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Molecular and Cellular Biology Volume 19, 1999 - Issue 7
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DNA Dynamics and Chromosome Structure

A RAG1 and RAG2 Tetramer Complex Is Active in Cleavage in V(D)J Recombination

Tu BailinProgram of Gene Regulation, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia30912-2650
,
Xianming MoProgram of Gene Regulation, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia30912-2650
&
Moshe J. SadofskyProgram of Gene Regulation, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia30912-2650Correspondence[email protected]
Pages 4664-4671 | Received 29 Jan 1999, Accepted 01 Apr 1999, Published online: 28 Mar 2023

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Alison Burgess Hickman, Michael Chandler & Fred Dyda. (2010) Integrating prokaryotes and eukaryotes: DNA transposases in light of structure. Critical Reviews in Biochemistry and Molecular Biology 45:1, pages 50-69.
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Patrick C. Swanson. (2002) A RAG-1/RAG-2 Tetramer Supports 12/23-Regulated Synapsis, Cleavage, and Transposition of V(D)J Recombination Signals. Molecular and Cellular Biology 22:22, pages 7790-7801.
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Leslie E. Huye, Mary M. Purugganan, Ming-Ming Jiang & David B. Roth. (2002) Mutational Analysis of All Conserved Basic Amino Acids in RAG-1 Reveals Catalytic, Step Arrest, and Joining-Deficient Mutants in the V(D)J Recombinase. Molecular and Cellular Biology 22:10, pages 3460-3473.
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Cynthia L. Mundy, Nadja Patenge, Adam G. W. Matthews & Marjorie A. Oettinger. (2002) Assembly of the RAG1/RAG2 Synaptic Complex. Molecular and Cellular Biology 22:1, pages 69-77.
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Mark A. Landree, Sam B. Kale & David B. Roth. (2001) Functional Organization of Single and Paired V(D)J Cleavage Complexes. Molecular and Cellular Biology 21:13, pages 4256-4264.
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Xianming Mo, Tu Bailin & Moshe J. Sadofsky. (2001) A C-Terminal Region of RAG1 Contacts the Coding DNA during V(D)J Recombination. Molecular and Cellular Biology 21:6, pages 2038-2047.
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Patrick C. Swanson. (2001) The DDE Motif in RAG-1 Is Contributed in trans to a Single Active Site That Catalyzes the Nicking and Transesterification Steps of V(D)J Recombination. Molecular and Cellular Biology 21:2, pages 449-458.
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Kefei Yu & Michael R. Lieber. (2000) The Nicking Step in V(D)J Recombination Is Independent of Synapsis: Implications for the Immune Repertoire. Molecular and Cellular Biology 20:21, pages 7914-7921.
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Sandra Lew, Daniel Franco & Yung Chang. (2000) Activation of V(D)J Recombination Induces the Formation of Interlocus Joints and Hybrid Joints in scid Pre-B-Cell Lines. Molecular and Cellular Biology 20:19, pages 7170-7177.
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Emily A. Agard & Susanna M. Lewis. (2000) Postcleavage Sequence Specificity in V(D)J Recombination. Molecular and Cellular Biology 20:14, pages 5032-5040.
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Articles from other publishers (41)

Shaun M. Christie, Carel Fijen & Eli Rothenberg. (2022) V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery. Frontiers in Cell and Developmental Biology 10.
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Justyna Mika, Sylwia Kabacik, Christophe Badie, Joanna Polanska & Serge M. Candéias. (2019) Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors. Frontiers in Immunology 10.
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Mihai Ciubotaru, Marius D. Surleac, Lauren Ann Metskas, Peter Koo, Elizabeth Rhoades, Andrei J. Petrescu & David G. Schatz. (2015) The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes. Nucleic Acids Research 43:2, pages 917-931.
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Alicia J. Little, Adam Matthews, Marjorie Oettinger, David B. Roth & David G. Schatz. 2015. Molecular Biology of B Cells. Molecular Biology of B Cells 13 34 .
Noriko Shimazaki & Michael R. Lieber. (2014) Histone methylation and V(D)J recombination. International Journal of Hematology 100:3, pages 230-237.
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Maxime G. Cuypers, Maryia Trubitsyna, Philip Callow, V. Trevor Forsyth & Julia M. Richardson. (2013) Solution conformations of early intermediates in Mos1 transposition. Nucleic Acids Research 41:3, pages 2020-2033.
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Guannan Wang, Kajari Dhar, Patrick C. Swanson, Marcia Levitus & Yung Chang. (2012) Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex. Nucleic Acids Research 40:13, pages 6082-6096.
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David G. SchatzPatrick C. Swanson. (2011) V(D)J Recombination: Mechanisms of Initiation. Annual Review of Genetics 45:1, pages 167-202.
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Stephen Desiderio. (2010) Temporal and spatial regulatory functions of the V(D)J recombinase. Seminars in Immunology 22:6, pages 362-369.
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William Cushley & Gillian Borland. 2010. Topley & Wilson's Microbiology and Microbial Infections. Topley & Wilson's Microbiology and Microbial Infections.
Gabrielle J. Grundy, Santiago Ramón-Maiques, Emilios K. Dimitriadis, Svetlana Kotova, Christian Biertümpfel, J. Bernard Heymann, Alasdair C. Steven, Martin Gellert & Wei Yang. (2009) Initial Stages of V(D)J Recombination: The Organization of RAG1/2 and RSS DNA in the Postcleavage Complex. Molecular Cell 35:2, pages 217-227.
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Fang Fang Yin, Scott Bailey, C Axel Innis, Mihai Ciubotaru, Satwik Kamtekar, Thomas A Steitz & David G Schatz. (2009) Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nature Structural & Molecular Biology 16:5, pages 499-508.
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William GiblinMonalisa ChatterjiGerwin Westfield, Tehmina Masud, Brian Theisen, Hwei-Ling Cheng, Jeffrey DeVido, Frederick W. Alt, David O. Ferguson, David G. Schatz & JoAnn Sekiguchi. (2009) Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood 113:13, pages 2965-2975.
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Patrick C. Swanson, Sushil Kumar & Prafulla Raval. 2009. V(D)J Recombination. V(D)J Recombination 1 15 .
Pallabi De, Shuying Zhao, Lori M Gwyn, LeAnn J Godderz, Mandy M Peak & Karla K Rodgers. (2008) Thermal dependency of RAG1 self-association properties. BMC Biochemistry 9:1.
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Masha V Poyurovsky, Christina Priest, Alex Kentsis, Katherine L B Borden, Zhen-Qiang Pan, Nikola Pavletich & Carol Prives. (2006) The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. The EMBO Journal 26:1, pages 90-101.
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Martin Gellert. 2007. Molecular Genetics of Recombination. Molecular Genetics of Recombination 469 486 .
E. M. Kuklina. (2006) Revision of the antigen receptor of T-lymphocytes. Biochemistry (Moscow) 71:8, pages 827-837.
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Jason D. Fowler & Zucai Suo. (2006) Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase. Chemical Reviews 106:6, pages 2092-2110.
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Darryll D. Dudley, Jayanta Chaudhuri, Craig H. Bassing & Frederick W. Alt. 2005. 43 112 .
Fumikiyo Nagawa, Satoshi Hirose, Hirofumi Nishizumi, Tadashi Nishihara & Hitoshi Sakano. (2004) Joining Mutants of RAG1 and RAG2 that Demonstrate Impaired Interactions with the Coding-end DNA. Journal of Biological Chemistry 279:37, pages 38360-38368.
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Jessica M. Jones & Martin Gellert. (2004) The taming of a transposon: V(D)J recombination and the immune system. Immunological Reviews 200:1, pages 233-248.
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Moshe J. Sadofsky. (2004) Recombination-activating gene proteins: more regulation, please. Immunological Reviews 200:1, pages 83-89.
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Vicky L. Brandt & David B. Roth. (2004) V(D)J recombination: how to tame a transposase. Immunological Reviews 200:1, pages 249-260.
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Patrick C. Swanson. (2004) The bounty of RAGs: recombination signal complexes and reaction outcomes. Immunological Reviews 200:1, pages 90-114.
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Pallabi De & Karla K. Rodgers. (2004) Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1. Immunological Reviews 200:1, pages 70-82.
Crossref
Jung Eun Ko, Choong Won Kim & Deok Ryong Kim. (2004) Amino Acid Residues in RAG1 Responsible for the Interaction with RAG2 during the V(D)J Recombination Process. Journal of Biological Chemistry 279:9, pages 7715-7720.
Crossref
Patrick C. Swanson, Dustin Volkmer & Lei Wang. (2004) Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration. Journal of Biological Chemistry 279:6, pages 4034-4044.
Crossref
Kefei Yu, Alex Taghva, Yunmei Ma & Michael R. Lieber. (2004) Kinetic analysis of the nicking and hairpin formation steps in V(D)J recombination. DNA Repair 3:1, pages 67-75.
Crossref
Klaus Schwarz, Yunmei Ma, Ulrich Pannicke & Michael R. Lieber. (2003) Human severe combined immune deficiency and DNA repair. BioEssays 25:11, pages 1061-1070.
Crossref
Vyacheslav Yurchenko, Zhu Xue & Moshe Sadofsky. (2003) The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes & Development 17:5, pages 581-585.
Crossref
Mihai Ciubotaru, Leon M. Ptaszek, Gary A. Baker, Sheila N. Baker, Frank V. Bright & David G. Schatz. (2003) RAG1-DNA Binding in V(D)J Recombination. Journal of Biological Chemistry 278:8, pages 5584-5596.
Crossref
Chia-Lun Tsai, Anna H. Drejer & David G. Schatz. (2002) Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes & Development 16:15, pages 1934-1949.
Crossref
Vicky L Brandt & David B Roth. (2002) A recombinase diversified: new functions of the RAG proteins. Current Opinion in Immunology 14:2, pages 224-229.
Crossref
Nobuyuki Yamashita, Noriko Shimazaki, Shiro Ibe, Reo Kaneko, Akiko Tanabe, Tsuguri Toyomoto, Kiyoko Fujita, Tomohiko Hasegawa, Shingo Toji, Katsuyuki Tamai, Hiroko Yamamoto & Osamu Koiwai. (2001) Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. Genes to Cells 6:7, pages 641-652.
Crossref
Kyung-Jong Lee, Juren Huang, Yoshihiko Takeda & William S. Dynan. (2000) DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System. Journal of Biological Chemistry 275:44, pages 34787-34796.
Crossref
Robert A Fenstermaker & Michael J Ciesielski. (2000) Deletion and tandem duplication of exons 2–7 in the epidermal growth factor receptor gene of a human malignant glioma. Oncogene 19:39, pages 4542-4548.
Crossref
Matthew L. Brown & Yung Chang. (2000) Metabolism of Recombination Coding Ends in scid Cells . The Journal of Immunology 164:8, pages 4135-4142.
Crossref
Sebastian D. FugmannAlfred Ian LeePenny E. ShockettIsabelle J. VilleyDavid G. Schatz. (2000) The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review of Immunology 18:1, pages 495-527.
Crossref
Julia B Scheerer, Liqiang Xi, Geremy W Knapp, R.Woodrow Setzer, William L Bigbee & James C Fuscoe. (1999) Quantification of illegitimate V(D)J recombinase-mediated mutations in lymphocytes of newborns and adults. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 431:2, pages 291-303.
Crossref
Alexandra Binnie, Stacy Olson, Gillian E. Wu & Susanna M. Lewis. (1999) Gamma-Irradiation Directly Affects the Formation of Coding Joints in SCID Cell Lines. The Journal of Immunology 163:10, pages 5418-5426.
Crossref

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