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Molecular and Cellular Biology Volume 20, 2000 - Issue 15
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Cell Growth and Development

CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily

Aristides G. Eliopoulos1 CRC Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TTCorrespondence[email protected]
,
Clare Davies1 CRC Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TT
,
Pauline G. Knox1 CRC Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TT
,
Neil J. Gallagher1 CRC Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TT
,
Simon C. Afford2 Liver Research Laboratories, The University of Birmingham Institute of Clinical Science, BirminghamB15 2TH, United Kingdom
,
David H. Adams2 Liver Research Laboratories, The University of Birmingham Institute of Clinical Science, BirminghamB15 2TH, United Kingdom
&
Lawrence S. Young1 CRC Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TT
 show all
Pages 5503-5515 | Received 15 Dec 1999, Accepted 08 May 2000, Published online: 28 Mar 2023

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Crossref
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Crossref
Margaret K. Callahan, Jedd D. Wolchok, James P. Allison & Padmanee Sharma. 2013. Cancer Immunotherapy. Cancer Immunotherapy 211 280 .
Uddipan Sarma, Archana Sareen, Moitrayee Maiti, Vanita Kamat, Raki Sudan, Sushmita Pahari, Neetu Srivastava, Somenath Roy, Sitabhra Sinha, Indira Ghosh, Ajit G. Chande, Robin Mukhopadhyaya & Bhaskar Saha. (2012) Modeling and Experimental Analyses Reveals Signaling Plasticity in a Bi-Modular Assembly of CD40 Receptor Activated Kinases. PLoS ONE 7:7, pages e39898.
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Crossref
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Crossref
A. Page, S. Srinivasan, K. Singh, M. Russell, K. Hamby, T. Deane, S. Sen, L. Stempora, F. Leopardi, A.A. Price, E. Strobert, K.A. Reimann, A.D. Kirk, C.P. Larsen & L.S. Kean. (2012) CD40 Blockade Combines with CTLA4Ig and Sirolimus to Produce Mixed Chimerism in an MHC-Defined Rhesus Macaque Transplant Model. American Journal of Transplantation 12:1, pages 115-125.
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Crossref
N Vanlangenakker, T Vanden Berghe & P Vandenabeele. (2011) Many stimuli pull the necrotic trigger, an overview. Cell Death & Differentiation 19:1, pages 75-86.
Crossref
Taha Elmetwali, Peter F Searle, Iain McNeish, Lawrence S Young & Daniel H Palmer. (2010) CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus. Molecular Cancer 9:1.
Crossref
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Crossref
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Crossref
John P. Graham, Kelly M. Arcipowski & Gail A. Bishop. (2010) Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1. Immunological Reviews 237:1, pages 226-248.
Crossref
Taha Elmetwali, Lawrence S. Young & Daniel H. Palmer. (2010) CD40 Ligand-Induced Carcinoma Cell Death: A Balance between Activation of TNFR-Associated Factor (TRAF) 3-Dependent Death Signals and Suppression of TRAF6-Dependent Survival Signals. The Journal of Immunology 184:2, pages 1111-1120.
Crossref
L Vardouli, C Lindqvist, K Vlahou, A S I Loskog & A G Eliopoulos. (2009) Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas. Cancer Gene Therapy 16:11, pages 848-860.
Crossref
Angelica S.I. Loskog & Aristides G. Eliopoulos. (2009) The Janus faces of CD40 in cancer. Seminars in Immunology 21:5, pages 301-307.
Crossref
William K. Decker & Amar Safdar. (2009) Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley's legacy revisited. Cytokine & Growth Factor Reviews 20:4, pages 271-281.
Crossref
Raul Elgueta, Micah J. Benson, Victor C. de Vries, Anna Wasiuk, Yanxia Guo & Randolph J. Noelle. (2009) Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunological Reviews 229:1, pages 152-172.
Crossref
A Wicovsky, F Henkler, S Salzmann, P Scheurich, C Kneitz & H Wajant. (2009) Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation. Oncogene 28:15, pages 1769-1781.
Crossref
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Crossref
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Danice E. C. Wilkins & William J. Murphy. 2009. Targeted Cancer Immune Therapy. Targeted Cancer Immune Therapy 227 239 .
Che-Leung Law & Iqbal S. Grewal. 2009. Therapeutic Targets of the TNF Superfamily. Therapeutic Targets of the TNF Superfamily 8 36 .
Enli Jiang, Xiang He, Xiancheng Chen, Guojuan Sun, Hongbing Wu, Yuquan Wei & Xia Zhao. (2018) Expression of CD40 in Ovarian Cancer and Adenovirus-Mediated CD40 Ligand Therapy on Ovarian Cancer in Vitro. Tumori Journal 94:3, pages 356-361.
Crossref
T Drewa, Z Wolski, B Misterek, R Debski & J Styczynski. (2007) The influence of α1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients. Prostate Cancer and Prostatic Diseases 11:1, pages 88-93.
Crossref
Torry A. Tucker & Lisa M. Schwiebert. (2008) CD40 ligation decreases its protein half-lifeat the cell surface. European Journal of Immunology 38:3, pages 864-869.
Crossref
K Tomihara, K Kato, Y Masuta, K Nakamura, H Uchida, K Sasaki, T Tanaka, J Huang, H Hiratsuka & H Hamada. (2007) Gene transfer of CD40-ligand to dendritic cells stimulates interferon-γ production to induce growth arrest and apoptosis of tumor cells. Gene Therapy 15:3, pages 203-213.
Crossref
Yugang Wu, Liang Wang, Xiaozhou He, Haiyan Xu, Lechang Zhou, Fang Zhao & Yanyun Zhang. (2008) Expression of CD40 and growth-inhibitory activity of CD40 ligand in colon cancer ex vivo. Cellular Immunology 253:1-2, pages 102-109.
Crossref
Bart H. J. van den Berg, Tya Harris, Fiona M. McCarthy, Susan J. Lamont & Shane C. Burgess. (2007) Non-electrophoretic differential detergent fractionation proteomics using frozen whole organs. Rapid Communications in Mass Spectrometry 21:23, pages 3905-3909.
Crossref
Nikolaos T. Georgopoulos, Alison Merrick, Nigel Scott, Peter J. Selby, Alan Melcher & Ludwik K. Trejdosiewicz. (2007) CD40-mediated death and cytokine secretion in colorectal cancer: A potential target for inflammatory tumour cell killing. International Journal of Cancer 121:6, pages 1373-1381.
Crossref
Magi Khalil & Robert H. Vonderheide. (2007) Anti-CD40 agonist antibodies: Preclinical and clinical experience. Update on Cancer Therapeutics 2:2, pages 61-65.
Crossref
Robert H. Vonderheide, Keith T. Flaherty, Magi Khalil, Molly S. Stumacher, David L. Bajor, Natalie A. Hutnick, Patricia Sullivan, J. Joseph Mahany, Maryann Gallagher, Amy Kramer, Stephanie J. Green, Peter J. O'Dwyer, Kelli L. Running, Richard D. Huhn & Scott J. Antonia. (2007) Clinical Activity and Immune Modulation in Cancer Patients Treated With CP-870,893, a Novel CD40 Agonist Monoclonal Antibody. Journal of Clinical Oncology 25:7, pages 876-883.
Crossref
E. Neppelberg, L. L. Loro, G. Øijordsbakken & A. C. Johannessen. (2007) Altered CD40 and E-cadherin expression - putative role in oral lichen planus. Journal of Oral Pathology & Medicine 36:3, pages 153-160.
Crossref
Bohuslav Melichar, Rebecca Patenia, Stacie Gallardo, Karolina Melicharová, Wei Hu & Ralph S. Freedman. (2007) Expression of CD40 and growth-inhibitory activity of CD40 ligand in ovarian cancer cell lines. Gynecologic Oncology 104:3, pages 707-713.
Crossref
Robert H. Vonderheide. (2007) Prospect of Targeting the CD40 Pathway for Cancer Therapy. Clinical Cancer Research 13:4, pages 1083-1088.
Crossref
Sergey V. Krysov, Tania F. Rowley & Aymen Al-Shamkhani. (2007) Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells. Molecular Cancer Therapeutics 6:2, pages 703-711.
Crossref
Kevin T. Williams, Steven P. Young, Alison Negus, Lawrence S. Young, David H. Adams & Simon C. Afford. (2007) C4b Binding Protein Binds to CD154 Preventing CD40 Mediated Cholangiocyte Apoptosis: A Novel Link between Complement and Epithelial Cell Survival. PLoS ONE 2:1, pages e159.
Crossref
N T Georgopoulos, L P Steele, M J Thomson, P J Selby, J Southgate & L K Trejdosiewicz. (2006) A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation. Cell Death & Differentiation 13:10, pages 1789-1801.
Crossref
Sean K Kelley, Thomas Gelzleichter, Dong Xie, Wyne P Lee, Walter C Darbonne, Ferhan Qureshi, Kim Kissler, Ezogelin Oflazoglu & Iqbal S Grewal. (2006) Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates. British Journal of Pharmacology 148:8, pages 1116-1123.
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Helena Dzojic, Angelica Loskog, Thomas H. Tötterman & Magnus Essand. (2006) Adenovirus-mediated CD40 ligand therapy induces tumor cell apoptosis and systemic immunity in the TRAMP-C2 mouse prostate cancer model. The Prostate 66:8, pages 831-838.
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Jalal Ahmed-Choudhury, Kevin T. Williams, Lawrence S. Young, David H. Adams & Simon C. Afford. (2006) CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular Signalling 18:4, pages 456-468.
Crossref
Koji Tamada & Lieping Chen. (2005) Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules. Cancer Immunology, Immunotherapy 55:4, pages 355-362.
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M. Villarroel Dorrego, S. A. Whawell, P. M. Speight & A. W. Barrett. (2006) Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro. Clinical and Experimental Dermatology 31:2, pages 266-271.
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M. Villarroel Dorrego, S.A. Whawell, P.M. Speight & A.W. Barrett. (2006) Transfection of CD40 in a human oral squamous cell carcinoma keratinocyte line upregulates immune potency and costimulatory molecules. British Journal of Dermatology 154:2, pages 231-238.
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Amanda J Baxendale, Chris W Dawson, Suzanne E Stewart, Vivek Mudaliar, Gary Reynolds, John Gordon, Paul G Murray, Lawrence S Young & Aristides G Eliopoulos. (2005) Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth. Oncogene 24:53, pages 7913-7923.
Crossref
Che-Leung Law, Kristine A. Gordon, John Collier, Kerry Klussman, Julie A. McEarchern, Charles G. Cerveny, Bruce J. Mixan, Wyne P. Lee, Zhonghau Lin, Patricia Valdez, Alan F. Wahl & Iqbal S. Grewal. (2005) Preclinical Antilymphoma Activity of a Humanized Anti-CD40 Monoclonal Antibody, SGN-40. Cancer Research 65:18, pages 8331-8338.
Crossref
Feng Zhou, Maureen N. Ajuebor, Paul L. Beck, Tai Le, Cory M. Hogaboam & Mark G. Swain. (2005) CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis. Hepatology 42:2, pages 372-380.
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Clare C. Davies, Danai Bem, Lawrence S. Young & Aristides G. Eliopoulos. (2005) NF-κB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells. Cellular Signalling 17:6, pages 729-738.
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Jörg Wischhusen, Dagmar Schneider, Michel Mittelbronn, Richard Meyermann, Hartmut Engelmann, Gundram Jung, Heinz Wiendl & Michael Weller. (2005) Death receptor-mediated apoptosis in human malignant glioma cells: Modulation by the CD40/CD40L system. Journal of Neuroimmunology 162:1-2, pages 28-42.
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Li Ping, Noriyoshi Ogawa & Susumu Sugai. (2005) Novel role of CD40 in Fas-dependent apoptosis of cultured salivary epithelial cells from patients with Sjögren's syndrome. Arthritis & Rheumatism 52:2, pages 573-581.
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Seran C. Hill, Sarah J. Youde, Stephen Man, Glyn R. Teale, Amanda J. Baxendale, Andrew Hislop, Clare C. Davies, David M. Luesley, Anna M. Blom, Alan B. Rickinson, Lawrence S. Young & Aristides G. Eliopoulos. (2005) Activation of CD40 in Cervical Carcinoma Cells Facilitates CTL Responses and Augments Chemotherapy-Induced Apoptosis. The Journal of Immunology 174:1, pages 41-50.
Crossref
Charlie T. Garnett, Claudia Palena, Mala Chakarborty, Kwong-Yok Tsang, Jeffrey Schlom & James W. Hodge. (2004) Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes. Cancer Research 64:21, pages 7985-7994.
Crossref
Giovanna D'Amico, Virna Marin, Andrea Biondi & Martin Hernán Bonamino. (2004) Potential use of CD40 ligand for immunotherapy of childhood B-cell precursor acute lymphoblastic leukaemia. Best Practice & Research Clinical Haematology 17:3, pages 465-477.
Crossref
Yufei Xu & Guoxing Song. (2004) The role of CD40-CD154 interaction in cell immunoregulation. Journal of Biomedical Science 11:4, pages 426-438.
Crossref
Chun-Jian Qi, Lu Zheng, Xuan Zhou, Yi Tao, Yan Ge, Yu-Mei Zhuang, Yin Xu, GeHua Yu & Xue-Guang Zhang. (2004) Cross-linking of CD40 using anti-CD40 antibody, 5C11, has different effects on XG2 multiple myeloma cells. Immunology Letters 93:2-3, pages 151-158.
Crossref
Francesca Cagnoni, Susanna Oddera, Julien Giron-Michel, Anna Maria Riccio, Susanna Olsson, Palmiro Dellacasa, Giovanni Melioli, G. Walter Canonica & Bruno Azzarone. (2004) CD40 on Adult Human Airway Epithelial Cells: Expression and Proinflammatory Effects. The Journal of Immunology 172:5, pages 3205-3214.
Crossref
Kyoung-Han Choi, Hye Young Choi, Jae-Kyun Ko, Sung-Shin Park, Yong-Nyun Kim & Chul-Woo Kim. (2004) Transcriptional regulation of TNF family receptors and Bcl-2 family by chemotherapeutic agents in murine CT26 cells. Journal of Cellular Biochemistry 91:2, pages 410-422.
Crossref
Clare C. Davies, Joanne Mason, Michael J.O. Wakelam, Lawrence S. Young & Aristides G. Eliopoulos. (2004) Inhibition of Phosphatidylinositol 3-Kinase- and ERK MAPK-regulated Protein Synthesis Reveals the Pro-apoptotic Properties of CD40 Ligation in Carcinoma Cells. Journal of Biological Chemistry 279:2, pages 1010-1019.
Crossref
Richard A. Watson, Miranda Thomas, Lawrence Banks & Sally Roberts. (2003) Activity of the human papillomavirus E6 PDZ-binding motif correlates with an enhanced morphological transformation of immortalized human keratinocytes. Journal of Cell Science 116:24, pages 4925-4934.
Crossref
I Airoldi, S Lualdi, S Bruno, L Raffaghello, M Occhino, C Gambini, V Pistoia & M V Corrias. (2003) Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40+ neuroblastoma cells undergo apoptosis following interaction with CD40L. British Journal of Cancer 88:10, pages 1527-1536.
Crossref
Jalal Ahmed Choudhury, Clare L. Russell, Satinder Randhawa, Lawrence S. Young, David H. Adams & Simon C. Afford. (2003) Differential Induction of Nuclear Factor-κB and Activator Protein-1 Activity after CD40 Ligation Is Associated with Primary Human Hepatocyte Apoptosis or Intrahepatic Endothelial Cell Proliferation. Molecular Biology of the Cell 14:4, pages 1334-1345.
Crossref
Pauline G. Knox, Anne E. Milner, Nicky K. Green, Aristides G. Eliopoulos & Lawrence S. Young. (2003) Inhibition of Metalloproteinase Cleavage Enhances the Cytotoxicity of Fas Ligand. The Journal of Immunology 170:2, pages 677-685.
Crossref
Masafumi Nakayama, Kazumi Ishidoh, Yuko Kojima, Norihiro Harada, Eiki Kominami, Ko Okumura & Hideo Yagita. (2003) Fibroblast Growth Factor-Inducible 14 Mediates Multiple Pathways of TWEAK-Induced Cell Death. The Journal of Immunology 170:1, pages 341-348.
Crossref
H Wajant, K Pfizenmaier & P Scheurich. (2003) Tumor necrosis factor signaling. Cell Death & Differentiation 10:1, pages 45-65.
Crossref
Ngan Lam & Bill Sugden. (2003) CD40 and its viral mimic, LMP1: similar means to different ends. Cellular Signalling 15:1, pages 9-16.
Crossref
Aymen Al-Shamkhani, Martin J. Glennie & Mark S. Cragg. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 319 322 .
M. Ohlsson, P. Szodoray, L. L. Loro, A. C. Johannessen & R. Jonsson. (2002) CD40, CD154, Bax and Bcl -2 Expression in Sjögren's Syndrome Salivary Glands: a Putative Anti-Apoptotic Role During its Effector Phases . Scandinavian Journal of Immunology 56:6, pages 561-571.
Crossref
Fabrice Bureau, Grégory Seumois, Fabrice Jaspar, Alain Vanderplasschen, Bruno Detry, Paul-Pierre Pastoret, Renaud Louis & Pierre Lekeux. (2002) CD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 expression: Possible involvement in allergic inflammation. Journal of Allergy and Clinical Immunology 110:3, pages 443-449.
Crossref
Benedetta Bussolati, Simona Russo, Ilaria Deambrosis, Vincenzo Cantaluppi, Alessandro Volpe, Ugo Ferrando & Giovanni Camussi. (2002) Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. International Journal of Cancer 100:6, pages 654-661.
Crossref
Anita ChallaAristides G. EliopoulosMichelle J. HolderAlondra Schweizer BurgueteJohn D. PoundAnita ChambaGillian GraftonRichard J. ArmitageChristopher D. GregoryHector Martinez-ValdezLawrence YoungJohn Gordon. (2002) Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells. Blood 99:9, pages 3411-3418.
Crossref
A E Milner, D H Palmer, E A Hodgkin, A G Eliopoulos, P G Knox, C J Poole, D J Kerr & L S Young. (2002) Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells. Cell Death & Differentiation 9:3, pages 287-300.
Crossref
Masafumi Nakayama, Kazumi Ishidoh, Nobuhiko Kayagaki, Yuko Kojima, Noriko Yamaguchi, Hiroyasu Nakano, Eiki Kominami, Ko Okumura & Hideo Yagita. (2002) Multiple Pathways of TWEAK-Induced Cell Death. The Journal of Immunology 168:2, pages 734-743.
Crossref
Anja M. Mehl, Matthew Jones, Martin Rowe & Paul Brennan. (2001) Characterization of a CD40-Dominant Inhibitory Receptor Mutant. The Journal of Immunology 167:11, pages 6388-6393.
Crossref
SIMON C. AFFORD, JALAL AHMED-CHOUDHURY, SATINDER RANDHAWA, CLARE RUSSELL, JANINE YOUSTER, HEATHER A. CROSBY, ARISTIDES ELIOPOULOS, STEFAN G. HUBSCHER, LAWRENCE S. YOUNG & DAVID H. ADAMS. (2001) CD40 activation‐induced, Fas‐dependent apoptosis and NF‐κB/AP‐1 signaling in human intrahepatic biliary epithelial cells. The FASEB Journal 15:13, pages 2345-2354.
Crossref
Robert H. VonderheideJanice P. DutcherJeanne E. AndersonS. Gail EckhardtKatherine F. StephansBetty RazvillasSusan GarlMichael D. ButineVicki P. PerryRichard J. ArmitageRichard GhalieDania A. CaronJohn G. Gribben. (2001) Phase I Study of Recombinant Human CD40 Ligand in Cancer Patients. Journal of Clinical Oncology 19:13, pages 3280-3287.
Crossref
Rakesh K. Srivastava. (2001) TRAIL/Apo-2L: Mechanisms and Clinical Applications in Cancer. Neoplasia 3:6, pages 535-546.
Crossref

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