15
Views
181
CrossRef citations to date
0
Altmetric
Research Article

The Structure and Function of P55PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

, , , , , , , & show all
Pages 4453-4465 | Received 15 Mar 1995, Accepted 18 May 1995, Published online: 30 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (17)

Chaoxing Li, Wenwen Li, Xiyao Cheng, Dapeng Zhang, Xiang Sun, Jingjing Zhou, Yin Zhou, Yongqi Huang, Xianmin Xia, Qi Ma & Zhengding Su. (2020) P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain. OncoTargets and Therapy 13, pages 5177-5190.
Read now
Mohsen Aghaei, Ali Khodadadian, Karimi-Nazari Elham, Majid Nazari & Emad Babakhanzadeh. (2020) Major miRNA Involved in Insulin Secretion and Production in Beta-Cells. International Journal of General Medicine 13, pages 89-97.
Read now
Attila Mokánszki, Zsuzsanna Molnár, Emese Varga Tóthné, Béla Bodnár, Attila Jakab, Bálint L. Bálint & István Balogh. (2020) Altered microRNAs expression levels of sperm and seminal plasma in patients with infertile ejaculates compared with normozoospermic males. Human Fertility 23:4, pages 246-255.
Read now
Sidikjan Ibrahim, Guodong Li, Fuqing Hu, Zhenlin Hou, Qianzhi Chen, Geng Li, Xuelai Luo, Junbo Hu & Yongdong Feng. (2018) PIK3R3 promotes chemotherapeutic sensitivity of colorectal cancer through PIK3R3/NF-kB/TP pathway. Cancer Biology & Therapy 19:3, pages 222-229.
Read now
Minchul Seo, Jong-Heon Kim & Kyoungho Suk. (2017) Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators. Cell Adhesion & Migration 11:3, pages 205-210.
Read now
Meilin Ma, Xiangming Wang, Xiaochang Chen, Rui Cai, Fenfen Chen, Wuzi Dong, Gongshe Yang & Weijun Pang. (2017) MicroRNA-432 targeting E2F3 and P55PIK inhibits myogenesis through PI3K/AKT/mTOR signaling pathway. RNA Biology 14:3, pages 347-360.
Read now
Saskia M. Brachmann, Claudine M. Yballe, Metello Innocenti, Jonathan A. Deane, David A. Fruman, Sheila M. Thomas & Lewis C. Cantley. (2005) Role of Phosphoinositide 3-Kinase Regulatory Isoforms in Development and Actin Rearrangement. Molecular and Cellular Biology 25:7, pages 2593-2606.
Read now
Dong Chen, Franck Mauvais-Jarvis, Matthias Bluher, Simon J. Fisher, Alison Jozsi, Laurie J. Goodyear, Kohjiro Ueki & C. Ronald Kahn. (2004) p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity. Molecular and Cellular Biology 24:1, pages 320-329.
Read now
Xianmin Xia, Aiwu Cheng, Damilola Akinmade & Anne W. Hamburger. (2003) The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest. Molecular and Cellular Biology 23:5, pages 1717-1725.
Read now
Kohjiro Ueki, David A. Fruman, Saskia M. Brachmann, Yu-Hua Tseng, Lewis C. Cantley & C. Ronald Kahn. (2002) Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival. Molecular and Cellular Biology 22:3, pages 965-977.
Read now
Kohjiro Ueki, Petra Algenstaedt, Franck Mauvais-Jarvis & C. Ronald Kahn. (2000) Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit. Molecular and Cellular Biology 20:21, pages 8035-8046.
Read now
Lynne Yenush, Christine Zanella, Tohru Uchida, Dolores Bernal & Morris F. White. (1998) The Pleckstrin Homology and Phosphotyrosine Binding Domains of Insulin Receptor Substrate 1 Mediate Inhibition of Apoptosis by Insulin. Molecular and Cellular Biology 18:11, pages 6784-6794.
Read now
Wendy J. Kivens, Stephen W. Hunt$suffix/text()$suffix/text(), James L. Mobley, Traci Zell, Cheryl L. Dell, Barbara E. Bierer & Yoji Shimizu. (1998) Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase. Molecular and Cellular Biology 18:9, pages 5291-5307.
Read now
Jinghua Yu, Yitao Zhang, James McIlroy, Tamara Rordorf-Nikolic, George A. Orr & Jonathan M. Backer. (1998) Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit. Molecular and Cellular Biology 18:3, pages 1379-1387.
Read now
James McIlroy, Daxin Chen, Christina Wjasow, Tamar Michaeli & Jonathan M. Backer. (1997) Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways. Molecular and Cellular Biology 17:1, pages 248-255.
Read now
Martin G. Myers$suffix/text()$suffix/text(), Yitao Zhang, Gladys A. I. Aldaz, Timothy Grammer, Erin M. Glasheen, Lynne Yenush, Ling Mei Wang, Xiao Jian Sun, John Blenis, Jacalyn H. Pierce & Morris F. White. (1996) YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites. Molecular and Cellular Biology 16:8, pages 4147-4155.
Read now
David A. Antonetti, Petra Algenstaedt & C. Ronald Kahn. (1996) Insulin Receptor Substrate 1 Binds Two Novel Splice Variants of the Regulatory Subunit of Phosphatidylinositol 3-Kinase in Muscle and Brain. Molecular and Cellular Biology 16:5, pages 2195-2203.
Read now

Articles from other publishers (164)

Pinaki Chaudhuri, Priya Putta, Linda M. Graham & Michael A. Rosenbaum. (2023) p85α regulatory subunit isoform controls PI3-kinase and TRPC6 membrane translocation. Cell Calcium 111, pages 102718.
Crossref
Liuqing Yang, Wenxue Liu, Linyuan Shi, Jing Wu, Wenchi Zhang, Yang-An Chuang, Javier Redding-Ochoa, Alfredo Kirkwood, Alena V. Savonenko & Paul F. Worley. (2023) NMDA Receptor–Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer’s Disease. Biological Psychiatry.
Crossref
Jianzhang Yang, Yu Chang, Jean Ching-Yi Tien, Zhen Wang, Yang Zhou, Pujuan Zhang, Weixue Huang, Josh Vo, Ingrid J. Apel, Cynthia Wang, Victoria Zhixuan Zeng, Yunhui Cheng, Shuqin Li, George Xiaoju Wang, Arul M. Chinnaiyan & Ke Ding. (2022) Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13. Journal of Medicinal Chemistry 65:16, pages 11066-11083.
Crossref
Tihitina Y. Aytenfisu, Hannah M. Campbell, Mayukh Chakrabarti, L. Mario Amzel & Sandra B. Gabelli. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 3 49 .
Ying Jiang, Yi Shen, Liyan Ding, Shengli Xia & Liying Jiang. (2021) Identification of transcription factors and construction of a novel miRNA regulatory network in primary osteoarthritis by integrated analysis. BMC Musculoskeletal Disorders 22:1.
Crossref
Neda Saebnia, Zeinab Neshati & Ahmad Reza Bahrami. (2021) Role of microRNAs in etiology of azoospermia and their application as non-invasive biomarkers in diagnosis of azoospermic patients. Journal of Gynecology Obstetrics and Human Reproduction 50:10, pages 102207.
Crossref
Ting Wang, Xiaohui Du, Zhihua Wang, Yiya Gu, Qian Huang, Jixing Wu, Yuan Zhan, Jinkun Chen, Chengfeng Xiao & Jungang Xie. (2021) p55PIK deficiency and its NH 2 -terminal derivative inhibit inflammation and emphysema in COPD mouse model . American Journal of Physiology-Lung Cellular and Molecular Physiology 321:1, pages L159-L173.
Crossref
Raju V.S. Rajala. (2021) Signaling roles of phosphoinositides in the retina. Journal of Lipid Research 62, pages 100041.
Crossref
Meijuan Zhu, Hongxia Yang, Zhen Chen, Xianmin Xia, Qinqin Deng & Yin Shen. (2020) A cell-permeable peptide inhibitor of p55PIK signaling alleviates ocular inflammation in mouse models of uveitis. Experimental Eye Research 199, pages 108180.
Crossref
Sidikjan Ibrahim, Xu Zhu, Xuelai Luo, Yongdong Feng & Jing Wang. (2020) PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease. International Immunopharmacology 85, pages 106610.
Crossref
Jesús Vallejo-Díaz, Monica Chagoyen, Manuel Olazabal-Morán, Ana González-García & Ana Clara Carrera. (2019) The Opposing Roles of PIK3R1/p85α and PIK3R2/p85β in Cancer. Trends in Cancer 5:4, pages 233-244.
Crossref
Elizabeth Michele Davies, Rajendra Gurung, Kai Qin Le & Christina Anne Mitchell. (2019) Effective angiogenesis requires regulation of phosphoinositide signaling. Advances in Biological Regulation 71, pages 69-78.
Crossref
Blanca Torroba, Antonio Herrera, Anghara Menendez & Sebastian Pons. (2018) PI3K regulates intraepithelial cell positioning through Rho GTP-ases in the developing neural tube. Developmental Biology 436:1, pages 42-54.
Crossref
Xi Yang, Yinjia Fu, Fuqing Hu, Xuelai Luo, Junbo Hu & Guihua Wang. (2018) PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis. Experimental & Molecular Medicine 50:1, pages e431-e431.
Crossref
Tanja Güntert, Max Gassmann & Omolara O. Ogunshola. (2016) Temporal Rac1 – HIF-1 crosstalk modulates hypoxic survival of aged neurons. Brain Research 1642, pages 298-307.
Crossref
Senyan Lai, Guihua Wang, Xiaonian Cao, Xuelai Luo, Guoping Wang, Xianmin Xia, Junbo Hu & Jing Wang. (2015) KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors. Oncotarget 7:2, pages 1367-1379.
Crossref
Jiaojiao Guo, Ning Xie, Geng Li, Yan Zhang, Fengxiang Lv, Sile Guo, Yuanqing Feng, Chun-Mei Cao & Rui-Ping Xiao. (2015) p55γ functional mimetic peptide N24 blocks vascular proliferative disorders. Journal of Molecular Medicine 93:10, pages 1107-1118.
Crossref
G Wang, X Cao, S Lai, X Luo, Y Feng, J Wu, Q Ning, X Xia, J Wang, J Gong & J Hu. (2014) Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. Oncogene 34:7, pages 912-921.
Crossref
Geng Li, Ning Xie, Yuan Yao, Yan Zhang, Jiaojiao Guo, Yuanqing Feng, Fengxiang Lv, Rui-Ping Xiao & Chun-Mei Cao. (2015) Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation. Cardiovascular Research 105:1, pages 75-85.
Crossref
Christian Hiepen, Andreas Benn, Agnieszka Denkis, Ilya Lukonin, Christoph Weise, Jan H Boergermann & Petra Knaus. (2014) BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex. BMC Biology 12:1.
Crossref
Y Zhou, F Li, X Tian, B Wang, M Ding & H Pang. (2013) Changes in phosphatidylinositol 3-kinase 55 kDa gamma expression and subcellular localization may be caspase 6 dependent in paraquat-induced SH-SY5Y apoptosis. Human & Experimental Toxicology 33:7, pages 761-771.
Crossref
Guihua Wang, Xi Yang, Chuan Li, Xiaonian Cao, Xuelai Luo & Junbo Hu. (2014) PIK3R3 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Colorectal Cancer. Molecular Cancer Therapeutics 13:7, pages 1837-1847.
Crossref
Katsuya Sato, Takahiro Suzuki, Yoshihiro Yamaguchi, Yukio Kitade, Takahiro Nagase & Hiroshi Ueda. (2014) PLEKHG2/FLJ00018, a Rho family-specific guanine nucleotide exchange factor, is tyrosine phosphorylated via the EphB2/cSrc signaling pathway. Cellular Signalling 26:4, pages 691-696.
Crossref
Elisa Ciraolo, Federico Gulluni & Emilio Hirsch. 2014. Cell-wide Metabolic Alterations Associated with Malignancy. Cell-wide Metabolic Alterations Associated with Malignancy 115 140 .
Guihua Wang, Xiaonian Cao, Senyan Lai, Xuelai Luo, Yongdong Feng, Xianmin Xia, Paul M. Yen, Jianping Gong & Junbo Hu. (2013) PI3K Stimulates DNA Synthesis and Cell-Cycle Progression via Its p55PIK Regulatory Subunit Interaction with PCNA. Molecular Cancer Therapeutics 12:10, pages 2100-2109.
Crossref
Wei Wu, Yufeng Qin, Zheng Li, Jing Dong, Juncheng Dai, Chuncheng Lu, Xuejiang Guo, Yang Zhao, Yong Zhu, Wei Zhang, Bo Hang, Jiahao Sha, Hongbing Shen, Yankai Xia, Zhibin Hu & Xinru Wang. (2013) Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. Human Reproduction 28:7, pages 1827-1836.
Crossref
Yu Deng, Jing Wang, Guihua Wang, Yuan Jin, Xuelai Luo, Xianmin Xia, Jianping Gong & Junbo Hu. (2013) p55PIK Transcriptionally Activated by MZF1 Promotes Colorectal Cancer Cell Proliferation. BioMed Research International 2013, pages 1-10.
Crossref
Jin Zhou, Geng Bo Chen, Yew Chung Tang, Rohit Anthony Sinha, Yonghui Wu, Chui Sun Yap, Guihua Wang, Junbo Hu, Xianmin Xia, Patrick Tan, Liang Kee Goh & Paul Michael Yen. (2012) Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC Medical Genomics 5:1.
Crossref
J A Brazzatti, M Klingler-Hoffmann, S Haylock-Jacobs, Y Harata-Lee, M Niu, M D Higgins, M Kochetkova, P Hoffmann & S R McColl. (2011) Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis. Oncogene 31:18, pages 2350-2361.
Crossref
Subha Krishnan, Raghuveer Singh Mali, Baskar Ramdas, Emily Sims, Peilin Ma, Joydeep Ghosh, Veerendra Munugalavadla, Philip Hanneman, Joal D. Beane & Reuben Kapur. (2012) p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis. Blood 119:17, pages 3951-3961.
Crossref
Yenny Y. Acosta, Maria Paz Zafra, Gloria Ojeda, Ilaria Seren Bernardone, Umberto Dianzani, Pilar Portolés & Jose M. Rojo. (2010) Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278). Cellular and Molecular Life Sciences 68:18, pages 3065-3079.
Crossref
Jonathon N. Winnay & C. Ronald Kahn. 2011. The Unfolded Protein Response and Cellular Stress, Part B. The Unfolded Protein Response and Cellular Stress, Part B 147 158 .
Raju V.S Rajala. (2010) Phosphoinositide 3-kinase signaling in the vertebrate retina. Journal of Lipid Research 51:1, pages 4-22.
Crossref
David A. Fruman. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 225 244 .
L. Salazar, T. Kashiwada, P. Krejci, P. Muchowski, D. Donoghue, W. R. Wilcox & L. M. Thompson. (2009) A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells. Human Molecular Genetics 18:11, pages 1951-1961.
Crossref
Klaartje Kok, Barbara Geering & Bart Vanhaesebroeck. (2009) Regulation of phosphoinositide 3-kinase expression in health and disease. Trends in Biochemical Sciences 34:3, pages 115-127.
Crossref
Yogesh Dwivedi, Hooriyah S Rizavi, Tara Teppen, Hui Zhang, Amal Mondal, Rosalinda C Roberts, Robert R Conley & Ghanshyam N Pandey. (2007) Lower Phosphoinositide 3-Kinase (PI 3-kinase) Activity and Differential Expression Levels of Selective Catalytic and Regulatory PI 3-Kinase Subunit Isoforms in Prefrontal Cortex and Hippocampus of Suicide Subjects. Neuropsychopharmacology 33:10, pages 2324-2340.
Crossref
Anna Malyala, Chunguang Zhang, Damani N. Bryant, Martin J. Kelly & Oline K. Rønnekleiv. (2008) PI3K signaling effects in hypothalamic neurons mediated by estrogen. The Journal of Comparative Neurology 506:6, pages 895-911.
Crossref
Yuichi Ikegami, Kouichi Inukai, Takuya Awata, Tomoichiro Asano & Shigehiro Katayama. (2008) SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1. Biochemical and Biophysical Research Communications 365:3, pages 433-438.
Crossref
Jan Domin. 2008. EGFR Signaling Networks in Cancer Therapy. EGFR Signaling Networks in Cancer Therapy 91 111 .
Nir Etkovitz, Sara Rubinstein, Limor Daniel & Haim Breitbart. (2007) Role of PI3-Kinase and PI4-Kinase in Actin Polymerization During Bovine Sperm Capacitation1. Biology of Reproduction 77:2, pages 263-273.
Crossref
Anders Kallin, Lene E. Johannessen, Patrice D. Cani, Catherine Y. Marbehant, Ahmed Essaghir, Fabienne Foufelle, Pascal Ferré, Carl-Henrik Heldin, Nathalie M. Delzenne & Jean-Baptiste Demoulin. (2007) SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55γ. Journal of Lipid Research 48:7, pages 1628-1636.
Crossref
Liliana SoroceanuSamir KharbandaRuihuan ChenRobert H. SorianoKen Aldape, Anjan Misra, Jiping ZhaWilliam F. Forrest, Janice M. Nigro, Zora ModrusanBurt G. Feuerstein & Heidi S. Phillips. (2007) Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proceedings of the National Academy of Sciences 104:9, pages 3466-3471.
Crossref
Tomoichiro Asano, Midori Fujishiro, Akifumi Kushiyama, Yusuke Nakatsu, Masayasu Yoneda, Hideaki Kamata & Hideyuki Sakoda. (2007) Role of Phosphatidylinositol 3-Kinase Activation on Insulin Action and Its Alteration in Diabetic Conditions. Biological and Pharmaceutical Bulletin 30:9, pages 1610-1616.
Crossref
Yoko Takahashi, Jackie A. Lavigne, Stephen D. Hursting, Gadisetti V.R. Chandramouli, Susan N. Perkins, Young S. Kim & Thomas T.Y. Wang. (2006) Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: A comparison study using DNA microarray. Molecular Carcinogenesis 45:12, pages 943-956.
Crossref
Naim Shehadeh, Igor Sukhotnik & Raanan Shamir. (2006) Gastrointestinal Tract as a Target Organ for Orally Administered Insulin. Journal of Pediatric Gastroenterology & Nutrition 43:3, pages 276-281.
Crossref
Julia C. Mallory, Gerard Crudden, Amelia Oliva, Christopher Saunders, Arnold Stromberg & Rolf J. Craven. (2005) A Novel Group of Genes Regulates Susceptibility to Antineoplastic Drugs in Highly Tumorigenic Breast Cancer Cells. Molecular Pharmacology 68:6, pages 1747-1756.
Crossref
A. Lulu Strat, Theresa A. Kokta, Michael V. Dodson, Arieh Gertler, Zida Wu & Rodney A. Hill. (2005) Early signaling interactions between the insulin and leptin pathways in bovine myogenic cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1744:2, pages 164-175.
Crossref
Kathrine Abell, Antonio Bilancio, Richard W. E. Clarkson, Paul G. Tiffen, Anton I. Altaparmakov, Thomas G. Burdon, Tomoichiro Asano, Bart Vanhaesebroeck & Christine J. Watson. (2005) Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nature Cell Biology 7:4, pages 392-398.
Crossref
I M Aparicio, M C Gil, M Garcia-Herreros, F J Peña & L J Garcia-Marin. (2005) Inhibition of phosphatidylinositol 3-kinase modifies boar sperm motion parameters. Reproduction 129:3, pages 283-289.
Crossref
Erik Procko & Shaun R. McColl. (2005) Leukocytes on the move with phosphoinositide 3-kinase and its downstream effectors. BioEssays 27:2, pages 153-163.
Crossref
P. R. Shepherd. (2005) Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues. Acta Physiologica Scandinavica 183:1, pages 3-12.
Crossref
Cristina M. Rondinone, Jill Clampit, Rebecca J. Gum, Bradley A. Zinker, Michael R. Jirousek & James M. Trevillyan. (2004) Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms. Biochemical and Biophysical Research Communications 323:2, pages 652-659.
Crossref
Miyuki Ihara-Watanabe, Takayuki Uchihashi, Yoshiteru Miyauchi, Norio Sakai, Masayo Yamagata, Keiichi Ozono & Toshimi Michigami. (2004) Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: Application of a gene-trap mutagenesis. Journal of Cellular Biochemistry 93:2, pages 418-426.
Crossref
Rodney A. Hill, A. Lulu Strat, Nikki J. Hughes, Theresa J. Kokta, Michael V. Dodson & Arieh Gertler. (2004) Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1693:3, pages 205-211.
Crossref
Jodel Giraud, Rebecca Leshan, Yong-Hee Lee & Morris F. White. (2004) Nutrient-dependent and Insulin-stimulated Phosphorylation of Insulin Receptor Substrate-1 on Serine 302 Correlates with Increased Insulin Signaling. Journal of Biological Chemistry 279:5, pages 3447-3454.
Crossref
E Garcia-Galloway, C Arango, S Pons & I Torres-Aleman. (2003) Glutamate excitotoxicity attenuates insulin-like growth factor-i prosurvival signaling. Molecular and Cellular Neuroscience 24:4, pages 1027-1037.
Crossref
Kohjiro Ueki, David A. Fruman, Claudine M. Yballe, Mathias Fasshauer, Johannes Klein, Tomoichiro Asano, Lewis C. Cantley & C. Ronald Kahn. (2003) Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling. Journal of Biological Chemistry 278:48, pages 48453-48466.
Crossref
Bryan A. Ballif, Lionel Arnaud & Jonathan A. Cooper. (2003) Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Molecular Brain Research 117:2, pages 152-159.
Crossref
Analia Bortolozzi, Merce Amargos-Bosch, Albert Adell, Llorenc Diaz-Mataix, Jordi Serrats, Sebastia Pons & Francesc Artigas. (2003) In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT2A receptors: effect of antipsychotic drugs. European Journal of Neuroscience 18:5, pages 1235-1246.
Crossref
Leonard J. Appleman & Vassiliki A. Boussiotis. (2003) T cell anergy and costimulation. Immunological Reviews 192:1, pages 161-180.
Crossref
Pablo Mendez, Iñigo Azcoitia & Luis M. Garcia-Segura. (2003) Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Molecular Brain Research 112:1-2, pages 170-176.
Crossref
Daniel Hallmann, Katja Trümper, Heidi Trusheim, Kohjiro Ueki, C. Ronald Kahn, Lewis C. Cantley, David A. Fruman & Dieter Hörsch. (2003) Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α. Journal of Biological Chemistry 278:7, pages 5099-5108.
Crossref
Morris F. White. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 409 419 .
Tai-Xing Cui, Hironori Nakagami, Clara Nahmias, Tetsuya Shiuchi, Yuko Takeda-Matsubara, Jian-Mei Li, Lan Wu, Masaru Iwai & Masatsugu Horiuchi. (2002) Angiotensin II Subtype 2 Receptor Activation Inhibits Insulin-Induced Phosphoinositide 3-Kinase and Akt and Induces Apoptosis in PC12W Cells. Molecular Endocrinology 16:9, pages 2113-2123.
Crossref
M Jücker, K Südel, S Horn, M Sickel, W Wegner, W Fiedler & RA Feldman. (2002) Expression of a mutated form of the p85α regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO). Leukemia 16:5, pages 894-901.
Crossref
Katrine Almind, Laurent Delahaye, Torben Hansen, Emmanuel Van Obberghen, Oluf Pedersen & C. Ronald Kahn. (2002) Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α. Proceedings of the National Academy of Sciences 99:4, pages 2124-2128.
Crossref
Kohjiro Ueki, Claudine M. Yballe, Saskia M. Brachmann, David Vicent, John M. Watt, C. Ronald Kahn & Lewis C. Cantley. (2001) Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences 99:1, pages 419-424.
Crossref
Franck Mauvais-Jarvis, Kohjiro Ueki, David A. Fruman, Michael F. Hirshman, Kei Sakamoto, Laurie J. Goodyear, Matteo Iannacone, Domenico Accili, Lewis C. Cantley & C. Ronald Kahn. (2002) Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation 109:1, pages 141-149.
Crossref
Vincent Aguirre, Eric D. Werner, Jodel Giraud, Yong Hee Lee, Steve E. Shoelson & Morris F. White. (2002) Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action. Journal of Biological Chemistry 277:2, pages 1531-1537.
Crossref
Alan R. Saltiel & C. Ronald Kahn. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:6865, pages 799-806.
Crossref
Renee Emkey & C. Ronald Kahn. 2011. Comprehensive Physiology. Comprehensive Physiology 413 433 .
Jos� L. Trejo & Sebasti�n Pons. (2001) Phosphatidylinositol-3-OH kinase regulatory subunits are differentially expressed during development of the rat cerebellum. Journal of Neurobiology 47:1, pages 39-50.
Crossref
Kouichi Inukai, Makoto Funaki, Motonobu Anai, Takehide Ogihara, Hideki Katagiri, Yasushi Fukushima, Hideyuki Sakoda, Yukiko Onishi, Hiraku Ono, Midori Fujishiro, Miho Abe, Yoshitomo Oka, Masatoshi Kikuchi & Tomoichiro Asano. (2001) Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. FEBS Letters 490:1-2, pages 32-38.
Crossref
Soheila MarandiNadine De KeyserAlain Saliez, Anne-Sophie MaernoudtEtienne Marc SokalCatherine StilmantMark H. Rider & Jean-Paul Buts. (2001) Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases. American Journal of Physiology-Gastrointestinal and Liver Physiology 280:2, pages G229-G240.
Crossref
Ryuichi AikawaMasao NawanoYaping GuHideki KatagiriTomoichiro AsanoWeidong ZhuRyozo NagaiIssei Komuro. (2000) Insulin Prevents Cardiomyocytes From Oxidative Stress–Induced Apoptosis Through Activation of PI3 Kinase/ Akt . Circulation 102:23, pages 2873-2879.
Crossref
Sebastian Pons & Ignacio Torres-Aleman. (2000) Insulin-like Growth Factor-I Stimulates Dephosphorylation of IκB through the Serine Phosphatase Calcineurin (Protein Phosphatase 2B). Journal of Biological Chemistry 275:49, pages 38620-38625.
Crossref
David A. Fruman, Franck Mauvais-Jarvis, Daniel A. Pollard, Claudine M. Yballe, Derek Brazil, Roderick T. Bronson, C. Ronald Kahn & Lewis C. Cantley. (2000) Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α. Nature Genetics 26:3, pages 379-382.
Crossref
Tomoichiro Asano, Akira Kanda, Hideki Katagiri, Masao Nawano, Takehide Ogihara, Kouichi Inukai, Motonobu Anai, Yasushi Fukushima, Yoshio Yazaki, Masatoshi Kikuchi, Roya Hooshmand-Rad, Carl-Henrik Heldin, Yoshitomo Oka & Makoto Funaki. (2000) p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity. Journal of Biological Chemistry 275:23, pages 17671-17676.
Crossref
Richard C. Hresko & Mike Mueckler. (2000) A Novel 68-kDa Adipocyte Protein Phosphorylated on Tyrosine in Response to Insulin and Osmotic Shock. Journal of Biological Chemistry 275:24, pages 18114-18120.
Crossref
Carl Sunshine, Sharon Francis & Kevin L. Kirk. (2000) Rab3B Regulates ZO-1 Targeting and Actin Organization in PC12 Neuroendocrine Cells. Experimental Cell Research 257:1, pages 1-10.
Crossref
Vincent Aguirre, Tohru Uchida, Lynne Yenush, Roger Davis & Morris F. White. (2000) The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307. Journal of Biological Chemistry 275:12, pages 9047-9054.
Crossref
Makoto Funaki, Hideki Katagiri, Kouichi Inukai, Masotoshi Kikuchi & Tomoichiro Asano. (2000) Structure and function of phosphatidylinositol-3,4 kinase. Cellular Signalling 12:3, pages 135-142.
Crossref
Wengui YuJessica CassaraPeter F. Weller. (2000) Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood 95:3, pages 1078-1085.
Crossref
Michael J. Quon & Simeon I. Taylor. 2000. Gene Engineering in Endocrinology. Gene Engineering in Endocrinology 17 38 .
Dieter H�rsch & C. Ronald Kahn. (1999) Region-specific mRNA expression of phosphatidylinositol 3-kinase regulatory isoforms in the central nervous system of C57BL/6J mice. The Journal of Comparative Neurology 415:1, pages 105-120.
Crossref
Lisa S. Smit, Debra J. Meyer, Lawrence S. Argetsinger, Jessica Schwartz & Christin Carter‐Su. 2011. Comprehensive Physiology. Comprehensive Physiology 445 480 .
Fredrik H Nystrom & Michael J Quon. (1999) Insulin Signalling. Cellular Signalling 11:8, pages 563-574.
Crossref
Tung O. ChanSusan E. RittenhousePhilip N. Tsichlis. (1999) AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation. Annual Review of Biochemistry 68:1, pages 965-1014.
Crossref
Sonja Krugmann, Phillip T. Hawkins, Nancy Pryer & Sylvia Braselmann. (1999) Characterizing the Interactions between the Two Subunits of the p101/p110γ Phosphoinositide 3-Kinase and Their Role in the Activation of This Enzyme by Gβγ Subunits. Journal of Biological Chemistry 274:24, pages 17152-17158.
Crossref
Mary C. Sugden, Mark J. Holness, Elaine Donald & Harjinder Lall. (1999) Substrate interactions in the short- and long-term regulation of renal glucose oxidation. Metabolism 48:6, pages 707-715.
Crossref
Caroline A Beeton, Pam Das, Michael D Waterfield & Peter R Shepherd. (1999) The SH3 and BH Domains of the p85α Adapter Subunit Play a Critical Role in Regulating Class Ia Phosphoinositide 3-Kinase Function. Molecular Cell Biology Research Communications 1:2, pages 153-157.
Crossref
Antti Virkamäki, Kohjiro Ueki & C. Ronald Kahn. (1999) Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. Journal of Clinical Investigation 103:7, pages 931-943.
Crossref
Ailsa G. Harpur, Meredith J. Layton, Pamela Das, Matthew J. Bottomley, George Panayotou, Paul C. Driscoll & Michael D. Waterfield. (1999) Intermolecular Interactions of the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase. Journal of Biological Chemistry 274:18, pages 12323-12332.
Crossref
Sven O. Johanson, Paul A. Naccache & Michael F. Crouch. (1999) A p85 Subunit-Independent p110α PI 3-Kinase Colocalizes with p70 S6 Kinase on Actin Stress Fibers and Regulates Thrombin-Stimulated Stress Fiber Formation in Swiss 3T3 Cells. Experimental Cell Research 248:1, pages 223-233.
Crossref
Yasuo Terauchi, Youki Tsuji, Shinobu Satoh, Hideaki Minoura, Koji Murakami, Akira Okuno, Kouichi Inukai, Tomoichiro Asano, Yasushi Kaburagi, Kohjiro Ueki, Hiromu Nakajima, Toshiaki Hanafusa, Yuji Matsuzawa, Hisahiko Sekihara, Yuxin Yin, J. Carl Barrett, Hideaki Oda, Takatoshi Ishikawa, Yasuo Akanuma, Issei Komuro, Misao Suzuki, Ken-ichi Yamamura, Tatsuhiko Kodama, Harumi Suzuki, Shigeo Koyasu, Shinichi Aizawa, Kazuyuki Tobe, Yasuhisa Fukui, Yoshio Yazaki & Takashi Kadowaki. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase. Nature Genetics 21:2, pages 230-235.
Crossref
Harumi SuzukiYasuo TerauchiMari FujiwaraShinichi AizawaYoshio YazakiTakashi KadowakiShigeo Koyasu. (1999) Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase . Science 283:5400, pages 390-392.
Crossref
Laurent DelahayeIsabelle Mothe-SatneyMartin G. Myers, Morris F. White & Emmanuel Van Obberghen. (1998) Interaction of Insulin Receptor Substrate-1 (IRS-1) with Phosphatidylinositol 3-Kinase: Effect of Substitution of Serine for Alanine in Potential IRS-1 Serine Phosphorylation Sites. Endocrinology 139:12, pages 4911-4919.
Crossref
Mercedes Blázquez, Peter T. Bosma, John P. ChangKevin Docherty & Vance L. Trudeau. (1998) γ-Aminobutyric Acid Up-Regulates the Expression of a Novel Secretogranin-II Messenger Ribonucleic Acid in the Goldfish Pituitary**The work was supported by the Welcome Trust (UK), Balaguer-Gonell Foundation (Spain), and Natural Sciences and Engineering Research Council (Canada).. Endocrinology 139:12, pages 4870-4880.
Crossref
Alexandre Arcaro, Stefano Volinia, Marketa J. Zvelebil, Rob Stein, Sandra J. Watton, Meredith J. Layton, Ivan Gout, Khatereh Ahmadi, Julian Downward & Michael D. Waterfield. (1998) Human Phosphoinositide 3-Kinase C2β, the Role of Calcium and the C2 Domain in Enzyme Activity. Journal of Biological Chemistry 273:49, pages 33082-33090.
Crossref
Matthias P Wymann & Luciano Pirola. (1998) Structure and function of phosphoinositide 3-kinases. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1436:1-2, pages 127-150.
Crossref
D.R. Alessi & C.P. Downes. (1998) The role of PI 3-kinase in insulin action. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1436:1-2, pages 151-164.
Crossref
Andreas Simm, Viviane Hoppe, Doris Karbach, Monika Leicht, Anke Fenn & Jürgen Hoppe. (1998) Late Signals from the PDGF Receptors Leading to the Activation of the p70S6-Kinase Are Necessary for the Transition from G1 to S phase in AKR-2B Cells. Experimental Cell Research 244:2, pages 379-393.
Crossref
Martin G. MyersJr.Jr., Raul Mendez, Ping Shi, Jacalyn H. Pierce, Robert Rhoads & Morris F. White. (1998) The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling. Journal of Biological Chemistry 273:41, pages 26908-26914.
Crossref
Yong-Jiang Hei. (1998) Recent progress in insulin signal transduction. Journal of Pharmacological and Toxicological Methods 40:3, pages 123-135.
Crossref
David A. FrumanRachel E. MeyersLewis C. Cantley. (1998) PHOSPHOINOSITIDE KINASES. Annual Review of Biochemistry 67:1, pages 481-507.
Crossref
Maria von Willebrand, Scott Williams, Pankaj Tailor & Tomas Mustelin. (1998) Phosphorylation of the Grb2- and Phosphatidylinositol 3-Kinase p85–binding p36/38 by Syk in Lck-Negative T Cells. Cellular Signalling 10:6, pages 407-413.
Crossref
Anne Marie Gagnon, Josée Chabot, Dheerja Pardasani & Alexander Sorisky. (1998) Extracellular matrix induced by TGFβ impairs insulin signal transduction in 3T3-L1 preadipose cells. Journal of Cellular Physiology 175:3, pages 370-378.
Crossref
R. Gregg Richards, Michael P. Walker, Joseph Sebastian & Richard P. DiAugustine. (1998) Insulin-like Growth Factor-1 (IGF-1) Receptor-Insulin Receptor Substrate Complexes in the Uterus. Journal of Biological Chemistry 273:19, pages 11962-11969.
Crossref
Bo-Chul Shin, Masakazu Suzuki, Kouichi Inukai, Motonobu Anai, Tomoichiro Asano & Kuniaki Takata. (1998) Multiple Isoforms of the Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI3-Kinase) Are Expressed in Neurons in the Rat Brain. Biochemical and Biophysical Research Communications 246:2, pages 313-319.
Crossref
Alirio J. Melendez, David J. Gillooly, Margaret M. Harnett & Janet M. Allen. (1998) Aggregation of the human high affinity immunoglobulin G receptor (FcγRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms. Proceedings of the National Academy of Sciences 95:5, pages 2169-2174.
Crossref
Bhakta R Dey, Richard W Furlanetto & S.Peter Nissley. (1998) Cloning of human p55γ, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. Gene 209:1-2, pages 175-183.
Crossref
Norman R. GeltzJames A. Augustine. (1998) The p85 and p110 Subunits of Phosphatidylinositol 3-Kinase-α Are Substrates, In Vitro, for a Constitutively Associated Protein Tyrosine Kinase in Platelets. Blood 91:3, pages 930-939.
Crossref
Norman R. GeltzJames A. Augustine. (1998) The p85 and p110 Subunits of Phosphatidylinositol 3-Kinase-α Are Substrates, In Vitro, for a Constitutively Associated Protein Tyrosine Kinase in Platelets. Blood 91:3, pages 930-939.
Crossref
Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery, Deborah J. Burks, Jian-Ming Ren, Stephen Previs, Yitao Zhang, Dolores Bernal, Sebastian Pons, Gerald I. Shulman, Susan Bonner-Weir & Morris F. White. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:6670, pages 900-904.
Crossref
Mohammed Taouis, Joelle Dupont, Anne Gillet, Michel Derouet & Jean Simon. (1998) Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC). Molecular and Cellular Endocrinology 137:2, pages 177-186.
Crossref
Perla Kaliman, Judith Canicio, Peter R. Shepherd, Carolyn A. Beeton, Xavier Testar, Manuel Palacín & Antonio Zorzano. (1998) Insulin-like Growth Factors Require Phosphatidylinositol 3-Kinase to Signal Myogenesis: Dominant Negative p85 Expression Blocks Differentiation of L6E9 Muscle Cells. Molecular Endocrinology 12:1, pages 66-77.
Crossref
Jeffrey A. Greenwood, Manuel A. Pallero, Anne B. Theibert & Joanne E. Murphy-Ullrich. (1998) Thrombospondin Signaling of Focal Adhesion Disassembly Requires Activation of Phosphoinositide 3-Kinase. Journal of Biological Chemistry 273:3, pages 1755-1763.
Crossref
Elizabeth A. Ottinger, Martyn C. Botfield & Steven E. Shoelson. (1998) Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling. Journal of Biological Chemistry 273:2, pages 729-735.
Crossref
Sandeep Robert Datta & Michael E. Greenberg. 1998. Hormones and Signaling. Hormones and Signaling 257 306 .
M. F. White & L. Yenush. 1998. Protein Modules in Signal Transduction. Protein Modules in Signal Transduction 179 208 .
Wataru Ogawa, Takashi Matozaki & Masato Kasuga. 1998. Insulin Action. Insulin Action 13 22 .
Morris F. White. 1998. Insulin Action. Insulin Action 3 11 .
Isabelle Mothe, Laurent Delahaye, Chantal Filloux, Sebastian Pons, Morris F. White & Emmanuel Van Obberghen. (1997) Interaction of Wild Type and Dominant-Negative p55PIK Regulatory Subunit of Phosphatidylinositol 3-Kinase with Insulin-Like Growth Factor-1 Signaling Proteins. Molecular Endocrinology 11:13, pages 1911-1923.
Crossref
Salvatore Sciacchitano & Simeon I. Taylor. (1997) Cloning, Tissue Expression, and Chromosomal Localization of the Mouse IRS-3 Gene. Endocrinology 138:11, pages 4931-4940.
Crossref
Deborah J. Burks, Sebastian Pons, Heather Towery, Jennifer Smith-Hall, Martin G. MyersJr.Jr., Lynne Yenush & Morris F. White. (1997) Heterologous Pleckstrin Homology Domains Do Not Couple IRS-1 to the Insulin Receptor. Journal of Biological Chemistry 272:44, pages 27716-27721.
Crossref
Takehide Ogihara, Toshiaki Isobe, Tohru Ichimura, Masato Taoka, Makoto Funaki, Hideyuki Sakoda, Yukiko Onishi, Kouichi Inukai, Motonobu Anai, Yasushi Fukushima, Masatoshi Kikuchi, Yoshio Yazaki, Yoshitomo Oka & Tomoichiro Asano. (1997) 14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain. Journal of Biological Chemistry 272:40, pages 25267-25274.
Crossref
Susanne Albert, Thomas Twardzik, Martin Heisenberg & Stephan Schneuwly. (1997) Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Gene 198:1-2, pages 181-189.
Crossref
Mark S. Burfoot, Neil C. Rogers, Diane Watling, Jon M. Smith, Sebastian Pons, Giacomo Paonessaw, Sandra Pellegrini, Morris F. White & Ian M. Kerr. (1997) Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons. Journal of Biological Chemistry 272:39, pages 24183-24190.
Crossref
Diana L. Esposito, Vicky A. Blakesley, Anatolii P. Koval, Angus G. Scrimgeour & Derek LeRoith. (1997) Tyrosine Residues in the C-Terminal Domain of the Insulin-Like Growth Factor-I Receptor Mediate Mitogenic and Tumorigenic Signals*. Endocrinology 138:7, pages 2979-2988.
Crossref
Peter R. Shepherd, Barbara T. Navé, Jorge Rincon, Lorraine A. Nolte, A. Paul Bevan, Kenneth Siddle, Juleen R. Zierath & Harriet Wallberg-Henriksson. (1997) Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle. Journal of Biological Chemistry 272:30, pages 19000-19007.
Crossref
Jennifer Smith-Hall, Sebastian Pons, Mary Elizabeth Patti, Deborah J. Burks, Lynne Yenush, Xiao Jian Sun, C. Ronald Kahn & Morris F. White. (1997) The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60 IRS3 ) in Adipose Cells . Biochemistry 36:27, pages 8304-8310.
Crossref
J. Domin & M.D. Waterfield. (1997) Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Letters 410:1, pages 91-95.
Crossref
Dominique Sawka-Verhelle, Véronique Baron, Isabelle Mothe, Chantal Filloux, Morris F. White & Emmanuel Van Obberghen. (1997) Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor. Journal of Biological Chemistry 272:26, pages 16414-16420.
Crossref
David Weinkove, Sally J. Leevers, Lindsay K. MacDougall & Michael D. Waterfield. (1997) p60 Is an Adaptor for the DrosophilaPhosphoinositide 3-Kinase, Dp110. Journal of Biological Chemistry 272:23, pages 14606-14610.
Crossref
Liza K.F. Ho, Dongxu Liu, Magdalena Rozycka, Richard A. Brown & Michael J. Fry. (1997) Identification of Four Novel Human Phosphoinositide 3-Kinases Defines a Multi-isoform Subfamily. Biochemical and Biophysical Research Communications 235:1, pages 130-137.
Crossref
Takehide Ogihara, Bo-Chul Shin, Motonobu Anai, Hideki Katagiri, Kouichi Inukai, Makoto Funaki, Yasushi Fukushima, Hisamitsu Ishihara, Kuniaki Takata, Masatoshi Kikuchi, Yoshio Yazaki, Yoshitomo Oka & Tomoichiro Asano. (1997) Insulin Receptor Substrate (IRS)-2 Is Dephosphorylated More Rapidly than IRS-1 via Its Association with Phosphatidylinositol 3-Kinase in Skeletal Muscle Cells. Journal of Biological Chemistry 272:19, pages 12868-12873.
Crossref
Guillaume Duménil, Michele Rubini, Garrett Dubois, Renato Baserga, Marc Fellous & Sandra Pellegrini. (1997) Identification of Signalling Components in Tyrosine Kinase Cascades Using Phosphopeptide Affinity Chromatography. Biochemical and Biophysical Research Communications 234:3, pages 748-753.
Crossref
Bart VanhaesebroeckMelanie J. WelhamKei KotaniRob SteinPatricia H. WarneMarkéta J. ZvelebilKyoichiro HigashiStefano VoliniaJulian DownwardMichael D. Waterfield. (1997) p110δ, a novel phosphoinositide 3-kinase in leukocytes. Proceedings of the National Academy of Sciences 94:9, pages 4330-4335.
Crossref
L.R Stephens, A Eguinoa, H Erdjument-Bromage, M Lui, F Cooke, J Coadwell, A.S Smrcka, M Thelen, K Cadwallader, P Tempst & P.T Hawkins. (1997) The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101. Cell 89:1, pages 105-114.
Crossref
Kouichi Inukai, Makoto Funaki, Takehide Ogihara, Hideki Katagiri, Akira Kanda, Motonobu Anai, Yasushi Fukushima, Toshio Hosaka, Masakazu Suzuki, Bo-Chul Shin, Kuniaki Takata, Yoshio Yazaki, Masatoshi Kikuchi, Yoshitomo Oka & Tomoichiro Asano. (1997) p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin. Journal of Biological Chemistry 272:12, pages 7873-7882.
Crossref
H. KatagiriT. AsanoK. InukaiT. OgiharaH. IshiharaY. ShibasakiT. MurataJ. TerasakiM. KikuchiY. YazakiY. Oka. (1997) Roles of PI 3-kinase and Ras on insulin-stimulated glucose transport in 3T3-L1 adipocytes. American Journal of Physiology-Endocrinology and Metabolism 272:2, pages E326-E331.
Crossref
Steven B. Waters, Kathleen H. Holt, Ann Louise Olson & Jeffrey E. Pessin. 1997. 161 202 .
A. Eguinoa, S. Krugmann, J. Coadwell, L. Stephens & P. Hawkins. 1997. Molecular Mechanisms of Signalling and Membrane Transport. Molecular Mechanisms of Signalling and Membrane Transport 175 188 .
P. De Meyts & K. Seedorf. 1997. Contributions of Physiology to the Understanding of Diabetes. Contributions of Physiology to the Understanding of Diabetes 89 107 .
Michelle M. Hill, Sharon F. Clark & David E. James. (1997) Insulin-regulatable phosphoproteins in 3T3-L1 adipocytes form detergent-insoluble complexes not associated with caveolin. Electrophoresis 18:14, pages 2629-2637.
Crossref
Ritsuko Yamamoto-Honda, Zen'ichiro Honda, Kohjiro Ueki, Kazuyuki Tobe, Yasushi Kaburagi, Yoshihiko Takahashi, Hiroyuki Tamemoto, Takeshi Suzuki, Kohji Itoh, Yasuo Akanuma, Yoshio Yazaki & Takashi Kadowaki. (1996) Mutant of Insulin Receptor Substrate-1 Incapable of Activating Phosphatidylinositol 3-Kinase Did Not Mediate Insulin-stimulated Maturation of Xenopus laevis Oocytes. Journal of Biological Chemistry 271:45, pages 28677-28681.
Crossref
Hans Joos, Sylvia Trouliaris, Gerd Helftenbein, Heiner Niemann & Teruko Tamura. (1996) Tyrosine Phosphorylation of the Juxtamembrane Domain of the v-Fms Oncogene Product Is Required for Its Association with a 55-kDa Protein. Journal of Biological Chemistry 271:40, pages 24476-24481.
Crossref
Franco Folli, Silvana Ghidella, Luca Bonfanti, C. Ronald Kahn & Adalberto Merighi. (1996) The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system. Molecular Neurobiology 13:2, pages 155-183.
Crossref
C Carpenter. (1996) Phosphoinositide 3-kinase and the regulation of cell growth. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1288:1, pages M11-M16.
Crossref
Jan Domin, Ritu Dhand & Michael D. Waterfield. (1996) Binding to the Platelet-derived Growth Factor Receptor Transiently Activates the p85α-p110α Phosphoinositide 3-Kinase Complex in Vivo. Journal of Biological Chemistry 271:35, pages 21614-21621.
Crossref
Jason Z. Morris, Heidi A. Tissenbaum & Gary Ruvkun. (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382:6591, pages 536-539.
Crossref
M. Kozak. (1996) Interpreting cDNA sequences: Some insights from studies on translation. Mammalian Genome 7:8, pages 563-574.
Crossref
Hideki Katagiri, Tomoichiro Asano, Hisamitsu Ishihara, Kouichi Inukai, Yoshikazu Shibasaki, Masatoshi Kikuchi, Yoshio Yazaki & Yoshitomo Oka. (1996) Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes. Journal of Biological Chemistry 271:29, pages 16987-16990.
Crossref
Isabelle Mothe & Emmanuel Van Obberghen. (1996) Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action. Journal of Biological Chemistry 271:19, pages 11222-11227.
Crossref
Xiao Jian Sun, Sebastian Pons, Tomoichiro Asano, Martin G. MyersJr.Jr., Erin Glasheen & Morris F. White. (1996) The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation. Journal of Biological Chemistry 271:18, pages 10583-10587.
Crossref
Stephen G. Ward, Carl H. June & Daniel Olive. (1996) PI 3-kinase: a pivotal pathway in T-cell activation?. Immunology Today 17:4, pages 187-197.
Crossref
Dominique Sawka-Verhelle, Sophie Tartare-Deckert, Morris F. White & Emmanuel Van Obberghen. (1996) Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591–786. Journal of Biological Chemistry 271:11, pages 5980-5983.
Crossref
Kouichi Inukai, Motonobu Anai, Eric Van Breda, Toshio Hosaka, Hideki Katagiri, Makoto Funaki, Yasushi Fukushima, Takehide Ogihara, Yoshio Yazaki, Masatoshi Kikuchi, Yoshitomo Oka & Tomoichiro Asano. (1996) A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene. Journal of Biological Chemistry 271:10, pages 5317-5320.
Crossref
Maria Willebrand, Thomas Jascur, Nathalie Bonnefoy-Berard, Hiroshi Yano, Amnon Altman, Yuzuru Matsuda & Tomas Mustelin. (1996) Inhibition of Phosphatidylinositol 3-Kinase Blocks T Cell Antigen Receptor/CD3-Induced Activation of the Mitogen-Activated Kinase Erk2. European Journal of Biochemistry 235:3, pages 828-835.
Crossref
Lindsay K. MacDougall, Jan Domin & Michael D. Waterfield. (1995) A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Current Biology 5:12, pages 1404-1415.
Crossref
Mary-Elizabeth Patti, Xiao-Jian Sun, Jens C. Bruening, Eiichi Araki, Myra A. Lipes, Morris F. White & C. Ronald Kahn. (1995) 4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice. Journal of Biological Chemistry 270:42, pages 24670-24673.
Crossref
Martin G. MyersJr.Jr. & Morris F. White. (1995) New frontiers in insulin receptor substrate signaling. Trends in Endocrinology & Metabolism 6:6, pages 209-215.
Crossref
A Chattopadhyay, H.L. James & D.S. Fair. (1992) Molecular recognition sites on factor Xa which participate in the prothrombinase complex.. Journal of Biological Chemistry 267:17, pages 12323-12329.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.