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Cell Growth and Development

A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction

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Pages 7119-7129 | Received 02 Apr 1998, Accepted 07 Sep 1998, Published online: 28 Mar 2023

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Christine M. Lynch, Luis A. Leandry & Ronald W. Matheny$suffix/text()$suffix/text(). (2013) Lysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts. Journal of Receptors and Signal Transduction 33:1, pages 41-48.
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David N Church, Romana Koppensteiner, Timothy A Yap, Daniel Fink & Konstantin J Dedes. (2012) PI3K–AKT–mTOR inhibitors for the systemic treatment of endometrial cancer. Expert Review of Obstetrics & Gynecology 7:5, pages 421-430.
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Amit Kumar, Javier Redondo-Muñoz, Vicente Perez-García, Isabel Cortes, Monica Chagoyen & Ana C. Carrera. (2011) Nuclear but Not Cytosolic Phosphoinositide 3-Kinase Beta Has an Essential Function in Cell Survival. Molecular and Cellular Biology 31:10, pages 2122-2133.
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Beth E Drees, Gordon B Mills, Christian Rommel & Glenn D Prestwich. (2004) Therapeutic potential of phosphoinositide 3-kinase inhibitors. Expert Opinion on Therapeutic Patents 14:5, pages 703-732.
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Lazaros C. Foukas, Caroline A. Beeton, Jorgen Jensen, Wayne A. Phillips & Peter R. Shepherd. (2004) Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo. Molecular and Cellular Biology 24:3, pages 966-975.
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Robbert H. Cool, Gudula Schmidt, Christian U. Lenzen, Heino Prinz, Dorothee Vogt & Alfred Wittinghofer. (1999) The Ras Mutant D119N Is Both Dominant Negative and Activated. Molecular and Cellular Biology 19:9, pages 6297-6305.
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Xianxiu Ge, Youli Wang, Yun Wang, Quanpeng Li, Hong Yu & Lin Miao. (2013) NK4 Gene Therapy Inhibits HGF/Met-Induced Growth of Human Cholangiocarcinoma Cells. Digestive Diseases and Sciences 58:6, pages 1636-1643.
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Jihye Yun, George Poulogiannis, Evan T. Brower, Samuel Klempner & Lewis L. Cantley. 2013. Molecular Pathogenesis of Colorectal Cancer. Molecular Pathogenesis of Colorectal Cancer 157 199 .
JING TIAN & YUYANG JIANG. (2012) Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells. Molecular Medicine Reports 6:6, pages 1379-1384.
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Irene Brana & Lillian L Siu. (2012) Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment. BMC Medicine 10:1.
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Evangelos Sarris, Muhammad Saif & Kostas Syrigos. (2012) The Biological Role of PI3K Pathway in Lung Cancer. Pharmaceuticals 5:11, pages 1236-1264.
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Navid Sadeghi & David E Gerber. (2012) Targeting the PI3K pathway for cancer therapy. Future Medicinal Chemistry 4:9, pages 1153-1169.
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Christopher R. Zito, Lucia B. Jilaveanu, Valsamo Anagnostou, David Rimm, Gerold Bepler, Sauveur-Michel Maira, Wolfgang Hackl, Robert Camp, Harriet M. Kluger & Herta H. Chao. (2012) Multi-Level Targeting of the Phosphatidylinositol-3-Kinase Pathway in Non-Small Cell Lung Cancer Cells. PLoS ONE 7:2, pages e31331.
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Matthias Wymann. 2012. Phosphoinositides I: Enzymes of Synthesis and Degradation. Phosphoinositides I: Enzymes of Synthesis and Degradation 111 181 .
Aymen A Elfiky, Saadia A Aziz, Patricia J Conrad, Summar Siddiqui, Wolfgang Hackl, Michel Maira, Camp L Robert & Harriet M Kluger. (2011) Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer. Journal of Translational Medicine 9:1.
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Yesid Alvarado, Monica M. Mita, Sushma Vemulapalli, Devalingam Mahalingam & Alain C. Mita. (2011) Clinical activity of mammalian target of rapamycin inhibitors in solid tumors. Targeted Oncology 6:2, pages 69-94.
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Yanggang Yuan, Aihua Zhang, Songming Huang, Guixia Ding & Ronghua Chen. (2011) A PPARγ agonist inhibits aldosterone-induced mesangial cell proliferation by blocking ROS-dependent EGFR intracellular signaling. American Journal of Physiology-Renal Physiology 300:2, pages F393-F402.
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Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli, Valentina Nocco, Giuditta Illuzzi, Laura Mauri, Manuela Valsecchi, Vanna Chigorno & Sandro Sonnino. 2011. The Molecular Immunology of Complex Carbohydrates-3. The Molecular Immunology of Complex Carbohydrates-3 643 667 .
Ian Willox, Irina Mirkina, John Westwick & Stephen G. Ward. (2010) Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells. Molecular Immunology 47:14, pages 2367-2377.
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Christine Bonnesen, Gitte-Mai Nelander, Bo Falck Hansen, Pia Jensen, Jonas S. Krabbe, Marianne B. Jensen, Anne Charlotte Hegelund, Jette E. Svendsen & Martin B. Oleksiewicz. (2009) Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin. Cell Biology and Toxicology 26:4, pages 293-307.
Crossref
Peter K. Vogt, Jonathan R. Hart, Marco Gymnopoulos, Hao Jiang, Sohye Kang, Andreas G. Bader, Li Zhao & Adam Denley. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 79 104 .
Bart Vanhaesebroeck, Peter K. Vogt & Christian Rommel. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 1 19 .
Nina Ilić & Thomas M. Roberts. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 55 77 .
Carlotta Costa & Emilio Hirsch. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 171 181 .
Rosa Gómez-Villafuertes, Ana del Puerto, Miguel Díaz-Hernández, Diego Bustillo, Juan I. Díaz-Hernández, Paula G. Huerta, Antonio R. Artalejo, Juan J. Garrido & Ma Teresa Miras-Portugal. (2009) Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells. FEBS Journal 276:18, pages 5307-5325.
Crossref
Jeffrey A. Engelman. (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nature Reviews Cancer 9:8, pages 550-562.
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Emmajayne Kingham & Melanie Welham. (2009) Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells. Journal of Cell Science 122:13, pages 2311-2321.
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Stephen G. WardFederica M. Marelli-Berg. (2009) Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation. Biochemical Journal 418:1, pages 13-27.
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John Papaconstantinou. (2009) Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Molecular and Cellular Endocrinology 299:1, pages 89-100.
Crossref
Shidong Jia, Zhenning Liu, Sen Zhang, Pixu Liu, Lei Zhang, Sang Hyun Lee, Jing Zhang, Sabina Signoretti, Massimo Loda, Thomas M. Roberts & Jean J. Zhao. (2008) Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis. Nature 454:7205, pages 776-779.
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Julie Guillermet-GuibertKatja BjorklofAshreena SalpekarCristiano GonellaFaruk Ramadani, Antonio BilancioStephen Meek, Andrew J. H. Smith, Klaus Okkenhaug & Bart Vanhaesebroeck. (2008) The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ. Proceedings of the National Academy of Sciences 105:24, pages 8292-8297.
Crossref
A Sirvent, C Leroy, A Boureux, V Simon & S Roche. (2008) The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner. Oncogene 27:24, pages 3494-3500.
Crossref
Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli, Vanna Chigorno & Sandro Sonnino. (2008) Regulation of tumor phenotypes by caveolin-1 and sphingolipid-controlled membrane signaling complexes. Biochimica et Biophysica Acta (BBA) - General Subjects 1780:3, pages 585-596.
Crossref
Jonathan M. Backer. (2008) The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochemical Journal 410:1, pages 1-17.
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Sohei Yamamoto, Hitoshi Tsuda, Kazufumi Honda, Tsunekazu Kita, Masashi Takano, Seiichi Tamai, Johji Inazawa, Tesshi Yamada & Osamu Matsubara. (2007) Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Modern Pathology 20:12, pages 1278-1285.
Crossref
Jeffrey A. Engelman. (2007) The Role of Phosphoinositide 3-Kinase Pathway Inhibitors in the Treatment of Lung Cancer. Clinical Cancer Research 13:15, pages 4637s-4640s.
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Claire Chaussade, Gordon W. Rewcastle, Jackie D. Kendall, William A. Denny, Kitty Cho, Line M. Grønning, Mei Ling Chong, Sasha H. Anagnostou, Shaun P. Jackson, Nathalie Daniele & Peter R. Shepherd. (2007) Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochemical Journal 404:3, pages 449-458.
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Youping Deng, Hu Xu & Heimo Riedel. (2007) PSM/SH2-B distributes selected mitogenic receptor signals to distinct components in the PI3-kinase and MAP kinase signaling pathways. Journal of Cellular Biochemistry 100:3, pages 557-573.
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Lazaros C. Foukas, Marc Claret, Wayne Pearce, Klaus Okkenhaug, Stephen Meek, Emma Peskett, Sara Sancho, Andrew J. H. Smith, Dominic J. Withers & Bart Vanhaesebroeck. (2006) Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441:7091, pages 366-370.
Crossref
Hiroshi Kubo, Kaoru Hazeki, Shunsuke Takasuga & Osamu Hazeki. (2005) Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt. Biochemical Journal 392:3, pages 607-614.
Crossref
Robert Newman, Yutaka Hasegawa, John Lahad, Andrew Morris, Gordon Mills, Rose Lapis, David Crotzer, Glenn Prestwich, Judith Wolf, Kwai Wa Cheng, Janos Tanyi, Makiko Umezu-Goto, Edward Felix & Shuangxing Yu. 2005. Functional Lipidomics. Functional Lipidomics 101 124 .
Nathan T. Ihle, Gillian Paine-Murrieta, Margareta I. Berggren, Amanda Baker, Wendy R. Tate, Peter Wipf, Robert T. Abraham, D. Lynn Kirkpatrick & Garth Powis. (2005) The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell lung cancer xenografts. Molecular Cancer Therapeutics 4:9, pages 1349-1357.
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Sirlene R. Cechin, Peter R. Dunkley & Richard Rodnight. (2005) Signal Transduction Mechanisms Involved in the Proliferation of C6 Glioma Cells Induced by Lysophosphatidic Acid. Neurochemical Research 30:5, pages 603-611.
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Bridget C. Fox, Tracey E. Crew & Melanie J. Welham. (2005) Phosphoinositide 3-kinases can act independently of p27Kip1 to regulate optimal IL-3-dependent cell cycle progression and proliferation. Cellular Signalling 17:4, pages 473-487.
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P. R. Shepherd. (2005) Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues. Acta Physiologica Scandinavica 183:1, pages 3-12.
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Evgenia V. Gerasimovskaya, Doug A. Tucker, Mary Weiser-Evans, Janet M. Wenzlau, Dwight J. Klemm, Mark Banks & Kurt R. Stenmark. (2005) Extracellular ATP-induced Proliferation of Adventitial Fibroblasts Requires Phosphoinositide 3-Kinase, Akt, Mammalian Target of Rapamycin, and p70 S6 Kinase Signaling Pathways. Journal of Biological Chemistry 280:3, pages 1838-1848.
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Timothy I Meier, James A Cook, James E Thomas, Jeffrey A Radding, Candice Horn, Trupti Lingaraj & Michele C Smith. (2004) Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms. Protein Expression and Purification 35:2, pages 218-224.
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Chang Shin Park, Ian C. Schneider & Jason M. Haugh. (2003) Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts. Journal of Biological Chemistry 278:39, pages 37064-37072.
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Lisa M. Ballou, Hong-Ying Lin, Gaofeng Fan, Ya-Ping Jiang & Richard Z. Lin. (2003) Activated Gαq Inhibits p110α Phosphatidylinositol 3-Kinase and Akt. Journal of Biological Chemistry 278:26, pages 23472-23479.
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Lazaros C Foukas & Klaus Okkenhaug. (2003) Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases. Archives of Biochemistry and Biophysics 414:1, pages 13-18.
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David A. Windmiller & Jonathan M. Backer. (2003) Distinct Phosphoinositide 3-Kinases Mediate Mast Cell Degranulation in Response to G-protein-coupled VersusFcεRI Receptors. Journal of Biological Chemistry 278:14, pages 11874-11878.
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Christine Peres, Armelle Yart, Bertrand Perret, Jean-Pierre Salles & Patrick Raynal. (2003) Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling. FEBS Letters 534:1-3, pages 164-168.
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James R Van Brocklyn, Catherine A Letterle, Pamela J Snyder & Thomas W Prior. (2002) Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase β. Cancer Letters 181:2, pages 195-204.
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Armelle Yart, Serge Roche, Reinhard Wetzker, Muriel Laffargue, Nicholas Tonks, Patrick Mayeux, Hugues Chap & Patrick Raynal. (2002) A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid. Journal of Biological Chemistry 277:24, pages 21167-21178.
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Ching-Chyuan Hsieh, James H. DeFord, Kevin Flurkey, David E. Harrison & John Papaconstantinou. (2002) Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm. Mechanisms of Ageing and Development 123:9, pages 1229-1244.
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Isabelle Gennero, Josette Fauvel, Michèle Niéto, Clotilde Cariven, Frédérique Gaits, Fabienne Briand-Mésange, Hugues Chap & Jean Pierre Salles. (2002) Apoptotic Effect of Sphingosine 1-Phosphate and Increased Sphingosine 1-Phosphate Hydrolysis on Mesangial Cells Cultured at Low Cell Density. Journal of Biological Chemistry 277:15, pages 12724-12734.
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Lei Bi, Ichiro Okabe, David J. Bernard & Robert L. Nussbaum. (2002) Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase. Mammalian Genome 13:3, pages 169-172.
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M. Sharon Stack & David A. FishmanGordon B. Mills, Astrid Eder, Xianjun Fang, Yutaka Hasegawa, Muling Mao, Yiling Lu, Janos Tanyi, Fazal Haq Tabassam, Jon Wiener, Ruth Lapushin, Shiangxing Yu, Jeff A. Parrott, Tim Compton, Walter Tribley, David Fishman, M. Sharon Stack, Douglas Gaudette, Robert Jaffe, Tatsuro Furui, Junken Aoki & James R. Erickson. 2002. Ovarian Cancer. Ovarian Cancer 259 283 .
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Jean-François Quignard, Jean Mironneau, Valérie Carricaburu, Bernard Fournier, Aleksei Babich, Bernd Nürnberg, Chantal Mironneau & Nathalie Macrez. (2001) Phosphoinositide 3-Kinase γ Mediates Angiotensin II-induced Stimulation of L-type Calcium Channels in Vascular Myocytes. Journal of Biological Chemistry 276:35, pages 32545-32551.
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S. Sanchez, C. L. Sayas, F. Lim, J. Diaz-Nido, J. Avila & F. Wandosell. (2001) The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3. Journal of Neurochemistry 78:3, pages 468-481.
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Toshiyuki Fujioka, Jae-Hoon Kim, Hideki Adachi, Kazuki Saito, Masafumi Tsujimoto, Shigeyuki Yokoyama & Michio Ui. (2001) Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase. European Journal of Biochemistry 268:15, pages 4158-4168.
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Steven M. Jones & Andrius Kazlauskas. (2001) Growth Factor-Dependent Signaling and Cell Cycle Progression. Chemical Reviews 101:8, pages 2413-2424.
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Bart Vanhaesebroeck, Sally J. Leevers, Khatereh Ahmadi, John Timms, Roy Katso, Paul C. Driscoll, Rudiger Woscholski, Peter J. Parker & Michael D. Waterfield. (2001) Synthesis and Function of 3-Phosphorylated Inositol Lipids. Annual Review of Biochemistry 70:1, pages 535-602.
Crossref
Bridget L. Craddock, Jennifer Hobbs, Christine E. Edmead & Melanie J. Welham. (2001) Phosphoinositide 3-Kinase-dependent Regulation of Interleukin-3-induced Proliferation. Journal of Biological Chemistry 276:26, pages 24274-24283.
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Andrew Grey, Tatjana Banovic, Dorit Naot, Bernadine Hill, Karen Callon, Ian Reid & Jill Cornish. (2001) Lysophosphatidic Acid Is an Osteoblast Mitogen Whose Proliferative Actions Involve Gi Proteins and Protein Kinase C, But Not P42/44 Mitogen-Activated Protein Kinases*. Endocrinology 142:3, pages 1098-1106.
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Armelle Yart, Muriel Laffargue, Patrick Mayeux, Stany Chretien, Christine Peres, Nicholas Tonks, Serge Roche, Bernard Payrastre, Hugues Chap & Patrick Raynal. (2001) A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor. Journal of Biological Chemistry 276:12, pages 8856-8864.
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Claire Bony, Serge Roche, Ueno Shuichi, Takehiko Sasaki, Michael A. Crackower, Josef Penninger, Hiroyuki Mano & Michel Pucéat. (2001) A Specific Role of Phosphatidylinositol 3–Kinase γ. Journal of Cell Biology 152:4, pages 717-728.
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Yan Xu, Yi-jin Xiao, Linnea M. Baudhuin & Benjamin M. Schwartz. (2016) The Role and Clinical Applications of Bioactive Lysolipids in Ovarian Cancer. Journal of the Society for Gynecologic Investigation 8:1, pages 1-13.
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Steven M Jones & Andrius Kazlauskas. (2000) Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene 19:49, pages 5558-5567.
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Christine Bénistant, H Chapuis & Serge Roche. (2000) A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 19:44, pages 5083-5090.
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Robert C. Stein & Michael D. Waterfield. (2000) PI3-kinase inhibition: a target for drug development?. Molecular Medicine Today 6:9, pages 347-358.
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Tomoichiro Asano, Akira Kanda, Hideki Katagiri, Masao Nawano, Takehide Ogihara, Kouichi Inukai, Motonobu Anai, Yasushi Fukushima, Yoshio Yazaki, Masatoshi Kikuchi, Roya Hooshmand-Rad, Carl-Henrik Heldin, Yoshitomo Oka & Makoto Funaki. (2000) p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity. Journal of Biological Chemistry 275:23, pages 17671-17676.
Crossref
K. Racké, R. Hammermann & U.R. Juergens. (2000) Potential Role of EDG Receptors and Lysophospholipids as their Endogenous Ligands in the Respiratory Tract. Pulmonary Pharmacology & Therapeutics 13:3, pages 99-114.
Crossref
Stephan Goetze, Sarah Kim, Xiao-Ping Xi, Kristof Graf, Dong C. Yang, Eckart Fleck, Woerner P. Meehan, Willa A. Hsueh & Ronald E. Law. (2000) Troglitazone Inhibits Mitogenic Signaling by Insulin in Vascular Smooth Muscle Cells. Journal of Cardiovascular Pharmacology 35:5, pages 749-757.
Crossref
Cristina Murga, Shigetomo Fukuhara & J.Silvio Gutkind. (2000) A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt. Journal of Biological Chemistry 275:16, pages 12069-12073.
Crossref
Makoto Funaki, Hideki Katagiri, Kouichi Inukai, Masotoshi Kikuchi & Tomoichiro Asano. (2000) Structure and function of phosphatidylinositol-3,4 kinase. Cellular Signalling 12:3, pages 135-142.
Crossref
Karen Hill, Susan Welti, Jinghua Yu, James T. Murray, Shu-Chin Yip, John S. Condeelis, Jeffrey E. Segall & Jonathan M. Backer. (2000) Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells. Journal of Biological Chemistry 275:6, pages 3741-3744.
Crossref
R. Hooshmand-RadL. HajkovaP. KlintR. KarlssonB. VanhaesebroeckL. Claesson-WelshC.H. Heldin. (2000) The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling. Journal of Cell Science 113:2, pages 207-214.
Crossref
Lina Paolucci, James Sinnett-Smith & Enrique Rozengurt. (2000) Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway. American Journal of Physiology-Cell Physiology 278:1, pages C33-C39.
Crossref
Muriel Laffargue, Patrick Raynal, Armelle Yart, Christine Peres, Reinhard Wetzker, Serge Roche, Bernard Payrastre & Hugues Chap. (1999) An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid. Journal of Biological Chemistry 274:46, pages 32835-32841.
Crossref
B. Vanhaesebroeck & M.D. Waterfield. (1999) Signaling by Distinct Classes of Phosphoinositide 3-Kinases. Experimental Cell Research 253:1, pages 239-254.
Crossref
Udo Maier, Aleksei Babich & Bernd Nürnberg. (1999) Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ. Journal of Biological Chemistry 274:41, pages 29311-29317.
Crossref
Isabel Barroso & Pilar Santisteban. (1999) Insulin-induced Early Growth Response Gene (Egr-1) Mediates a Short Term Repression of Rat Malic Enzyme Gene Transcription. Journal of Biological Chemistry 274:25, pages 17997-18004.
Crossref
Bart Vanhaesebroeck, Gareth E. Jones, William E. Allen, Daniel Zicha, Roya Hooshmand-Rad, Carol Sawyer, Claire Wells, Michael D. Waterfield & Anne J. Ridley. (1999) Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nature Cell Biology 1:1, pages 69-71.
Crossref
Steven M. Jones, Richard Klinghoffer, Glenn D. Prestwich, Alex Toker & Andrius Kazlauskas. (1999) PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Current Biology 9:10, pages 512-521.
Crossref

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