Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 9
Submit an article Journal homepage
89
Views
172
CrossRef citations to date
0
Altmetric
Gene Expression

SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast

Michelle F. Page1 Department of Genetics
,
Brian Carr1 Department of Genetics
,
Kirk R. Anders2 Program in Cell and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706
,
Andrew Grimson2 Program in Cell and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706
&
Philip Anderson1 Department of Genetics;2 Program in Cell and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706Correspondence[email protected]
Pages 5943-5951 | Received 05 Oct 1998, Accepted 25 May 1999, Published online: 27 Mar 2023

Citations (172)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (16)

Yuval Nevo, Joseph Sperling & Ruth Sperling. (2015) Heat shock activates splicing at latent alternative 5′ splice sites in nematodes. Nucleus 6:3, pages 225-235.
Read now
Feng He, Robin Ganesan & Allan Jacobson. (2013) Intra- and Intermolecular Regulatory Interactions in Upf1, the RNA Helicase Central to Nonsense-Mediated mRNA Decay in Yeast. Molecular and Cellular Biology 33:23, pages 4672-4684.
Read now
Claus M. Azzalin. (2012) UPF1. Nucleus 3:1, pages 16-21.
Read now
Nadine Wittkopp, Eric Huntzinger, Catrin Weiler, Jérôme Saulière, Steffen Schmidt, Mahendra Sonawane & Elisa Izaurralde. (2009) Nonsense-Mediated mRNA Decay Effectors Are Essential for Zebrafish Embryonic Development and Survival. Molecular and Cellular Biology 29:13, pages 3517-3528.
Read now
Lisa Johns, Andrew Grimson, Sherry L. Kuchma, Carrie Loushin Newman & Philip Anderson. (2007) Caenorhabditis elegans SMG-2 Selectively Marks mRNAs Containing Premature Translation Termination Codons. Molecular and Cellular Biology 27:16, pages 5630-5638.
Read now
Weirong Wang, Iván J. Cajigas, Stuart W. Peltz, Miles F. Wilkinson & Carlos I. González. (2006) Role for Upf2p Phosphorylation in Saccharomyces cerevisiae Nonsense-Mediated mRNA Decay. Molecular and Cellular Biology 26:9, pages 3390-3400.
Read now
Jürgen Wittmann, Elly M. Hol & Hans-Martin Jäck. (2006) hUPF2 Silencing Identifies Physiologic Substrates of Mammalian Nonsense-Mediated mRNA Decay. Molecular and Cellular Biology 26:4, pages 1272-1287.
Read now
Andrew Grimson, Sean O'Connor, Carrie Loushin Newman & Philip Anderson. (2004) SMG-1 Is a Phosphatidylinositol Kinase-Related Protein Kinase Required for Nonsense-Mediated mRNA Decay in Caenorhabditis elegans. Molecular and Cellular Biology 24:17, pages 7483-7490.
Read now
Chyi-Ying A. Chen & Ann-Bin Shyu. (2003) Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway. Molecular and Cellular Biology 23:14, pages 4805-4813.
Read now
Jens Lykke-Andersen. (2002) Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay. Molecular and Cellular Biology 22:23, pages 8114-8121.
Read now
Kavitha S. Rajavel & Elizabeth F. Neufeld. (2001) Nonsense-Mediated Decay of HumanHEXA mRNA. Molecular and Cellular Biology 21:16, pages 5512-5519.
Read now
Ryu Ueda. (2001) RNAi: A New Technology in the Post-Genomic Sequencing Era. Journal of Neurogenetics 15:3-4, pages 193-204.
Read now
Guillaume Serin, Anand Gersappe, Jennifer D. Black, Rachel Aronoff & Lynne E. Maquat. (2001) Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4). Molecular and Cellular Biology 21:1, pages 209-223.
Read now
Joshua T. Mendell, Susan M. Medghalchi, Ross G. Lake, Erick N. Noensie & Harry C. Dietz. (2000) Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes. Molecular and Cellular Biology 20:23, pages 8944-8957.
Read now
Alan B. Maderazo, Feng He, David A. Mangus & Allan Jacobson. (2000) Upf1p Control of Nonsense mRNA Translation Is Regulated by Nmd2p and Upf3p. Molecular and Cellular Biology 20:13, pages 4591-4603.
Read now
Biswadip Das, Zijian Guo, Patrick Russo, Pascal Chartrand & Fred Sherman. (2000) The Role of Nuclear Cap Binding Protein Cbc1p of Yeast in mRNA Termination and Degradation. Molecular and Cellular Biology 20:8, pages 2827-2838.
Read now

Articles from other publishers (156)

Christin S. Adamo, Aude Beyens, Alvise Schiavinato, Douglas R. Keene, Sara F. Tufa, Matthias Mörgelin, Jürgen Brinckmann, Takako Sasaki, Anja Niehoff, Maren Dreiner, Lore Pottie, Laura Muiño-Mosquera, Elif Yilmaz Gulec, Alper Gezdirici, Paola Braghetta, Paolo Bonaldo, Raimund Wagener, Mats Paulsson, Helen Bornaun, Riet De Rycke, Michiel De Bruyne, Femke Baeke, Walter P. Devine, Balram Gangaram, Allison Tam, Meena Balasubramanian, Sian Ellard, Sandra Moore, Sofie Symoens, Joseph Shen, Stacey Cole, Ulrike Schwarze, Kathryn W. Holmes, Susan J. Hayflick, Wojciech Wiszniewski, Sheela Nampoothiri, Elaine C. Davis, Lynn Y. Sakai, Gerhard Sengle & Bert Callewaert. (2022) EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis. The American Journal of Human Genetics 109:12, pages 2230-2252.
Crossref
Anna Orlova, Daria Guseva & Oxana Ryzhkova. (2022) Identification of a Novel de Novo Variant in the CASZ1 Causing a Rare Type of Dilated Cardiomyopathy. International Journal of Molecular Sciences 23:20, pages 12506.
Crossref
Sarah E Fritz, Soumya Ranganathan, Clara D Wang & J Robert Hogg. (2022) An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay. The EMBO Journal 41:10.
Crossref
Sung Ho Boo, Hongseok Ha, Yujin Lee, Min-Kyung Shin, Sena Lee & Yoon Ki Kim. (2022) UPF1 promotes rapid degradation of m6A-containing RNAs. Cell Reports 39:8, pages 110861.
Crossref
Agathe Gilbert & Cosmin Saveanu. (2022) Unusual SMG suspects recruit degradation enzymes in nonsense‐mediated mRNA decay. BioEssays 44:5.
Crossref
G. A. Zhouravleva, S. A. Bondarev, O. M. Zemlyanko & S. E. Moskalenko. (2022) Role of Proteins Interacting with the eRF1 and eRF3 Release Factors in the Regulation of Translation and Prionization. Molecular Biology 56:2, pages 147-165.
Crossref
Bernard Nsengimana, Faiz Ali Khan, Ebenezeri Erasto Ngowi, Xuefeng Zhou, Yu Jin, Yuting Jia, Wenqiang Wei & Shaoping Ji. (2022) Processing body (P-body) and its mediators in cancer. Molecular and Cellular Biochemistry 477:4, pages 1217-1238.
Crossref
Eun Ji E. Kim, Heehwa G. Son, Hae-Eun H. Park, Yoonji Jung, Sujeong Kwon & Seung-Jae V. Lee. (2020) Caenorhabditis elegans algn-2 Is Critical for Longevity Conferred by Enhanced Nonsense-Mediated mRNA Decay. iScience 23:11, pages 101713.
Crossref
Joshua A Arribere, Hidehito Kuroyanagi & Heather A Hundley. (2020) mRNA Editing, Processing and Quality Control in Caenorhabditis elegans . Genetics 215:3, pages 531-568.
Crossref
Kamila Pawlicka, Umesh Kalathiya & Javier Alfaro. (2020) Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics. Cancers 12:3, pages 765.
Crossref
Xing Chen, Wen‐Jian Tang, Jing Bo Shi, Ming Ming Liu & Xin‐Hua Liu. (2020) Therapeutic strategies for targeting telomerase in cancer. Medicinal Research Reviews 40:2, pages 532-585.
Crossref
Li Zhu, Liang Li, Yilun Qi, Zishuo Yu & Yanhui Xu. (2019) Cryo-EM structure of SMG1–SMG8–SMG9 complex. Cell Research 29:12, pages 1027-1034.
Crossref
Yanjie Tan, Zhenfa Ma, Yi Jin, Ruojun Zong, Jian Wu & Zhuqing Ren. (2019) MicroRNA 4651 regulates nonsense-mediated mRNA decay by targeting SMG9 mRNA. Gene 701, pages 65-71.
Crossref
Jonathan O Nelson, Dominique Förster, Kimberly A Frizzell, Stefan Luschnig & Mark M Metzstein. (2018) Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila . Genetics 209:4, pages 1073-1084.
Crossref
Cheng Wang, Roel Oldenkamp, Ronald J.W. Oellers & Colin Logie. 2018. Corticosteroids. Corticosteroids.
Pamela Nicholson, Asimina Gkratsou, Christoph Josi, Martino Colombo & Oliver Mühlemann. (2018) Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells. RNA 24:4, pages 557-573.
Crossref
Ruo-Bing Guan, Hai-Chao Li, Yu-Jie Fan, Shao-Ru Hu, Olivier Christiaens, Guy Smagghe & Xue-Xia Miao. (2018) A nuclease specific to lepidopteran insects suppresses RNAi. Journal of Biological Chemistry 293:16, pages 6011-6021.
Crossref
Puneet Gupta & Yan-Ruide Li. (2017) Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay. Molecular Biology Reports 45:1, pages 39-55.
Crossref
Virginia S Muir, Audrey P Gasch & Philip Anderson. (2018) The Substrates of Nonsense-Mediated mRNA Decay in Caenorhabditis elegans . G3 Genes|Genomes|Genetics 8:1, pages 195-205.
Crossref
Akio Yamashita. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4885 4893 .
Sangsoon Park, Hae-Eun H. Park, Heehwa G. Son & Seung-Jae V. Lee. (2017) The role of RNA helicases in aging and lifespan regulation. Translational Medicine of Aging 1, pages 24-31.
Crossref
Jing-Jing Zhang, Jun-Jun Hao, Yu-Ru Zhang, Yan-Li Wang, Ming-Yi Li, Hui-Lai Miao, Xiao-Ju Zou & Bin Liang. (2017) Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans. Journal of Lipid Research 58:9, pages 1845-1854.
Crossref
Saba Dehghani-Tafti & Cyril M. Sanders. (2017) DNA substrate recognition and processing by the full-length human UPF1 helicase. Nucleic Acids Research 45:12, pages 7354-7366.
Crossref
Min-Kung Hsu, Hsuan-Yu Lin & Feng-Chi Chen. (2017) NMD Classifier: A reliable and systematic classification tool for nonsense-mediated decay events. PLOS ONE 12:4, pages e0174798.
Crossref
Sébastien Durand, Tobias M. Franks & Jens Lykke-Andersen. (2016) Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nature Communications 7:1.
Crossref
Greg M. Arndt & Karen L. MacKenzie. (2016) New prospects for targeting telomerase beyond the telomere. Nature Reviews Cancer 16:8, pages 508-524.
Crossref
Nancy Martínez-Montiel, Laura Morales-Lara, Julio M. Hernández-Pérez & Rebeca D. Martínez-Contreras. (2016) In Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydis. PLOS ONE 11:2, pages e0148191.
Crossref
Akio Yamashita. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 9 .
Tobias Fatscher, Volker Boehm & Niels H. Gehring. (2015) Mechanism, factors, and physiological role of nonsense-mediated mRNA decay. Cellular and Molecular Life Sciences 72:23, pages 4523-4544.
Crossref
Feng HeAllan Jacobson. (2015) Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story. Annual Review of Genetics 49:1, pages 339-366.
Crossref
Francesca Fiorini, Debjani Bagchi, Hervé Le Hir & Vincent Croquette. (2015) Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities. Nature Communications 6:1.
Crossref
Lam Son Nguyen, Miles F. Wilkinson & Jozef Gecz. (2014) Nonsense-mediated mRNA decay: Inter-individual variability and human disease. Neuroscience & Biobehavioral Reviews 46, pages 175-186.
Crossref
Megan Peccarelli & Bessie W. Kebaara. (2014) Regulation of Natural mRNAs by the Nonsense-Mediated mRNA Decay Pathway. Eukaryotic Cell 13:9, pages 1126-1135.
Crossref
Nele Hug & Javier F. Cáceres. (2014) The RNA Helicase DHX34 Activates NMD by Promoting a Transition from the Surveillance to the Decay-Inducing Complex. Cell Reports 8:6, pages 1845-1856.
Crossref
Cristina Tocchini, Jeremy J. Keusch, Sarah B. Miller, Susanne Finger, Heinz Gut, Michael B. Stadler & Rafal Ciosk. (2014) The TRIM-NHL Protein LIN-41 Controls the Onset of Developmental Plasticity in Caenorhabditis elegans. PLoS Genetics 10:8, pages e1004533.
Crossref
Pamela Nicholson, Christoph Josi, Hitomi Kurosawa, Akio Yamashita & Oliver Mühlemann. (2014) A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Research 42:14, pages 9217-9235.
Crossref
Sutapa Chakrabarti, Fabien Bonneau, Steffen Schüssler, Elfriede Eppinger & Elena Conti. (2014) Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6. Nucleic Acids Research 42:14, pages 9447-9460.
Crossref
Valentin Flury, Umberto Restuccia, Angela Bachi & Oliver Mühlemann. (2014) Characterization of Phosphorylation- and RNA-Dependent UPF1 Interactors by Quantitative Proteomics. Journal of Proteome Research 13:6, pages 3038-3053.
Crossref
Jason W. Chin. (2014) Expanding and Reprogramming the Genetic Code of Cells and Animals. Annual Review of Biochemistry 83:1, pages 379-408.
Crossref
Clarivel Lasalde, Andrea V. Rivera, Alfredo J. León, José A. González-Feliciano, Luis A. Estrella, Eva N. Rodríguez-Cruz, María E. Correa, Iván J. Cajigas, Dina P. Bracho, Irving E. Vega, Miles F. Wilkinson & Carlos I. González. (2014) Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Research 42:3, pages 1916-1929.
Crossref
Hana Cho, Sisu Han, Ok Hyun Park & Yoon Ki Kim. (2013) SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:12, pages 1276-1287.
Crossref
Stefanie Metze, Veronika A. Herzog, Marc-David Ruepp & Oliver Mühlemann. (2013) Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways. RNA 19:10, pages 1432-1448.
Crossref
Dasa Longman, Nele Hug, Marianne Keith, Corina Anastasaki, E. Elizabeth Patton, Graeme Grimes & Javier F. Cáceres. (2013) DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Research 41:17, pages 8319-8331.
Crossref
Jason LeBlanc, Jason Weil & Karen Beemon. (2013) Posttranscriptional regulation of retroviral gene expression: primary RNA transcripts play three roles as pre‐ mRNA , mRNA , and genomic RNA . WIREs RNA 4:5, pages 567-580.
Crossref
David Zünd, Andreas R Gruber, Mihaela Zavolan & Oliver Mühlemann. (2013) Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs. Nature Structural & Molecular Biology 20:8, pages 936-943.
Crossref
Christoph Schweingruber, Simone C. Rufener, David Zünd, Akio Yamashita & Oliver Mühlemann. (2013) Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:6-7, pages 612-623.
Crossref
Akio Yamashita. (2013) Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay. Genes to Cells 18:3, pages 161-175.
Crossref
Stefanie Jonas, Oliver Weichenrieder & Elisa Izaurralde. (2013) An unusual arrangement of two 14-3-3-like domains in the SMG5–SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes & Development 27:2, pages 211-225.
Crossref
Yiwen Fang, John F. Bateman, Julian F. Mercer & Shireen R. Lamandé. (2013) Nonsense-mediated mRNA decay of collagen – emerging complexity in RNA surveillance mechanisms. Journal of Cell Science.
Crossref
I. M. Palacios. (2012) Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health. Briefings in Functional Genomics 12:1, pages 25-36.
Crossref
Stephanie Kvas, Gregory B Gloor & Christopher J Brandl. (2012) Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1. BMC Genetics 13:1.
Crossref
Stephanie Kervestin & Allan Jacobson. (2012) NMD: a multifaceted response to premature translational termination. Nature Reviews Molecular Cell Biology 13:11, pages 700-712.
Crossref
Lulu Huang & Miles F. Wilkinson. (2012) Regulation of nonsense-mediated mRNA decay. Wiley Interdisciplinary Reviews: RNA 3:6, pages 807-828.
Crossref
Kimberly A. Frizzell, Shawn G. Rynearson & Mark M. Metzstein. (2012) Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6 . RNA 18:8, pages 1475-1486.
Crossref
Stephanie Kervestin, Chunfang Li, Richard Buckingham & Allan Jacobson. (2012) Testing the faux-UTR model for NMD: Analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p. Biochimie 94:7, pages 1560-1571.
Crossref
Yukiko Okada-Katsuhata, Akio Yamashita, Kei Kutsuzawa, Natsuko Izumi, Fumiki Hirahara & Shigeo Ohno. (2012) N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Research 40:3, pages 1251-1266.
Crossref
Thomas Schalch, Godwin Job, Sreenath Shanker, Janet F Partridge & Leemor Joshua-Tor. (2011) The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural & Molecular Biology 18:12, pages 1351-1357.
Crossref
Claire E. Richardson, Stephanie Kinkel & Dennis H. Kim. (2011) Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity. PLoS Genetics 7:11, pages e1002391.
Crossref
Raghav Chawla, Sophie Redon, Christina Raftopoulou, Harry Wischnewski, Sarantis Gagos & Claus M Azzalin. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. The EMBO Journal 30:19, pages 4047-4058.
Crossref
Sebastian GreissJason W. Chin. (2011) Expanding the Genetic Code of an Animal. Journal of the American Chemical Society 133:36, pages 14196-14199.
Crossref
Jungwook Hwang & Lynne E Maquat. (2011) Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Current Opinion in Genetics & Development 21:4, pages 422-430.
Crossref
Corina Anastasaki, Dasa Longman, Amy Capper, E. Elizabeth Patton & Javier F. Cáceres. (2011) Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Research 39:9, pages 3686-3694.
Crossref
Sutapa Chakrabarti, Uma Jayachandran, Fabien Bonneau, Francesca Fiorini, Claire Basquin, Silvia Domcke, Hervé Le Hir & Elena Conti. (2011) Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2. Molecular Cell 41:6, pages 693-703.
Crossref
Pamela Nicholson & Oliver Mühlemann. (2010) Cutting the nonsense: the degradation of PTC-containing mRNAs. Biochemical Society Transactions 38:6, pages 1615-1620.
Crossref
Tobias M. Franks, Guramrit Singh & Jens Lykke-Andersen. (2010) Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay. Cell 143:6, pages 938-950.
Crossref
Isao Kashima, Stefanie Jonas, Uma Jayachandran, Gretel Buchwald, Elena Conti, Andrei N. Lupas & Elisa Izaurralde. (2010) SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes & Development 24:21, pages 2440-2450.
Crossref
Shubhendu Ghosh, Robin Ganesan, Nadia Amrani & Allan Jacobson. (2010) Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA 16:9, pages 1832-1847.
Crossref
Jungwook Hwang, Hanae Sato, Yalan Tang, Daiki Matsuda & Lynne E. Maquat. (2010) UPF1 Association with the Cap-Binding Protein, CBP80, Promotes Nonsense-Mediated mRNA Decay at Two Distinct Steps. Molecular Cell 39:3, pages 396-409.
Crossref
Portia Gloria Loh & Haiwei Song. 2010. RNA Helicases. RNA Helicases 189 212 .
Pamela Nicholson, Hasmik Yepiskoposyan, Stefanie Metze, Rodolfo Zamudio Orozco, Nicole Kleinschmidt & Oliver Mühlemann. (2009) Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cellular and Molecular Life Sciences 67:5, pages 677-700.
Crossref
Kouichi Ogami & Shinichi Hoshino. (2010) Research on mRNA degradation and drug discovery. Folia Pharmacologica Japonica 136:3, pages 150-154.
Crossref
Alisson M Gontijo, Sylvie Aubert, Ingele Roelens & Bernard Lakowski. (2009) Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans. BMC Genetics 10:1.
Crossref
Weifeng Gu, Masaki Shirayama, Darryl ConteJr.Jr., Jessica Vasale, Pedro J. Batista, Julie M. Claycomb, James J. Moresco, Elaine M. Youngman, Jennifer Keys, Matthew J. Stoltz, Chun-Chieh G. Chen, Daniel A. Chaves, Shenghua Duan, Kristin D. Kasschau, Noah Fahlgren, John R. YatesIIIIII, Shohei Mitani, James C. Carrington & Craig C. Mello. (2009) Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline. Molecular Cell 36:2, pages 231-244.
Crossref
Maia Dorsett, Bethany Westlund & Tim Schedl. (2009) METT-10, A Putative Methyltransferase, Inhibits Germ Cell Proliferative Fate in Caenorhabditis elegans . Genetics 183:1, pages 233-247.
Crossref
Yongjun Dang, Woon-Kai Low, Jing Xu, Niels H. Gehring, Harry C. Dietz, Daniel Romo & Jun O. Liu. (2009) Inhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIII. Journal of Biological Chemistry 284:35, pages 23613-23621.
Crossref
Indrani Rebbapragada & Jens Lykke-Andersen. (2009) Execution of nonsense-mediated mRNA decay: what defines a substrate?. Current Opinion in Cell Biology 21:3, pages 394-402.
Crossref
Saverio Brogna & Jikai Wen. (2009) Nonsense-mediated mRNA decay (NMD) mechanisms. Nature Structural & Molecular Biology 16:2, pages 107-113.
Crossref
Hana Cho, Kyoung Mi Kim & Yoon Ki Kim. (2009) Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex. Molecular Cell 33:1, pages 75-86.
Crossref
Eric Huntzinger, Isao Kashima, Maria Fauser, Jérôme Saulière & Elisa Izaurralde. (2008) SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14:12, pages 2609-2617.
Crossref
Yi-Hsiu Chen, Li-Hsin Su, Yu-Chang Huang, Yi-Ting Wang, Yu-Yun Kao & Chin-Hung Sun. (2008) UPF1, a Conserved Nonsense-Mediated mRNA Decay Factor, Regulates Cyst Wall Protein Transcripts in Giardia lamblia. PLoS ONE 3:10, pages e3609.
Crossref
Olaf Isken & Lynne E. Maquat. (2008) The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nature Reviews Genetics 9:9, pages 699-712.
Crossref
Chengang Zhu, Zhouzhou Zhao, Mingxiong Guo, Huanjie Shao, Hongling Qiu, Di Wang, Junhua Xu, Lu Xue & Wenxin Li. (2008) The mammalian gene ZNF268 is regulated by hUpf1. Biochemistry (Moscow) 73:8, pages 881-885.
Crossref
Saverio BrognaPreethi RamanathanJikai Wen. (2008) UPF1 P-body localization. Biochemical Society Transactions 36:4, pages 698-700.
Crossref
Lukas Stalder & Oliver Mühlemann. (2008) The meaning of nonsense. Trends in Cell Biology 18:7, pages 315-321.
Crossref
Olaf Isken, Yoon Ki Kim, Nao Hosoda, Greg L. Mayeur, John W.B. Hershey & Lynne E. Maquat. (2008) Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay. Cell 133:2, pages 314-327.
Crossref
Pavel V Ivanov, Niels H Gehring, Joachim B Kunz, Matthias W Hentze & Andreas E Kulozik. (2008) Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. The EMBO Journal 27:5, pages 736-747.
Crossref
Sergio Barberan-Soler & Alan M. Zahler. (2008) Alternative Splicing Regulation During C. elegans Development: Splicing Factors as Regulated Targets. PLoS Genetics 4:2, pages e1000001.
Crossref
Ann-Bin Shyu, Miles F Wilkinson & Ambro van Hoof. (2008) Messenger RNA regulation: to translate or to degrade. The EMBO Journal 27:3, pages 471-481.
Crossref
Gabriele Neu‐Yilik & Andreas E. Kulozik. 2008. 185 243 .
Sébastien Durand, Nicolas Cougot, Florence Mahuteau-Betzer, Chi-Hung Nguyen, David S. Grierson, Edouard Bertrand, Jamal Tazi & Fabrice Lejeune. (2007) Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies. Journal of Cell Biology 178:7, pages 1145-1160.
Crossref
Michael R Culbertson. (2007) Navigating Without a Road Map. Genetics 177:1, pages 1-7.
Crossref
Olaf Isken & Lynne E. Maquat. (2007) Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes & Development 21:15, pages 1833-3856.
Crossref
Isabelle Behm-Ansmant, Isao Kashima, Jan Rehwinkel, Jérôme Saulière, Nadine Wittkopp & Elisa Izaurralde. (2007) mRNA quality control: An ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Letters 581:15, pages 2845-2853.
Crossref
Yao-Fu ChangJ. Saadi ImamMiles F. Wilkinson. (2007) The Nonsense-Mediated Decay RNA Surveillance Pathway. Annual Review of Biochemistry 76:1, pages 51-74.
Crossref
Dasa Longman, Ronald H.A. Plasterk, Iain L. Johnstone & Javier F. Cáceres. (2007) Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway . Genes & Development 21:9, pages 1075-1085.
Crossref
Daniel Blanchard, Harald Hutter, Jamie Fleenor & Andrew Fire. (2006) A Differential Cytolocalization Assay for Analysis of Macromolecular Assemblies in the Eukaryotic Cytoplasm. Molecular & Cellular Proteomics 5:11, pages 2175-2184.
Crossref
Filip Glavan, Isabelle Behm-Ansmant, Elisa Izaurralde & Elena Conti. (2006) Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. The EMBO Journal 25:21, pages 5117-5125.
Crossref
Jan Rehwinkel, Jeroen Raes & Elisa Izaurralde. (2006) Nonsense-mediated mRNA decay: target genes and functional diversification of effectors. Trends in Biochemical Sciences 31:11, pages 639-646.
Crossref
Mehrdad Khajavi, Ken Inoue & James R Lupski. (2006) Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease. European Journal of Human Genetics 14:10, pages 1074-1081.
Crossref
Luis Arciga-Reyes, Lucie Wootton, Martin Kieffer & Brendan Davies. (2006) UPF1 is required for nonsense-mediated mRNA decay (NMD) and RNAi in Arabidopsis. The Plant Journal 47:3, pages 480-489.
Crossref
Prema Sundaram, Benjamin Echalier, Wang Han, Dawn Hull & Lisa Timmons. (2006) ATP-binding Cassette Transporters Are Required for Efficient RNA Interference in Caenorhabditis elegans . Molecular Biology of the Cell 17:8, pages 3678-3688.
Crossref
Ujwal Sheth & Roy Parker. (2006) Targeting of Aberrant mRNAs to Cytoplasmic Processing Bodies. Cell 125:6, pages 1095-1109.
Crossref
Isabelle Behm-Ansmant & Elisa Izaurralde. (2006) Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes & Development 20:4, pages 391-398.
Crossref
Bettina Meier, Iuval Clejan, Yan Liu, Mia Lowden, Anton Gartner, Jonathan Hodgkin & Shawn Ahmed. (2006) trt-1 Is the Caenorhabditis elegans Catalytic Subunit of Telomerase. PLoS Genetics 2:2, pages e18.
Crossref
Amanda S. Ford, Qiaoning Guan, Eric Neeno-Eckwall & Michael R. Culbertson. (2006) Ebs1p, a Negative Regulator of Gene Expression Controlled by the Upf Proteins in the Yeast Saccharomyces cerevisiae . Eukaryotic Cell 5:2, pages 301-312.
Crossref
Isao Kashima, Akio Yamashita, Natsuko Izumi, Naoyuki Kataoka, Ryo Morishita, Shinichi Hoshino, Mutsuhito Ohno, Gideon Dreyfuss & Shigeo Ohno. (2006) Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes & Development 20:3, pages 355-367.
Crossref
Claus M. Azzalin & Joachim Lingner. (2006) The Human RNA Surveillance Factor UPF1 Is Required for S Phase Progression and Genome Stability. Current Biology 16:4, pages 433-439.
Crossref
Akio Yamashita, Isao Kashima & Shigeo Ohno. (2005) The role of SMG-1 in nonsense-mediated mRNA decay. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1754:1-2, pages 305-315.
Crossref
JAN REHWINKEL, IVICA LETUNIC, JEROEN RAES, PEER BORK & ELISA IZAURRALDE. (2005) Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA 11:10, pages 1530-1544.
Crossref
Shveta Bagga, John Bracht, Shaun Hunter, Katlin Massirer, Janette Holtz, Rachel Eachus & Amy E. Pasquinelli. (2005) Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation. Cell 122:4, pages 553-563.
Crossref
Elena Conti & Elisa Izaurralde. (2005) Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Current Opinion in Cell Biology 17:3, pages 316-325.
Crossref
Lynne E. Maquat. (2005) Nonsense-mediated mRNA decay in mammals. Journal of Cell Science 118:9, pages 1773-1776.
Crossref
Noemi Fukuhara, Judith Ebert, Leonie Unterholzner, Doris Lindner, Elisa Izaurralde & Elena Conti. (2005) SMG7 Is a 14-3-3-like Adaptor in the Nonsense-Mediated mRNA Decay Pathway. Molecular Cell 17:4, pages 537-547.
Crossref
KRISTIAN E. BAKER & CIARÁN CONDON. (2004) Under the Tucson sun: A meeting in the desert on mRNA decay. RNA 10:11, pages 1680-1691.
Crossref
Marco A. Valencia-Sánchez & Lynne E. Maquat. (2004) An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends in Cell Biology 14:11, pages 594-597.
Crossref
Leonie Unterholzner & Elisa Izaurralde. (2004) SMG7 Acts as a Molecular Link between mRNA Surveillance and mRNA Decay. Molecular Cell 16:4, pages 587-596.
Crossref
Avril Coghlan & Kenneth H. Wolfe. (2004) Origins of recently gained introns in Caenorhabditis . Proceedings of the National Academy of Sciences 101:31, pages 11362-11367.
Crossref
Jill A Holbrook, Gabriele Neu-Yilik, Matthias W Hentze & Andreas E Kulozik. (2004) Nonsense-mediated decay approaches the clinic. Nature Genetics 36:8, pages 801-808.
Crossref
Kathryn M. Brumbaugh, Diane M. Otterness, Christoph Geisen, Vasco Oliveira, John Brognard, Xiaojie Li, Fabrice Lejeune, Randal S. Tibbetts, Lynne E. Maquat & Robert T. Abraham. (2004) The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells. Molecular Cell 14:5, pages 585-598.
Crossref
Kristian E Baker & Roy Parker. (2004) Nonsense-mediated mRNA decay: terminating erroneous gene expression. Current Opinion in Cell Biology 16:3, pages 293-299.
Crossref
Min-Ho Lee & Tim Schedl. (2004) Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans . Genes & Development 18:9, pages 1047-1059.
Crossref
Pavan Kadandale & Andrew Singson. (2004) Oocyte production and sperm utilization patterns in semi-fertile strains of Caenorhabditis elegans. BMC Developmental Biology 4:1.
Crossref
B. de Pinto, R. Lippolis, R. Castaldo & N. Altamura. (2004) Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance. Molecular Microbiology 51:4, pages 1129-1142.
Crossref
Lynne E. Maquat. (2004) Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nature Reviews Molecular Cell Biology 5:2, pages 89-99.
Crossref
Neema Agrawal, P. V. N. Dasaradhi, Asif Mohmmed, Pawan Malhotra, Raj K. Bhatnagar & Sunil K. Mukherjee. (2003) RNA Interference: Biology, Mechanism, and Applications. Microbiology and Molecular Biology Reviews 67:4, pages 657-685.
Crossref
Ollivier Milhavet, Devin S. Gary & Mark P. Mattson. (2003) RNA Interference in Biology and Medicine. Pharmacological Reviews 55:4, pages 629-648.
Crossref
Feng He, Xiangrui Li, Phyllis Spatrick, Ryan Casillo, Shuyun Dong & Allan Jacobson. (2003) Genome-Wide Analysis of mRNAs Regulated by the Nonsense-Mediated and 5′ to 3′ mRNA Decay Pathways in Yeast. Molecular Cell 12:6, pages 1439-1452.
Crossref
Miles F Wilkinson. (2003) The Cycle of Nonsense. Molecular Cell 12:5, pages 1059-1061.
Crossref
Tetsuo Ohnishi, Akio Yamashita, Isao Kashima, Thomas Schell, Kirk R. Anders, Andrew Grimson, Takahisa Hachiya, Matthias W. Hentze, Philip Anderson & Shigeo Ohno. (2003) Phosphorylation of hUPF1 Induces Formation of mRNA Surveillance Complexes Containing hSMG-5 and hSMG-7. Molecular Cell 12:5, pages 1187-1200.
Crossref
Guramrit Singh & Jens Lykke-Andersen. (2003) New insights into the formation of active nonsense-mediated decay complexes. Trends in Biochemical Sciences 28:9, pages 464-466.
Crossref
Niels H. Gehring, Gabriele Neu-Yilik, Thomas Schell, Matthias W. Hentze & Andreas E. Kulozik. (2003) Y14 and hUpf3b Form an NMD-Activating Complex. Molecular Cell 11:4, pages 939-949.
Crossref
Michael R Culbertson & Peter F Leeds. (2003) Looking at mRNA decay pathways through the window of molecular evolution. Current Opinion in Genetics & Development 13:2, pages 207-214.
Crossref
SHANG-YI CHIU, GUILLAUME SERIN, OSAMU OHARA & LYNNE E. MAQUAT. (2003) Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 . RNA 9:1, pages 77-87.
Crossref
JAMES E. DAHLBERG, ELSEBET LUND & ELIZABETH B. GOODWIN. (2003) Nuclear translation: What is the evidence?. RNA 9:1, pages 1-8.
Crossref
Joanna B. Grabarek. 2003. Peroxisomal Disorders and Regulation of Genes. Peroxisomal Disorders and Regulation of Genes 145 158 .
Lois Wingerson. (2002) New drugs from nonsense. TARGETS 1:5, pages 148-149.
Crossref
Eileen Wagner & Jens Lykke-Andersen. (2002) mRNA surveillance: the perfect persist. Journal of Cell Science 115:15, pages 3033-3038.
Crossref
Renee L Shirley, Amanda S Ford, M Rachel Richards, Markus Albertini & Michael R Culbertson. (2002) Nuclear Import of Upf3p Is Mediated by Importin-α/-β and Export to the Cytoplasm Is Required for a Functional Nonsense-Mediated mRNA Decay Pathway in Yeast. Genetics 161:4, pages 1465-1482.
Crossref
Sabine Brantl. (2002) Antisense-RNA regulation and RNA interference. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1575:1-3, pages 15-25.
Crossref
Carol J. Wilusz, Weirong Wang & Stuart W. Peltz. (2001) Curbing the nonsense: the activation and regulation of mRNA surveillance: Figure 1.. Genes & Development 15:21, pages 2781-2785.
Crossref
Susan E Mango. (2001) Stop making nonSense: the C. elegans smg genes. Trends in Genetics 17:11, pages 646-653.
Crossref
Jens Lykke-AndersenMei-Di ShuJoan A. Steitz. (2001) Communication of the Position of Exon-Exon Junctions to the mRNA Surveillance Machinery by the Protein RNPS1. Science 293:5536, pages 1836-1839.
Crossref
Akio Yamashita, Tetsuo Ohnishi, Isao Kashima, Yoichi Taya & Shigeo Ohno. (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes & Development 15:17, pages 2215-2228.
Crossref
Carlos I González, Anirban Bhattacharya, Weirong Wang & Stuart W Peltz. (2001) Nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Gene 274:1-2, pages 15-25.
Crossref
Gabriela Denning, Lee Jamieson, Lynne E. Maquat, E. Aubrey Thompson & Alan P. Fields. (2001) Cloning of a Novel Phosphatidylinositol Kinase-related Kinase. Journal of Biological Chemistry 276:25, pages 22709-22714.
Crossref
Rachel Aronoff, Renee Baran & Jonathan Hodgkin. (2001) Molecular identification of smg-4 , required for mRNA surveillance in C. elegans. Gene 268:1-2, pages 153-164.
Crossref
Carol J. Wilusz, Michael Wormington & Stuart W. Peltz. (2001) The cap-to-tail guide to mRNA turnover. Nature Reviews Molecular Cell Biology 2:4, pages 237-246.
Crossref
Richard W Carthew. (2001) Gene silencing by double-stranded RNA. Current Opinion in Cell Biology 13:2, pages 244-248.
Crossref
Phillip A. Sharp. (2001) RNA interference—2001. Genes & Development 15:5, pages 485-490.
Crossref
Scott M. Hammond, Amy A. Caudy & Gregory J. Hannon. (2001) Post-transcriptional gene silencing by double-stranded RNA. Nature Reviews Genetics 2:2, pages 110-119.
Crossref
C.I. GONZALEZ, W. WANG & S.W. PELTZ. (2001) Nonsense-mediated mRNA Decay in Saccharomyces cerevisiae: A Quality Control Mechanism That Degrades Transcripts Harboring Premature Termination Codons. Cold Spring Harbor Symposia on Quantitative Biology 66:0, pages 321-328.
Crossref
L.E. MAQUAT & G. SERIN. (2001) Nonsense-mediated mRNA Decay: Insights into Mechanism from the Cellular Abundance of Human Upf1, Upf2, Upf3, and Upf3X Proteins. Cold Spring Harbor Symposia on Quantitative Biology 66:0, pages 313-320.
Crossref
Patricia M. Clissold & Chris P. Ponting. (2000) PIN domains in nonsense-mediated mRNA decay and RNAi. Current Biology 10:24, pages R888-R890.
Crossref
Jens Lykke-Andersen, Mei-Di Shu & Joan A. Steitz. (2000) Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon. Cell 103:7, pages 1121-1131.
Crossref
Mary Ellen DomeierDaniel P. MorseScott W. KnightMichael PortereikoBrenda L. BassSusan E. Mango. (2000) A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans . Science 289:5486, pages 1928-1930.
Crossref
Quinn M. Mitrovich & Philip Anderson. (2000) Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans . Genes & Development 14:17, pages 2173-2184.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.