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Molecular and Cellular Biology Volume 17, 1997 - Issue 10
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Research Article

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

Kuo-Liang Wu1 Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Maureen Gannon2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Mina Peshavaria1 Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Martin F. Offield2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Eva Henderson1 Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Michael Ray2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Antonio Marks2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Laura W. Gamer2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232
,
Christopher V. E. Wright2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232
&
Roland Stein1 Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee37232;2 Department of Cell Biology, Vanderbilt Medical Center, Nashville, Tennessee37232Correspondence[email protected]
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Pages 6002-6013 | Received 27 Jan 1997, Accepted 30 Jun 1997, Published online: 29 Mar 2023

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Reshmi Dassaye, Strini Naidoo & Marlon E. Cerf. (2016) Transcription factor regulation of pancreatic organogenesis, differentiation and maturation. Islets 8:1, pages 13-34.
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Takeshi Miyatsuka, Taka-aki Matsuoka & Hideaki Kaneto. (2008) Transcription factors as therapeutic targets for diabetes. Expert Opinion on Therapeutic Targets 12:11, pages 1431-1442.
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Peter O. Wiebe, Jay D. Kormish, Venus T. Roper, Yoshio Fujitani, Ninche I. Alston, Kenneth S. Zaret, Christopher V. E. Wright, Roland W. Stein & Maureen Gannon. (2007) Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-Wide Pdx1 Expression. Molecular and Cellular Biology 27:11, pages 4093-4104.
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Matthew G. Hartman, Dan Lu, Mi-Lyang Kim, Gary J. Kociba, Tala Shukri, Jean Buteau, Xiaozhong Wang, Wendy L. Frankel, Denis Guttridge, Marc Prentki, Shane T. Grey, David Ron & Tsonwin Hai. (2004) Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis. Molecular and Cellular Biology 24:13, pages 5721-5732.
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Taka-aki Matsuoka, Li Zhao, Isabella Artner, Harry W. Jarrett, David Friedman, Anna Means & Roland Stein. (2003) Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells. Molecular and Cellular Biology 23:17, pages 6049-6062.
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Susan E. Samaras, Michelle A. Cissell, Kevin Gerrish, Christopher V. E. Wright, Maureen Gannon & Roland Stein. (2002) Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic β Cells: Role for Hepatocyte Nuclear Factor 3β and Pax6. Molecular and Cellular Biology 22:13, pages 4702-4713.
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Sonya Marshak, Etty Benshushan, Michal Shoshkes, Leora Havin, Erol Cerasi & Danielle Melloul. (2000) Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression. Molecular and Cellular Biology 20:20, pages 7583-7590.
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Patrick Jacquemin, Serge M. Durviaux, Jan Jensen, Catherine Godfraind, Gerard Gradwohl, François Guillemot, Ole D. Madsen, Peter Carmeliet, Mieke Dewerchin, Désiré Collen, Guy G. Rousseau & Frédéric P. Lemaigre. (2000) Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3. Molecular and Cellular Biology 20:12, pages 4445-4454.
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Galvin H. Swift, Ying Liu, Scott D. Rose, Larry J. Bischof, Scott Steelman, Arthur M. Buchberg, Christopher V. E. Wright & Raymond J. MacDonald. (1998) An Endocrine-Exocrine Switch in the Activity of the Pancreatic Homeodomain Protein PDX1 through Formation of a Trimeric Complex with PBX1b and MRG1 (MEIS2). Molecular and Cellular Biology 18:9, pages 5109-5120.
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