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Cell Growth and Development

CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily

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Pages 5503-5515 | Received 15 Dec 1999, Accepted 08 May 2000, Published online: 28 Mar 2023

REFERENCES

  • Afford, S. C., Randhawa, S., Eliopoulos, A. G., Hubscher, S. G., Young, L. S., and Adams, D. H.. 1999. CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface Fas ligand expression and amplifies Fas-mediated hepatocyte death during allograft rejection. J. Exp. Med. 189:441–446
  • Baker, M. P., Eliopoulos, A. G., Young, L. S., Armitage, R. J., Gregory, C. D., and Gordon, J.. 1998. Prolonged phenotypic, functional and molecular changes in group I Burkitt lymphoma cells on short term exposure to CD40 ligand. Blood 92:2830–2843
  • Barkett, M., and Gilmore, T. D.. 1999. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18:6910–6924
  • Blake, N., Lee, S., Redchenko, I., Thomas, W., Steven, N., Leese, A., Steigerwald-Mullen, P., Kurilla, M. G., Frappier, L., and Rickinson, A. B.. 1997. Human CD8(+) T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing. Immunity 7:791–802
  • Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E.. 1999. Akt promotes cell survival by phosphorylating and inhibiting a forkead transcription factor. Cell 96:857–868
  • Callard, R. E., Armitage, R. J., Fanslow, W. C., and Spriggs, M. K.. 1993. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol. Today 14:559–564
  • Cheng, G., and Baltimore, D.. 1996. TANK, a co-inducer with TRAF2 of TNF- and CD40L-mediated NF-κB activation. Genes Dev. 10:963–973
  • Cheng, J. Q., Godwin, A. K., Ballacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N., and Testa, J. R.. 1992. Akt2, a putative oncogene encoding a member of a subfamily of protein serine threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. USA 89:9267–9271
  • Chinnaiyan, A. M., O'Rourk, K., Tewari, M., and Dixit, V. M.. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505–512
  • Choi, M. S. K., Boise, L. H., Gottschalk, A. R., Quintans, J., Thompson, C. B., and Klaus, G. G. B.. 1995. The role of Bcl-x(L) in CD40-mediated rescue from anti-Mu-induced apoptosis in WEHI-231 B-cell lymphoma cells. Eur. J. Immunol. 25:1352–1357
  • Clark, E. A., and Shu, G.. 1990. Association between IL-6 and CD40 signalling: IL-6 induces phosphorylation of CD40 receptors. J. Immunol. 145:1400–1406
  • Cleveland, J. L., and Ihle, J. N.. 1995. Contenders in FasL/TNF death signalling. Cell 81:479–482
  • Courtois, G., Whiteside, S. T., Sibley, C. H., and Israel, A.. 1997. Characterization of a mutant cell line that does not activate NF-κB in response to multiple stimuli. Mol. Cell. Biol. 17:1441–1449
  • Devergne, O., Hatzivassiliou, E., Izumi, K. M., Kaye, K. M., Kleijner, M., Kieff, E., and Mosialos, G.. 1996. TRAF1, TRAF2 and TRAF3 effect NF-κB activation by an Epstein-Barr Virus LMP1 domain important for B lymphocyte transformation. Mol. Cell. Biol. 16:7098–7108
  • Eliopoulos, A. G., Dawson, C. W., Mosialos, G., Floettmann, J. E., Rowe, M., Armitage, R. J., Dawson, J., Zapata, J. M., Kerr, D. J., Wakelam, M. J. O., Reed, J. C., Kieff, E., and Young, L. S.. 1996. CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene 13:2243–2254
  • Eliopoulos, A. G., Gallagher, N. J., Blake, S. M. S., Dawson, C. W., and Young, L. S.. 1999. Activation of the p38 MAPK pathway by Epstein-Barr virus encoded latent membrane protein 1 (LMP1) co-regulates interleukin-6 and interleukin-8 production. J. Biol. Chem. 274:16085–16096
  • Eliopoulos, A. G., Kerr, D. J., Herod, J., Hodgkin, L., Krajewski, S., Reed, J. C., and Young, L. S.. 1995. The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and bcl-2. Oncogene 11:1217–1228
  • Eliopoulos, A. G., Stack, M., Dawson, C. W., Kaye, K. M., Hodgkin, L., Sihota, S., Rowe, M., and Young, L. S.. 1997. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors. Oncogene 14:2899–2916
  • Eliopoulos, A. G., and Young, L. S.. 1998. Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 16:1731–1742
  • Fanslow, W. C., Srinivasan, S. P., Gibson, R. M. G., Spriggs, M. K., and Armitage, R. J.. 1994. Structural characteristics of CD40 ligand that determine biological function. Semin. Immunol. 6:267–278
  • Friesen, C., Herr, I., Krammer, P. H., and Debatin, K. M.. 1996. Involvement of the CD95 (Apo-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2:574–577
  • Funakoshi, S., Longo, D. L., Beckwith, M., Conley, D. K., Tsarfaty, G., Tsarfaty, I., Armitage, R. J., Fanslow, W. C., Spriggs, M. K., and Murphy, W. J.. 1994. Inhibition of B-cell lymphoma growth by CD40 stimulation. Blood 83:2787–2794
  • Garrone, P., Neidhardt, E.-M., Garcia, E., Galibert, L., van Kooten, C., and Banchereau, J.. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265–1273
  • Gilligan, M. G., Knox, P., Weedon, S., Barton, R., Kerr, D. J., Searle, P., and Young, L. S.. 1998. Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells. Gene Ther. 5:965–974
  • Goldstein, M. D., and Watts, T. H.. 1996. Identification of distinct domains in CD40 involved in B7.1 induction or growth inhibition. J. Immunol. 157:2837–2843
  • Gordon, J.. 1995. CD40 and its ligand: central players in B lymphocyte survival, growth and differentiation. Blood Rev. 9:53–56
  • Grell, M., Zimmermann, G., Gottfried, E., Chen, C.-M., Grunwald, U., Huang, D. C. S., Lee, Y.-H. W., Durkop, H., Engelmann, H., Scheurich, P., Wajant, H., and Strasser, A.. 1999. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J. 18:3034–3043
  • Grimm, S., Bauer, M. K. A., Baeuerle, P. A., and Schulze-Osthoff, K.. 1996. Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J. Cell Biol. 134:13–23
  • Hanissian, S. H., and Geha, R. S.. 1997. JAK3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 6:379–387
  • Hayward, A. R., Levy, J., Facchetti, F., Notarangelo, L., Ochs, H. D., Etzioni, A., Bonnefoy, J.-Y., Cosyns, M., and Weinberg, A.. 1997. Cholangiopathy and tumours of the pancreas, liver and biliary tree in boys with X-linked immunodeficiency with hyper-IgM. J. Immunol. 158:977–983
  • Hess, S., and Engelmann, H.. 1996. A novel function of CD40: induction of cell death in transformed cells. J. Exp. Med. 183:159–167
  • Hirano, A., Longo, D. L., Taub, D. D., Ferris, D. K., Young, L. S., Eliopoulos, A. G., Agathanggelou, A., Cullen, N., Macartney, J., Fanslow, W. C., and Murphy, W. J.. 1999. Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand. Blood 93:2999–3007
  • Hostager, B. S., Hsing, Y., Harms, D. E., and Bishop, G. A.. 1996. Different CD40-mediated signalling events require distinct CD40 structural features. J. Immunol. 157:1047–1053
  • Hueber, A.-O., Zornig, M., Lyon, D., Suda, T., Nagata, S., and Evan, G. I.. 1997. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science 278:1305–1309
  • Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., Yamamoto, T., and Inoue, J.. 1996. Identification of TRAF6, a novel tumour necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 271:28745–28748
  • Jaattela, M., Benedict, M., Tewari, M., Shayman, J. A., and Dixit, V. M.. 1995. Bcl-x and bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 10:2297–2305
  • Kashiwada, M., Shirakata, Y., Inoue, J.-I., Nakano, H., Okazaki, K., Okumura, K., Yamamoto, T., Nagaoka, H., and Takemori, T.. 1998. Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signalling along a Ras-independent pathway. J. Exp. Med. 187:237–244
  • Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., and Green, D. R.. 1998. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell 1:543–551
  • Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., and Kikutani, H.. 1994. The immune responses in CD40 deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167–178
  • Kawahara, A., Kobayashi, T., and Nagata, S.. 1998. Inhibition of Fas-induced apoptosis by Bcl-2. Oncogene 17:2549–2554
  • Kiener, P. A., Davis, P. M., Rankin, B. M., Klebanoff, S. J., Ledbetter, J. A., Starling, G. C., and Liles, W. C.. 1997. Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation. J. Immunol. 159:1594–1598
  • Lee, H. H., Dadgostar, H., Cheng, Q., Shu, J., and Cheng, G.. 1999. NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signalling in B lymphocytes. Proc. Natl. Acad. Sci. USA 96:9136–9141
  • Lee, H. H., Dempsey, P. W., Parks, T. P., Zhu, X., Baltimore, D., and Cheng, G.. 1999. Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-κB activation and intercellular adhesion molecule-1 up-regulation. Proc. Natl. Acad. Sci. USA 96:1421–1426
  • Lee, S. Y., Reichlin, A., Santana, A., Sokol, K. A., Nussenzweig, M. C., and Choi, Y.. 1997. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 7:703–713
  • Lin, B., Williams-Skipp, C., Tao, Y., Schleicher, M. S., Cano, L. L., Duke, R. C., and Scheinman, R. I.. 1999. NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ. 6:570–582
  • Mapara, M. Y., Bargou, R., Zugck, C., Dohner, H., Ustaoglou, F., Jonker, R. R., Krammer, P. H., and Dorken, B.. 1993. APO-1 mediated apoptosis or proliferation in human chronic B-lymphocytic leukemia—correlation with bcl-2 oncogene expression. Eur. J. Immunol. 23:702–708
  • Martinez-Lorenzo, M. J., Alava, M. A., Gamen, S., Kim, K. J., Chuntharapai, A., Pineiro, A., Naval, J., and Anel, A.. 1998. Involvement of Apo2 ligand/TRAIL in activation induced death in Jurkat and human peripheral blood T cells. Eur. J. Immunol. 28:2714–2725
  • McCarthy, J. V., Ni, J., and Dixit, V. M.. 1998. RIP2 is a novel NF-κB-activating and cell death-inducing kinase. J. Biol. Chem. 273:16968–16975
  • McGrory, W. J., Bautista, D. S., and Graham, F. L.. 1988. A simple technique for the rescue of early region-1 mutations into infectious human adenovirus type-5. Virol. 163:614–617
  • McWhirter, S. M., Pullen, S. S., Holton, J. M., Crute, J. J., Kehry, M. R., and Alber, T.. 1999. Crystallographic analysis of CD40 recognition and signaling by human TRAF2. Proc. Natl. Acad. Sci. USA 96:8408–8413
  • Miura, M., Friedlander, R. M., and Yuan, J.. 1995. Tumor necrosis factor-induced apoptosis is mediated by a crmA-sensitive cell death pathway. Proc. Natl. Acad. Sci. USA 92:8318–8322
  • Morris, A. E., Remmele, R. L., Klinke, R., Macduff, B. M., Fanslow, W. C., and Armitage, R. J.. 1999. Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L (CD154). J. Biol. Chem. 274:418–423
  • Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., and Levrerop, M.. 1997. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 275:200–203
  • Noelle, R. J.. 1996. CD40 and its ligand in host defense. Immunity 4:415–419
  • Peguet-Navarro, J., Dalbiez-Gauthier, C., Moulon, C., Berthier, O., Reano, A., Gaucherand, M., Banchereau, J., Rousset, F., and Schmitt, D.. 1997. CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation. J. Immunol. 158:144–152
  • Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., and Ashkenazi, A.. 1996. Induction of apoptosis by Apo-2 ligand, a new member of the tumour necrosis factor cytokine family. J. Biol. Chem. 271:12687–12690
  • Ren, C. L., Morio, T., Fu, S. F., and Geha, R. S.. 1994. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase and phosphorylation of phospholipase Cγ2. J. Exp. Med. 179:673–680
  • Rothe, M., Sarma, V., Dixit, V. M., and Goeddel, D. V.. 1995. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424–1427
  • Rothstein, T. L., Wang, J. K. M., Panka, D. J., Foote, L. C., Wang, Z., Stanger, B., Cui, H., Ju, S., and Marshak-Rothstein, A.. 1995. Protection against Fas-dependent Th-1-mediated apoptosis by antigen receptor engagement in B cells. Nature (London) 374:163–165
  • Rytomaa, M., Martins, L. M., and Downward, J.. 1999. Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Curr. Biol. 9:1043–1046
  • Sakata, N., Patel, H. R., Terada, N., Aruffo, A., Johnson, G. L., and Gelfand, E. W.. 1995. Selective activation of c-Jun kinase-activated protein kinase by CD40 on human B cells. J. Biol. Chem. 270:30823–30828
  • Sarma, V., Lin, Z., Clark, L., Rust, B. M., Tewari, M., Noelle, R. J., and Dixit, V. M.. 1995. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc-finger protein that inhibits apoptosis. J. Biol. Chem. 270:12343–12346
  • Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K.-M., Krammer, P. H., and Peter, M. E.. 1998. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17:1675–1687
  • Smith, C. A., Farrah, T., and Goodwin, R. G.. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation and death. Cell 76:959–962
  • Tewari, M., and Dixit, V. M.. 1995. Fas- and tumour necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270:3255–3260
  • Tsukamoto, N., Kobayashi, N., Azuma, S., Yamamoto, T., and Inoue, J.-I.. 1999. Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40. Proc. Natl. Acad. Sci. USA 96:1234–1239
  • VanArsdale, T. L., VanArsdale, S. L., Force, W. R., Walter, B. N., Mosialos, G., Kieff, E., Reed, J. C., and Ware, C. F.. 1997. Lymphotoxin-b receptor signalling complex: role of tumour necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB. Proc. Natl. Acad. Sci. USA 94:2460–2465
  • Wang, C.-Y., Mayo, M. W., Baldwin, A. S.Jr.. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784–787
  • Wang, C.-Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., and Baldwin, A. S.. 1998. NF-κB anti-apoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP1 to suppress caspase-8 activation. Science 281:1680–1683
  • Wilkinson, G. W. G., and Akrigg, A.. 1992. Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucleic Acids Res. 20:2233–2239
  • Wood, K. M., Roff, M., and Hay, R. T.. 1998. Defective IkBa in Hodgkin cell lines with constitutively active NF-κB. Oncogene 16:2131–2139
  • Xu, J., Foy, T. M., Laman, J. D., Elliot, E. A., Dun, J. J., Waldscmidt, T. J., Elsemore, J., Noelle, R. J., and Flavell, R. A.. 1994. Mice deficient for the CD40 ligand. Immunity 1:423–431
  • Younes, A., Snell, V., Consoli, U., Clodi, K., Zhao, S., Palmer, J. L., Thomas, E. K., Armitage, R. J., and Andreff, M.. 1998. Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia. Br. J. Haematol. 100:135–141
  • Young, L. S., Dawson, C. W., Brown, K. W., and Rickinson, A. B.. 1989. Identification of a human epithelial cell surface protein sharing an epitope with C3d/Epstein-Barr virus receptor molecule of B lymphocytes. Int. J. Cancer 43:786–794
  • Young, L. S., Eliopoulos, A. G., Gallagher, N. J., and Dawson, C. W.. 1998. CD40 and epithelial cells: across the great divide. Immunol. Today 19:502–505

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