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Article

Differential Modification of p27Kip1 Controls Its Cyclin D-cdk4 Inhibitory Activity

Melissa K. James1 Program in Molecular and Cellular Biology of the School of Graduate Studies
,
Arpita Ray1 Program in Molecular and Cellular Biology of the School of Graduate Studies
,
Dina Leznova2 Departments of Pediatrics and Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York11203
&
Stacy W. Blain2 Departments of Pediatrics and Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York11203Correspondence[email protected]
Pages 498-510 | Received 20 Nov 2006, Accepted 18 Sep 2007, Published online: 27 Mar 2023

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Wei Li, Jamie Katy Hu & Miaofen G Hu. (2023) CDK6: an attractive therapeutic target for T-ALL/LBL. Expert Opinion on Therapeutic Targets 27:11, pages 1087-1096.
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Sarah E. Nataraj & Stacy W. Blain. (2021) A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity. Cell Cycle 20:8, pages 808-818.
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Sung Hee Choi, Emily C. Barker, Kyle J. Gerber, John J. Letterio & Byung-Gyu Kim. (2020) Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4. OncoImmunology 9:1.
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Gustavo Baldassarre & Barbara Belletti. (2016) Meet me in the cytoplasm: A role for p27Kip1 in the control of H-Ras. Small GTPases 7:2, pages 71-75.
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Priyank Patel, Benedikt Asbach, Elina Shteyn, Cindy Gomez, Alexander Coltoff, Sadia Bhuyan, Angela L. Tyner, Ralf Wagner & Stacy W. Blain. (2015) Brk/Protein Tyrosine Kinase 6 Phosphorylates p27KIP1, Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4. Molecular and Cellular Biology 35:9, pages 1506-1522.
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Debora Bencivenga, Annunziata Tramontano, Alessia Borgia, Aide Negri, Ilaria Caldarelli, Adriana Oliva, Silverio Perrotta, Fulvio Della Ragione & Adriana Borriello. (2014) p27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases. Cell Cycle 13:23, pages 3768-3782.
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Antonio Cerqueira, Alberto Martín, Catherine E. Symonds, Junko Odajima, Pierre Dubus, Mariano Barbacid & David Santamaría. (2014) Genetic Characterization of the Role of the Cip/Kip Family of Proteins as Cyclin-Dependent Kinase Inhibitors and Assembly Factors. Molecular and Cellular Biology 34:8, pages 1452-1459.
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Heidelinde Jäkel, Ines Peschel, Clarissa Kunze, Christina Weinl & Ludger Hengst. (2012) Regulation of p27 by mitogen-induced tyrosine phosphorylation. Cell Cycle 11:10, pages 1910-1917.
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Bobby Bhatia, Arfa Malik, Africa Fernandez-L & Anna M. Kenney. (2010) p27Kip1, a double-edged sword in Shh-mediated medulloblastoma. Cell Cycle 9:21, pages 4307-4314.
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Laurence Bockstaele, Xavier Bisteau, Sabine Paternot & Pierre P. Roger. (2009) Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation. Molecular and Cellular Biology 29:15, pages 4188-4200.
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Arpita Ray, Melissa K. James, Stéphane Larochelle, Robert P. Fisher & Stacy W. Blain. (2009) p27Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes. Molecular and Cellular Biology 29:4, pages 986-999.
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Michelle D. Larrea, Jiyong Liang, Thiago Da Silva, Feng Hong, Shan H. Shao, Kathy Han, D. Dumont & Joyce M. Slingerland. (2008) Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4. Molecular and Cellular Biology 28:20, pages 6462-6472.
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