, pages 587-592.
Crossref
Pierre Beukelaers, Renaud Vandenbosch, Nicolas Caron, Laurent Nguyen, Shibeshih Belachew, Gustave Moonen, Hiroaki Kiyokawa, Mariano Barbacid, David Santamaria & Brigitte Malgrange. (2011) Cdk6-Dependent Regulation of G1 Length Controls Adult Neurogenesis. Stem Cells 29:4, pages 713-724.
Crossref
Józefa Węsierska-Gądek, Margarita Maurer, Nora Zulehner & Oxana Komina. (2011) Whether to target single or multiple CDKs for therapy? That is the question. Journal of Cellular Physiology 226:2, pages 341-349.
Crossref
Xian Wang, Christopher Sistrunk & Marcelo L. Rodriguez-Puebla. (2011) Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis. The American Journal of Pathology 178:1, pages 345-354.
Crossref
Lakshmi Gopinathan, Chandrahas Koumar Ratnacaram & Philipp Kaldis. 2011. Cell Cycle in Development. Cell Cycle in Development 365 389 .
Xia Chen, Jianzhong Li, Wei Hu, Shengli Yang & Yi Gong. (2010) Differential gene expression of human keratinocyte HaCaT cells induced by fibroblast growth factor 10 treatment. Molecular and Cellular Biochemistry 342:1-2, pages 71-85.
Crossref
Sara Blancquaert, Lifu Wang, Sabine Paternot, Katia Coulonval, Jacques E. Dumont, Thurl E. Harris & Pierre P. Roger. (2010) cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4. Molecular Endocrinology 24:7, pages 1453-1468.
Crossref
Felipe C. Gomes, Nahla Osman M. Ali, Elaine Brown, Roderick G. Walker, Karen M. Grant & Jeremy C. Mottram. (2010) Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. Molecular and Biochemical Parasitology 171:2, pages 89-96.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.