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Gene Expression

A Novel Genetic Screen for snRNP Assembly Factors in Yeast Identifies a Conserved Protein, Sad1p, Also Required for Pre-mRNA Splicing

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Pages 2008-2020 | Received 12 Jun 1998, Accepted 23 Nov 1998, Published online: 27 Mar 2023

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Gonzalo I. Mendoza-Ochoa, J. David Barrass, Isabella E. Maudlin & Jean D. Beggs. (2019) Blocking late stages of splicing quickly limits pre-spliceosome assembly in vivo. RNA Biology 16:12, pages 1775-1784.
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Yu-Hsin Huang, Che-Sheng Chung, Der-I Kao, Tzu-Chung Kao & Soo-Chen Cheng. (2014) Sad1 Counteracts Brr2-Mediated Dissociation of U4/U6.U5 in Tri-snRNP Homeostasis. Molecular and Cellular Biology 34:2, pages 210-220.
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Giuseppe Ianiri, Sandra A.I. Wright, Raffaello Castoria & Alexander Idnurm. (2011) Development of resources for the analysis of gene function in Pucciniomycotina red yeasts. Fungal Genetics and Biology 48:7, pages 685-695.
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Yesenia Ríos, Shlomo Melmed, Shuo Lin & Ning-Ai Liu. (2011) Zebrafish usp39 Mutation Leads to rb1 mRNA Splicing Defect and Pituitary Lineage Expansion. PLoS Genetics 7:1, pages e1001271.
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Martin A. M. Reijns, Tatsiana Auchynnikava & Jean D. Beggs. (2009) Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast. FEBS Journal 276:13, pages 3602-3617.
Crossref
Priya Bellare, Eliza C Small, Xinhua Huang, James A Wohlschlegel, Jonathan P Staley & Erik J Sontheimer. (2008) A role for ubiquitin in the spliceosome assembly pathway. Nature Structural & Molecular Biology 15:5, pages 444-451.
Crossref
Euiyoung Bae, Nicholas J. Reiter, Craig A. Bingman, Sharon S. Kwan, Donghan Lee, George N. PhillipsJrJr, Samuel E. Butcher & David A. Brow. (2007) Structure and Interactions of the First Three RNA Recognition Motifs of Splicing Factor Prp24. Journal of Molecular Biology 367:5, pages 1447-1458.
Crossref
Chun-Hong Chen, Der-I Kao, Shih-Peng Chan, Tsu-Chung Kao, Jui-Yen Lin & Soo-Chen Cheng. (2006) Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA 12:5, pages 765-774.
Crossref
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Crossref
Sebastian M.B. Nijman, Mark P.A. Luna-Vargas, Arno Velds, Thijn R. Brummelkamp, Annette M.G. Dirac, Titia K. Sixma & René Bernards. (2005) A Genomic and Functional Inventory of Deubiquitinating Enzymes. Cell 123:5, pages 773-786.
Crossref
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Crossref
RICHARD J. GRAINGER & JEAN D. BEGGS. (2005) Prp8 protein: At the heart of the spliceosome. RNA 11:5, pages 533-557.
Crossref
Vı́ctor Quesada, Araceli Dı́az-Perales, Ana Gutiérrez-Fernández, Cecilia Garabaya, Santiago Cal & Carlos López-Otı́n. (2004) Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochemical and Biophysical Research Communications 314:1, pages 54-62.
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Qiang Wang, Kathryn Hobbs, Bert Lynn & Brian C. Rymond. (2003) The Clf1p Splicing Factor Promotes Spliceosome Assembly through N-terminal Tetratricopeptide Repeat Contacts. Journal of Biological Chemistry 278:10, pages 7875-7883.
Crossref
Annie Mougin, Alexander Gottschalk, Patrizia Fabrizio, Reinhard Lührmann & Christiane Branlant. (2002) Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell’s and yeast spliceosomal U4/U6.U5 tri-snRNP particles 1 1Edited by J. Doudna. Journal of Molecular Biology 317:5, pages 631-649.
Crossref
K. Stuart, A. K. Panigrahi, A. Schnaufer, M. Drozdz, C. Clayton & R. Salavati. (2002) Composition of the editing complex of Trypanosoma brucei . Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 357:1417, pages 71-79.
Crossref
Scott W. Stevens, Daniel E. Ryan, Helen Y. Ge, Roger E. Moore, Mary K. Young, Terry D. Lee & John Abelson. (2002) Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP. Molecular Cell 9:1, pages 31-44.
Crossref
Juri Rappsilber, Paul Ajuh, Angus I. Lamond & Matthias Mann. (2001) SPF30 Is an Essential Human Splicing Factor Required for Assembly of the U4/U5/U6 Tri-small Nuclear Ribonucleoprotein into the Spliceosome. Journal of Biological Chemistry 276:33, pages 31142-31150.
Crossref
Regina M Vidaver, David M Fortner, Liana S Loos-Austin & David A Brow. (1999) Multiple Functions of Saccharomyces cerevisiae Splicing Protein Prp24 in U6 RNA Structural Rearrangements. Genetics 153:3, pages 1205-1218.
Crossref
Katja Sträßer & Ed Hurt. (1999) Nuclear RNA export in yeast. FEBS Letters 452:1-2, pages 77-81.
Crossref

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