Citations (471)
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Giselle A. Joseph, Min Lu, Maria Radu, Jennifer K. Lee, Steven J. Burden, Jonathan Chernoff & Robert S. Krauss. (2017) Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro. Molecular and Cellular Biology 37:4.
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Fang Nie, Xiao-Feng Wang, Shi-Yi Zhao, Lan Bu & Xue-Hui Liu. (2015) Gene silencing of Rac1 with RNA interference mediated by ultrasound and microbubbles in human LoVo cells: evaluation of cell invasion inhibition and metastatic. Journal of Drug Targeting 23:4, pages 380-386.
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Pooneh Memar Ardestani & Fengyi Liang. (2012) Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells. Nucleus 3:5, pages 442-451.
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Zhuo-shen Zhao & Ed Manser. (2012) PAK family kinases. Cellular Logistics 2:2, pages 59-68.
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Yunbo Ke, Ming Lei, Xin Wang & R. John Solaro. (2012) Novel roles of PAK1 in the heart. Cellular Logistics 2:2, pages 89-94.
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Kazunori Kageyama, Naoki Tamasawa & Toshihiro Suda. (2011) Signal transduction in the hypothalamic corticotropin-releasing factor system and its clinical implications. Stress 14:4, pages 357-367.
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Xosé R. Bustelo. (2010)
A transcriptional cross–talk between RhoA and c–Myc inhibits the RhoA/Rock–dependent cytoskeleton
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Xiaodong Li, Funan Liu & Feng Li. (2010) PAK as a therapeutic target in gastric cancer. Expert Opinion on Therapeutic Targets 14:4, pages 419-433.
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Jeffrey M. Robens, Lee Yeow-Fong, Elsa Ng, Christine Hall & Ed Manser. (2010) Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization. Molecular and Cellular Biology 30:3, pages 829-844.
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Yunbo Ke & R John Solaro. (2008) Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation. Biologics: Targets and Therapy 2:4, pages 903-909.
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Salvatore J. Coniglio, Salvatore Zavarella & Marc H. Symons. (2008) Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms. Molecular and Cellular Biology 28:12, pages 4162-4172.
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Katharine J. M. Marler, Robert Kozma, Sohail Ahmed, Jing-Ming Dong, Christine Hall & Louis Lim. (2005) Outgrowth of Neurites from NIE-115 Neuroblastoma Cells Is Prevented on Repulsive Substrates through the Action of PAK. Molecular and Cellular Biology 25:12, pages 5226-5241.
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Ashok Pullikuth, Evangeline McKinnon, Hans-Joerg Schaeffer & Andrew D. Catling. (2005) The MEK1 Scaffolding Protein MP1 Regulates Cell Spreading by Integrating PAK1 and Rho Signals. Molecular and Cellular Biology 25:12, pages 5119-5133.
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Maddy Parsons, James Monypenny, Simon M. Ameer-Beg, Thomas H. Millard, Laura M. Machesky, Marion Peter, Melanie D. Keppler, Giampietro Schiavo, Rose Watson, Jonathan Chernoff, Daniel Zicha, Borivoj Vojnovic & Tony Ng. (2005) Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells. Molecular and Cellular Biology 25:5, pages 1680-1695.
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Tsui-Han Loo, Yuen-Wai Ng, Louis Lim & Ed Manser. (2004) GIT1 Activates p21-Activated Kinase through a Mechanism Independent of p21 Binding. Molecular and Cellular Biology 24:9, pages 3849-3859.
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Guo-Lei Zhou, Ya Zhuo, Charles C. King, Benjamin H. Fryer, Gary M. Bokoch & Jeffrey Field. (2003) Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration. Molecular and Cellular Biology 23:22, pages 8058-8069.
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Xiaofan Li & Audrey Minden. (2003) Targeted Disruption of the Gene for the PAK5 Kinase in Mice. Molecular and Cellular Biology 23:20, pages 7134-7142.
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Jian Qu, Xiaofan Li, Bennet G. Novitch, Ye Zheng, Matthew Kohn, Jian-Ming Xie, Spencer Kozinn, Roderick Bronson, Amer A. Beg & Audrey Minden. (2003) PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development. Molecular and Cellular Biology 23:20, pages 7122-7133.
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Sophie Cotteret, Zahara M. Jaffer, Alexander Beeser & Jonathan Chernoff. (2003) p21-Activated Kinase 5 (Pak5) Localizes to Mitochondria and Inhibits Apoptosis by Phosphorylating BAD. Molecular and Cellular Biology 23:16, pages 5526-5539.
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Jeffrey M. Masuda-Robens, Sara N. Kutney, Hongwei Qi & Margaret M. Chou. (2003) The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling. Molecular and Cellular Biology 23:6, pages 2151-2161.
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Jocelyn H. Wright, Xueyan Wang, Gerard Manning, Brandon J. LaMere, Phuong Le, Shirley Zhu, Deepak Khatry, Peter M. Flanagan, Sharon D. Buckley, David B. Whyte, Anthony R. Howlett, James R. Bischoff, Kenneth E. Lipson & Bahija Jallal. (2003) The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion. Molecular and Cellular Biology 23:6, pages 2068-2082.
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G. Herma Renkema, Kati Pulkkinen & Kalle Saksela. (2002) Cdc42/Rac1-Mediated Activation Primes PAK2 for Superactivation by Tyrosine Phosphorylation. Molecular and Cellular Biology 22:19, pages 6719-6725.
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Chuntao Dan, Niharika Nath, Muriel Liberto & Audrey Minden. (2002) PAK5, a New Brain-Specific Kinase, Promotes Neurite Outgrowth in N1E-115 Cells. Molecular and Cellular Biology 22:2, pages 567-577.
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Naoyuki Nishiya, Kouichi Tachibana, Motoko Shibanuma, Jun-Ichi Mashimo & Kiyoshi Nose. (2001) Hic-5-Reduced Cell Spreading on Fibronectin: Competitive Effects between Paxillin and Hic-5 through Interaction with Focal Adhesion Kinase. Molecular and Cellular Biology 21:16, pages 5332-5345.
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Gretel Buchwald, Eva Hostinova, Markus G. Rudolph, Astrid Kraemer, Albert Sickmann, Helmut E. Meyer, Klaus Scheffzek & Alfred Wittinghofer. (2001) Conformational Switch and Role of Phosphorylation in PAK Activation. Molecular and Cellular Biology 21:15, pages 5179-5189.
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Jian Qu, Marta S. Cammarano, Qing Shi, Kenneth C. Ha, Primal de Lanerolle & Audrey Minden. (2001) Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth. Molecular and Cellular Biology 21:10, pages 3523-3533.
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Ivan Tan, Kah Tong Seow, Louis Lim & Thomas Leung. (2001) Intermolecular and Intramolecular Interactions Regulate Catalytic Activity of Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase α. Molecular and Cellular Biology 21:8, pages 2767-2778.
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Zhou-shen Zhao, Edward Manser, Tsui-Han Loo & Louis Lim. (2000) Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly. Molecular and Cellular Biology 20:17, pages 6354-6363.
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Zhou-shen Zhao, Edward Manser & Louis Lim. (2000) Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation. Molecular and Cellular Biology 20:11, pages 3906-3917.
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Luc A. Sabourin, Patrick Seale, Julian Wagner & Michael A. Rudnicki. (2000) Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region. Molecular and Cellular Biology 20:2, pages 684-696.
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Shula Sarner, Robert Kozma, Sohail Ahmed & Louis Lim. (2000) Phosphatidylinositol 3-Kinase, Cdc42, and Rac1 Act Downstream of Ras in Integrin-Dependent Neurite Outgrowth in N1E-115 Neuroblastoma Cells. Molecular and Cellular Biology 20:1, pages 158-172.
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Eric Chang, Geoffrey Bartholomeusz, Ruth Pimental, Jing Chen, Hong Lai, Li-hua L. Wang, Peirong Yang & Stevan Marcus. (1999) Direct Binding and In Vivo Regulation of the Fission Yeast p21-Activated Kinase Shk1 by the SH3 Domain Protein Scd2. Molecular and Cellular Biology 19:12, pages 8066-8074.
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Yi Tang, Jong Yu & Jeffrey Field. (1999) Signals from the Ras, Rac, and Rho GTPases Converge on the Pak Protein Kinase in Rat-1 Fibroblasts. Molecular and Cellular Biology 19:3, pages 1881-1891.
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RiYun Huang, Jian P. Lian, Dwight Robinson & John A. Badwey. (1998) Neutrophils Stimulated with a Variety of Chemoattractants Exhibit Rapid Activation of p21-Activated Kinases (Paks): Separate Signals Are Required for Activation and Inactivation of Paks. Molecular and Cellular Biology 18:12, pages 7130-7138.
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Wun-Chey Sin, Xiang-Qun Chen, Thomas Leung & Louis Lim. (1998) RhoA-Binding Kinase α Translocation Is Facilitated by the Collapse of the Vimentin Intermediate Filament Network. Molecular and Cellular Biology 18:11, pages 6325-6339.
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Zhou-Shen Zhao, Edward Manser, Xiang-Qun Chen, Claire Chong, Thomas Leung & Louis Lim. (1998) A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1. Molecular and Cellular Biology 18:4, pages 2153-2163.
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Thomas Leung, Xiang-Qun Chen, Ivan Tan, Edward Manser & Louis Lim. (1998) Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization. Molecular and Cellular Biology 18:1, pages 130-140.
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Bahareh Tabanifar, Zhuoshen Zhao & Ed Manser. (2016) PAK5 is auto-activated by a central domain that promotes kinase oligomerization. Biochemical Journal 473:12, pages 1777-1789.
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Wei Zhao, Jie Liu, Xiaoming Zhang & Lih-Wen Deng. (2016) MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1. Journal of Cell Biology 212:7, pages 829-843.
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Hoyee TsuiMin ZiShunyao WangSanjoy K. ChowdhurySukhpal PreharQiangrong LiangElizabeth J. CartwrightMing LeiWei LiuXin Wang. (2015) Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32. Hypertension 66:6, pages 1176-1183.
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Yohendran Baskaran, Khay C. Ang, Praju V. Anekal, Wee L. Chan, Jonathan M. Grimes, Ed Manser & Robert C. Robinson. (2015) An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. Nature Communications 6:1.
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Gang Luo, Ya-Ling Chao, Bo Tang, Bo-Sheng Li, Yu-Feng Xiao, Rui Xie, Shu-Ming Wang, Yu-Yun Wu, Hui Dong, Xiang-De Liu & Shi-Ming Yang. (2015) miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F. Oncotarget 6:35, pages 37808-37823.
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V.I. Pinto, H. Mohammadi, W.S. Lee, A.H. Cheung & C.A. McCulloch. (2015) PAK1 is involved in sensing the orientation of collagen stiffness gradients in mouse fibroblasts. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:10, pages 2526-2538.
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Manuel Oropesa Ávila, Alejandro Fernández Vega, Juan Garrido Maraver, Marina Villanueva Paz, Isabel De Lavera, Mario De La Mata, Mario D. Cordero, Elizabet Alcocer Gómez, Ana Delgado Pavón, Mónica Álvarez Córdoba, David Cotán & José Antonio Sánchez-Alcázar. (2015) Emerging roles of apoptotic microtubules during the execution phase of apoptosis. Cytoskeleton 72:9, pages 435-446.
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Widyawilis Selamat, Pei-Ling Felicia Tay, Yohendran Baskaran & Ed Manser. (2015) The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity. PLOS ONE 10:6, pages e0129634.
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Alan Hammer, Peter Oladimeji, Luis E. De Las Casas & Maria Diakonova. (2014) Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover. The FASEB Journal 29:3, pages 943-959.
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Praju Vikas Anekal, Jeffery Yong & Ed Manser. (2015) Arg Kinase-binding Protein 2 (ArgBP2) Interaction with α-Actinin and Actin Stress Fibers Inhibits Cell Migration. Journal of Biological Chemistry 290:4, pages 2112-2125.
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Laila Elsherif, Mehmet Ozler, Mohamed A. Zayed, Jessica H. Shen, Jonathan Chernoff, James E. Faber & Leslie V. Parise. (2014) Potential Compensation among Group I PAK Members in Hindlimb Ischemia and Wound Healing. PLoS ONE 9:11, pages e112239.
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JinBin Tian, Chhavy Tep, Alex Benedick, Nabila Saidi, Jae Cheon Ryu, Mi Lyang Kim, Shankar Sadasivan, John Oberdick, Richard Smeyne, Michael X. Zhu & Sung Ok Yoon. (2014) p75 Regulates Purkinje Cell Firing by Modulating SK Channel Activity through Rac1. Journal of Biological Chemistry 289:45, pages 31458-31472.
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ELIZABETH FLATE & JOHN R.D. STALVEY. (2014) Motility of select ovarian cancer cell lines: Effect of extracellular matrix proteins and the involvement of PAK2. International Journal of Oncology 45:4, pages 1401-1411.
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Ge Meng, Chan Tian, Hui Wang, Yin Xu, Bao-Yun Zhang, Qi Shi, Chen Gao, Cao Chen, Xue-Yu Fan, Jing Wang, Kang Xiao, Ke Ren, Ming-Ming Xue & Xiao-Ping Dong. (2014) Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss. Medical Microbiology and Immunology 203:5, pages 291-302.
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Hung Thanh Nguyen, Xin Hong, Sam Tan, Qingfeng Chen, Lifang Chan, Marc Fivaz, Stephen M. Cohen & P. Mathijs Voorhoeve. (2014) Viral Small T Oncoproteins Transform Cells by Alleviating Hippo-Pathway-Mediated Inhibition of the YAP Proto-oncogene. Cell Reports 8:3, pages 707-713.
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Rui Wang, Yanwen Wang, Wee K. Lin, Yanmin Zhang, Wei Liu, Kai Huang, Derek A. Terrar, R. John Solaro, Xin Wang, Yunbo Ke & Ming Lei. (2014) Inhibition of Angiotensin II-Induced Cardiac Hypertrophy and Associated Ventricular Arrhythmias by a p21 Activated Kinase 1 Bioactive Peptide. PLoS ONE 9:7, pages e101974.
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Katherine A. Sheehan, Yunbo Ke & R. John Solaro. (2007) p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293:3, pages R963-R973.
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Nikolaus Machuy, Fanny Campa, Oliver Thieck & Thomas Rudel. (2007) c-Abl-binding Protein Interacts with p21-activated Kinase 2 (PAK-2) to Regulate PDGF-induced Membrane Ruffles. Journal of Molecular Biology 370:4, pages 620-632.
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Monika Weisz Hubsman, Natalia Volinsky, Edward Manser, Deborah Yablonski & Ami Aronheim. (2007) Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. Biochemical Journal 404:3, pages 487-497.
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