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Molecular and Cellular Biology Volume 15, 1995 - Issue 4
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Research Article

The Orphan Receptor Hepatic Nuclear Factor 4 Functions as a Transcriptional Activator for Tissue-Specific and Hypoxia-Specific Erythropoietin Gene Expression and Is Antagonized by EAR3/COUP-TF1

Deborah L. Galson1 Division of Hematology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts02115
,
Terumasa Tsuchiya1 Division of Hematology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts02115
,
Drory S. Tendler1 Division of Hematology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts02115
,
L. Eric Huang1 Division of Hematology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts02115
,
Yan Ren1 Division of Hematology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts02115
,
Toshihiko Ogura2 Gene Expression Laboratory, Salk Institute for Biological Studies, and Howard Hughes Medical Institute, La Jolla, California92186
&
H. Franklin Bunn1 Division of Hematology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts02115Correspondence[email protected]
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Pages 2135-2144 | Received 09 Aug 1994, Accepted 19 Jan 1995, Published online: 30 Mar 2023

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Norio Suzuki, Naoshi Obara, Xiaoqing Pan, Miho Watanabe, Kou-Ichi Jishage, Naoko Minegishi & Masayuki Yamamoto. (2011) Specific Contribution of the Erythropoietin Gene 3′ Enhancer to Hepatic Erythropoiesis after Late Embryonic Stages. Molecular and Cellular Biology 31:18, pages 3896-3905.
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Shingo Kajimura, Katsumi Aida & Cunming Duan. (2006) Understanding Hypoxia-Induced Gene Expression in Early Development: In Vitro and In Vivo Analysis of Hypoxia-Inducible Factor 1-Regulated Zebra Fish Insulin-Like Growth Factor Binding Protein 1 Gene Expression. Molecular and Cellular Biology 26:3, pages 1142-1155.
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Stephen C. Land. (2003) Oxygen-sensing pathways and the development of mammalian gas exchange. Redox Report 8:6, pages 325-340.
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Tomoyuki Yano, Takashi Kishimoto, Utano Tomaru, You Kawarada, Hiroyuki Kato, Takashi Yoshiki & Hiroshi Ishikura. (2003) Further evidence of hepatic transdifferentiation in hepatoid adenocarcinomas of the stomach: quantitative analysis of mRNA for albumin and hepatocyte nuclear factor-4α. Pathology 35:1, pages 75-78.
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Ryuzo SASAKI, Seiji MASUDA & Masaya NAGAO. (2000) Erythropoietin: Multiple Physiological Functions and Regulation of Biosynthesis. Bioscience, Biotechnology, and Biochemistry 64:9, pages 1775-1793.
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Benjamin L. Ebert & H. Franklin Bunn. (1998) Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein. Molecular and Cellular Biology 18:7, pages 4089-4096.
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G. Achatz, B. Hölzl, R. Speckmayer, C. Hauser, F. Sandhofer & B. Paulweber. (1997) Functional Domains of the Human Orphan Receptor ARP-1/ COUP-TFII Involved in Active Repression and Transrepression. Molecular and Cellular Biology 17:9, pages 4914-4932.
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Benoît Viollet, Axel Kahn & Michel Raymondjean. (1997) Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4. Molecular and Cellular Biology 17:8, pages 4208-4219.
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Bei Hu, Elizabeth Wright, Laura Campbell & K. L. Blanchard. (1997) In Vivo Analysis of DNA-Protein Interactions on the Human Erythropoietin Enhancer. Molecular and Cellular Biology 17:2, pages 851-856.
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Sohail Malik & Sotirios K. Karathanasis. (1996) TFIIB-Directed Transcriptional Activation by the Orphan Nuclear Receptor Hepatocyte Nuclear Factor 4. Molecular and Cellular Biology 16:4, pages 1824-1831.
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G. L. Wang & G. L. Semenza. (1996) Oxygen sensing and response to hypoxia by mammalian cells. Redox Report 2:2, pages 89-96.
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